Regorafenib Pathway, Pharmacokinetics
Pathways in the Regorafenib Pathway, Pharmacokinetics SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Regorafenib Pathway, Pharmacokinetics | PharmGKB |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | UGT1A9 | UDP Glucuronosyltransferase Family 1 Member A9 | Protein Coding | 1 |
| 2 | CYP2J2 | Cytochrome P450 Family 2 Subfamily J Member 2 | Protein Coding | 1 |
| 3 | CYP3A4 | Cytochrome P450 Family 3 Subfamily A Member 4 | Protein Coding | 1 |
| 4 | ADH1A | Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide | Protein Coding | 1 |
Disorders associated with Regorafenib Pathway, Pharmacokinetics SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Vitamin d-dependent rickets, type 3 | Enrichment | CYP3A4 | 3.53 |
| 2 | Crigler-najjar syndrome, type i | Enrichment | UGT1A9 | 2.53 |
| 3 | Hyperbilirubinemia, transient familial neonatal | Enrichment | UGT1A9 | 2.53 |
| 4 | Bilirubin, serum level of, quantitative trait locus 1 | Enrichment | UGT1A9 | 2.53 |
| 5 | Crigler-najjar syndrome, type ii | Enrichment | UGT1A9 | 2.53 |
| 6 | Gilbert syndrome | Enrichment | UGT1A9 | 2.49 |
| 7 | Bilirubin metabolic disorder | Enrichment | UGT1A9 | 2.49 |
