Regulated Necrosis

Pathway network for the Regulated Necrosis SuperPath

Sources:

Reactome

Pathways in the Regulated Necrosis SuperPath

#	Name	Source	Genes
1	Regulated Necrosis	Reactome	BIRC2 BIRC3 CASP1 CASP4 CASP5 CASP8 CDC37 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 ELANE FADD GSDMD GSDME HMGB1 HSP90AA1 IL18 IL1A IL1B IRF1 IRF2 ITCH PELI1 PRKN RIPK1 RIPK3 RNF103-CHMP3 RPS27A STUB1 TP53 TRAF2 UBA52 UBB UBC UBE2L3 (see all 40) (see less)
2	Pyroptosis	Reactome	CASP1 CASP4 CASP5 CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP6 CHMP7 ELANE GSDMD GSDME HMGB1 IL18 IL1A IL1B IRF1 IRF2 RNF103-CHMP3 TP53 (see all 22) (see less)
3	RIPK1-mediated regulated necrosis	Reactome	BIRC2 BIRC3 CASP8 CDC37 FADD HSP90AA1 ITCH PELI1 PRKN RIPK1 RIPK3 RPS27A STUB1 TRAF2 UBA52 UBB UBC UBE2L3 (see all 18) (see less)
4	Regulation of necroptotic cell death	Reactome	BIRC2 BIRC3 CASP8 CDC37 FADD HSP90AA1 ITCH PELI1 PRKN RIPK1 RIPK3 RPS27A STUB1 TRAF2 UBA52 UBB UBC UBE2L3 (see all 18) (see less)

Gene overlap in member pathways for Regulated Necrosis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	3
2	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	3
3	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	3
4	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	3
5	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	3
6	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	3
7	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	3
8	PELI1	Pellino E3 Ubiquitin Protein Ligase 1	Protein Coding	3
9	RPS27A	Ribosomal Protein S27a	Protein Coding	3
10	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	3
11	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
12	UBB	Ubiquitin B	Protein Coding	3
13	UBC	Ubiquitin C	Protein Coding	3
14	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	3
15	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	3
16	CASP8	Caspase 8	Protein Coding	3
17	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	3
18	FADD	Fas Associated Via Death Domain	Protein Coding	3
19	RNF103-CHMP3	RNF103-CHMP3 Readthrough	Protein Coding	2
20	CHMP4B	Charged Multivesicular Body Protein 4B	Protein Coding	2
21	GSDME	Gasdermin E	Protein Coding	2
22	ELANE	Elastase, Neutrophil Expressed	Protein Coding	2
23	CHMP2B	Charged Multivesicular Body Protein 2B	Protein Coding	2
24	CHMP2A	Charged Multivesicular Body Protein 2A	Protein Coding	2
25	CHMP4A	Charged Multivesicular Body Protein 4A	Protein Coding	2
26	HMGB1	High Mobility Group Box 1	Protein Coding	2
27	IL1A	Interleukin 1 Alpha	Protein Coding	2
28	IL1B	Interleukin 1 Beta	Protein Coding	2
29	IL18	Interleukin 18	Protein Coding	2
30	IRF1	Interferon Regulatory Factor 1	Protein Coding	2
31	IRF2	Interferon Regulatory Factor 2	Protein Coding	2
32	CHMP3	Charged Multivesicular Body Protein 3	Protein Coding	2
33	TP53	Tumor Protein P53	Protein Coding	2
34	CHMP6	Charged Multivesicular Body Protein 6	Protein Coding	2
35	GSDMD	Gasdermin D	Protein Coding	2
36	CASP1	Caspase 1	Protein Coding	2
37	CASP4	Caspase 4	Protein Coding	2
38	CASP5	Caspase 5	Protein Coding	2
39	CHMP7	Charged Multivesicular Body Protein 7	Protein Coding	2
40	CHMP4C	Charged Multivesicular Body Protein 4C	Protein Coding	2

Disorders associated with Regulated Necrosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Gastric cancer	Enrichment	IL1B, IRF1, TP53	4.36
2	Lung cancer	Enrichment	CASP8, IRF1, PRKN	3.95
3	Adult hepatocellular carcinoma	Enrichment	CASP8, TP53	3.52
4	Lung cancer susceptibility 3	Enrichment	PRKN, TP53	3.12
5	Caspase 8 deficiency	Enrichment	CASP8	2.88
6	Leprosy 2	Enrichment	PRKN	2.88
7	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.88
8	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.88
9	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.88
10	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.88
11	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.79
12	Cataract 31, multiple types	Enrichment	CHMP4B	2.79
13	Bone marrow failure syndrome 5	Enrichment	TP53	2.79
14	Papilloma of choroid plexus	Enrichment	TP53	2.79
15	Basal cell carcinoma 7	Enrichment	TP53	2.79
16	Anaplastic thyroid carcinoma	Enrichment	TP53	2.79
17	Deafness, autosomal dominant 5	Enrichment	GSDME	2.79
18	Ductal carcinoma in situ	Enrichment	TP53	2.79
19	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.79
20	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.79
21	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.79
22	Choroid plexus cancer	Enrichment	TP53	2.79
23	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.79
24	Hepatocellular carcinoma	Enrichment	CASP8, TP53	2.72
25	Parkinson disease 12	Enrichment	PRKN	2.58
26	Spinocerebellar ataxia 48	Enrichment	STUB1	2.58
27	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.58
28	Oculootodental syndrome	Enrichment	FADD	2.58
29	Submucosal cleft palate	Enrichment	UBB	2.58
30	Cleft hard palate	Enrichment	UBB	2.58
31	Cyclic neutropenia	Enrichment	ELANE	2.49
32	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.49
33	Neutropenia, severe congenital, x-linked	Enrichment	ELANE	2.49
34	Cervical cancer	Enrichment	TP53	2.49
35	Lymphoma, hodgkin, classic	Enrichment	TP53	2.49
36	Congenital fibrosarcoma	Enrichment	TP53	2.49
37	Li-fraumeni syndrome 1	Enrichment	TP53	2.49
38	Sarcoma	Enrichment	TP53	2.49
39	Cervix carcinoma	Enrichment	TP53	2.49
40	Hodgkin's lymphoma	Enrichment	TP53	2.49
41	Immunodeficiency 117	Enrichment	IRF1	2.49
42	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.49
43	Uvula, bifid	Enrichment	UBB	2.40
44	Cleft soft palate	Enrichment	UBB	2.40
45	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	ELANE	2.31
46	Osteogenic sarcoma	Enrichment	TP53	2.31
47	Nasopharyngeal carcinoma	Enrichment	TP53	2.31
48	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.31
49	Anaplastic astrocytoma	Enrichment	TP53	2.31
50	Squamous cell carcinoma	Enrichment	TP53	2.31
51	Adenocarcinoma	Enrichment	TP53	2.31
52	Bone osteosarcoma	Enrichment	TP53	2.31
53	Complex hereditary spastic paraplegia	Enrichment	PRKN	2.28
54	Small cell cancer of the lung	Enrichment	TP53	2.19
55	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.19
56	Lung sarcomatoid carcinoma	Enrichment	TP53	2.19
57	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.19
58	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	2.18
59	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	2.18
60	Parkin type of early-onset parkinson disease	Enrichment	PRKN	2.18
61	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.10
62	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	2.10
63	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.10
64	Cataract 6, multiple types	Enrichment	CHMP4B	2.09
65	Rhabdomyosarcoma 2	Enrichment	TP53	2.09
66	Lymphoma	Enrichment	TP53	2.09
67	Acute megakaryocytic leukemia	Enrichment	TP53	2.09
68	Autosomal dominant severe congenital neutropenia	Enrichment	ELANE	2.09
69	Li-fraumeni syndrome	Enrichment	TP53	2.01
70	Adrenocortical carcinoma	Enrichment	TP53	2.01
71	Breast adenocarcinoma	Enrichment	TP53	2.01
72	Esophageal cancer	Enrichment	TP53	1.95
73	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.95
74	Semantic dementia	Enrichment	CHMP2B	1.95
75	Neutropenia	Enrichment	ELANE	1.95
76	Essential thrombocythemia	Enrichment	TP53	1.95
77	Gallbladder cancer	Enrichment	TP53	1.95
78	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.95
79	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1, TP53	1.94
80	Glioma susceptibility 1	Enrichment	TP53	1.89
81	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.89
82	Early-onset posterior polar cataract	Enrichment	CHMP4B	1.89
83	Immune deficiency disease	Enrichment	RIPK1	1.84
84	Progressive non-fluent aphasia	Enrichment	CHMP2B	1.84
85	Primary hyperaldosteronism	Enrichment	TP53	1.84
86	Behavioral variant of frontotemporal dementia	Enrichment	CHMP2B	1.84
87	Early-onset parkinson's disease	Enrichment	PRKN	1.80
88	Leukemia, chronic lymphocytic	Enrichment	TP53	1.79
89	Familial colorectal cancer	Enrichment	TP53	1.79
90	Myelodysplastic syndrome	Enrichment	TP53	1.75
91	Lung non-small cell carcinoma	Enrichment	IRF1	1.75
92	Lip and oral cavity carcinoma	Enrichment	TP53	1.71
93	Breast cancer	Enrichment	CASP8, TP53	1.69
94	Parkinson's disease	Enrichment	PRKN	1.60
95	Rhabdomyosarcoma	Enrichment	TP53	1.59
96	Gliosarcoma	Enrichment	TP53	1.59
97	Giant cell glioblastoma	Enrichment	TP53	1.56
98	Diffuse large b-cell lymphoma	Enrichment	TP53	1.52
99	Parkinson disease, late-onset	Enrichment	PRKN	1.50
100	Hepatoblastoma	Enrichment	TP53	1.47
101	Ovarian cancer	Enrichment	PRKN, TP53	1.45
102	Diamond-blackfan anemia 1	Enrichment	TP53	1.44
103	Autoinflammatory disease	Enrichment	ELANE	1.42
104	Pancreatic cancer	Enrichment	TP53	1.40
105	Bladder cancer	Enrichment	TP53	1.34
106	Prostate cancer	Enrichment	TP53	1.34
107	Systemic lupus erythematosus	Enrichment	UBE2L3	1.30
108	Diamond-blackfan anemia	Enrichment	TP53	1.25
109	Leukemia, acute myeloid	Enrichment	TP53	1.20
110	Hereditary breast carcinoma	Enrichment	TP53	1.16
111	Schizophrenia	Enrichment	PRKN	1.12
112	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	GSDME	1.09
113	Myeloma, multiple	Enrichment	TP53	1.06
114	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CHMP2B	1.05
115	Autism	Enrichment	PRKN	1.04
116	Rare genetic deafness	Enrichment	GSDME	0.92
117	Colorectal cancer	Enrichment	TP53	0.88
118	Autism spectrum disorder	Enrichment	PRKN	0.87
119	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulated Necrosis

Pathway Network for Regulated Necrosis

Pathway network for the Regulated Necrosis SuperPath

Member Pathways for Regulated Necrosis

Pathways in the Regulated Necrosis SuperPath

Gene overlap in member pathways for Regulated Necrosis SuperPath

Associated Genes for Regulated Necrosis

Associated Disorders for Regulated Necrosis

Disorders associated with Regulated Necrosis SuperPath

STRING Interaction Network for Regulated Necrosis

Sources for Regulated Necrosis