Regulation by c-FLIP

Sources:

#	Name	Source	Genes
1	Regulation by c-FLIP	Reactome	CASP8 FADD RIPK1 TRAF2
2	Dimerization of procaspase-8	Reactome	CASP8 FADD RIPK1 TRAF2
3	CASP8 activity is inhibited	Reactome	CASP8 FADD RIPK1 TRAF2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	3
2	CASP8	Caspase 8	Protein Coding	3
3	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	3
4	FADD	Fas Associated Via Death Domain	Protein Coding	3

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Caspase 8 deficiency	Enrichment	CASP8	3.53
2	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	3.53
3	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	3.53
4	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	3.23
5	Oculootodental syndrome	Enrichment	FADD	3.23
6	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.75
7	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.75
8	Adult hepatocellular carcinoma	Enrichment	CASP8	2.58
9	Immune deficiency disease	Enrichment	RIPK1	2.49
10	Hepatocellular carcinoma	Enrichment	CASP8	2.19
11	Lung cancer	Enrichment	CASP8	2.03
12	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.79
13	Breast cancer	Enrichment	CASP8	1.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Regulation by c-FLIP