Regulation of actin cytoskeleton

No Pathway Network information available for Regulation of actin cytoskeleton

Pathways in the Regulation of actin cytoskeleton SuperPath

#	Name	Source	Genes
1	Regulation of actin cytoskeleton	WikiPathways	ABI2 ACTB ACTG1 ACTN1 APC APC2 ARHGAP35 ARHGEF1 ARHGEF4 ARHGEF6 ARHGEF7 ARPC5 BAIAP2 BCAR1 BDKRB1 BDKRB2 BRAF BRK1 CD14 CDC42 CFL1 CFL2 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 CRK CSK CYFIP2 DIAPH1 DIAPH3 DOCK1 EGF EGFR ENAH EZR F2 F2R FGD1 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FN1 GIT1 GNA12 GNA13 GNG12 GSN IQGAP1 ITGA1 KRAS LIMK1 MAP2K1 MAP2K2 MAPK1 MAPK3 MAPK4 MAPK6 MOS MRAS MSN MYH10 MYL1 MYL3 MYLK NCKAP1 NRAS PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PDGFA PDGFB PDGFRA PDGFRB PFN1 PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIP5KL1 PPP1R12A PTK2 PXN RAC1 RAC1P2 RAC1P4 RAC2 RAC3 RAF1 RASSF7 RDX RHOA ROCK1 ROCK2 RRAS RRAS2 SLC9A1 SOS1 SOS2 SSH1 SSH2 SSH3 TMSB4X VAV1 VCL VIL1 WAS WASF1 WASF2 (see all 151) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIP4K2B	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta	Protein Coding	1
2	PIP5K1B	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta	Protein Coding	1
3	PIP4K2C	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma	Protein Coding	1
4	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
5	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	1
6	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
7	PIP5KL1	Phosphatidylinositol-4-Phosphate 5-Kinase Like 1	Protein Coding	1
8	LIMK1	LIM Domain Kinase 1	Protein Coding	1
9	CDC42	Cell Division Cycle 42	Protein Coding	1
10	FGF19	Fibroblast Growth Factor 19	Protein Coding	1
11	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
12	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
13	CD14	CD14 Molecule	Protein Coding	1
14	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
15	FGF16	Fibroblast Growth Factor 16	Protein Coding	1
16	FGF17	Fibroblast Growth Factor 17	Protein Coding	1
17	FGF18	Fibroblast Growth Factor 18	Protein Coding	1
18	ACTN1	Actinin Alpha 1	Protein Coding	1
19	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
20	DIAPH3	Diaphanous Related Formin 3	Protein Coding	1
21	FGF23	Fibroblast Growth Factor 23	Protein Coding	1
22	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
23	EZR	Ezrin	Protein Coding	1
24	VIL1	Villin 1	Protein Coding	1
25	VCL	Vinculin	Protein Coding	1
26	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
27	TMSB4X	Thymosin Beta 4 X-Linked	Protein Coding	1
28	ACTG1	Actin Gamma 1	Protein Coding	1
29	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
30	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
31	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
32	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	1
33	BDKRB2	Bradykinin Receptor B2	Protein Coding	1
34	RRAS	RAS Related	Protein Coding	1
35	BDKRB1	Bradykinin Receptor B1	Protein Coding	1
36	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
37	ACTB	Actin Beta	Protein Coding	1
38	RDX	Radixin	Protein Coding	1
39	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
40	RAC3	Rac Family Small GTPase 3	Protein Coding	1
41	RAC2	Rac Family Small GTPase 2	Protein Coding	1
42	RAC1	Rac Family Small GTPase 1	Protein Coding	1
43	PXN	Paxillin	Protein Coding	1
44	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
45	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
46	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
47	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
48	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
49	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
50	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
51	ENAH	ENAH Actin Regulator	Protein Coding	1
52	PIP4K2A	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Alpha	Protein Coding	1
53	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
54	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
55	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
56	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
57	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
58	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
59	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	1
60	PFN1	Profilin 1	Protein Coding	1
61	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
62	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
63	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
64	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
65	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
66	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
67	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
68	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
69	MYLK	Myosin Light Chain Kinase	Protein Coding	1
70	MYL3	Myosin Light Chain 3	Protein Coding	1
71	MYL1	Myosin Light Chain 1	Protein Coding	1
72	MYH10	Myosin Heavy Chain 10	Protein Coding	1
73	MSN	Moesin	Protein Coding	1
74	RHOA	Ras Homolog Family Member A	Protein Coding	1
75	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
76	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
77	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
78	GSN	Gelsolin	Protein Coding	1
79	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	1
80	GIT1	GIT ArfGAP 1	Protein Coding	1
81	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
82	FGF21	Fibroblast Growth Factor 21	Protein Coding	1
83	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
84	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
85	FN1	Fibronectin 1	Protein Coding	1
86	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
87	RRAS2	RAS Related 2	Protein Coding	1
88	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
89	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
90	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
91	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
92	FGF14	Fibroblast Growth Factor 14	Protein Coding	1
93	FGF13	Fibroblast Growth Factor 13	Protein Coding	1
94	FGF12	Fibroblast Growth Factor 12	Protein Coding	1
95	FGF10	Fibroblast Growth Factor 10	Protein Coding	1
96	FGF9	Fibroblast Growth Factor 9	Protein Coding	1
97	FGF8	Fibroblast Growth Factor 8	Protein Coding	1
98	FGF7	Fibroblast Growth Factor 7	Protein Coding	1
99	FGF6	Fibroblast Growth Factor 6	Protein Coding	1
100	FGF5	Fibroblast Growth Factor 5	Protein Coding	1
101	FGF4	Fibroblast Growth Factor 4	Protein Coding	1
102	FGF3	Fibroblast Growth Factor 3	Protein Coding	1
103	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
104	FGF1	Fibroblast Growth Factor 1	Protein Coding	1
105	FGD1	FYVE, RhoGEF And PH Domain Containing 1	Protein Coding	1
106	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	1
107	F2	Coagulation Factor II, Thrombin	Protein Coding	1
108	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
109	EGF	Epidermal Growth Factor	Protein Coding	1
110	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
111	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
112	CSK	C-Terminal Src Kinase	Protein Coding	1
113	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
114	CHRM5	Cholinergic Receptor Muscarinic 5	Protein Coding	1
115	CHRM4	Cholinergic Receptor Muscarinic 4	Protein Coding	1
116	CHRM3	Cholinergic Receptor Muscarinic 3	Protein Coding	1
117	CHRM2	Cholinergic Receptor Muscarinic 2	Protein Coding	1
118	CHRM1	Cholinergic Receptor Muscarinic 1	Protein Coding	1
119	NCKAP1	NCK Associated Protein 1	Protein Coding	1
120	CFL2	Cofilin 2	Protein Coding	1
121	CFL1	Cofilin 1	Protein Coding	1
122	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
123	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
124	APC2	APC Regulator Of Wnt Signaling Pathway 2	Protein Coding	1
125	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
126	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
127	WASF1	WASP Family Member 1	Protein Coding	1
128	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
129	SSH2	Slingshot Protein Phosphatase 2	Protein Coding	1
130	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
131	BAIAP2	BAR/IMD Domain Containing Adaptor Protein 2	Protein Coding	1
132	WASF2	WASP Family Member 2	Protein Coding	1
133	ABI2	Abl Interactor 2	Protein Coding	1
134	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	1
135	RASSF7	Ras Association Domain Family Member 7	Protein Coding	1
136	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
137	GNG12	G Protein Subunit Gamma 12	Protein Coding	1
138	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	1
139	BRK1	BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex	Protein Coding	1
140	SSH3	Slingshot Protein Phosphatase 3	Protein Coding	1
141	SSH1	Slingshot Protein Phosphatase 1	Protein Coding	1
142	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	1
143	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
144	RAC1P2	Rac Family Small GTPase 1 Pseudogene 2	Pseudogene	1
145	MOS	MOS Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
146	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
147	RAC1P4	Rac Family Small GTPase 1 Pseudogene 4	Pseudogene	1
148	FGF22	Fibroblast Growth Factor 22	Protein Coding	1
149	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	1
150	FGF20	Fibroblast Growth Factor 20	Protein Coding	1
151	FGF11	Fibroblast Growth Factor 11	Protein Coding	1

Disorders associated with Regulation of actin cytoskeleton SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	10.50
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	9.90
4	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, KRAS, MAP2K1, NRAS, PIK3CA	9.12
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	7.83
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	7.83
7	Lung squamous cell carcinoma	Enrichment	EGFR, FGFR3, KRAS, PIK3CA	6.66
8	Nevus, epidermal	Enrichment	FGFR3, KRAS, NRAS, PIK3CA	6.30
9	Pilomyxoid astrocytoma	Enrichment	BRAF, FGFR1, KRAS, RAF1	6.30
10	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2, FGFR3	5.87
11	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	5.87
12	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRA, PDGFRB	4.88
13	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR, FGF10, KRAS	4.87
14	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	4.34
15	Noonan syndrome 3	Enrichment	KRAS, RAF1, SOS1	4.34
16	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	4.34
17	Colorectal cancer	Enrichment	APC, BRAF, FGFR2, FGFR3, NRAS, PIK3CA, PIK3R1	4.29
18	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, NRAS, RAF1	4.14
19	Pulmonic stenosis	Enrichment	BRAF, SOS1	3.91
20	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	3.91
21	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	3.91
22	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	3.91
23	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	3.91
24	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	3.91
25	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	3.91
26	Immune system disease	Enrichment	CDC42, PIK3CD	3.91
27	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	3.91
28	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	3.56
29	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR, PIK3CA	3.56
30	Bladder cancer	Enrichment	EGFR, FGFR3, KRAS, PIK3CA	3.55
31	Crouzon syndrome	Enrichment	FGFR2, FGFR3	3.44
32	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.44
33	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.44
34	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.44
35	Lung cancer	Enrichment	BRAF, EGFR, KRAS, PIK3CA	3.38
36	Gliosarcoma	Enrichment	EGFR, FGFR1, FGFR3	3.17
37	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS, NRAS	3.14
38	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.14
39	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	3.14
40	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.14
41	Craniopharyngioma	Enrichment	APC, BRAF	3.14
42	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.14
43	Giant cell glioblastoma	Enrichment	EGFR, FGFR1, FGFR3	3.09
44	Ovarian cancer	Enrichment	APC, EGFR, KRAS, PDGFRA, PIK3CA, RRAS2	3.04
45	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8, FGFR1	3.01
46	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR, KRAS	2.94
47	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	2.92
48	Holoprosencephaly	Enrichment	FGF8, FGFR1	2.92
49	Gastric cancer	Enrichment	APC, FGFR2, KRAS, PIK3CA	2.89
50	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	2.75
51	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	2.75
52	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	2.75
53	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	2.75
54	Kallmann syndrome	Enrichment	FGF17, FGF8, FGFR1	2.69
55	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, NRAS	2.60
56	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.60
57	Follicular thyroid carcinoma	Enrichment	BRAF, NRAS	2.60
58	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	2.48
59	Myeloma, multiple	Enrichment	BRAF, FGFR3, KRAS, PIK3R2	2.46
60	Differentiated thyroid carcinoma	Enrichment	BRAF, KRAS, NRAS	2.40
61	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	2.38
62	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA	2.38
63	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	2.28
64	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.28
65	Meningioma	Enrichment	PDGFB, PIK3CA	2.12
66	Hypochondroplasia	Enrichment	FGFR3	1.95
67	Macrodactyly	Enrichment	PIK3CA	1.95
68	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	1.95
69	Osteoglophonic dysplasia	Enrichment	FGFR1	1.95
70	Thanatophoric dysplasia, type i	Enrichment	FGFR3	1.95
71	Trigonocephaly 1	Enrichment	FGFR1	1.95
72	Spinocerebellar ataxia 27a	Enrichment	FGF14	1.95
73	Baraitser-winter syndrome 1	Enrichment	ACTB	1.95
74	Oculoectodermal syndrome	Enrichment	KRAS	1.95
75	Muenke syndrome	Enrichment	FGFR3	1.95
76	Thrombocytopenia 1	Enrichment	WAS	1.95
77	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	1.95
78	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	1.95
79	Immunodeficiency 50	Enrichment	MSN	1.95
80	Noonan syndrome 5	Enrichment	RAF1	1.95
81	Hypomagnesemia 4, renal	Enrichment	EGF	1.95
82	Noonan syndrome 4	Enrichment	SOS1	1.95
83	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	1.95
84	Deafness, autosomal recessive 24	Enrichment	RDX	1.95
85	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	1.95
86	Cardiomyopathy, familial hypertrophic, 8	Enrichment	MYL3	1.95
87	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	1.95
88	Melorheostosis, isolated	Enrichment	MAP2K1	1.95
89	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.95
90	Prothrombin deficiency, congenital	Enrichment	F2	1.95
91	Noonan syndrome 7	Enrichment	BRAF	1.95
92	Leopard syndrome 3	Enrichment	BRAF	1.95
93	Apert syndrome	Enrichment	FGFR2	1.95
94	Amyloidosis, finnish type	Enrichment	GSN	1.95
95	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	1.95
96	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	1.95
97	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	1.95
98	Cowden syndrome 5	Enrichment	PIK3CA	1.95
99	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	1.95
100	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	1.95
101	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	1.95
102	Melanosis, neurocutaneous	Enrichment	NRAS	1.95
103	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	1.95
104	Amyotrophic lateral sclerosis 18	Enrichment	PFN1	1.95
105	Noonan syndrome 9	Enrichment	SOS2	1.95
106	Noonan syndrome 6	Enrichment	NRAS	1.95
107	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	1.95
108	Gist-plus syndrome	Enrichment	PDGFRA	1.95
109	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	1.95
110	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	1.95
111	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	1.95
112	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	1.95
113	Immunodeficiency 62	Enrichment	ARHGEF1	1.95
114	Noonan syndrome 11	Enrichment	MRAS	1.95
115	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.95
116	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	1.95
117	Noonan syndrome 13	Enrichment	MAPK1	1.95
118	Intellectual developmental disorder, x-linked 110	Enrichment	FGF13	1.95
119	Spinocerebellar ataxia 27b, late-onset	Enrichment	FGF14	1.95
120	Knobloch syndrome 2	Enrichment	PAK2	1.95
121	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	1.95
122	Cortical dysplasia, complex, with other brain malformations 10	Enrichment	APC2	1.95
123	Short syndrome	Enrichment	PIK3R1	1.95
124	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.95
125	Oocyte/zygote/embryo maturation arrest 20	Enrichment	MOS	1.95
126	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.95
127	Oculoskeletodental syndrome	Enrichment	PIK3C2A	1.95
128	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	1.95
129	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	1.95
130	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	1.95
131	Developmental and epileptic encephalopathy 90	Enrichment	FGF13	1.95
132	Metacarpal 4-5 fusion	Enrichment	FGF16	1.95
133	Intellectual developmental disorder, autosomal recessive 74	Enrichment	APC2	1.95
134	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	1.95
135	Familial isolated trichomegaly	Enrichment	FGF5	1.95
136	Nemaline myopathy 7	Enrichment	CFL2	1.95
137	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	1.95
138	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.95
139	Cardiomyopathy, dilated, 1w	Enrichment	VCL	1.95
140	Lymphangioma	Enrichment	BRAF	1.95
141	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	1.95
142	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.95
143	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.95
144	Phace association	Enrichment	BRAF	1.95
145	Becker nevus syndrome	Enrichment	ACTB	1.95
146	Melorheostosis	Enrichment	MAP2K1	1.95
147	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.95
148	Leopard syndrome 2	Enrichment	RAF1	1.95
149	Multiple synostoses syndrome 3	Enrichment	FGF9	1.95
150	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	1.95
151	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	1.95
152	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.95
153	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	1.95
154	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	1.95
155	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	1.95
156	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	1.95
157	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.95
158	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	1.95
159	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	1.95
160	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	1.95
161	Pregnancy loss, recurrent 2	Enrichment	F2	1.95
162	Kosaki overgrowth syndrome	Enrichment	PDGFRB	1.95
163	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	1.95
164	Hartsfield syndrome	Enrichment	FGFR1	1.95
165	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	1.95
166	Was-related disorders	Enrichment	WAS	1.95
167	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	1.95
168	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.95
169	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.95
170	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	1.95
171	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.95
172	Developmental and epileptic encephalopathy 47	Enrichment	FGF12	1.95
173	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	1.95
174	Congenital myopathy 14	Enrichment	MYL1	1.95
175	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.95
176	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	1.95
177	Trigonitis	Enrichment	RAF1	1.95
178	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.95
179	Sotos syndrome 3	Enrichment	APC2	1.95
180	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	1.95
181	Baraitser-winter syndrome	Enrichment	ACTB	1.95
182	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	1.95
183	Hypospadias	Enrichment	PIK3CA	1.95
184	Prothrombin deficiency	Enrichment	F2	1.95
185	Congenital pulmonary airway malformation	Enrichment	KRAS	1.95
186	Rare venous malformation	Enrichment	PIK3CA	1.95
187	Familial adenomatous polyposis	Enrichment	APC	1.95
188	Spinocerebellar ataxia type 27b	Enrichment	FGF14	1.95
189	Diaphragmatic eventration	Enrichment	PIK3CA	1.95
190	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	1.95
191	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	1.95
192	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.95
193	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	1.95
194	Nocarh syndrome	Enrichment	CDC42	1.95
195	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.95
196	Syringocystadenoma papilliferum	Enrichment	BRAF	1.95
197	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.95
198	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	1.95
199	Rare combined vascular malformation	Enrichment	PIK3CA	1.95
200	Ganglioglioma	Enrichment	BRAF	1.95
201	Cavernous lymphangioma	Enrichment	PIK3CA	1.95
202	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.95
203	Nongerminomatous germ cell tumor	Enrichment	BRAF	1.95
204	Phace syndrome	Enrichment	BRAF	1.95
205	Oculocerebrodental syndrome	Enrichment	PIK3C2A	1.95
206	Gardner syndrome	Enrichment	APC	1.95
207	5q22 microdeletion syndrome	Enrichment	APC	1.95
208	Attenuated familial adenomatous polyposis	Enrichment	APC	1.95
209	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.95
210	Classic hairy cell leukemia	Enrichment	BRAF	1.95
211	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	1.95
212	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.95
213	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.95
214	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	1.95
215	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.95
216	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	1.95
217	Interstitial lung disease specific to childhood	Enrichment	FGF10	1.95
218	Macrodactyly of toe	Enrichment	PIK3CA	1.95
219	Neurocutaneous melanocytosis	Enrichment	NRAS	1.95
220	Temporomandibular joint anomaly	Enrichment	DOCK1	1.95
221	Hydrocephalus	Enrichment	FGFR2, PDGFRB	1.93
222	Lynch syndrome	Enrichment	KRAS, PIK3CA	1.93
223	Microcephaly	Enrichment	ACTB, ACTG1, DIAPH1, MAPK1, PAK3	1.92
224	Hereditary breast carcinoma	Enrichment	APC, KRAS, PIK3CA	1.89
225	Microform holoprosencephaly	Enrichment	FGF8, FGFR1	1.87
226	Lobar holoprosencephaly	Enrichment	FGF8, FGFR1	1.87
227	Dandy-walker syndrome	Enrichment	BRAF, PDGFRB	1.82
228	Semilobar holoprosencephaly	Enrichment	FGF8, FGFR1	1.78
229	Hypertelorism	Enrichment	FGFR2, MYH10, PIK3CA	1.70
230	Craniosynostosis	Enrichment	FGFR2, FGFR3	1.69
231	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.65
232	Fibromatosis, gingival, 1	Enrichment	SOS1	1.65
233	Otodental dysplasia	Enrichment	FGF3	1.65
234	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.65
235	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.65
236	Trichomegaly	Enrichment	FGF5	1.65
237	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.65
238	Pulmonary hypoplasia, primary	Enrichment	FGF10	1.65
239	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	1.65
240	Cervical cancer	Enrichment	FGFR3	1.65
241	Wiskott-aldrich syndrome	Enrichment	WAS	1.65
242	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	1.65
243	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.65
244	Aural atresia, congenital	Enrichment	FGFR2	1.65
245	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.65
246	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	1.65
247	Neutrophilia, hereditary	Enrichment	PIP4K2B	1.65
248	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.65
249	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.65
250	Noonan syndrome 8	Enrichment	PIK3CA	1.65
251	Spermatogenic failure 17	Enrichment	PIK3C2G	1.65
252	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	PIP4K2B	1.65
253	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.65
254	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.65
255	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1	1.65
256	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.65
257	Noonan syndrome 12	Enrichment	RRAS2	1.65
258	Infantile myofibromatosis	Enrichment	PDGFRB	1.65
259	Split hand-foot malformation	Enrichment	FGFR2	1.65
260	Severe congenital neutropenia 7	Enrichment	PIP4K2B	1.65
261	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	1.65
262	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	1.65
263	Periampullary adenoma	Enrichment	APC	1.65
264	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.65
265	Cervix carcinoma	Enrichment	FGFR3	1.65
266	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	PIP4K2A	1.65
267	Aarskog syndrome	Enrichment	FGD1	1.65
268	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.65
269	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.65
270	Chronic eosinophilic leukemia	Enrichment	PDGFRA	1.65
271	Immunodeficiency 133	Enrichment	ARPC5	1.65
272	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	1.65
273	Immunodeficiency 72	Enrichment	NCKAP1	1.65
274	Tafro syndrome	Enrichment	MAP2K2	1.65
275	Oculootodental syndrome	Enrichment	FGF3	1.65
276	Endometrial cancer	Enrichment	FGFR2, PIK3CA	1.65
277	Hepatoblastoma	Enrichment	APC, FGFR3	1.65
278	Undetermined early-onset epileptic encephalopathy	Enrichment	CYFIP2, FGF12, LIMK1	1.61
279	Hepatocellular carcinoma	Enrichment	APC, PIK3CA	1.61
280	Desmoid disease, hereditary	Enrichment	APC	1.48
281	Prune belly syndrome	Enrichment	CHRM3	1.48
282	Achondroplasia	Enrichment	FGFR3	1.48
283	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.48
284	Larsen syndrome	Enrichment	FGFR3	1.48
285	Ataxia-telangiectasia	Enrichment	BRAF	1.48
286	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23	1.48
287	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	1.48
288	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.48
289	Aarskog-scott syndrome	Enrichment	FGD1	1.48
290	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	FGD1	1.48
291	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.48
292	Nuchal bleb, familial	Enrichment	SOS1	1.48
293	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	1.48
294	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.48
295	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.48
296	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.48
297	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	1.48
298	Tethered spinal cord syndrome	Enrichment	BRAF	1.48
299	Large congenital melanocytic nevus	Enrichment	NRAS	1.48
300	Desmoid tumor	Enrichment	APC	1.48
301	Hamartoma	Enrichment	FGFR3	1.48
302	Testicular germ cell cancer	Enrichment	FGFR3	1.48
303	Spermatocytoma	Enrichment	FGFR3	1.48
304	Colon adenocarcinoma	Enrichment	APC	1.48
305	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.48
306	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	FGD1	1.48
307	Testicular cancer	Enrichment	FGFR3	1.48
308	Keratoacanthoma	Enrichment	PIK3CA	1.48
309	Cerebral sinovenous thrombosis	Enrichment	F2	1.48
310	Apc-associated polyposis conditions	Enrichment	APC	1.48
311	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.36
312	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	1.36
313	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.36
314	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.36
315	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.36
316	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.36
317	Aminoacylase 1 deficiency	Enrichment	ACTB	1.36
318	Multiple synostoses syndrome	Enrichment	FGF9	1.36
319	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.36
320	Cerebrovascular disease	Enrichment	PIK3CA	1.36
321	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.36
322	Pilocytic astrocytoma	Enrichment	KRAS	1.36
323	Newborn respiratory distress syndrome	Enrichment	BRAF	1.36
324	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.36
325	Knobloch syndrome	Enrichment	PAK2	1.36
326	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.36
327	Glioma	Enrichment	FGFR2	1.36
328	Gingival fibromatosis	Enrichment	SOS1	1.36
329	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.36
330	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.36
331	Complex neurodevelopmental disorder	Enrichment	MYH10, PAK3, RAC3, WASF1	1.30
332	Breast cancer	Enrichment	APC, KRAS, PIK3CA	1.29
333	Familial hypertrophic cardiomyopathy	Enrichment	MYL3, RAF1	1.28
334	Capillary malformations, congenital	Enrichment	PIK3CA	1.26
335	Sotos syndrome	Enrichment	APC2	1.26
336	Visceral myopathy 1	Enrichment	MYLK	1.26
337	Martsolf syndrome 1	Enrichment	ARHGAP35	1.26
338	Knobloch syndrome 1	Enrichment	PAK2	1.26
339	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	1.26
340	Familial adenomatous polyposis 1	Enrichment	APC	1.26
341	Congenital ptosis	Enrichment	MYH10	1.26
342	Hemimegalencephaly	Enrichment	PIK3CA	1.26
343	Coloboma of choroid and retina	Enrichment	ACTG1	1.26
344	Rare genetic deafness	Enrichment	ACTG1, DIAPH1, RDX	1.24
345	Dilated cardiomyopathy	Enrichment	BRAF, RAF1, VCL	1.22
346	Non-syndromic genetic deafness	Enrichment	ACTG1, RDX	1.22
347	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.19
348	Split-hand/foot malformation 1	Enrichment	FGFR2	1.19
349	Moyamoya disease 1	Enrichment	DIAPH1	1.19
350	Testicular germ cell tumor	Enrichment	FGFR3	1.19
351	Wilms tumor 5	Enrichment	BRAF	1.19
352	Pendred syndrome	Enrichment	DIAPH1	1.19
353	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.19
354	46,xy disorder of sex development	Enrichment	FGFR3	1.19
355	Typical nemaline myopathy	Enrichment	CFL2	1.19
356	Cerebral palsy	Enrichment	F2, PDGFRB	1.16
357	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.14
358	Thrombophilia due to thrombin defect	Enrichment	F2	1.12
359	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.12
360	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.12
361	Overgrowth syndrome	Enrichment	PIK3R1	1.12
362	Hypophosphatemic rickets	Enrichment	FGF23	1.12
363	Nonsyndromic hearing loss	Enrichment	ACTG1, RDX	1.10
364	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.07
365	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	1.07
366	Orofacial cleft 1	Enrichment	FGF10	1.02
367	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.02
368	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	APC2	1.02
369	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.02
370	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.02
371	Primary hyperaldosteronism	Enrichment	BRAF	1.02
372	Ventricular septal defect	Enrichment	BRAF	1.02
373	Colonic benign neoplasm	Enrichment	APC	1.02
374	Cowden syndrome	Enrichment	PIK3CA	1.02
375	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.02
376	Renal agenesis, bilateral	Enrichment	FGF20	1.02
377	Thrombocytopenia	Enrichment	ACTN1, WAS	1.00
378	Cat eye syndrome	Enrichment	ACTG1	0.97
379	Meier-gorlin syndrome 1	Enrichment	FGFR2	0.97
380	Peters-plus syndrome	Enrichment	ARHGAP35	0.97
381	Stroke, ischemic	Enrichment	F2	0.97
382	Melanoma	Enrichment	BRAF	0.97
383	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	0.97
384	Isolated tracheo-esophageal fistula	Enrichment	APC2	0.97
385	Primary bone dysplasia	Enrichment	FGFR3	0.97
386	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, DIAPH3	0.94
387	Meningioma, familial	Enrichment	PDGFB	0.94
388	Osteochondrodysplasia	Enrichment	FGFR3	0.94
389	Specific learning disability	Enrichment	MAPK1	0.94
390	Familial isolated dilated cardiomyopathy	Enrichment	RAF1, VCL	0.93
391	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, KRAS	0.90
392	Septooptic dysplasia	Enrichment	FGFR1	0.90
393	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	0.90
394	Aortic valve disease 1	Enrichment	SOS1	0.87
395	Microphthalmia/coloboma 12	Enrichment	MYH10	0.87
396	Protein-deficiency anemia	Enrichment	NRAS	0.87
397	Nk-cell enteropathy	Enrichment	PIK3CB	0.87
398	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	0.84
399	Medulloblastoma	Enrichment	APC	0.84
400	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	0.84
401	Generalized epilepsy with febrile seizures plus	Enrichment	FGF13	0.84
402	Cleft lip/palate	Enrichment	PDGFRA	0.84
403	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.84
404	Coloboma of macula	Enrichment	MYH10	0.81
405	Wilms tumor 1	Enrichment	BRAF	0.81
406	Septopreoptic holoprosencephaly	Enrichment	FGF8	0.81
407	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	0.81
408	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.76
409	Alobar holoprosencephaly	Enrichment	FGF8	0.76
410	Inherited cancer-predisposing syndrome	Enrichment	APC, EGFR, PDGFRA	0.74
411	Heart, malformation of	Enrichment	MAPK1	0.74
412	Diffuse large b-cell lymphoma	Enrichment	BRAF	0.72
413	Esophageal atresia/tracheoesophageal fistula	Enrichment	APC2	0.72
414	Williams-beuren syndrome	Enrichment	LIMK1	0.70
415	Lissencephaly	Enrichment	ACTG1	0.68
416	Centronuclear myopathy	Enrichment	CFL2	0.68
417	Tooth agenesis	Enrichment	FGFR1	0.66
418	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.63
419	Pancreatic cancer	Enrichment	KRAS	0.61
420	Auditory neuropathy	Enrichment	DIAPH1	0.60
421	Prostate cancer	Enrichment	PIK3CA	0.56
422	Non-immune hydrops fetalis	Enrichment	KRAS	0.53
423	Connective tissue disease	Enrichment	FGFR3	0.52
424	Cakut	Enrichment	ACTG1	0.50
425	Left ventricular noncompaction	Enrichment	RAF1	0.49
426	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.48
427	Epilepsy	Enrichment	DIAPH1	0.44
428	Nephrotic syndrome	Enrichment	FN1	0.42
429	Hypertrophic cardiomyopathy	Enrichment	MYL3	0.42
430	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYLK	0.41
431	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8	0.33
432	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PFN1	0.32
433	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.32
434	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	RDX	0.20
435	Congenital nervous system abnormality	Enrichment	FGFR3	0.16
436	Nervous system disease	Enrichment	FGFR3	0.16
437	Autism spectrum disorder	Enrichment	MAP2K1	0.15

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of actin cytoskeleton

Pathway Network for Regulation of actin cytoskeleton

Member Pathways for Regulation of actin cytoskeleton

Pathways in the Regulation of actin cytoskeleton SuperPath

Associated Genes for Regulation of actin cytoskeleton

Associated Disorders for Regulation of actin cytoskeleton

Disorders associated with Regulation of actin cytoskeleton SuperPath

STRING Interaction Network for Regulation of actin cytoskeleton

Sources for Regulation of actin cytoskeleton