Regulation of actin dynamics for phagocytic cup formation

Pathway network for the Regulation of actin dynamics for phagocytic cup formation SuperPath

Sources:

Reactome

Pathways in the Regulation of actin dynamics for phagocytic cup formation SuperPath

#	Name	Source	Genes
1	Regulation of actin dynamics for phagocytic cup formation	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CFL1 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR1A FCGR2A FCGR3A GRB2 HSP90AA1 HSP90AB1 LIMK1 MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD NF2 PAK1 PTK2 RAC1 SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 (see all 61) (see less)
2	Fcgamma receptor (FCGR) dependent phagocytosis	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 AHCYL1 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CFL1 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR1A FCGR2A FCGR3A FGR FYN GRB2 HCK HSP90AA1 HSP90AB1 ITPR1 ITPR2 ITPR3 LIMK1 LYN MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD NF2 PAK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G6 PLCG1 PLCG2 PLD1 PLD2 PLD3 PLD4 PLPP4 PLPP5 PRKCD PRKCE PTK2 RAC1 SRC SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 YES1 (see all 86) (see less)
3	Parasite infection	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR3A FGR FYN GRB2 HCK LYN MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD PTK2 RAC1 SRC SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 YES1 (see all 59) (see less)
4	Leishmania phagocytosis	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR3A FGR FYN GRB2 HCK LYN MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD PTK2 RAC1 SRC SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 YES1 (see all 59) (see less)
5	FCGR3A-mediated phagocytosis	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CD247 CD3G CDC42 CRK CYFIP1 CYFIP2 DOCK1 ELMO1 ELMO2 FCGR3A FGR FYN GRB2 HCK LYN MAPK1 MAPK3 MYH2 MYH9 MYO10 MYO1C MYO5A MYO9B NCK1 NCKAP1 NCKAP1L NCKIPSD PTK2 RAC1 SRC SYK VAV1 VAV2 VAV3 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 YES1 (see all 59) (see less)
6	RHO GTPases Activate WASPs and WAVEs	Reactome	ABI1 ABI2 ABL1 ACTB ACTG1 ACTR2 ACTR3 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 BAIAP2 BRK1 BTK CDC42 CYFIP1 CYFIP2 GRB2 MAPK1 MAPK3 NCK1 NCKAP1 NCKAP1L NCKIPSD PTK2 RAC1 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 (see all 36) (see less)

Gene overlap in member pathways for Regulation of actin dynamics for phagocytic cup formation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABI1	Abl Interactor 1	Protein Coding	6
2	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	6
3	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	6
4	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	6
5	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	6
6	ACTR3	Actin Related Protein 3	Protein Coding	6
7	ACTR2	Actin Related Protein 2	Protein Coding	6
8	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	6
9	ABI2	Abl Interactor 2	Protein Coding	6
10	WASF2	WASP Family Member 2	Protein Coding	6
11	BAIAP2	BAR/IMD Domain Containing Adaptor Protein 2	Protein Coding	6
12	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	6
13	NCKAP1	NCK Associated Protein 1	Protein Coding	6
14	WASF3	WASP Family Member 3	Protein Coding	6
15	WIPF2	WAS/WASL Interacting Protein Family Member 2	Protein Coding	6
16	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	Protein Coding	6
17	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	6
18	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	6
19	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	6
20	NCKAP1L	NCK Associated Protein 1 Like	Protein Coding	6
21	NCK1	NCK Adaptor Protein 1	Protein Coding	6
22	NCKIPSD	NCK Interacting Protein With SH3 Domain	Protein Coding	6
23	BRK1	BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex	Protein Coding	6
24	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	6
25	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	6
26	PTK2	Protein Tyrosine Kinase 2	Protein Coding	6
27	RAC1	Rac Family Small GTPase 1	Protein Coding	6
28	ACTB	Actin Beta	Protein Coding	6
29	WIPF3	WAS/WASL Interacting Protein Family Member 3	Protein Coding	6
30	BTK	Bruton Tyrosine Kinase	Protein Coding	6
31	ACTG1	Actin Gamma 1	Protein Coding	6
32	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	6
33	WIPF1	WAS/WASL Interacting Protein Family Member 1	Protein Coding	6
34	WASF1	WASP Family Member 1	Protein Coding	6
35	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	6
36	CDC42	Cell Division Cycle 42	Protein Coding	6
37	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	5
38	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	5
39	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	5
40	FCGR3A	Fc Gamma Receptor IIIa	Protein Coding	5
41	MYH2	Myosin Heavy Chain 2	Protein Coding	5
42	MYH9	Myosin Heavy Chain 9	Protein Coding	5
43	MYO1C	Myosin IC	Protein Coding	5
44	MYO5A	Myosin VA	Protein Coding	5
45	MYO9B	Myosin IXB	Protein Coding	5
46	MYO10	Myosin X	Protein Coding	5
47	ELMO2	Engulfment And Cell Motility 2	Protein Coding	5
48	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	5
49	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	5
50	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	5
51	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	5
52	CD247	CD247 Molecule	Protein Coding	5
53	ELMO1	Engulfment And Cell Motility 1	Protein Coding	5
54	FGR	FGR Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4
55	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4
56	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4
57	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4
58	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	4
59	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	4
60	CFL1	Cofilin 1	Protein Coding	2
61	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	2
62	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	2
63	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
64	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	2
65	LIMK1	LIM Domain Kinase 1	Protein Coding	2
66	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	2
67	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
68	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	1
69	PLD4	Phospholipase D Family Member 4	Protein Coding	1
70	PLPP4	Phospholipid Phosphatase 4	Protein Coding	1
71	PLD3	Phospholipase D Family Member 3	Protein Coding	1
72	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
73	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
74	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
75	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
76	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
77	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
78	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
79	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
80	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
81	PLD1	Phospholipase D1	Protein Coding	1
82	PLD2	Phospholipase D2	Protein Coding	1
83	PRKCD	Protein Kinase C Delta	Protein Coding	1
84	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
85	PLA2G6	Phospholipase A2 Group VI	Protein Coding	1
86	PLPP5	Phospholipid Phosphatase 5	Protein Coding	1

Disorders associated with Regulation of actin dynamics for phagocytic cup formation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cutaneous leishmaniasis	Direct
2	Wiskott-aldrich syndrome	Enrichment	WAS, WIPF1	5.16
3	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1, NCKAP1L	5.16
4	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.16
5	Immunodeficiency 72	Enrichment	NCKAP1, NCKAP1L	5.16
6	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.93
7	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.63
8	Microcephaly	Enrichment	ABL1, ACTB, ACTG1, MAPK1	3.52
9	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, MYH9, MYO1C	2.79
10	Meningioma	Enrichment	NF2, PIK3CA	2.60
11	Lip and oral cavity carcinoma	Enrichment	ABL1, PIK3CA	2.60
12	Baraitser-winter syndrome 1	Enrichment	ACTB	2.58
13	Thrombocytopenia 1	Enrichment	WAS	2.58
14	Wiskott-aldrich syndrome 2	Enrichment	WIPF1	2.58
15	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	2.58
16	Noonan syndrome 13	Enrichment	MAPK1	2.58
17	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.58
18	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	2.58
19	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.58
20	Becker nevus syndrome	Enrichment	ACTB	2.58
21	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.58
22	Was-related disorders	Enrichment	WAS	2.58
23	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.58
24	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.58
25	Baraitser-winter syndrome	Enrichment	ACTB	2.58
26	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.58
27	Nocarh syndrome	Enrichment	CDC42	2.58
28	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.58
29	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.58
30	Thrombocytopenia	Enrichment	MYH9, SRC, WAS	2.46
31	Ramon syndrome	Enrichment	ELMO2	2.35
32	Deafness, autosomal dominant 17	Enrichment	MYH9	2.35
33	Schwannomatosis, vestibular	Enrichment	NF2	2.35
34	Griscelli syndrome, type 1	Enrichment	MYO5A	2.35
35	Immunodeficiency 20	Enrichment	FCGR3A	2.35
36	Elejalde neuroectodermal melanolysosomal syndrome	Enrichment	MYO5A	2.35
37	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.35
38	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.35
39	Vascular malformation, primary intraosseous	Enrichment	ELMO2	2.35
40	Immunodeficiency 25	Enrichment	CD247	2.35
41	Celiac disease 4	Enrichment	MYO9B	2.35
42	Primary intraosseous venous malformation	Enrichment	ELMO2	2.35
43	Colitis	Enrichment	SYK	2.35
44	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	2.35
45	Acoustic neuroma	Enrichment	NF2	2.35
46	Temporomandibular joint anomaly	Enrichment	DOCK1	2.35
47	Neutropenia, severe congenital, x-linked	Enrichment	WAS	2.28
48	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.28
49	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.28
50	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.28
51	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.28
52	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	2.28
53	Agammaglobulinemia, x-linked	Enrichment	BTK	2.28
54	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.28
55	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	2.28
56	Immune system disease	Enrichment	CDC42	2.28
57	Immunodeficiency 133	Enrichment	ARPC5	2.28
58	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.20
59	Macrodactyly	Enrichment	PIK3CA	2.20
60	Osteopetrosis and infantile neuroaxonal dystrophy	Enrichment	PLA2G6	2.20
61	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.20
62	Cowden syndrome 5	Enrichment	PIK3CA	2.20
63	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.20
64	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.20
65	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.20
66	Neurodegeneration with brain iron accumulation 2a	Enrichment	PLA2G6	2.20
67	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.20
68	Short syndrome	Enrichment	PIK3R1	2.20
69	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.20
70	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.20
71	Parkinson disease 14, autosomal recessive	Enrichment	PLA2G6	2.20
72	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.20
73	Neurodegeneration with brain iron accumulation 2b	Enrichment	PLA2G6	2.20
74	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.20
75	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.20
76	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.20
77	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.20
78	Thrombocytopenia 6	Enrichment	SRC	2.20
79	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.20
80	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.20
81	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.20
82	Hypospadias	Enrichment	PIK3CA	2.20
83	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.20
84	Systemic lupus erythematosus 18	Enrichment	PLD4	2.20
85	Rare venous malformation	Enrichment	PIK3CA	2.20
86	Diaphragmatic eventration	Enrichment	PIK3CA	2.20
87	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.20
88	Rare combined vascular malformation	Enrichment	PIK3CA	2.20
89	Cavernous lymphangioma	Enrichment	PIK3CA	2.20
90	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.20
91	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.20
92	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.20
93	Macrodactyly of toe	Enrichment	PIK3CA	2.20
94	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	2.10
95	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	2.10
96	Agammaglobulinemia 1	Enrichment	BTK	2.10
97	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.10
98	Cataract 35	Enrichment	MYH9	2.05
99	Schwannomatosis 1	Enrichment	NF2	2.05
100	Griscelli syndrome, type 3	Enrichment	MYO5A	2.05
101	Hereditary inclusion body myopathy-joint contractures-ophthalmoplegia syndrome	Enrichment	MYH2	2.05
102	Immunodeficiency 17	Enrichment	CD3G	2.05
103	Pseudosarcomatous fibromatosis	Enrichment	MYH9	2.05
104	Arthritis	Enrichment	SYK	2.05
105	Childhood-onset autosomal recessive myopathy with external ophthalmoplegia	Enrichment	MYH2	2.05
106	Severe combined immunodeficiency	Enrichment	CD247, CD3G	2.02
107	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.98
108	Aminoacylase 1 deficiency	Enrichment	ACTB	1.98
109	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.98
110	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.98
111	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.98
112	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.90
113	Charcot-marie-tooth disease, demyelinating, type 4f	Enrichment	PLD3	1.90
114	Keratosis, seborrheic	Enrichment	PIK3CA	1.90
115	Noonan syndrome 8	Enrichment	PIK3CA	1.90
116	Spinocerebellar ataxia 46	Enrichment	PLD3	1.90
117	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.90
118	Charcot-marie-tooth disease type 4f	Enrichment	PLD3	1.90
119	Infantile osteopetrosis with neuroaxonal dysplasia	Enrichment	PLA2G6	1.90
120	Coloboma of choroid and retina	Enrichment	ACTG1	1.88
121	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	MYH9	1.87
122	Cellular ependymoma	Enrichment	NF2	1.87
123	Tanycytic ependymoma	Enrichment	NF2	1.87
124	Papillary ependymoma	Enrichment	NF2	1.87
125	Spindle cell sarcoma	Enrichment	NF2	1.87
126	Clear cell ependymoma	Enrichment	NF2	1.87
127	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247	1.87
128	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, SRC	1.75
129	Congenital myopathy 6 with ophthalmoplegia	Enrichment	MYH2	1.75
130	Full schwannomatosis	Enrichment	NF2	1.75
131	Benign ependymoma	Enrichment	NF2	1.75
132	Leukemia, chronic myeloid	Enrichment	ABL1	1.73
133	Moyamoya angiopathy	Enrichment	ABL1	1.73
134	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.73
135	Gillespie syndrome	Enrichment	ITPR1	1.72
136	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.72
137	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.72
138	Immunodeficiency 14	Enrichment	PIK3R1	1.72
139	Keratoacanthoma	Enrichment	PIK3CA	1.72
140	Deafness, autosomal recessive 63	Enrichment	MYH9	1.65
141	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.63
142	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.60
143	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.60
144	Cerebrovascular disease	Enrichment	PIK3CA	1.60
145	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.60
146	Undetermined early-onset epileptic encephalopathy	Enrichment	CYFIP2, LIMK1	1.58
147	Cat eye syndrome	Enrichment	ACTG1	1.58
148	Hemangioma, capillary infantile	Enrichment	MYH9	1.57
149	Combined immunodeficiency	Enrichment	ARPC1B	1.54
150	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	1.54
151	Specific learning disability	Enrichment	MAPK1	1.54
152	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	1.54
153	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.51
154	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.51
155	Capillary malformations, congenital	Enrichment	PIK3CA	1.50
156	Hemimegalencephaly	Enrichment	PIK3CA	1.50
157	Heart disease	Enrichment	ABL1	1.44
158	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.43
159	Cowden syndrome 1	Enrichment	PIK3CA	1.43
160	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.43
161	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.43
162	Breast adenocarcinoma	Enrichment	PIK3CA	1.43
163	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.43
164	Nevus, epidermal	Enrichment	PIK3CA	1.36
165	Myelofibrosis	Enrichment	SRC	1.36
166	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.36
167	Gallbladder cancer	Enrichment	PIK3CA	1.36
168	Overgrowth syndrome	Enrichment	PIK3R1	1.36
169	Spastic ataxia	Enrichment	ITPR1, PLA2G6	1.35
170	Heart, malformation of	Enrichment	MAPK1	1.33
171	Immune deficiency disease	Enrichment	SYK	1.32
172	Meningioma, familial	Enrichment	NF2	1.32
173	Rare genetic deafness	Enrichment	ACTG1, MYH9	1.31
174	Diffuse large b-cell lymphoma	Enrichment	BTK	1.31
175	Lissencephaly	Enrichment	ACTG1	1.27
176	Arteriovenous malformation	Enrichment	PIK3CA	1.25
177	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.25
178	Cowden syndrome	Enrichment	PIK3CA	1.25
179	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.23
180	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.21
181	Neurodegeneration with brain iron accumulation	Enrichment	PLA2G6	1.21
182	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.21
183	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.17
184	Hypertension	Enrichment	MYH9	1.16
185	Congenital long qt syndrome	Enrichment	ITPR3	1.13
186	Nk-cell enteropathy	Enrichment	PIK3CB	1.10
187	Multiple sclerosis	Enrichment	ITPR1	1.07
188	Osteoporosis	Enrichment	SRC	1.07
189	Williams-beuren syndrome	Enrichment	LIMK1	1.06
190	Cakut	Enrichment	ACTG1	1.06
191	Anterior segment dysgenesis	Enrichment	ITPR1	1.04
192	Lynch syndrome	Enrichment	PIK3CA	1.04
193	Non-syndromic genetic deafness	Enrichment	ACTG1	1.04
194	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PLA2G6	1.01
195	Malaria	Enrichment	FCGR2A	1.01
196	Nonsyndromic hearing loss	Enrichment	ACTG1	0.98
197	Charcot-marie-tooth disease type 4	Enrichment	PLD3	0.97
198	Endometrial cancer	Enrichment	PIK3CA	0.90
199	Hepatocellular carcinoma	Enrichment	PIK3CA	0.88
200	Cystic fibrosis	Enrichment	FCGR2A	0.87
201	Dystonia	Enrichment	MYO5A	0.84
202	Systemic lupus erythematosus	Enrichment	FCGR2A	0.79
203	Myopathy	Enrichment	MYH2	0.78
204	Bladder cancer	Enrichment	PIK3CA	0.77
205	Prostate cancer	Enrichment	PIK3CA	0.77
206	Long qt syndrome 1	Enrichment	ITPR3	0.76
207	Lung cancer	Enrichment	PIK3CA	0.73
208	Body mass index quantitative trait locus 11	Enrichment	MYH9	0.69
209	Charcot-marie-tooth disease	Enrichment	PLD3	0.64
210	Gastric cancer	Enrichment	PIK3CA	0.62
211	Hereditary breast carcinoma	Enrichment	PIK3CA	0.61
212	Deafness, autosomal recessive	Enrichment	MYH9	0.61
213	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	0.60
214	Complex neurodevelopmental disorder	Enrichment	WASF1	0.55
215	Hypertelorism	Enrichment	PIK3CA	0.55
216	Myeloma, multiple	Enrichment	PIK3R2	0.52
217	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYH9	0.48
218	Breast cancer	Enrichment	PIK3CA	0.42
219	Inherited cancer-predisposing syndrome	Enrichment	NF2	0.35
220	Ovarian cancer	Enrichment	PIK3CA	0.32
221	Congenital nervous system abnormality	Enrichment	PLA2G6	0.31
222	Nervous system disease	Enrichment	PLA2G6	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of actin dynamics for phagocytic cup formation

Pathway Network for Regulation of actin dynamics for phagocytic cup formation

Pathway network for the Regulation of actin dynamics for phagocytic cup formation SuperPath

Member Pathways for Regulation of actin dynamics for phagocytic cup formation

Pathways in the Regulation of actin dynamics for phagocytic cup formation SuperPath

Gene overlap in member pathways for Regulation of actin dynamics for phagocytic cup formation SuperPath

Associated Genes for Regulation of actin dynamics for phagocytic cup formation

Associated Disorders for Regulation of actin dynamics for phagocytic cup formation

Disorders associated with Regulation of actin dynamics for phagocytic cup formation SuperPath

STRING Interaction Network for Regulation of actin dynamics for phagocytic cup formation

Sources for Regulation of actin dynamics for phagocytic cup formation