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Regulation of activated PAK-2p34 by proteasome mediated degradation SuperPath

Pathway network for Regulation of activated PAK-2p34 by proteasome mediated degradation SuperPath
109 Pathways in the Regulation of activated PAK-2p34 by proteasome mediated degradation SuperPath
ABC transporter disorders PCP/CE pathway
PAOs oxidise polyamines to amines DNA Replication Pre-Initiation
p53-Dependent G1 DNA Damage Response Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Regulation of DNA replication Ca2+ pathway
Removal of licensing factors from origins Dectin-1 mediated noncanonical NF-kB signaling
Disorders of transmembrane transporters M/G1 Transition
CDC6 association with the ORC-origin complex Regulation of RAS by GAPs
Cdc20-Phospho-APC/C mediated degradation of Cyclin A Ubiquitin-dependent degradation of Cyclin D
WNT5A-dependent internalization of FZD4 p53-Dependent G1/S DNA damage checkpoint
Establishment of Sister Chromatid Cohesion ABC transporters in lipid homeostasis
MAPK6/MAPK4 signaling Release of Hh-Np from the secreting cell
APC/C-mediated degradation of cell cycle proteins Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
Repression of WNT target genes ABC transporters
HHAT G278V abrogates palmitoylation of Hh-Np SCF-beta-TrCP mediated degradation of Emi1
APC/C-Cdc20 mediated degradation of mitotic proteins Metabolism of polyamines
Assembly of the pre-replicative complex Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Asymmetric localization of PCP proteins Regulation of APC/C activators between G1/S and early anaphase
Autodegradation of the E3 ubiquitin ligase COP1 Hh mutants abrogate ligand secretion
UCH proteinases Urea cycle
Stabilization of p53 SCF(Skp2)-mediated degradation of p27/p21
Synthesis of DNA Vpu mediated degradation of CD4
Activation of NF-kappaB in B cells Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC)
Cross-presentation of soluble exogenous antigens (endosomes) HuR (ELAVL1) binds and stabilizes mRNA
Regulation of gene expression by Hypoxia-inducible Factor creatine biosynthesis
G1/S DNA Damage Checkpoints NIK-->noncanonical NF-kB signaling
Regulation of Apoptosis FCERI mediated NF-kB activation
Degradation of AXIN Autodegradation of Cdh1 by Cdh1-APC/C
Regulation of PAK-2p34 activity by PS-GAP/RHG10 S Phase
Phosphorylation of the APC/C urea cycle
Orc1 removal from chromatin Regulation of activated PAK-2p34 by proteasome mediated degradation
CDK-mediated phosphorylation and removal of Cdc6 Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Mitochondrial ABC transporters Cellular response to hypoxia
Canonical Wnt Pathway Proteasome
Degradation of GLI1 by the proteasome Switching of origins to a post-replicative state
creatine-phosphate biosynthesis PTK6 Regulates Cell Cycle
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Proteasome Degradation
GLI3 is processed to GLI3R by the proteasome DNA Replication
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint CDT1 association with the CDC6-ORC-origin complex
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Creatine metabolism
Cyclin A-Cdk2-associated events at S phase entry Degradation of beta-catenin by the destruction complex
Ubiquitin-dependent degradation of Cyclin D1 Regulation of mitotic cell cycle
The role of GTSE1 in G2/M progression after G2 checkpoint Degradation of GLI2 by the proteasome
KSRP (KHSRP) binds and destabilizes mRNA Association of licensing factors with the pre-replicative complex
Defective CFTR causes cystic fibrosis TCF7L2 mutants dont bind CTBP
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Cyclin E associated events during G1/S transition
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1 p53-Independent G1/S DNA damage checkpoint
SLC transporter disorders Interconversion of polyamines
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD TNFR2 non-canonical NF-kB pathway
Conversion from APC/C-Cdc20 to APC/C-Cdh1 in late anaphase Degradation of DVL
Vif-mediated degradation of APOBEC3G Beta-catenin independent WNT signaling
ABC-family proteins mediated transport p53-Independent DNA Damage Response
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Hedgehog ligand biogenesis APC/C-Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) binds and destabilizes mRNA Regulation of mRNA stability by proteins that bind AU-rich elements
Regulation of ornithine decarboxylase (ODC)
776 Genes in the Regulation of activated PAK-2p34 by proteasome mediated degradation SuperPath
PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5
PSMB6 PSMB7 PSMB8 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3
PSMD4 PSMD7 PSMD8 PSMD11 PSMD12 PSMD13 PSMD6 PSMB9 PSMB10 PSMD5 PSMD9 PSMD10
PSME1 PSME2 PSME3 PSMD14 SEM1 PSMF1 MIR7703 UBB UBC RPS27A UBA52 PSME4
PSMB11 PSMA8 CDK2 CCNA2 CCNA1 SKP1 CUL1 UBE2D1 FZR1 BTRC CDC6 CDKN1A
CDKN1B ORC1 ORC2 ORC4 ORC5 ORC3 ANAPC10 ANAPC15 ANAPC2 ANAPC5 ANAPC11 ANAPC16
ORC6 CDT1 MCM8 CDC27 UBE2E1 CDC23 CDC16 UBE2C ANAPC4 ANAPC7 ANAPC1 CDC26
RBX1 CDC20 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 CDK1 RB1 GMNN ATM
CCNE1 CCND1 SEL1L VCP OS9 ERLEC1 DERL2 WNT5A E2F1 E2F2 E2F3 CCNE2
CHEK2 BUB1B MAD2L1 BUB3 CDK4 CCNB1 PLK1 SKP2 CDC25A FZD2 PRKCA FZD5
FZD4 TP53 PTTG1 CFTR DVL2 POLA1 POLE POLE2 PRIM1 PRIM2 RPA1 RPA2
RPA3 CDC45 POLA2 POLE3 MCM10 POLE4 COP1 TCF7L2 LEF1 CHUK FBXW11 MYC
SHH NEK2 PTK6 UBE2D2 RNF5 ABCC8 ERLIN1 ERLIN2 DERL1 DERL3 AP2A1 AP2A2
AP2B1 AP2M1 AP2S1 CLTA CLTB CLTC PRKCB RNF185 WNT11 FZD3 FZD1 SMURF2
MDM2 MDM4 AKT1 EXOSC9 EXOSC8 DIS3 EXOSC7 EXOSC2 EXOSC3 EXOSC1 EXOSC4 EXOSC5
EXOSC6 DCP2 MIR6847 CTNNB1 MAP3K7 TCF7 TCF7L1 MAP3K14 PAK2 PRKACA PRKACB PRKACG
CDC14A IHH DHH AURKA FBXO5 CKS1B EPAS1 HIF1A HIF3A CHEK1 ELOC ELOB
UBE2D3 GSK3B CSNK1A1 KCNJ11 ARRB2 DVL1 DVL3 ROR1 ROR2 PRKCG RAC1 WNT1
FZD6 FZD7 FZD8 SCRIB PARD6A WNT4 SMURF1 VANGL2 WNT5B PRICKLE1 MIR937 MIR4683
MIR6808 SMOX PAOX CDC7 DBF4 RPA4 ZNF385A PCBP4 YWHAB MAPKAPK2 XRN1 DCP1A
MOV10 TNRC6B AGO1 AGO2 TNRC6A TNRC6C AGO3 AGO4 NFKB2 RELA RELB UBA3
UBE2M GCK GCKR ABCA2 ABCA3 ABCD1 ABCD2 ABCD3 ABCG1 ABCA7 ABCA10 ABCA9
ABCA6 ABCA5 ABCA12 ABCG4 ABCG5 ABCG8 HSPB1 XPO1 AURKB CTBP1 CTBP2 TLE1
ABCB6 ABCB8 ABCB7 ABCB10 ASL ASS1 CKM CKMT1B CKMT2 CPS1 GAMT OTC
SYVN1 MIR6751 DNA2 FEN1 LIG1 PCNA POLD1 POLD2 RFC1 RFC2 RFC3 RFC4
RFC5 GINS1 POLD3 GINS2 POLD4 GINS3 GINS4 TNFSF13 ARNT CA9 CREBBP EP300
EPO VEGFA CITED2 HIGD1A MIR1281 AXIN1 CCNH CDK7 MAX MNAT1 WEE1 VHL
CUL2 LIMD1 EGLN1 AJUBA EGLN2 EGLN3 WTIP SUFU SFTPB SFTPC SFTPD SFTPA1
SFTPA2 RHOA PFN1 RAC2 RAC3 RYK DAAM1 ZFP36L1 CALM1 CALM2 CALM3 CAMK2A
GNAO1 GNAT2 GNB1 GNB2 GNB3 GNG3 GNG4 GNG5 GNG7 GNG10 GNG11 GNGT1
GNGT2 ITPR1 ITPR2 ITPR3 NFATC1 PDE6A PDE6G PDE6B PLCB2 PLCB3 PPP3CA PPP3CB
PPP3R1 PRKG1 PRKG2 GNB5 PLCB1 NLK GNG13 GNG2 GNG12 GNB4 GNG8 ALB
AVP AVPR1A AVPR1B AVPR2 CUL3 RAD21 SMC1A SMC3 STAG1 STAG2 PDS5B WAPL
PDS5A CDCA5 ESCO1 ESCO2 MIR3610 APOA1 PEX19 PEX3 GPC5 ADAM17 SCUBE2 DISP2
NOTUM TLE5 HDAC1 TLE2 TLE3 TLE4 ABCC5 ABCC9 ABCC4 ABCA8 ABCC2 ABCB9
ABCA4 ABCB5 ABCC6 ABCC1 ABCB1 ABCB4 ABCC11 ABCC3 ABCC10 ARG1 ARG2 CKB
NQO1 GATM OAZ1 OAZ2 ODC1 SAT1 SLC6A7 SLC6A8 SLC6A11 SLC6A12 SLC25A15 AZIN1
OAZ3 NMRAL1 SLC25A2 NAGS CKMT1A TNPO1 ZFP36 UCHL1 UCHL3 H2AC4 ADRM1 IKBKB
NFKB1 NFKBIA IKBKG BCL10 MALT1 CARD11 ELAVL1 PRKCD SET NUP214 ANP32A ARHGAP10
CDC25B HIF1AN IFNG MAPK14 PARN MAPK11 YWHAZ KHSRP MIR3940 BIRC2 BIRC3 CD40
CD40LG LTA LTB LTBR TRAF2 TRAF3 TNFSF11 TNFSF14 TNFSF12 TNFRSF11A TNFSF13B TNFRSF12A
TNFRSF13C MIR378I EIF4G1 HNRNPD HSPA1A HSPA8 PABPC1 MIR7705 HRAS KRAS NF1 NRAS
RASA1 RASA2 RASAL1 SYNGAP1 RASAL2 RASA4 RASA3 RASAL3 KBTBD7 DAB2IP SPRED1 SPRED2
SPRED3 MIR5004 CCND3 SEPTIN7 CDC42 ETV4 FOXO1 FOXO3 DNAJB1 JUN PAK1 PAK3
MAPK4 MAPK6 RAG1 RAG2 NCOA3 MAPKAPK5 CDC14B KALRN CDC42EP2 CDC42EP3 IGF2BP1 CDC42EP5
ABCA13 DEFB1 ABCA1 ABCD4 TAP1 TAP2 ABCB11 ABCC12 ABCG2 AMD1 GOT1 MTAP
SMS SRM APIP ADI1 ENOPH1 AGMAT MRI1 AZIN2 ACTB ACTL6A BARD1 H2AC8
H2AC7 HCFC1 FOXK2 SMAD7 NEDD8 NFRKB TGFB1 TGFBR1 TGFBR2 YY1 BAP1 H2AC13
H2AC15 H2AC14 H2AC16 H2AC6 H2AC17 H2AC18 H2AC20 OGT RUVBL1 H2AC11 USP15 MCRS1
TFPT UCHL5 INO80 INO80D ASXL2 MBD5 ACTR5 INO80B H2AC12 H2AW ACTR8 MBD6
SENP8 INO80C ASXL1 H2AC1 KDM1B FOXK1 INO80E H2AC21 H2AC19 MIR6125 MIR6764 CD4
NFKBIB NFKBIE REL FCGR1A FCGR1B MRC1 MRC2 CD207 OPA1 OMA1 CDC34 IGHE
IGLC1 IGLC6 LYN PDPK1 PRKCQ TRAF6 UBE2N UBE2V1 RASGRP1 RASGRP2 TAB1 TAB2
IGKV3D-11 IGKV5-2 IGKV4-1 RASGRP4 TAB3 AXIN2 TNKS TNKS2 RNF146 BCL9 ADAM10 CDH8
CDH16 CDH2 DKK1 DKK2 DKK3 DKK4 FN1 FZD10 FZD9 LRP6 MMP3 ANAPC13
CDH11 CDH12 CDH15 CDH17 CDH6 CDH13 CDH18 CDH19 CDH26 CDH3 CDH1 CDH4
CDH5 CDH24 LRP5 SNAI2 TCF4 TCF21 TCF25 WNT10A WNT16 WNT2 WNT3A WNT3
WNT6 WNT7A WNT7B WNT9A CTNNA1 CTNNA2 POMP GLI1 NUMB ITCH LOC101928143 H2AX
H2AZ1 HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HLA-H HLA-J NEDD4 RPN1 RPN2
UBA1 UBA7 UBE2B MIR5193 GLI3 FBXL7 FBXL18 APC PPP2CA PPP2CB PPP2R1A PPP2R1B
PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E FRAT1 FRAT2 AMER1 HSP90AA1 HSP90AB1 CCNB2 MAPRE1
GTSE1 FKBPL GLI2 AKT2 AKT3 FASLG TNFRSF17 CD27 TNFRSF8 TNFSF8 CD70 EDA
TNFRSF9 TNFRSF11B TNF TNFRSF1A TNFRSF1B TNFSF4 TNFRSF4 TNFRSF25 TNFSF9 TNFRSF14 TNFRSF6B TNFRSF18
TNFSF18 TNFSF15 EDAR TNFRSF13B EDA2R EDARADD MIR7846 HECW1 DACT1 KLHL12 CUL5 APOBEC3G
ABCF1 EIF2S1 EIF2S3 RNASEL ABCE1 EIF2S2 P4HB HHAT
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network for Regulation of activated PAK-2p34 by proteasome mediated degradation SuperPath