Regulation of Androgen receptor activity

No Pathway Network information available for Regulation of Androgen receptor activity

Pathways in the Regulation of Androgen receptor activity SuperPath

#	Name	Source	Genes
1	Regulation of Androgen receptor activity	PubChem	APPBP2 AR CARM1 CEBPA DNAJA1 EGR1 EHMT2 FLNA FOXO1 GATA2 GSK3B HDAC1 HDAC7 HOXB13 HSP90AA1 JUN KAT2B KAT5 KAT7 KLK2 KLK3 MAP2K4 MAP2K6 MAPK14 MAPK8 MDM2 NCOA1 NCOA2 NR0B1 NR2C1 NR2C2 NR3C1 PDE9A PKN1 POU2F1 RACK1 RCHY1 REL SENP1 SIRT1 SMARCA2 SMARCC1 SMARCE1 SPDEF SRC SRY TMPRSS2 TRIM24 ZMIZ2 (see all 49) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SPDEF	SAM Pointed Domain Containing ETS Transcription Factor	Protein Coding	1
2	HOXB13	Homeobox B13	Protein Coding	1
3	ZMIZ2	Zinc Finger MIZ-Type Containing 2	Protein Coding	1
4	APPBP2	Amyloid Beta Precursor Protein Binding Protein 2	Protein Coding	1
5	NR0B1	Nuclear Receptor Subfamily 0 Group B Member 1	Protein Coding	1
6	SENP1	SUMO Specific Peptidase 1	Protein Coding	1
7	KLK2	Kallikrein Related Peptidase 2	Protein Coding	1
8	KLK3	Kallikrein Related Peptidase 3	Protein Coding	1
9	PDE9A	Phosphodiesterase 9A	Protein Coding	1
10	NR2C2	Nuclear Receptor Subfamily 2 Group C Member 2	Protein Coding	1
11	HDAC7	Histone Deacetylase 7	Protein Coding	1
12	SMARCA2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2	Protein Coding	1
13	SMARCE1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit E1	Protein Coding	1
14	SRY	Sex Determining Region Y	Protein Coding	1
15	TMPRSS2	Transmembrane Serine Protease 2	Protein Coding	1
16	GATA2	GATA Binding Protein 2~Name Same As:- HGNC:18350	Protein Coding	1
17	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
18	SMARCC1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C1	Protein Coding	1
19	KAT7	Lysine Acetyltransferase 7	Protein Coding	1
20	TRIM24	Tripartite Motif Containing 24	Protein Coding	1
21	NR2C1	Nuclear Receptor Subfamily 2 Group C Member 1	Protein Coding	1
22	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
23	DNAJA1	DnaJ Heat Shock Protein Family (Hsp40) Member A1	Protein Coding	1
24	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	1
25	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
26	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
27	PKN1	Protein Kinase N1	Protein Coding	1
28	AR	Androgen Receptor	Protein Coding	1
29	EGR1	Early Growth Response 1	Protein Coding	1
30	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	1
31	POU2F1	POU Class 2 Homeobox 1	Protein Coding	1
32	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
33	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
34	RCHY1	Ring Finger And CHY Zinc Finger Domain Containing 1	Protein Coding	1
35	FLNA	Filamin A	Protein Coding	1
36	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
37	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
38	SIRT1	Sirtuin 1	Protein Coding	1
39	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
40	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
41	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
42	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	1
43	FOXO1	Forkhead Box O1	Protein Coding	1
44	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
45	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
46	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
47	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
48	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
49	HDAC1	Histone Deacetylase 1	Protein Coding	1

Disorders associated with Regulation of Androgen receptor activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	46,xy complete gonadal dysgenesis	Enrichment	AR, NR0B1, SRY	5.14
2	46,xy sex reversal 1	Enrichment	AR, SRY	4.89
3	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	NR0B1, SRY	3.90
4	46,xy partial gonadal dysgenesis	Enrichment	NR0B1, SRY	2.95
5	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.44
6	Androgen insensitivity, partial	Enrichment	AR	2.44
7	Otopalatodigital syndrome, type i	Enrichment	FLNA	2.44
8	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	2.44
9	Coffin-siris syndrome 5	Enrichment	SMARCE1	2.44
10	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.44
11	Accelerated tumor formation	Enrichment	MDM2	2.44
12	Hydrocephalus, congenital, 5	Enrichment	SMARCC1	2.44
13	Immunodeficiency 92	Enrichment	REL	2.44
14	46,xy sex reversal 2	Enrichment	NR0B1	2.44
15	Adrenal hypoplasia, congenital	Enrichment	NR0B1	2.44
16	Terminal osseous dysplasia	Enrichment	FLNA	2.44
17	Lessel-kubisch syndrome	Enrichment	MDM2	2.44
18	Fg syndrome 2	Enrichment	FLNA	2.44
19	Lymphedema, primary, with myelodysplasia	Enrichment	GATA2	2.44
20	Prostate cancer, hereditary, 9	Enrichment	HOXB13	2.44
21	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	2.44
22	Immunodeficiency 21	Enrichment	GATA2	2.44
23	Thrombocytopenia 6	Enrichment	SRC	2.44
24	X-linked ehlers-danlos syndrome	Enrichment	FLNA	2.44
25	Deafness-lymphedema-leukemia syndrome	Enrichment	GATA2	2.44
26	Blepharophimosis-impaired intellectual development syndrome	Enrichment	SMARCA2	2.44
27	45,x/46,xy mixed gonadal dysgenesis	Enrichment	SRY	2.44
28	Facial cleft	Enrichment	SMARCE1	2.44
29	Complete androgen insensitivity syndrome	Enrichment	AR	2.44
30	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.44
31	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	2.44
32	Prostate cancer	Enrichment	AR, HOXB13	2.31
33	Galactosemia ii	Enrichment	NR3C1	2.14
34	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	2.14
35	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.14
36	Otopalatodigital syndrome, type ii	Enrichment	FLNA	2.14
37	Melnick-needles syndrome	Enrichment	FLNA	2.14
38	Frontometaphyseal dysplasia 1	Enrichment	FLNA	2.14
39	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	2.14
40	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	2.14
41	Androgen insensitivity syndrome	Enrichment	AR	2.14
42	Hypospadias 1, x-linked	Enrichment	AR	2.14
43	Blepharophimosis - intellectual disability syndrome	Enrichment	SMARCA2	2.14
44	Posterior hypospadias	Enrichment	AR	2.14
45	Leukemia, acute myeloid	Enrichment	CEBPA, GATA2	2.04
46	Prune belly syndrome	Enrichment	FLNA	1.97
47	Arterial tortuosity syndrome	Enrichment	FLNA	1.97
48	Periventricular nodular heterotopia 1	Enrichment	FLNA	1.97
49	46,xx sex reversal 1	Enrichment	SRY	1.97
50	Congenital short bowel syndrome	Enrichment	FLNA	1.97
51	Dedifferentiated liposarcoma	Enrichment	MDM2	1.97
52	Frontometaphyseal dysplasia	Enrichment	FLNA	1.97
53	Well-differentiated liposarcoma	Enrichment	MDM2	1.97
54	Inherited cancer-predisposing syndrome	Enrichment	CEBPA, HOXB13, SMARCE1	1.92
55	Nicolaides-baraitser syndrome	Enrichment	SMARCA2	1.84
56	Blepharophimosis	Enrichment	SMARCA2	1.84
57	Smarca2-related nicolaides-baraitser syndrome	Enrichment	SMARCA2	1.84
58	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.75
59	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.75
60	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.75
61	Li-fraumeni syndrome	Enrichment	MDM2	1.67
62	Patent ductus arteriosus	Enrichment	FLNA	1.67
63	46,xy disorder of sex development	Enrichment	SRY	1.67
64	Myelofibrosis	Enrichment	SRC	1.60
65	Congenital hydrocephalus	Enrichment	SMARCC1	1.60
66	Fanconi anemia, complementation group c	Enrichment	FLNA	1.54
67	Difference of sex development	Enrichment	AR	1.54
68	Primary hyperaldosteronism	Enrichment	NR3C1	1.49
69	Meningioma, familial	Enrichment	SMARCE1	1.41
70	Myelodysplastic syndrome	Enrichment	GATA2	1.41
71	Meningioma	Enrichment	SMARCE1	1.37
72	Osteoporosis	Enrichment	SRC	1.31
73	Periventricular nodular heterotopia	Enrichment	FLNA	1.31
74	Pituitary stalk interruption syndrome	Enrichment	SMARCA2	1.31
75	Ovarian cancer	Enrichment	AR, TRIM24	1.29
76	Coffin-siris syndrome 1	Enrichment	SMARCE1	1.28
77	Cleft palate, isolated	Enrichment	FLNA	1.22
78	Patent foramen ovale	Enrichment	FLNA	1.20
79	Diffuse large b-cell lymphoma	Enrichment	FOXO1	1.18
80	Pancreatic cancer	Enrichment	HOXB13	1.06
81	Differentiated thyroid carcinoma	Enrichment	TRIM24	1.00
82	Male infertility	Enrichment	AR	0.94
83	Gastric cancer	Enrichment	HOXB13	0.84
84	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FLNA	0.83
85	Thrombocytopenia	Enrichment	SRC	0.80
86	Hereditary breast ovarian cancer syndrome	Enrichment	HOXB13	0.74
87	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR	0.74
88	Breast cancer	Enrichment	JUN	0.62
89	Colorectal cancer	Enrichment	SRC	0.57

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of Androgen receptor activity

Pathway Network for Regulation of Androgen receptor activity

Member Pathways for Regulation of Androgen receptor activity

Pathways in the Regulation of Androgen receptor activity SuperPath

Associated Genes for Regulation of Androgen receptor activity

Associated Disorders for Regulation of Androgen receptor activity

Disorders associated with Regulation of Androgen receptor activity SuperPath

STRING Interaction Network for Regulation of Androgen receptor activity

Sources for Regulation of Androgen receptor activity