Regulation of CDC42 activity

No Pathway Network information available for Regulation of CDC42 activity

Pathways in the Regulation of CDC42 activity SuperPath

#	Name	Source	Genes
1	Regulation of CDC42 activity	PubChem	APC ARHGAP1 ARHGAP10 ARHGAP17 ARHGDIA ARHGEF25 ARHGEF6 ARHGEF7 ARHGEF9 BCAR3 CDC42 DNMBP DOCK10 DOCK11 DOCK6 DOCK9 FARP2 FGD1 GIT1 ITSN1 ITSN2 MCF2 MCF2L NGEF NME1 PLCG1 RACGAP1 RALBP1 SPATA13 VAV2 VAV3 (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DOCK11	Dedicator Of Cytokinesis 11	Protein Coding	1
2	DOCK9	Dedicator Of Cytokinesis 9	Protein Coding	1
3	DOCK10	Dedicator Of Cytokinesis 10	Protein Coding	1
4	ITSN2	Intersectin 2	Protein Coding	1
5	BCAR3	BCAR3 Adaptor Protein, NSP Family Member	Protein Coding	1
6	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	1
7	FGD1	FYVE, RhoGEF And PH Domain Containing 1	Protein Coding	1
8	DNMBP	Dynamin Binding Protein	Protein Coding	1
9	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
10	DOCK6	Dedicator Of Cytokinesis 6	Protein Coding	1
11	ARHGEF25	Rho Guanine Nucleotide Exchange Factor 25	Protein Coding	1
12	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	1
13	SPATA13	Spermatogenesis Associated 13	Protein Coding	1
14	ARHGAP17	Rho GTPase Activating Protein 17	Protein Coding	1
15	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	1
16	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
17	ARHGAP10	Rho GTPase Activating Protein 10	Protein Coding	1
18	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
19	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	1
20	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	1
21	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
22	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
23	GIT1	GIT ArfGAP 1	Protein Coding	1
24	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	1
25	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
26	ITSN1	Intersectin 1	Protein Coding	1
27	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
28	CDC42	Cell Division Cycle 42	Protein Coding	1
29	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
30	FARP2	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2	Protein Coding	1
31	RALBP1	RalA Binding Protein 1	Protein Coding	1

Disorders associated with Regulation of CDC42 activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.64
2	Autoinflammatory disease, multisystem, with immune dysregulation, x-linked	Enrichment	DOCK11	2.64
3	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.64
4	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.64
5	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.64
6	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.64
7	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.64
8	Familial adenomatous polyposis	Enrichment	APC	2.64
9	Nocarh syndrome	Enrichment	CDC42	2.64
10	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.64
11	Gardner syndrome	Enrichment	APC	2.64
12	5q22 microdeletion syndrome	Enrichment	APC	2.64
13	Attenuated familial adenomatous polyposis	Enrichment	APC	2.64
14	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	2.34
15	Adams-oliver syndrome 2	Enrichment	DOCK6	2.34
16	Periampullary adenoma	Enrichment	APC	2.34
17	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.34
18	Immune system disease	Enrichment	CDC42	2.34
19	Paget's disease of bone	Enrichment	DOCK6	2.34
20	Aarskog syndrome	Enrichment	FGD1	2.34
21	Cataract 48	Enrichment	DNMBP	2.34
22	Desmoid disease, hereditary	Enrichment	APC	2.16
23	Aarskog-scott syndrome	Enrichment	FGD1	2.16
24	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	FGD1	2.16
25	Hypercholanemia, familial 1	Enrichment	DOCK6	2.16
26	Adams-oliver syndrome 1	Enrichment	DOCK6	2.16
27	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.16
28	Desmoid tumor	Enrichment	APC	2.16
29	Colon adenocarcinoma	Enrichment	APC	2.16
30	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	FGD1	2.16
31	Apc-associated polyposis conditions	Enrichment	APC	2.16
32	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	2.04
33	Craniopharyngioma	Enrichment	APC	2.04
34	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.04
35	Familial adenomatous polyposis 1	Enrichment	APC	1.94
36	Adams-oliver syndrome	Enrichment	DOCK6	1.80
37	Moyamoya angiopathy	Enrichment	ARHGEF25	1.80
38	Colonic benign neoplasm	Enrichment	APC	1.69
39	Hypercholesterolemia, familial, 1	Enrichment	DOCK6	1.53
40	Medulloblastoma	Enrichment	APC	1.50
41	Familial hypercholesterolemia	Enrichment	DOCK6	1.47
42	Cataract 44	Enrichment	DNMBP	1.42
43	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	1.37
44	Hepatoblastoma	Enrichment	APC	1.33
45	Hepatocellular carcinoma	Enrichment	APC	1.31
46	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	1.13
47	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	1.10
48	Gastric cancer	Enrichment	APC	1.03
49	Hereditary breast carcinoma	Enrichment	APC	1.02
50	Autosomal dominant non-syndromic intellectual disability	Enrichment	ITSN1	0.97
51	Breast cancer	Enrichment	APC	0.80
52	Colorectal cancer	Enrichment	APC	0.74
53	Ovarian cancer	Enrichment	APC	0.68
54	Inherited cancer-predisposing syndrome	Enrichment	APC	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of CDC42 activity

Pathway Network for Regulation of CDC42 activity

Member Pathways for Regulation of CDC42 activity

Pathways in the Regulation of CDC42 activity SuperPath

Associated Genes for Regulation of CDC42 activity

Associated Disorders for Regulation of CDC42 activity

Disorders associated with Regulation of CDC42 activity SuperPath

STRING Interaction Network for Regulation of CDC42 activity

Sources for Regulation of CDC42 activity