Regulation of CDH1 Function

No Pathway Network information available for Regulation of CDH1 Function

Pathways in the Regulation of CDH1 Function SuperPath

#	Name	Source	Genes
1	Regulation of CDH1 Function	Reactome	ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 ADRM1 BANP CBLL1 CTNNA1 CTNNB1 CTNND1 CTSB CTSL CTSS DNM2 EPS15 FYN JUP MDM2 MTBP PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RACK1 RPS27A SEM1 SRC UBA52 UBB UBC VCL (see all 59) (see less)
2	Degradation of CDH1	Reactome	ADRM1 BANP CBLL1 CTNNA1 CTNNB1 CTNND1 CTSB CTSL CTSS DNM2 EPS15 FYN JUP MDM2 MTBP PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RACK1 RPS27A SEM1 SRC UBA52 UBB UBC (see all 52) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	2
2	RACK1	Receptor For Activated C Kinase 1	Protein Coding	2
3	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	2
4	CTNNA1	Catenin Alpha 1	Protein Coding	2
5	CTNNB1	Catenin Beta 1	Protein Coding	2
6	CTNND1	Catenin Delta 1	Protein Coding	2
7	CTSB	Cathepsin B	Protein Coding	2
8	CTSL	Cathepsin L	Protein Coding	2
9	CTSS	Cathepsin S	Protein Coding	2
10	DNM2	Dynamin 2	Protein Coding	2
11	EPS15	Epidermal Growth Factor Receptor Pathway Substrate 15	Protein Coding	2
12	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
13	MTBP	MDM2 Binding Protein	Protein Coding	2
14	JUP	Junction Plakoglobin	Protein Coding	2
15	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
16	BANP	BTG3 Associated Nuclear Protein	Protein Coding	2
17	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
18	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
19	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
20	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
21	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
22	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
23	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
24	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
25	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
26	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
27	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
28	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
29	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
30	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
31	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	2
32	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	2
33	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	2
34	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	2
35	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	2
36	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	2
37	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	2
38	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	2
39	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	2
40	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	2
41	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	2
42	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	2
43	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	2
44	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	2
45	RPS27A	Ribosomal Protein S27a	Protein Coding	2
46	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
47	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
48	UBB	Ubiquitin B	Protein Coding	2
49	UBC	Ubiquitin C	Protein Coding	2
50	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	2
51	CBLL1	Cbl Proto-Oncogene Like 1	Protein Coding	2
52	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	2
53	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
54	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
55	ACTB	Actin Beta	Protein Coding	1
56	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
57	ACTG1	Actin Gamma 1	Protein Coding	1
58	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
59	VCL	Vinculin	Protein Coding	1

Disorders associated with Regulation of CDH1 Function SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.73
2	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1, JUP, VCL	3.40
3	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1, PSMC3	2.70
4	Patent foramen ovale	Enrichment	ACTC1, PSMC3	2.57
5	Centronuclear myopathy	Enrichment	ACTA1, DNM2	2.43
6	Keratolytic winter erythema	Enrichment	CTSB	2.42
7	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.42
8	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.42
9	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.42
10	Accelerated tumor formation	Enrichment	MDM2	2.42
11	Naxos disease	Enrichment	JUP	2.42
12	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.42
13	Lessel-kubisch syndrome	Enrichment	MDM2	2.42
14	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.42
15	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.42
16	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.42
17	Thrombocytopenia 6	Enrichment	SRC	2.42
18	Adenoid ameloblastoma	Enrichment	CTNNB1	2.42
19	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.42
20	Microcystic stromal tumor	Enrichment	CTNNB1	2.42
21	Baraitser-winter syndrome 1	Enrichment	ACTB	2.36
22	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.36
23	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.36
24	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.36
25	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.36
26	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.36
27	Becker nevus syndrome	Enrichment	ACTB	2.36
28	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.36
29	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.36
30	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.36
31	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.36
32	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.36
33	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.36
34	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.36
35	Baraitser-winter syndrome	Enrichment	ACTB	2.36
36	Zebra body myopathy	Enrichment	ACTA1	2.36
37	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.36
38	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.36
39	Actin-accumulation myopathy	Enrichment	ACTA1	2.36
40	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.36
41	Actg2 visceral myopathy	Enrichment	ACTG2	2.36
42	Colorectal cancer	Enrichment	CTNNA1, CTNNB1, SRC	2.35
43	Blepharocheilodontic syndrome 1	Enrichment	CTNND1	2.12
44	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.12
45	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.12
46	Birk-aharoni syndrome	Enrichment	PSMC1	2.12
47	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	2.12
48	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.12
49	17q24.2 microdeletion syndrome	Enrichment	PSMD12	2.12
50	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.12
51	Teratoma	Enrichment	CTNNB1	2.12
52	Submucosal cleft palate	Enrichment	UBB	2.12
53	Cleft hard palate	Enrichment	UBB	2.12
54	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.06
55	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.06
56	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.06
57	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.06
58	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.06
59	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.06
60	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.06
61	Moyamoya disease 5	Enrichment	ACTA2	2.06
62	Atrial septal defect 5	Enrichment	ACTC1	2.06
63	Intestinal obstruction	Enrichment	ACTG2	2.06
64	Desmoid disease, hereditary	Enrichment	CTNNB1	1.94
65	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.94
66	Uvula, bifid	Enrichment	UBB	1.94
67	Myopathy, centronuclear, x-linked	Enrichment	DNM2	1.94
68	Cleft soft palate	Enrichment	UBB	1.94
69	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.94
70	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.94
71	Anus, imperforate	Enrichment	CTNNB1	1.94
72	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.94
73	Desmoid tumor	Enrichment	CTNNB1	1.94
74	Dedifferentiated liposarcoma	Enrichment	MDM2	1.94
75	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.94
76	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.94
77	Well-differentiated liposarcoma	Enrichment	MDM2	1.94
78	Thyroid hemiagenesis	Enrichment	PSMD3	1.94
79	Myopathy	Enrichment	ACTA1, DNM2	1.88
80	Distal arthrogryposis	Enrichment	ACTA1, ACTC1	1.84
81	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CTNNA1	1.82
82	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.82
83	Pilomatrixoma	Enrichment	CTNNB1	1.82
84	Alazami syndrome	Enrichment	CTNNB1	1.82
85	Craniopharyngioma	Enrichment	CTNNB1	1.82
86	Nemaline myopathy 2	Enrichment	ACTA1	1.76
87	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.76
88	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.76
89	Aminoacylase 1 deficiency	Enrichment	ACTB	1.76
90	Intermediate nemaline myopathy	Enrichment	ACTA1	1.76
91	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.76
92	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.72
93	Visceral myopathy 1	Enrichment	ACTG2	1.67
94	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.67
95	Coloboma of choroid and retina	Enrichment	ACTG1	1.67
96	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.67
97	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1, VCL	1.65
98	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.64
99	Li-fraumeni syndrome	Enrichment	MDM2	1.64
100	Myopathy, centronuclear, 1	Enrichment	DNM2	1.64
101	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.64
102	Patent ductus arteriosus	Enrichment	PSMC3	1.64
103	Adrenocortical carcinoma	Enrichment	CTNNB1	1.64
104	Cleft lip with or without cleft palate	Enrichment	CTNND1	1.64
105	Moyamoya disease 1	Enrichment	ACTA2	1.59
106	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.59
107	Typical nemaline myopathy	Enrichment	ACTA1	1.59
108	Myelofibrosis	Enrichment	SRC	1.58
109	Gallbladder cancer	Enrichment	CTNNB1	1.58
110	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.52
111	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.52
112	Isolated split hand-split foot malformation	Enrichment	SEM1	1.52
113	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.47
114	Polymicrogyria	Enrichment	PSMC3	1.42
115	Cat eye syndrome	Enrichment	ACTG1	1.37
116	Nemaline myopathy	Enrichment	ACTA1	1.37
117	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.35
118	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.35
119	Osteoporosis	Enrichment	SRC	1.28
120	Medulloblastoma	Enrichment	CTNNB1	1.28
121	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.28
122	Lung cancer susceptibility 3	Enrichment	ACTA2	1.23
123	Wolff-parkinson-white syndrome	Enrichment	JUP	1.22
124	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	1.22
125	Polycystic liver disease	Enrichment	CTNNB1	1.20
126	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.20
127	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.20
128	Craniosynostosis	Enrichment	CTNNA1	1.13
129	Neuromuscular disease	Enrichment	ACTA1	1.12
130	Hepatoblastoma	Enrichment	CTNNB1	1.11
131	Congenital myopathy	Enrichment	ACTA1	1.10
132	Hepatocellular carcinoma	Enrichment	CTNNB1	1.09
133	Myocardial infarction	Enrichment	PSMA6	1.09
134	Lissencephaly	Enrichment	ACTG1	1.06
135	Bladder cancer	Enrichment	CTNNB1	0.98
136	Hydrops fetalis, nonimmune	Enrichment	ACTA1	0.97
137	Non-immune hydrops fetalis	Enrichment	ACTA1	0.90
138	Lung cancer	Enrichment	ACTA2	0.88
139	Connective tissue disease	Enrichment	ACTA2	0.88
140	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	0.87
141	Cakut	Enrichment	ACTG1	0.86
142	Left ventricular noncompaction	Enrichment	ACTC1	0.85
143	Non-syndromic genetic deafness	Enrichment	ACTG1	0.84
144	Charcot-marie-tooth disease	Enrichment	DNM2	0.84
145	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.83
146	Nonsyndromic hearing loss	Enrichment	ACTG1	0.78
147	Thrombocytopenia	Enrichment	SRC	0.77
148	Hypertrophic cardiomyopathy	Enrichment	ACTC1	0.77
149	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.76
150	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1	0.72
151	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.69
152	Rare genetic deafness	Enrichment	ACTG1	0.53
153	Ovarian cancer	Enrichment	CTNNB1	0.49
154	Congenital nervous system abnormality	Enrichment	CTNNB1	0.47
155	Nervous system disease	Enrichment	CTNNB1	0.47
156	Complex neurodevelopmental disorder	Enrichment	PSMD12	0.42
157	Inherited cancer-predisposing syndrome	Enrichment	CTNNA1	0.40
158	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.17
159	Fundus dystrophy	Enrichment	CTNNA1	0.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of CDH1 Function

Pathway Network for Regulation of CDH1 Function

Member Pathways for Regulation of CDH1 Function

Pathways in the Regulation of CDH1 Function SuperPath

Associated Genes for Regulation of CDH1 Function

Associated Disorders for Regulation of CDH1 Function

Disorders associated with Regulation of CDH1 Function SuperPath

STRING Interaction Network for Regulation of CDH1 Function

Sources for Regulation of CDH1 Function