Regulation of CDH1 Gene Transcription

Pathway network for the Regulation of CDH1 Gene Transcription SuperPath

Sources:

Reactome

Pathways in the Regulation of CDH1 Gene Transcription SuperPath

#	Name	Source	Genes
1	Regulation of CDH1 Gene Transcription	Reactome	ARID1A CTBP1 CTBP2 DNTTIP1 EED EZH2 FOXA2 FOXJ2 FOXP2 FOXQ1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 KDM1A KLF4 KLF9 KMT5A MAPK1 MAPK3 MCRIP1 MPHOSPH8 PKM RB1 RBBP4 RBBP7 SIRT1 SMARCA4 SNAI1 SNAI2 SP1 STRAP SUZ12 TCF12 TCF3 TFAP2A TGIF2 TLE1 TWIST1 TWIST2 WT1 ZBTB33 ZEB1 ZEB2 ZMYM2 ZNF217 (see all 103) (see less)
2	Negative Regulation of CDH1 Gene Transcription	Reactome	CTBP1 CTBP2 DNTTIP1 EED EZH2 FOXQ1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 KDM1A KMT5A MAPK1 MAPK3 MCRIP1 MPHOSPH8 PKM RBBP4 RBBP7 SIRT1 SMARCA4 SNAI1 SNAI2 SUZ12 TCF12 TCF3 TGIF2 TLE1 TWIST1 TWIST2 WT1 ZBTB33 ZEB1 ZEB2 ZMYM2 ZNF217 (see all 93) (see less)
3	Positive Regulation of CDH1 Gene Transcription	Reactome	ARID1A FOXA2 FOXJ2 FOXP2 KLF4 KLF9 RB1 SP1 STRAP TFAP2A ZEB2 (see all 11) (see less)

Gene overlap in member pathways for Regulation of CDH1 Gene Transcription SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ZEB2	Zinc Finger E-Box Binding Homeobox 2	Protein Coding	3
2	ZBTB33	Zinc Finger And BTB Domain Containing 33	Protein Coding	2
3	STRAP	Serine/Threonine Kinase Receptor Associated Protein	Protein Coding	2
4	DNTTIP1	Deoxynucleotidyltransferase Terminal Interacting Protein 1	Protein Coding	2
5	TWIST2	Twist Family BHLH Transcription Factor 2	Protein Coding	2
6	H4C16	H4 Histone 16	Protein Coding	2
7	H3C14	H3 Clustered Histone 14	Protein Coding	2
8	H2BC26	H2B Clustered Histone 26	Protein Coding	2
9	CTBP1	C-Terminal Binding Protein 1	Protein Coding	2
10	CTBP2	C-Terminal Binding Protein 2	Protein Coding	2
11	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
12	KDM1A	Lysine Demethylase 1A	Protein Coding	2
13	SIRT1	Sirtuin 1	Protein Coding	2
14	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
15	H2BC1	H2B Clustered Histone 1	Protein Coding	2
16	H2AC8	H2A Clustered Histone 8	Protein Coding	2
17	H2AC7	H2A Clustered Histone 7	Protein Coding	2
18	H2AX	H2A.X Variant Histone	Protein Coding	2
19	H2BC5	H2B Clustered Histone 5	Protein Coding	2
20	H2BC3	H2B Clustered Histone 3	Protein Coding	2
21	H3-3A	H3.3 Histone A	Protein Coding	2
22	H3-3B	H3.3 Histone B	Protein Coding	2
23	HDAC1	Histone Deacetylase 1	Protein Coding	2
24	HDAC2	Histone Deacetylase 2	Protein Coding	2
25	FOXA2	Forkhead Box A2	Protein Coding	2
26	H3C15	H3 Clustered Histone 15	Protein Coding	2
27	MCRIP1	MAPK Regulated Corepressor Interacting Protein 1	Protein Coding	2
28	KMT5A	Lysine Methyltransferase 5A	Protein Coding	2
29	H2AB1	H2A.B Variant Histone 1	Protein Coding	2
30	PKM	Pyruvate Kinase M1/2	Protein Coding	2
31	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	2
32	MPHOSPH8	M-Phase Phosphoprotein 8	Protein Coding	2
33	H4C15	H4 Clustered Histone 15	Protein Coding	2
34	H2AJ	H2A.J Histone	Protein Coding	2
35	FOXJ2	Forkhead Box J2	Protein Coding	2
36	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
37	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
38	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
39	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
40	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	2
41	TGIF2	TGFB Induced Factor Homeobox 2	Protein Coding	2
42	H3C13	H3 Clustered Histone 13	Protein Coding	2
43	SNAI2	Snail Family Transcriptional Repressor 2	Protein Coding	2
44	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	2
45	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	2
46	SP1	Sp1 Transcription Factor	Protein Coding	2
47	KLF9	KLF Transcription Factor 9	Protein Coding	2
48	TCF3	Transcription Factor 3	Protein Coding	2
49	ZEB1	Zinc Finger E-Box Binding Homeobox 1	Protein Coding	2
50	TCF12	Transcription Factor 12	Protein Coding	2
51	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	2
52	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	2
53	H2AC19	H2A Clustered Histone 19	Protein Coding	2
54	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	2
55	WT1	WT1 Transcription Factor	Protein Coding	2
56	ZMYM2	Zinc Finger MYM-Type Containing 2	Protein Coding	2
57	ZNF217	Zinc Finger Protein 217	Protein Coding	2
58	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	2
59	H4C9	H4 Clustered Histone 9	Protein Coding	2
60	H2AC14	H2A Clustered Histone 14	Protein Coding	2
61	H2AC6	H2A Clustered Histone 6	Protein Coding	2
62	H2AC4	H2A Clustered Histone 4	Protein Coding	2
63	H2AC18	H2A Clustered Histone 18	Protein Coding	2
64	H2AC20	H2A Clustered Histone 20	Protein Coding	2
65	H2BC8	H2B Clustered Histone 8	Protein Coding	2
66	H2BC13	H2B Clustered Histone 13	Protein Coding	2
67	H2BC15	H2B Clustered Histone 15	Protein Coding	2
68	H2BC14	H2B Clustered Histone 14	Protein Coding	2
69	H2BC7	H2B Clustered Histone 7	Protein Coding	2
70	H2BC6	H2B Clustered Histone 6	Protein Coding	2
71	H2BC9	H2B Clustered Histone 9	Protein Coding	2
72	H2BC10	H2B Clustered Histone 10	Protein Coding	2
73	H2BC4	H2B Clustered Histone 4	Protein Coding	2
74	H2BC17	H2B Clustered Histone 17	Protein Coding	2
75	H2BC21	H2B Clustered Histone 21	Protein Coding	2
76	H3C1	H3 Clustered Histone 1	Protein Coding	2
77	H3C4	H3 Clustered Histone 4	Protein Coding	2
78	H3C3	H3 Clustered Histone 3	Protein Coding	2
79	H3C6	H3 Clustered Histone 6	Protein Coding	2
80	H3C11	H3 Clustered Histone 11	Protein Coding	2
81	H3C8	H3 Clustered Histone 8	Protein Coding	2
82	H3C12	H3 Clustered Histone 12	Protein Coding	2
83	H3C10	H3 Clustered Histone 10	Protein Coding	2
84	H3C2	H3 Clustered Histone 2	Protein Coding	2
85	H4C1	H4 Clustered Histone 1	Protein Coding	2
86	H4C4	H4 Clustered Histone 4	Protein Coding	2
87	H4C6	H4 Clustered Histone 6	Protein Coding	2
88	H4C12	H4 Clustered Histone 12	Protein Coding	2
89	H4C11	H4 Clustered Histone 11	Protein Coding	2
90	H4C3	H4 Clustered Histone 3	Protein Coding	2
91	H4C8	H4 Clustered Histone 8	Protein Coding	2
92	H4C2	H4 Clustered Histone 2	Protein Coding	2
93	H4C5	H4 Clustered Histone 5	Protein Coding	2
94	H4C13	H4 Clustered Histone 13	Protein Coding	2
95	H4C14	H4 Clustered Histone 14	Protein Coding	2
96	H2BC12	H2B Clustered Histone 12	Protein Coding	2
97	EED	Embryonic Ectoderm Development	Protein Coding	2
98	H3C7	H3 Clustered Histone 7	Protein Coding	2
99	H2BC11	H2B Clustered Histone 11	Protein Coding	2
100	KLF4	KLF Transcription Factor 4	Protein Coding	2
101	FOXP2	Forkhead Box P2	Protein Coding	2
102	FOXQ1	Forkhead Box Q1	Protein Coding	2
103	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	2

Disorders associated with Regulation of CDH1 Gene Transcription SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	6.51
2	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.33
3	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.33
4	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.33
5	Weaver syndrome	Enrichment	EZH2, SUZ12	3.86
6	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	3.86
7	Bladder cancer	Enrichment	ARID1A, RB1	3.62
8	Non-syndromic bicoronal craniosynostosis	Enrichment	TCF12, TWIST1	3.56
9	Trilateral retinoblastoma	Enrichment	RB1	3.09
10	Non-acquired combined pituitary hormone deficiency	Enrichment	FOXA2	3.09
11	7q31 microdeletion syndrome	Enrichment	FOXP2	3.09
12	Lung oat cell carcinoma	Enrichment	RB1	3.09
13	Glioma susceptibility 1	Enrichment	H3-3A, H3C1	2.90
14	Mowat-wilson syndrome	Enrichment	ZEB2	2.79
15	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.79
16	Esotropia	Enrichment	TFAP2A	2.79
17	Familial retinoblastoma	Enrichment	RB1	2.79
18	Lens subluxation	Enrichment	TFAP2A	2.79
19	Retinoblastoma	Enrichment	RB1	2.61
20	Osteogenic sarcoma	Enrichment	RB1	2.61
21	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.61
22	Hypotrichosis 8	Enrichment	RB1	2.61
23	Coffin-siris syndrome 2	Enrichment	ARID1A	2.61
24	Squamous cell carcinoma	Enrichment	RB1	2.61
25	Periventricular leukomalacia	Enrichment	ARID1A	2.61
26	Bone osteosarcoma	Enrichment	RB1	2.61
27	Childhood apraxia of speech	Enrichment	FOXP2	2.61
28	Branchiooculofacial syndrome	Enrichment	TFAP2A	2.49
29	Small cell cancer of the lung	Enrichment	RB1	2.49
30	Lynch syndrome 4	Enrichment	RB1	2.49
31	Amblyopia	Enrichment	TFAP2A	2.39
32	Branchiootorenal syndrome 1	Enrichment	TFAP2A	2.31
33	Coffin-siris syndrome 1	Enrichment	ARID1A, SMARCA4	2.25
34	Branchiootorenal syndrome	Enrichment	TFAP2A	2.25
35	Megacolon	Enrichment	ZEB2	2.25
36	Melanocytic nevus syndrome, congenital	Enrichment	ZEB2	2.19
37	Combined pituitary hormone deficiency	Enrichment	FOXA2	2.19
38	Barber-say syndrome	Enrichment	TWIST2	2.16
39	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.16
40	Focal facial dermal dysplasia 2, brauer-setleis type	Enrichment	TWIST2	2.16
41	Focal facial dermal dysplasia 3, setleis type	Enrichment	TWIST2	2.16
42	Ablepharon-macrostomia syndrome	Enrichment	TWIST2	2.16
43	Noonan syndrome 13	Enrichment	MAPK1	2.16
44	Agammaglobulinemia 8b, autosomal recessive	Enrichment	TCF3	2.16
45	Imagawa-matsumoto syndrome	Enrichment	SUZ12	2.16
46	Neurodevelopmental-craniofacial syndrome with variable renal and cardiac abnormalities	Enrichment	ZMYM2	2.16
47	Agammaglobulinemia 8a, autosomal dominant	Enrichment	TCF3	2.16
48	Meacham syndrome	Enrichment	WT1	2.16
49	Craniosynostosis 3	Enrichment	TCF12	2.16
50	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.16
51	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.16
52	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.16
53	Cohen-gibson syndrome	Enrichment	EED	2.16
54	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.16
55	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.16
56	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.16
57	Hypogonadotropic hypogonadism 26 with or without anosmia	Enrichment	TCF12	2.16
58	Cat eye syndrome	Enrichment	TFAP2A	2.09
59	Epicanthus	Enrichment	TFAP2A	2.01
60	Septooptic dysplasia	Enrichment	ARID1A	2.01
61	Lip and oral cavity carcinoma	Enrichment	RB1	2.01
62	Complex neurodevelopmental disorder	Enrichment	H4C3, H4C5, H4C9, ZMYM2	1.98
63	Lung cancer susceptibility 3	Enrichment	RB1	1.95
64	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	ARID1A	1.89
65	Robinow-sorauf syndrome	Enrichment	TWIST1	1.86
66	Denys-drash syndrome	Enrichment	WT1	1.86
67	Nephrotic syndrome, type 4	Enrichment	WT1	1.86
68	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.86
69	Piebald trait	Enrichment	SNAI2	1.86
70	Frasier syndrome	Enrichment	WT1	1.86
71	Sweeney-cox syndrome	Enrichment	TWIST1	1.86
72	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	1.86
73	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4	1.86
74	Otosclerosis 12	Enrichment	SMARCA4	1.86
75	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.86
76	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	TCF3	1.86
77	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	1.86
78	B-lymphoblastic leukemia/lymphoma with t(17;19)	Enrichment	TCF3	1.86
79	Desmoplastic small round cell tumor	Enrichment	WT1	1.86
80	Microphthalmia	Enrichment	TFAP2A	1.75
81	Inherited cancer-predisposing syndrome	Enrichment	EZH2, RB1, SMARCA4, WT1	1.74
82	Craniosynostosis 1	Enrichment	TWIST1	1.69
83	Mesothelioma, malignant	Enrichment	WT1	1.69
84	Corneal dystrophy, posterior polymorphous, 3	Enrichment	ZEB1	1.69
85	Corneal dystrophy, fuchs endothelial, 6	Enrichment	ZEB1	1.69
86	Intraocular pressure quantitative trait locus	Enrichment	ZEB1	1.69
87	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	1.69
88	Hydrops fetalis, nonimmune	Enrichment	ARID1A	1.68
89	Non-immune hydrops fetalis	Enrichment	ARID1A	1.60
90	Aniridia 1	Enrichment	WT1	1.57
91	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.57
92	Saethre-chotzen syndrome	Enrichment	TWIST1	1.57
93	Corneal dystrophy	Enrichment	ZEB1	1.57
94	Chondrosarcoma, extraskeletal myxoid	Enrichment	TCF12	1.47
95	Leber congenital amaurosis 10	Enrichment	WT1	1.47
96	Fuchs' endothelial dystrophy	Enrichment	ZEB1	1.47
97	Endometrial stromal sarcoma	Enrichment	SUZ12	1.47
98	Corneal dystrophy, posterior polymorphous, 1	Enrichment	ZEB1	1.39
99	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.39
100	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	WT1	1.39
101	Wilms tumor 5	Enrichment	WT1	1.39
102	Hypertelorism	Enrichment	TFAP2A	1.38
103	Waardenburg syndrome, type 2e	Enrichment	SNAI2	1.33
104	Neuroblastoma	Enrichment	SMARCA4	1.27
105	Difference of sex development	Enrichment	WT1	1.27
106	Myeloma, multiple	Enrichment	H3C1, TCF3	1.25
107	Leukemia, acute lymphoblastic 3	Enrichment	WT1	1.22
108	Ventricular septal defect	Enrichment	SMARCA4	1.22
109	Autosomal non-syndromic agammaglobulinemia	Enrichment	TCF3	1.18
110	Colorectal cancer	Enrichment	ARID1A	1.17
111	Atrial heart septal defect	Enrichment	SMARCA4	1.14
112	46,xy complete gonadal dysgenesis	Enrichment	WT1	1.14
113	Interatrial communication	Enrichment	SMARCA4	1.14
114	Specific learning disability	Enrichment	MAPK1	1.14
115	Ovarian cancer	Enrichment	RB1	1.10
116	Congenital nervous system abnormality	Enrichment	ZEB2	1.08
117	Nervous system disease	Enrichment	ZEB2	1.08
118	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.07
119	46,xy partial gonadal dysgenesis	Enrichment	WT1	1.04
120	Microcephaly	Enrichment	ARID1A	1.02
121	Wilms tumor 1	Enrichment	WT1	1.01
122	Familial hypercholesterolemia	Enrichment	SMARCA4	1.01
123	Kidney disease	Enrichment	WT1	1.01
124	Cleft palate, isolated	Enrichment	SMARCA4	0.96
125	Heart, malformation of	Enrichment	MAPK1	0.93
126	Craniosynostosis	Enrichment	TCF12	0.89
127	Focal segmental glomerulosclerosis	Enrichment	WT1	0.89
128	Autism spectrum disorder	Enrichment	EED, TCF12	0.77
129	Cakut	Enrichment	ZMYM2	0.68
130	Genetic steroid-resistant nephrotic syndrome	Enrichment	WT1	0.68
131	Cerebral palsy	Enrichment	SMARCA4	0.63
132	Primary ovarian insufficiency	Enrichment	WT1	0.48

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of CDH1 Gene Transcription

Pathway Network for Regulation of CDH1 Gene Transcription

Pathway network for the Regulation of CDH1 Gene Transcription SuperPath

Member Pathways for Regulation of CDH1 Gene Transcription

Pathways in the Regulation of CDH1 Gene Transcription SuperPath

Gene overlap in member pathways for Regulation of CDH1 Gene Transcription SuperPath

Associated Genes for Regulation of CDH1 Gene Transcription

Associated Disorders for Regulation of CDH1 Gene Transcription

Disorders associated with Regulation of CDH1 Gene Transcription SuperPath

STRING Interaction Network for Regulation of CDH1 Gene Transcription

Sources for Regulation of CDH1 Gene Transcription