Regulation of commissural axon pathfinding by SLIT and ROBO

No Pathway Network information available for Regulation of commissural axon pathfinding by SLIT and ROBO

#	Name	Source	Genes
1	Regulation of commissural axon pathfinding by SLIT and ROBO	Reactome	NELL2 NTN1 ROBO1 ROBO2 ROBO3 SLIT1 SLIT2 SLIT3 SRC (see all 9) (see less)
2	Regulation of cortical dendrite branching	Reactome	NCK2 ROBO1 ROBO2 SLIT1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ROBO1	Roundabout Guidance Receptor 1	Protein Coding	2
2	ROBO2	Roundabout Guidance Receptor 2	Protein Coding	2
3	SLIT1	Slit Guidance Ligand 1	Protein Coding	2
4	NELL2	Neural EGFL Like 2	Protein Coding	1
5	ROBO3	Roundabout Guidance Receptor 3	Protein Coding	1
6	SLIT3	Slit Guidance Ligand 3	Protein Coding	1
7	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
8	SLIT2	Slit Guidance Ligand 2	Protein Coding	1
9	NTN1	Netrin 1	Protein Coding	1
10	NCK2	NCK Adaptor Protein 2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cakut	Enrichment	ROBO1, SLIT2	3.66
2	Nystagmus 8, congenital, autosomal recessive	Enrichment	ROBO1	3.53
3	Vesicoureteral reflux 2	Enrichment	ROBO2	3.53
4	Autosomal recessive congenital nystagmus	Enrichment	ROBO1	3.53
5	Pituitary hormone deficiency, combined or isolated, 8	Enrichment	ROBO1	3.53
6	Neurooculorenal syndrome	Enrichment	ROBO1	3.53
7	Congenital nystagmus	Enrichment	ROBO1	3.53
8	Mirror movements 4	Enrichment	NTN1	3.18
9	Conjugate gaze palsy	Enrichment	ROBO3	3.18
10	Thrombocytopenia 6	Enrichment	SRC	3.18
11	Familial vesicoureteral reflux	Enrichment	ROBO2	3.05
12	Amyotrophy, monomelic	Enrichment	SLIT1	2.93
13	Gaze palsy, familial horizontal, with progressive scoliosis 1	Enrichment	ROBO3	2.88
14	Horizontal gaze palsy with progressive scoliosis	Enrichment	ROBO3	2.88
15	Mirror movements 1	Enrichment	NTN1	2.58
16	Renal agenesis, bilateral	Enrichment	ROBO1	2.58
17	Pituitary stalk interruption syndrome	Enrichment	ROBO1	2.38
18	Myelofibrosis	Enrichment	SRC	2.33
19	Tetralogy of fallot	Enrichment	ROBO1	2.12
20	Osteoporosis	Enrichment	SRC	2.03
21	Thrombocytopenia	Enrichment	SRC	1.50
22	Colorectal cancer	Enrichment	SRC	1.25

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Regulation of commissural axon pathfinding by SLIT and ROBO