Regulation of cytoplasmic and nuclear SMAD2/3 signaling

No Pathway Network information available for Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Pathways in the Regulation of cytoplasmic and nuclear SMAD2/3 signaling SuperPath

#	Name	Source	Genes
1	Regulation of cytoplasmic and nuclear SMAD2/3 signaling	PubChem	CTDSP1 KPNA2 KPNB1 MAP3K1 MAPK3 NUP153 NUP214 PIAS4 PPM1A SMAD2 SMAD3 SMAD4 UBE2I (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CTDSP1	CTD Small Phosphatase 1	Protein Coding	1
2	PPM1A	Protein Phosphatase, Mg2+/Mn2+ Dependent 1A	Protein Coding	1
3	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	1
4	PIAS4	Protein Inhibitor Of Activated STAT 4	Protein Coding	1
5	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
6	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	1
7	SMAD4	SMAD Family Member 4	Protein Coding	1
8	SMAD2	SMAD Family Member 2	Protein Coding	1
9	SMAD3	SMAD Family Member 3	Protein Coding	1
10	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
11	NUP153	Nucleoporin 153	Protein Coding	1
12	NUP214	Nucleoporin 214	Protein Coding	1
13	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1

Disorders associated with Regulation of cytoplasmic and nuclear SMAD2/3 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4	5.05
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3	4.52
3	46,xy sex reversal 6	Enrichment	MAP3K1	3.02
4	Loeys-dietz syndrome 6	Enrichment	SMAD2	3.02
5	Encephalopathy, acute, infection-induced 9	Enrichment	NUP214	3.02
6	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	3.02
7	Heritable thoracic aortic disease	Enrichment	SMAD4	3.02
8	Myhre syndrome	Enrichment	SMAD4	2.72
9	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.72
10	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.72
11	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	NUP214	2.72
12	Juvenile polyposis syndrome	Enrichment	SMAD4	2.54
13	Loeys-dietz syndrome 1	Enrichment	SMAD2	2.54
14	Aortic aneurysm	Enrichment	SMAD3	2.42
15	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.32
16	Gallbladder cancer	Enrichment	SMAD4	2.17
17	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	2.17
18	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	2.07
19	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.98
20	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.87
21	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.87
22	Ehlers-danlos syndrome	Enrichment	SMAD3	1.74
23	Precursor t-cell acute lymphoblastic leukemia	Enrichment	NUP214	1.66
24	Pancreatic cancer	Enrichment	SMAD4	1.63
25	Connective tissue disease	Enrichment	SMAD3	1.52
26	Leukemia, acute myeloid	Enrichment	NUP214	1.42
27	Gastric cancer	Enrichment	SMAD4	1.39
28	Thrombocytopenia	Enrichment	SMAD4	1.35
29	Colorectal cancer	Enrichment	SMAD4	1.10
30	Ovarian cancer	Enrichment	MAP3K1	1.03
31	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Pathway Network for Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Member Pathways for Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Pathways in the Regulation of cytoplasmic and nuclear SMAD2/3 signaling SuperPath

Associated Genes for Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Associated Disorders for Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Disorders associated with Regulation of cytoplasmic and nuclear SMAD2/3 signaling SuperPath

STRING Interaction Network for Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Sources for Regulation of cytoplasmic and nuclear SMAD2/3 signaling