Regulation of degradation of deltaF508 CFTR in CF

No Pathway Network information available for Regulation of degradation of deltaF508 CFTR in CF

Pathways in the Regulation of degradation of deltaF508 CFTR in CF SuperPath

#	Name	Source	Genes
1	Regulation of degradation of deltaF508 CFTR in CF	GeneGo (Thomson Reuters)	AMFR ATXN3 BAG2 CFTR CRYAA DERL1 DNAJA1 DNAJC5 DYNC1H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 HDAC6 HSPA14 HSPA1A HSPA1B HSPA1L HSPA2 HSPA4 HSPA5 HSPA6 HSPA7 HSPA8 HSPA9 HSPB1 HSPBP1 NPLOC4 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 RNF5 SEC61A1 SEC61A2 SEC61B SEC61G STUB1 UBA1 UBA52 UBB UBC UBE2D1 UBE2J1 UFD1 VCP (see all 63) (see less)
2	Regulation of degradation of wt-CFTR	GeneGo (Thomson Reuters)	ATXN3 BAG2 CFTR DERL1 DNAJC5 HSPA8 HSPBP1 NPLOC4 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 RNF5 SEC61A1 SEC61A2 SEC61B SEC61G STUB1 UBA1 UBA52 UBB UBC UBE2D1 UBE2J1 UFD1 VCP (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	2
2	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	2
3	ATXN3	Ataxin 3	Protein Coding	2
4	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
5	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
6	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
7	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
8	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
9	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
10	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
11	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
12	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
13	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
14	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
15	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
16	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
17	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
18	RNF5	Ring Finger Protein 5	Protein Coding	2
19	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
20	UBB	Ubiquitin B	Protein Coding	2
21	UBC	Ubiquitin C	Protein Coding	2
22	UBA1	Ubiquitin Like Modifier Activating Enzyme 1	Protein Coding	2
23	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
24	UFD1	Ubiquitin Recognition Factor In ER Associated Degradation 1	Protein Coding	2
25	VCP	Valosin Containing Protein	Protein Coding	2
26	BAG2	BAG Cochaperone 2	Protein Coding	2
27	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	2
28	SEC61B	SEC61 Translocon Subunit Beta	Protein Coding	2
29	SEC61G	SEC61 Translocon Subunit Gamma	Protein Coding	2
30	HSPBP1	HSPA (Hsp70) Binding Protein 1	Protein Coding	2
31	SEC61A1	SEC61 Translocon Subunit Alpha 1	Protein Coding	2
32	UBE2J1	Ubiquitin Conjugating Enzyme E2 J1	Protein Coding	2
33	SEC61A2	SEC61 Translocon Subunit Alpha 2	Protein Coding	2
34	NPLOC4	NPL4 Homolog, Ubiquitin Recognition Factor	Protein Coding	2
35	DERL1	Derlin 1	Protein Coding	2
36	DNAJC5	DnaJ Heat Shock Protein Family (Hsp40) Member C5	Protein Coding	2
37	PSMA8	Proteasome 20S Subunit Alpha 8	Protein Coding	2
38	AMFR	Autocrine Motility Factor Receptor	Protein Coding	1
39	CRYAA	Crystallin Alpha A	Protein Coding	1
40	DYNC1H1	Dynein Cytoplasmic 1 Heavy Chain 1	Protein Coding	1
41	DYNC1I1	Dynein Cytoplasmic 1 Intermediate Chain 1	Protein Coding	1
42	DYNC1I2	Dynein Cytoplasmic 1 Intermediate Chain 2	Protein Coding	1
43	DYNC1LI2	Dynein Cytoplasmic 1 Light Intermediate Chain 2	Protein Coding	1
44	DNAJA1	DnaJ Heat Shock Protein Family (Hsp40) Member A1	Protein Coding	1
45	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
46	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	1
47	HSPA1L	Heat Shock Protein Family A (Hsp70) Member 1 Like	Protein Coding	1
48	HSPA2	Heat Shock Protein Family A (Hsp70) Member 2	Protein Coding	1
49	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	1
50	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	1
51	HSPA6	Heat Shock Protein Family A (Hsp70) Member 6	Protein Coding	1
52	HSPA7	Heat Shock Protein Family A (Hsp70) Member 7 (Pseudogene)	Pseudogene	1
53	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	1
54	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
55	DYNLT3	Dynein Light Chain Tctex-Type 3	Protein Coding	1
56	DYNLT1	Dynein Light Chain Tctex-Type 1	Protein Coding	1
57	DYNLL1	Dynein Light Chain LC8-Type 1	Protein Coding	1
58	HDAC6	Histone Deacetylase 6	Protein Coding	1
59	DYNC1LI1	Dynein Cytoplasmic 1 Light Intermediate Chain 1	Protein Coding	1
60	HSPA14	Heat Shock Protein Family A (Hsp70) Member 14	Protein Coding	1
61	DYNLRB2	Dynein Light Chain Roadblock-Type 2	Protein Coding	1
62	DYNLRB1	Dynein Light Chain Roadblock-Type 1	Protein Coding	1
63	DYNLL2	Dynein Light Chain LC8-Type 2	Protein Coding	1

Disorders associated with Regulation of degradation of deltaF508 CFTR in CF SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ceroid lipofuscinosis, neuronal, 4	Enrichment	DNAJC5	2.56
2	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	2.56
3	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.56
4	Tubulointerstitial kidney disease, autosomal dominant 5	Enrichment	SEC61A1	2.56
5	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	2.56
6	Multisystem proteinopathy	Enrichment	VCP	2.56
7	Neutropenia, severe congenital, 11, autosomal dominant	Enrichment	SEC61A1	2.56
8	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	2.56
9	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.56
10	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.33
11	Even-plus syndrome	Enrichment	HSPA9	2.33
12	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.33
13	Cataract 9, multiple types	Enrichment	CRYAA	2.33
14	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.33
15	Dync1h1-related disorders	Enrichment	DYNC1H1	2.33
16	Neurodevelopmental disorder with microcephaly and structural brain anomalies	Enrichment	DYNC1I2	2.33
17	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.26
18	Vexas syndrome	Enrichment	UBA1	2.26
19	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	2.26
20	Immunodeficiency, common variable, 15	Enrichment	SEC61A1	2.26
21	Spinocerebellar ataxia 48	Enrichment	STUB1	2.26
22	Spinal muscular atrophy, x-linked 2	Enrichment	UBA1	2.26
23	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	2.26
24	Submucosal cleft palate	Enrichment	UBB	2.26
25	Cleft hard palate	Enrichment	UBB	2.26
26	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	2.26
27	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	2.09
28	Uvula, bifid	Enrichment	UBB	2.09
29	Nuchal bleb, familial	Enrichment	CFTR	2.09
30	Cleft soft palate	Enrichment	UBB	2.09
31	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	2.09
32	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	2.09
33	Spinal muscular atrophy, lower extremity-predominant, 1, autosomal dominant	Enrichment	DYNC1H1	2.03
34	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.03
35	Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies	Enrichment	DYNC1I2	2.03
36	Cortical dysplasia, complex, with other brain malformations 13	Enrichment	DYNC1H1	2.03
37	Spinal muscular atrophy with lower extremity predominant	Enrichment	DYNC1H1	2.03
38	Charcot-marie-tooth disease, axonal, type 2o	Enrichment	DYNC1H1	2.03
39	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.03
40	Spastic paraplegia 89, autosomal recessive	Enrichment	AMFR	2.03
41	Idiopathic bronchiectasis	Enrichment	CFTR	1.96
42	Dementia, lewy body	Enrichment	VCP	1.87
43	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	1.87
44	Charcot-marie-tooth disease	Enrichment	DYNC1H1, HSPB1	1.81
45	Machado-joseph disease	Enrichment	ATXN3	1.79
46	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.79
47	Early-onset anterior polar cataract	Enrichment	CRYAA	1.73
48	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.64
49	Spinal muscular atrophy	Enrichment	DYNC1H1	1.64
50	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.61
51	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.61
52	Progressive non-fluent aphasia	Enrichment	VCP	1.61
53	Behavioral variant of frontotemporal dementia	Enrichment	VCP	1.61
54	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	1.57
55	Digeorge syndrome	Enrichment	UFD1	1.49
56	Alzheimer's disease	Enrichment	VCP	1.46
57	Cataract - microcornea syndrome	Enrichment	CRYAA	1.44
58	Hereditary chronic pancreatitis	Enrichment	CFTR	1.43
59	Neuronal ceroid lipofuscinosis	Enrichment	DNAJC5	1.40
60	Lynch syndrome	Enrichment	CFTR	1.40
61	Alzheimer disease, familial, 1	Enrichment	VCP	1.34
62	Pancreatitis, hereditary	Enrichment	CFTR	1.34
63	Polycystic liver disease	Enrichment	SEC61A1	1.34
64	Autosomal dominant polycystic liver disease	Enrichment	SEC61A1	1.34
65	Polymicrogyria	Enrichment	DYNC1H1	1.34
66	Early-onset lamellar cataract	Enrichment	CRYAA	1.30
67	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	VCP	1.30
68	Parkinson's disease	Enrichment	ATXN3	1.30
69	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	DYNC1H1	1.26
70	Myocardial infarction	Enrichment	PSMA6	1.23
71	Parkinson disease, late-onset	Enrichment	ATXN3	1.20
72	Cataract 44	Enrichment	CRYAA	1.12
73	Charcot-marie-tooth disease type 4	Enrichment	DYNC1H1	1.09
74	Early-onset nuclear cataract	Enrichment	CRYAA	1.09
75	Cystic fibrosis	Enrichment	CFTR	1.08
76	Male infertility	Enrichment	CFTR	1.05
77	Lissencephaly	Enrichment	DYNC1H1	1.03
78	Peripheral nervous system disease	Enrichment	DYNC1H1	0.86
79	Neuropathy	Enrichment	DYNC1H1	0.86
80	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.85
81	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VCP	0.83
82	Eye disease	Enrichment	CRYAA	0.82
83	Myopathy	Enrichment	DYNC1H1	0.77
84	Autosomal dominant non-syndromic intellectual disability	Enrichment	DYNC1H1	0.68
85	Congenital nervous system abnormality	Enrichment	DYNC1H1	0.41
86	Nervous system disease	Enrichment	DYNC1H1	0.41
87	Autism spectrum disorder	Enrichment	DYNC1H1	0.40
88	Microcephaly	Enrichment	DYNC1H1	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of degradation of deltaF508 CFTR in CF

Pathway Network for Regulation of degradation of deltaF508 CFTR in CF

Member Pathways for Regulation of degradation of deltaF508 CFTR in CF

Pathways in the Regulation of degradation of deltaF508 CFTR in CF SuperPath

Associated Genes for Regulation of degradation of deltaF508 CFTR in CF

Associated Disorders for Regulation of degradation of deltaF508 CFTR in CF

Disorders associated with Regulation of degradation of deltaF508 CFTR in CF SuperPath

STRING Interaction Network for Regulation of degradation of deltaF508 CFTR in CF

Sources for Regulation of degradation of deltaF508 CFTR in CF