Regulation of FZD by ubiquitination

No Pathway Network information available for Regulation of FZD by ubiquitination

Pathways in the Regulation of FZD by ubiquitination SuperPath

#	Name	Source	Genes
1	Regulation of FZD by ubiquitination	Reactome	FZD4 FZD5 FZD6 FZD8 LGR4 LGR5 LGR6 LRP5 LRP6 RNF43 RPS27A RSPO1 RSPO2 RSPO3 RSPO4 UBA52 UBB UBC USP8 WNT3A ZNRF3 (see all 21) (see less)
2	Signaling by RNF43 mutants	Reactome	FZD4 FZD5 FZD6 FZD8 LRP5 LRP6 RNF43 WNT3A (see all 8) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LRP6	LDL Receptor Related Protein 6	Protein Coding	2
2	LRP5	LDL Receptor Related Protein 5	Protein Coding	2
3	RNF43	Ring Finger Protein 43	Protein Coding	2
4	FZD5	Frizzled Class Receptor 5	Protein Coding	2
5	FZD4	Frizzled Class Receptor 4	Protein Coding	2
6	FZD6	Frizzled Class Receptor 6	Protein Coding	2
7	FZD8	Frizzled Class Receptor 8	Protein Coding	2
8	WNT3A	Wnt Family Member 3A	Protein Coding	2
9	RSPO1	R-Spondin 1	Protein Coding	1
10	RSPO2	R-Spondin 2	Protein Coding	1
11	RSPO4	R-Spondin 4	Protein Coding	1
12	LGR4	Leucine Rich Repeat Containing G Protein-Coupled Receptor 4	Protein Coding	1
13	LGR6	Leucine Rich Repeat Containing G Protein-Coupled Receptor 6	Protein Coding	1
14	RPS27A	Ribosomal Protein S27a	Protein Coding	1
15	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
16	UBB	Ubiquitin B	Protein Coding	1
17	UBC	Ubiquitin C	Protein Coding	1
18	ZNRF3	Zinc And Ring Finger 3	Protein Coding	1
19	RSPO3	R-Spondin 3	Protein Coding	1
20	LGR5	Leucine Rich Repeat Containing G Protein-Coupled Receptor 5	Protein Coding	1
21	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	1

Disorders associated with Regulation of FZD by ubiquitination SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Retinopathy of prematurity	Enrichment	FZD4, LRP5	5.74
2	Exudative vitreoretinopathy 1	Enrichment	FZD4, LRP5	5.52
3	Exudative vitreoretinopathy	Enrichment	FZD4, LRP5	5.07
4	Polycystic liver disease	Enrichment	LRP5, LRP6	4.39
5	Autosomal dominant polycystic liver disease	Enrichment	LRP5, LRP6	4.39
6	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	3.23
7	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	3.23
8	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	3.23
9	Exudative vitreoretinopathy 4	Enrichment	LRP5	3.23
10	Tooth agenesis, selective, 7	Enrichment	LRP6	3.23
11	Sessile serrated polyposis cancer syndrome	Enrichment	RNF43	3.23
12	Exudative vitreoretinopathy 8	Enrichment	LRP6	3.23
13	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	3.23
14	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	3.23
15	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	3.23
16	Microphthalmia/coloboma 11	Enrichment	FZD5	3.23
17	Hyperplastic polyposis syndrome	Enrichment	RNF43	3.23
18	Lrp5-related primary osteoporosis	Enrichment	LRP5	3.23
19	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	3.23
20	Van buchem disease	Enrichment	LRP5	2.93
21	Osteosclerosis	Enrichment	LRP5	2.93
22	Bone mineral density quantitative trait locus 17	Enrichment	LGR4	2.81
23	Humerofemoral hypoplasia with radiotibial ray deficiency	Enrichment	RSPO2	2.81
24	Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal	Enrichment	RSPO1	2.81
25	Tetraamelia syndrome 2	Enrichment	RSPO2	2.81
26	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	2.81
27	Palmoplantar keratoderma-xx sex reversal-predisposition to squamous cell carcinoma syndrome	Enrichment	RSPO1	2.81
28	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	2.75
29	Osteoporosis, juvenile	Enrichment	WNT3A	2.75
30	Nail disease	Enrichment	FZD6	2.75
31	Orofacial cleft	Enrichment	LRP6	2.63
32	Eyelid coloboma	Enrichment	FZD5	2.63
33	Vitreoretinopathy	Enrichment	LRP5	2.63
34	Orofacial clefting syndrome	Enrichment	LRP6	2.63
35	Lens coloboma	Enrichment	FZD5	2.63
36	Norrie disease	Enrichment	FZD4	2.53
37	Persistent hyperplastic primary vitreous	Enrichment	FZD4	2.53
38	Coloboma of choroid and retina	Enrichment	FZD5	2.53
39	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	2.51
40	Delayed puberty, self-limited	Enrichment	LGR4	2.51
41	Submucosal cleft palate	Enrichment	UBB	2.51
42	Cleft hard palate	Enrichment	UBB	2.51
43	Coloboma of optic nerve	Enrichment	FZD5	2.45
44	Coats disease	Enrichment	FZD4	2.38
45	Nail disorder, nonsyndromic congenital, 4	Enrichment	RSPO4	2.33
46	Uvula, bifid	Enrichment	UBB	2.33
47	Cleft soft palate	Enrichment	UBB	2.33
48	Tetraamelia syndrome	Enrichment	RSPO2	2.33
49	Cat eye syndrome	Enrichment	FZD5	2.23
50	Microphthalmia/coloboma 12	Enrichment	FZD5	2.12
51	Osteoporosis	Enrichment	LRP5	2.08
52	Coloboma of macula	Enrichment	FZD5	2.05
53	Adrenocortical carcinoma	Enrichment	ZNRF3	2.03
54	Hereditary retinal dystrophy	Enrichment	FZD4, LRP5	1.93
55	Fundus dystrophy	Enrichment	FZD4, LRP5	1.93
56	Tooth agenesis	Enrichment	LRP6	1.89
57	Brittle bone disorder	Enrichment	LRP5	1.87
58	Primary hyperaldosteronism	Enrichment	USP8	1.86
59	Hydrops fetalis, nonimmune	Enrichment	FZD6	1.82
60	Non-immune hydrops fetalis	Enrichment	FZD6	1.74

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of FZD by ubiquitination

Pathway Network for Regulation of FZD by ubiquitination

Member Pathways for Regulation of FZD by ubiquitination

Pathways in the Regulation of FZD by ubiquitination SuperPath

Associated Genes for Regulation of FZD by ubiquitination

Associated Disorders for Regulation of FZD by ubiquitination

Disorders associated with Regulation of FZD by ubiquitination SuperPath

STRING Interaction Network for Regulation of FZD by ubiquitination

Sources for Regulation of FZD by ubiquitination