Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

No Pathway Network information available for Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Pathways in the Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) SuperPath

#	Name	Source	Genes
1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	Reactome	ADAM10 AFP AHSG ALB AMBN AMELX AMTN ANO8 APLP2 APOA1 APOA2 APOA5 APOB APOE APOL1 APP BMP15 BMP4 BPIFB2 C3 C4A C4B CALU CCN1 CDH2 CHGB CHRDL1 CKAP4 CP CSF1 CST3 CTSG DMP1 DNAJC3 ENAM EVA1A F2 F5 FAM20A FAM20C FBN1 FGA FGF23 FGG FN1 FSTL1 FSTL3 FUCA2 GAS6 GOLM1 GPC3 GZMH HRC HSP90B1 IGF1 IGF2 IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IL6 ITIH2 KLK1 KLK13 KLK2 KLK3 KNG1 KTN1 LAMB1 LAMB2 LAMC1 LGALS1 LTBP1 MATN3 MBTPS1 MELTF MEN1 MEPE MFGE8 MGAT4A MIA3 MMP1 MMP2 MSLN MXRA8 NOTUM NUCB1 P4HB PAPPA PAPPA2 PCSK9 PDIA6 PENK PLG PNPLA2 PRKCSH PROC PRSS23 QSOX1 RCN1 SCG2 SCG3 SDC2 SERPINA1 SERPINA10 SERPINC1 SERPIND1 SHISA5 SPARCL1 SPP1 SPP2 STC2 TF TGOLN2 TIMP1 TMEM132A TNC VCAN VGF VWA1 WFS1 (see all 125) (see less)
2	Post-translational protein phosphorylation	Reactome	ADAM10 AFP AHSG ALB AMBN AMELX AMTN ANO8 APLP2 APOA1 APOA2 APOA5 APOB APOE APOL1 APP BMP15 BMP4 BPIFB2 C3 C4A C4B CALU CCN1 CDH2 CHGB CHRDL1 CKAP4 CP CSF1 CST3 DMP1 DNAJC3 ENAM EVA1A F5 FAM20A FAM20C FBN1 FGA FGF23 FGG FN1 FSTL1 FSTL3 FUCA2 GAS6 GOLM1 GPC3 HRC HSP90B1 IGFBP1 IGFBP3 IGFBP4 IGFBP5 IGFBP7 IL6 ITIH2 KNG1 KTN1 LAMB1 LAMB2 LAMC1 LGALS1 LTBP1 MATN3 MBTPS1 MELTF MEN1 MEPE MFGE8 MGAT4A MIA3 MSLN MXRA8 NOTUM NUCB1 P4HB PCSK9 PDIA6 PENK PNPLA2 PRKCSH PROC PRSS23 QSOX1 RCN1 SCG2 SCG3 SDC2 SERPINA1 SERPINA10 SERPINC1 SERPIND1 SHISA5 SPARCL1 SPP1 SPP2 STC2 TF TGOLN2 TIMP1 TMEM132A TNC VCAN VGF VWA1 WFS1 (see all 108) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDH2	Cadherin 2	Protein Coding	2
2	ENAM	Enamelin	Protein Coding	2
3	PDIA6	Protein Disulfide Isomerase Family A Member 6	Protein Coding	2
4	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	2
5	MSLN	Mesothelin	Protein Coding	2
6	FSTL3	Follistatin Like 3	Protein Coding	2
7	TGOLN2	Trans-Golgi Network Protein 2	Protein Coding	2
8	CKAP4	Cytoskeleton Associated Protein 4	Protein Coding	2
9	PRSS23	Serine Protease 23	Protein Coding	2
10	CHGB	Chromogranin B	Protein Coding	2
11	FSTL1	Follistatin Like 1	Protein Coding	2
12	MGAT4A	Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A	Protein Coding	2
13	APOA5	Apolipoprotein A5	Protein Coding	2
14	CP	Ceruloplasmin	Protein Coding	2
15	CSF1	Colony Stimulating Factor 1	Protein Coding	2
16	VCAN	Versican	Protein Coding	2
17	CST3	Cystatin C	Protein Coding	2
18	NOTUM	Notum, Palmitoleoyl-Protein Carboxylesterase	Protein Coding	2
19	AFP	Alpha Fetoprotein	Protein Coding	2
20	DMP1	Dentin Matrix Acidic Phosphoprotein 1	Protein Coding	2
21	AHSG	Alpha 2-HS Glycoprotein	Protein Coding	2
22	ALB	Albumin	Protein Coding	2
23	F5	Coagulation Factor V	Protein Coding	2
24	FBN1	Fibrillin 1	Protein Coding	2
25	FGA	Fibrinogen Alpha Chain	Protein Coding	2
26	FGG	Fibrinogen Gamma Chain	Protein Coding	2
27	FN1	Fibronectin 1	Protein Coding	2
28	FUCA2	Alpha-L-Fucosidase 2	Protein Coding	2
29	PCSK9	Proprotein Convertase Subtilisin/Kexin Type 9	Protein Coding	2
30	AMBN	Ameloblastin	Protein Coding	2
31	GAS6	Growth Arrest Specific 6	Protein Coding	2
32	AMELX	Amelogenin X-Linked	Protein Coding	2
33	GPC3	Glypican 3	Protein Coding	2
34	SCG3	Secretogranin III	Protein Coding	2
35	SERPIND1	Serpin Family D Member 1	Protein Coding	2
36	HRC	Histidine Rich Calcium Binding Protein	Protein Coding	2
37	APLP2	Amyloid Beta Precursor Like Protein 2	Protein Coding	2
38	APOA1	Apolipoprotein A1	Protein Coding	2
39	APOA2	Apolipoprotein A2	Protein Coding	2
40	TNC	Tenascin C	Protein Coding	2
41	APOB	Apolipoprotein B	Protein Coding	2
42	APOE	Apolipoprotein E	Protein Coding	2
43	IGFBP1	Insulin Like Growth Factor Binding Protein 1	Protein Coding	2
44	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	2
45	IGFBP4	Insulin Like Growth Factor Binding Protein 4	Protein Coding	2
46	IGFBP5	Insulin Like Growth Factor Binding Protein 5	Protein Coding	2
47	IGFBP7	Insulin Like Growth Factor Binding Protein 7	Protein Coding	2
48	CCN1	Cellular Communication Network Factor 1	Protein Coding	2
49	APP	Amyloid Beta Precursor Protein	Protein Coding	2
50	IL6	Interleukin 6	Protein Coding	2
51	ITIH2	Inter-Alpha-Trypsin Inhibitor Heavy Chain 2	Protein Coding	2
52	MIA3	MIA SH3 Domain ER Export Factor 3	Protein Coding	2
53	KNG1	Kininogen 1	Protein Coding	2
54	KTN1	Kinectin 1	Protein Coding	2
55	LAMB1	Laminin Subunit Beta 1	Protein Coding	2
56	LAMB2	Laminin Subunit Beta 2	Protein Coding	2
57	LAMC1	Laminin Subunit Gamma 1	Protein Coding	2
58	LGALS1	Galectin 1	Protein Coding	2
59	AMTN	Amelotin	Protein Coding	2
60	LTBP1	Latent Transforming Growth Factor Beta Binding Protein 1	Protein Coding	2
61	MATN3	Matrilin 3	Protein Coding	2
62	MEN1	Menin 1	Protein Coding	2
63	MFGE8	Milk Fat Globule EGF And Factor V/VIII Domain Containing	Protein Coding	2
64	MELTF	Melanotransferrin	Protein Coding	2
65	SERPINC1	Serpin Family C Member 1	Protein Coding	2
66	NUCB1	Nucleobindin 1	Protein Coding	2
67	P4HB	Prolyl 4-Hydroxylase Subunit Beta	Protein Coding	2
68	SERPINA10	Serpin Family A Member 10	Protein Coding	2
69	SHISA5	Shisa Family Member 5	Protein Coding	2
70	GOLM1	Golgi Membrane Protein 1	Protein Coding	2
71	PENK	Proenkephalin	Protein Coding	2
72	SERPINA1	Serpin Family A Member 1	Protein Coding	2
73	MXRA8	Matrix Remodeling Associated 8	Protein Coding	2
74	FAM20A	FAM20A Golgi Associated Secretory Pathway Pseudokinase	Protein Coding	2
75	TMEM132A	Transmembrane Protein 132A	Protein Coding	2
76	PRKCSH	PRKCSH Beta Subunit Of Glucosidase II	Protein Coding	2
77	DNAJC3	DnaJ Heat Shock Protein Family (Hsp40) Member C3	Protein Coding	2
78	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	2
79	MEPE	Matrix Extracellular Phosphoglycoprotein	Protein Coding	2
80	FAM20C	FAM20C Golgi Associated Secretory Pathway Kinase	Protein Coding	2
81	PNPLA2	Patatin Like Domain 2, Triacylglycerol Lipase	Protein Coding	2
82	QSOX1	Quiescin Sulfhydryl Oxidase 1	Protein Coding	2
83	ANO8	Anoctamin 8	Protein Coding	2
84	RCN1	Reticulocalbin 1	Protein Coding	2
85	SDC2	Syndecan 2	Protein Coding	2
86	VWA1	Von Willebrand Factor A Domain Containing 1	Protein Coding	2
87	BMP4	Bone Morphogenetic Protein 4	Protein Coding	2
88	SPP2	Secreted Phosphoprotein 2	Protein Coding	2
89	SPP1	Secreted Phosphoprotein 1	Protein Coding	2
90	TF	Transferrin	Protein Coding	2
91	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	2
92	C3	Complement C3	Protein Coding	2
93	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	2
94	C4A	Complement C4A (Chido/Rodgers Blood Group)	Protein Coding	2
95	C4B	Complement C4B (Chido/Rodgers Blood Group)	Protein Coding	2
96	VGF	VGF Nerve Growth Factor Inducible	Protein Coding	2
97	WFS1	Wolframin ER Transmembrane Glycoprotein	Protein Coding	2
98	SCG2	Secretogranin II	Protein Coding	2
99	BPIFB2	BPI Fold Containing Family B Member 2	Protein Coding	2
100	FGF23	Fibroblast Growth Factor 23	Protein Coding	2
101	CALU	Calumenin	Protein Coding	2
102	SPARCL1	SPARC Like 1	Protein Coding	2
103	EVA1A	Eva-1 Homolog A, Regulator Of Programmed Cell Death	Protein Coding	2
104	APOL1	Apolipoprotein L1	Protein Coding	2
105	STC2	Stanniocalcin 2	Protein Coding	2
106	MBTPS1	Membrane Bound Transcription Factor Peptidase, Site 1	Protein Coding	2
107	CHRDL1	Chordin Like 1	Protein Coding	2
108	BMP15	Bone Morphogenetic Protein 15	Protein Coding	2
109	CTSG	Cathepsin G	Protein Coding	1
110	F2	Coagulation Factor II, Thrombin	Protein Coding	1
111	KLK13	Kallikrein Related Peptidase 13	Protein Coding	1
112	GZMH	Granzyme H	Protein Coding	1
113	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
114	IGF2	Insulin Like Growth Factor 2	Protein Coding	1
115	IGFALS	Insulin Like Growth Factor Binding Protein Acid Labile Subunit	Protein Coding	1
116	IGFBP2	Insulin Like Growth Factor Binding Protein 2	Protein Coding	1
117	IGFBP6	Insulin Like Growth Factor Binding Protein 6	Protein Coding	1
118	KLK3	Kallikrein Related Peptidase 3	Protein Coding	1
119	KLK1	Kallikrein 1	Protein Coding	1
120	KLK2	Kallikrein Related Peptidase 2	Protein Coding	1
121	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
122	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
123	PAPPA	Pappalysin 1	Protein Coding	1
124	PLG	Plasminogen	Protein Coding	1
125	PAPPA2	Pappalysin 2	Protein Coding	1

Disorders associated with Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial hypercholesterolemia	Enrichment	APOA2, APOB, APOE, PCSK9	5.31
2	Amelogenesis imperfecta, type ie	Enrichment	AMBN, AMELX, ENAM	4.25
3	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP, CST3	4.20
4	Stroke, ischemic	Enrichment	F2, F5, FBN1	4.06
5	Hypercholesterolemia, familial, 1	Enrichment	APOA2, APOB, PCSK9	3.88
6	Dysfibrinogenemia, congenital	Enrichment	FGA, FGG	3.73
7	Familial dysfibrinogenemia	Enrichment	FGA, FGG	3.73
8	Familial hypofibrinogenemia	Enrichment	FGA, FGG	3.73
9	Cerebral sinovenous thrombosis	Enrichment	F2, F5	3.60
10	Afibrinogenemia, congenital	Enrichment	FGA, FGG	3.43
11	Polycystic liver disease 1 with or without kidney cysts	Enrichment	FBN1, PRKCSH	3.21
12	Amyloidosis, hereditary systemic 2	Enrichment	APOA1, FGA	3.21
13	Polycystic liver disease 1	Enrichment	FBN1, PRKCSH	3.21
14	Hypophosphatemic rickets	Enrichment	DMP1, FGF23	2.89
15	Homozygous familial hypercholesterolemia	Enrichment	APOB, PCSK9	2.77
16	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C4A, C4B	2.77
17	Thrombophilia due to thrombin defect	Enrichment	F2, FGA	2.77
18	Stickler syndrome	Enrichment	BMP4, VCAN	2.57
19	Diabetes mellitus	Enrichment	MEN1, WFS1	2.48
20	Systemic lupus erythematosus	Enrichment	C4A, C4B, SPP1	2.44
21	Alzheimer's disease	Enrichment	APOE, APP	2.33
22	Amelogenesis imperfecta	Enrichment	AMELX, ENAM	2.33
23	Alzheimer disease, familial, 1	Enrichment	APOE, APP	2.10
24	Cole-carpenter syndrome 1	Enrichment	P4HB	2.10
25	Cataract 41	Enrichment	WFS1	2.10
26	Thrombophilia due to protein c deficiency, autosomal dominant	Enrichment	PROC	2.10
27	Ectopia lentis 1, isolated, autosomal dominant	Enrichment	FBN1	2.10
28	High molecular weight kininogen deficiency	Enrichment	KNG1	2.10
29	Hypophosphatemic rickets, autosomal recessive, 1	Enrichment	DMP1	2.10
30	Sea-blue histiocyte disease	Enrichment	APOE	2.10
31	Wolfram syndrome 1	Enrichment	WFS1	2.10
32	Deafness, autosomal dominant 6	Enrichment	WFS1	2.10
33	Raine syndrome	Enrichment	FAM20C	2.10
34	Aceruloplasminemia	Enrichment	CP	2.10
35	Macular degeneration, age-related, 11	Enrichment	CST3	2.10
36	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	2.10
37	Focal segmental glomerulosclerosis 4	Enrichment	APOL1	2.10
38	Lipoprotein glomerulopathy	Enrichment	APOE	2.10
39	Factor v deficiency	Enrichment	F5	2.10
40	Lissencephaly 5	Enrichment	LAMB1	2.10
41	Weill-marchesani syndrome 2	Enrichment	FBN1	2.10
42	Wolfram-like syndrome, autosomal dominant	Enrichment	WFS1	2.10
43	Deafness, autosomal dominant 56	Enrichment	TNC	2.10
44	Hyperthyroxinemia, familial dysalbuminemic	Enrichment	ALB	2.10
45	Geleophysic dysplasia 2	Enrichment	FBN1	2.10
46	Protrusio acetabuli	Enrichment	FBN1	2.10
47	Thrombophilia due to activated protein c resistance	Enrichment	F5	2.10
48	Amelogenesis imperfecta, type ic	Enrichment	ENAM	2.10
49	Atransferrinemia	Enrichment	TF	2.10
50	Alopecia-intellectual disability syndrome 1	Enrichment	AHSG	2.10
51	Alpha-fetoprotein, hereditary persistence of	Enrichment	AFP	2.10
52	Odontochondrodysplasia 2 with hearing loss and diabetes	Enrichment	MIA3	2.10
53	Ovarian dysgenesis 2	Enrichment	BMP15	2.10
54	Amelogenesis imperfecta, type iiib	Enrichment	AMTN	2.10
55	Complement component 4a deficiency	Enrichment	C4A	2.10
56	Microphthalmia, syndromic 6	Enrichment	BMP4	2.10
57	Adrenal cortical adenoma	Enrichment	MEN1	2.10
58	Lymphoplasmacytic lymphoma	Enrichment	FBN1	2.10
59	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.10
60	Orofacial cleft 11	Enrichment	BMP4	2.10
61	Angioedema, hereditary, 6	Enrichment	KNG1	2.10
62	Familial apolipoprotein a5 deficiency	Enrichment	APOA5	2.10
63	Alzheimer disease 18	Enrichment	ADAM10	2.10
64	Thrombophilia due to protein c deficiency, autosomal recessive	Enrichment	PROC	2.10
65	Hypercholesterolemia, familial, 3	Enrichment	PCSK9	2.10
66	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.10
67	Antithrombin iii deficiency	Enrichment	SERPINC1	2.10
68	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.10
69	Retinal arterial macroaneurysm with supravalvular pulmonic stenosis	Enrichment	IGFBP7	2.10
70	Blood group, chido/rodgers system	Enrichment	C4A	2.10
71	Complement component 4b deficiency	Enrichment	C4B	2.10
72	Amelogenesis imperfecta, type if	Enrichment	AMBN	2.10
73	Cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome	Enrichment	MBTPS1	2.10
74	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.10
75	Alpha-fetoprotein deficiency	Enrichment	AFP	2.10
76	Alpha-1-antitrypsin deficiency	Enrichment	SERPINA1	2.10
77	Macular degeneration, age-related, 9	Enrichment	C3	2.10
78	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	2.10
79	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	2.10
80	Neuronopathy, distal hereditary motor, autosomal recessive 7	Enrichment	VWA1	2.10
81	Cutis laxa, autosomal recessive, type iie	Enrichment	LTBP1	2.10
82	Congenital analbuminemia	Enrichment	ALB	2.10
83	Factor v atlanta bleeding disorder	Enrichment	F5	2.10
84	Immature teratoma of ovary	Enrichment	BMP15	2.10
85	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.10
86	Analbuminemia	Enrichment	ALB	2.10
87	Complement component 3 deficiency	Enrichment	C3	2.10
88	Congenital fibrinogen deficiency	Enrichment	FGG	2.10
89	Leukodystrophy, adult-onset, autosomal dominant, without amyloid angiopathy	Enrichment	CST3	2.10
90	Hemorrhagic disease due to alpha-1-antitrypsin pittsburgh mutation	Enrichment	SERPINA1	2.10
91	Factor v leiden thrombophilia	Enrichment	F5	2.10
92	Wolfram-like syndrome	Enrichment	WFS1	2.10
93	Membranoproliferative glomerulonephritis	Enrichment	C3	2.10
94	Primary membranoproliferative glomerulonephritis	Enrichment	C3	2.10
95	Severe hereditary thrombophilia due to congenital protein c deficiency	Enrichment	PROC	2.10
96	Protein c deficiency	Enrichment	PROC	2.10
97	Adrenal adenoma	Enrichment	MEN1	2.10
98	Primary triglyceride deposit cardiomyovasculopathy	Enrichment	PNPLA2	2.10
99	Neonatal marfan syndrome	Enrichment	FBN1	2.10
100	Factor v amsterdam bleeding disorder	Enrichment	F5	2.10
101	Stromal corneal dystrophy	Enrichment	SPARCL1	2.10
102	Aapoaii amyloidosis	Enrichment	APOA2	2.10
103	Wfs1 spectrum disorder	Enrichment	WFS1	2.10
104	Isolated congenital megalocornea	Enrichment	CHRDL1	2.10
105	Wilms tumor 1	Enrichment	GPC3, IGF2	2.09
106	Prothrombin deficiency, congenital	Enrichment	F2	2.04
107	Angioedema, hereditary, 4	Enrichment	PLG	2.04
108	Acid-labile subunit deficiency	Enrichment	IGFALS	2.04
109	Short stature, dauber-argente type	Enrichment	PAPPA2	2.04
110	Pregnancy loss, recurrent 2	Enrichment	F2	2.04
111	Prothrombin deficiency	Enrichment	F2	2.04
112	Arteriovenous malformations of the brain	Enrichment	CDH2, IL6	2.01
113	Acromicric dysplasia	Enrichment	FBN1	1.80
114	Amelogenesis imperfecta, type ib	Enrichment	ENAM	1.80
115	Wagner vitreoretinopathy	Enrichment	VCAN	1.80
116	Hyperlipoproteinemia, type v	Enrichment	APOA5	1.80
117	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.80
118	Amelogenesis imperfecta, type ig	Enrichment	FAM20A	1.80
119	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.80
120	Stiff skin syndrome	Enrichment	FBN1	1.80
121	Myasthenic syndrome, congenital, 5	Enrichment	LAMB2	1.80
122	Alzheimer disease 3	Enrichment	APOE	1.80
123	Epiphyseal dysplasia, multiple, 5	Enrichment	MATN3	1.80
124	Neutral lipid storage disease with myopathy	Enrichment	PNPLA2	1.80
125	Hyperparathyroidism 1	Enrichment	MEN1	1.80
126	Corneal dystrophy, congenital stromal	Enrichment	SPARCL1	1.80
127	Lissencephaly 1	Enrichment	LAMB1	1.80
128	Beaulieu-boycott-innes syndrome	Enrichment	FBN1	1.80
129	Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	Enrichment	DNAJC3	1.80
130	Spondyloepimetaphyseal dysplasia, borochowitz-cormier-daire type	Enrichment	MATN3	1.80
131	Pierson syndrome	Enrichment	LAMB2	1.80
132	Hermansky-pudlak syndrome 3	Enrichment	CP	1.80
133	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	1.80
134	Hyperlipoproteinemia, type iii	Enrichment	APOE	1.80
135	Bleeding disorder, east texas type	Enrichment	F5	1.80
136	Nephrotic syndrome, type 5, with or without ocular abnormalities	Enrichment	LAMB2	1.80
137	Autosomal recessive hypophosphatemic rickets	Enrichment	DMP1	1.80
138	Aortic dissection	Enrichment	FBN1	1.80
139	Marfanoid-progeroid-lipodystrophy syndrome	Enrichment	FBN1	1.80
140	Glomerulonephritis	Enrichment	APOL1	1.80
141	Medullary thyroid carcinoma	Enrichment	MEN1	1.80
142	Wolfram syndrome	Enrichment	WFS1	1.80
143	Neuronopathy, distal hereditary motor, autosomal recessive 5	Enrichment	VWA1	1.80
144	Hypobetalipoproteinemia	Enrichment	APOB	1.80
145	Insulinoma	Enrichment	MEN1	1.80
146	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	1.80
147	Spondyloepiphyseal dysplasia, kondo-fu type	Enrichment	MBTPS1	1.80
148	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	1.80
149	Wagner disease	Enrichment	VCAN	1.80
150	Lens subluxation	Enrichment	FBN1	1.80
151	Null pituitary adenoma	Enrichment	MEN1	1.80
152	Silent pituitary adenoma	Enrichment	MEN1	1.80
153	Gigantism	Enrichment	MEN1	1.80
154	Plasminogen deficiency, type i	Enrichment	PLG	1.74
155	Kallikrein, decreased urinary activity of	Enrichment	KLK1	1.74
156	Silver-russell syndrome 3	Enrichment	IGF2	1.74
157	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	1.74
158	Hereditary angioedema	Enrichment	PLG	1.74
159	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	1.74
160	Silver-russell syndrome due to an imprinting defect of 11p15	Enrichment	IGF2	1.74
161	Silver-russell syndrome due to 11p15 microduplication	Enrichment	IGF2	1.74
162	Contractural arachnodactyly, congenital	Enrichment	FBN1	1.63
163	Achondroplasia	Enrichment	FBN1	1.63
164	Mccune-albright syndrome	Enrichment	FBN1	1.63
165	Hypercholesterolemia, familial, 2	Enrichment	APOB	1.63
166	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23	1.63
167	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	1.63
168	Megalocornea	Enrichment	CHRDL1	1.63
169	Simpson-golabi-behmel syndrome, type 1	Enrichment	GPC3	1.63
170	Intellectual developmental disorder, x-linked 109	Enrichment	SERPINA1	1.63
171	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.63
172	Alzheimer disease 4	Enrichment	APOE	1.63
173	Heparin cofactor ii deficiency	Enrichment	SERPIND1	1.63
174	Pituitary adenoma 1, multiple types	Enrichment	MEN1	1.63
175	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	1.63
176	Weill-marchesani syndrome 1	Enrichment	FBN1	1.63
177	Autosomal recessive cutis laxa type i	Enrichment	LTBP1	1.63
178	Isolated ectopia lentis	Enrichment	FBN1	1.63
179	Cellular ependymoma	Enrichment	MEN1	1.63
180	Tanycytic ependymoma	Enrichment	MEN1	1.63
181	Papillary ependymoma	Enrichment	MEN1	1.63
182	Parathyroid adenoma	Enrichment	MEN1	1.63
183	Growth hormone secreting pituitary adenoma	Enrichment	MEN1	1.63
184	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	1.63
185	Aip familial isolated pituitary adenomas	Enrichment	MEN1	1.63
186	Familial isolated hyperparathyroidism	Enrichment	MEN1	1.63
187	Cole-carpenter syndrome	Enrichment	P4HB	1.63
188	Clear cell ependymoma	Enrichment	MEN1	1.63
189	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3	1.63
190	Geleophysic dysplasia	Enrichment	FBN1	1.63
191	Alopecia - intellectual disability syndrome	Enrichment	AHSG	1.63
192	Angioedema, hereditary, 1	Enrichment	PLG	1.56
193	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.56
194	Beckwith-wiedemann syndrome due to imprinting defect of 11p15	Enrichment	IGF2	1.56
195	Kaposi sarcoma	Enrichment	IL6	1.50
196	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	ALB	1.50
197	Amelogenesis imperfecta, type iiia	Enrichment	AMTN	1.50
198	Hypertriglyceridemia 1	Enrichment	APOA5	1.50
199	Dowling-degos disease 1	Enrichment	ADAM10	1.50
200	Macular degeneration, age-related, 1	Enrichment	APOE	1.50
201	Budd-chiari syndrome	Enrichment	F5	1.50
202	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	1.50
203	Weill-marchesani syndrome	Enrichment	FBN1	1.50
204	Retinopathy of prematurity	Enrichment	PRSS23	1.50
205	Aortic aneurysm	Enrichment	FBN1	1.50
206	Prolactinoma	Enrichment	MEN1	1.50
207	Pregnancy loss, recurrent 1	Enrichment	F5	1.50
208	Mitral valve insufficiency	Enrichment	FBN1	1.50
209	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.50
210	Primary hyperparathyroidism	Enrichment	MEN1	1.50
211	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.50
212	Benign ependymoma	Enrichment	MEN1	1.50
213	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	KNG1	1.50
214	Cystic fibrosis	Enrichment	PLG, SERPINA1	1.46
215	Silver-russell syndrome due to a point mutation	Enrichment	IGF2	1.44
216	Alzheimer disease 2	Enrichment	APOE	1.41
217	Hyperlipidemia, familial combined, 3	Enrichment	APOB	1.41
218	Exudative vitreoretinopathy 1	Enrichment	PRSS23	1.41
219	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	FBN1	1.41
220	Norrie disease	Enrichment	PRSS23	1.41
221	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.41
222	Goldberg-shprintzen syndrome	Enrichment	FBN1	1.41
223	Systemic lupus erythematosus 16	Enrichment	C4A	1.41
224	Type 2 diabetes mellitus	Enrichment	IL6, WFS1	1.36
225	Insulin-like growth factor i	Enrichment	IGF1	1.34
226	Nephrotic syndrome	Enrichment	FN1, LAMB2	1.34
227	Osteogenesis imperfecta, type i	Enrichment	P4HB	1.33
228	Type 1 diabetes mellitus	Enrichment	IL6	1.33
229	Anterior segment dysgenesis 5	Enrichment	BMP4	1.33
230	Inguinal hernia	Enrichment	FBN1	1.33
231	Lipid metabolism disorder	Enrichment	APOE	1.33
232	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3	1.33
233	Cerebral palsy	Enrichment	F2, PROC	1.30
234	Hemihyperplasia, isolated	Enrichment	IGF2	1.27
235	Multiple endocrine neoplasia, type i	Enrichment	MEN1	1.26
236	Brugada syndrome 1	Enrichment	FBN1	1.26
237	Coats disease	Enrichment	PRSS23	1.26
238	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	WFS1	1.26
239	Gastrointestinal stromal tumor	Enrichment	MEN1	1.26
240	Alzheimer's disease 1	Enrichment	APP	1.26
241	Amelogenesis imperfecta type 2	Enrichment	AMELX	1.26
242	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.26
243	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.21
244	Orthostatic intolerance	Enrichment	FBN1	1.21
245	Exudative vitreoretinopathy	Enrichment	PRSS23	1.21
246	Silver-russell syndrome 1	Enrichment	IGF2	1.20
247	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TNC, WFS1	1.19
248	Inflammatory bowel disease 1	Enrichment	IL6	1.16
249	Coronary heart disease 5	Enrichment	APOB	1.16
250	Loeys-dietz syndrome	Enrichment	FBN1	1.16
251	Bilateral perisylvian polymicrogyria	Enrichment	WFS1	1.16
252	Familial thoracic aortic aneurysm and dissection	Enrichment	FBN1	1.16
253	Marfan syndrome	Enrichment	FBN1	1.11
254	Peters-plus syndrome	Enrichment	BMP4	1.11
255	Neurodegeneration with brain iron accumulation	Enrichment	CP	1.11
256	Melanoma	Enrichment	FBN1	1.11
257	Pectus excavatum	Enrichment	FBN1	1.07
258	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.04
259	46 xx gonadal dysgenesis	Enrichment	BMP15	1.04
260	Diaphragmatic hernia, congenital	Enrichment	FBN1	1.01
261	Pulmonary disease, chronic obstructive	Enrichment	SERPINA1	1.01
262	Multiple sclerosis	Enrichment	LAMB1	0.98
263	Aortic aneurysm, familial thoracic 1	Enrichment	FBN1	0.98
264	Cleft lip/palate	Enrichment	BMP4	0.98
265	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	0.98
266	Corpus callosum, agenesis of	Enrichment	CDH2	0.95
267	Myopia	Enrichment	FBN1	0.95
268	Atypical hemolytic-uremic syndrome	Enrichment	C3	0.95
269	Hermansky-pudlak syndrome	Enrichment	CP	0.95
270	Kidney disease	Enrichment	LAMB2	0.95
271	Isolated corpus callosum agenesis	Enrichment	CDH2	0.95
272	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	0.95
273	Hermansky-pudlak syndrome 1	Enrichment	CP	0.92
274	Perrault syndrome 1	Enrichment	FBN1	0.92
275	Hypertension	Enrichment	MEN1	0.92
276	Polycystic liver disease	Enrichment	PRKCSH	0.90
277	Autosomal dominant polycystic liver disease	Enrichment	PRKCSH	0.90
278	Neuromuscular disease	Enrichment	VWA1	0.87
279	Early-onset nuclear cataract	Enrichment	WFS1	0.87
280	Behcet syndrome	Enrichment	C4A	0.85
281	Focal segmental glomerulosclerosis	Enrichment	APOL1	0.83
282	Beckwith-wiedemann syndrome	Enrichment	IGF2	0.81
283	Scoliosis	Enrichment	FBN1	0.76
284	Auditory neuropathy	Enrichment	CDH2	0.73
285	Hereditary retinal dystrophy	Enrichment	PRSS23, SPP2, VCAN, WFS1	0.70
286	Fundus dystrophy	Enrichment	PRSS23, SPP2, VCAN, WFS1	0.70
287	Connective tissue disease	Enrichment	FBN1	0.65
288	Genetic steroid-resistant nephrotic syndrome	Enrichment	APOL1	0.62
289	Non-syndromic genetic deafness	Enrichment	WFS1	0.60
290	Myopathy	Enrichment	FBN1	0.56
291	Nonsyndromic hearing loss	Enrichment	WFS1	0.54
292	Optic atrophy plus syndrome	Enrichment	WFS1	0.53
293	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FBN1	0.53
294	Thrombocytopenia	Enrichment	FGG	0.50
295	Spastic ataxia	Enrichment	WFS1	0.46
296	Hereditary breast ovarian cancer syndrome	Enrichment	MEN1	0.45
297	Primary ovarian insufficiency	Enrichment	AFP	0.42
298	Rare genetic deafness	Enrichment	WFS1	0.33
299	Dilated cardiomyopathy	Enrichment	FBN1	0.32
300	Colorectal cancer	Enrichment	IGF2	0.26
301	Inherited cancer-predisposing syndrome	Enrichment	MEN1	0.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Pathway Network for Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Member Pathways for Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Pathways in the Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) SuperPath

Associated Genes for Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Associated Disorders for Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Disorders associated with Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) SuperPath

STRING Interaction Network for Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Sources for Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)