Regulation of p38-alpha and p38-beta

No Pathway Network information available for Regulation of p38-alpha and p38-beta

#	Name	Source	Genes
1	Regulation of p38-alpha and p38-beta	PubChem	CCM2 DUSP1 DUSP10 DUSP16 DUSP8 LCK MAP2K3 MAP2K4 MAP2K6 MAP3K12 MAP3K3 MAPK11 MAPK14 RAC1 RIPK1 TAB1 TRAF6 (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAP3K12	Mitogen-Activated Protein Kinase Kinase Kinase 12	Protein Coding	1
2	DUSP8	Dual Specificity Phosphatase 8	Protein Coding	1
3	DUSP10	Dual Specificity Phosphatase 10	Protein Coding	1
4	CCM2	CCM2 Scaffold Protein	Protein Coding	1
5	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
6	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
7	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
8	DUSP16	Dual Specificity Phosphatase 16	Protein Coding	1
9	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
10	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
11	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
12	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
13	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
14	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
15	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
16	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
17	RAC1	Rac Family Small GTPase 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immunodeficiency 22	Enrichment	LCK	2.90
2	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.90
3	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.90
4	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.90
5	Verrucous hemangioma	Enrichment	MAP3K3	2.90
6	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.60
7	Cerebral cavernous malformations 2	Enrichment	CCM2	2.60
8	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.60
9	Cerebral cavernous malformations	Enrichment	CCM2	2.43
10	Cavernous hemangioma	Enrichment	CCM2	2.43
11	Familial cerebral cavernous malformations	Enrichment	CCM2	2.30
12	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.20
13	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.13
14	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.13
15	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.95
16	Immune deficiency disease	Enrichment	RIPK1	1.86
17	Severe combined immunodeficiency	Enrichment	LCK	1.39
18	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Regulation of p38-alpha and p38-beta