Regulation of pyruvate metabolism

Pathway network for the Regulation of pyruvate metabolism SuperPath

Sources:

Reactome
PubChem

Pathways in the Regulation of pyruvate metabolism SuperPath

#	Name	Source	Genes
1	Regulation of pyruvate metabolism	Reactome	ARMC8 DLAT DLD GID4 GID8 GSTZ1 LDHA MAEA ME1 MKLN1 NEK1 PDHA1 PDHA2 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR PGAM5 PKM RANBP9 RMND5A RMND5B RPS27A SIRT4 UBA52 UBB UBC WDR26 (see all 33) (see less)
2	Pyruvate metabolism	Reactome	ARMC8 DLAT DLD FAHD1 GID4 GID8 GLO1 GPT GSTZ1 HAGH LDHA LDHAL6A LDHAL6B LDHB LDHC MAEA ME1 ME2 ME3 MKLN1 MPC1 MPC1L MPC2 NEK1 PC PDHA1 PDHA2 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR PGAM5 PKLR PKM RANBP9 RMND5A RMND5B RPS27A SIRT4 UBA52 UBB UBC VDAC1 WDR26 (see all 49) (see less)
3	Regulation of pyruvate dehydrogenase (PDH) complex	Reactome	DLAT DLD GSTZ1 PDHA1 PDHA2 PDHB PDHX PDK1 PDK2 PDK3 PDK4 PDP1 PDP2 PDPR SIRT4 (see all 15) (see less)
4	PDH complex synthesizes acetyl-CoA from PYR	Reactome	DLAT DLD PDHA1 PDHA2 PDHB PDHX (see all 6) (see less)
5	pyruvate decarboxylation to acetyl CoA	PubChem	DLAT DLD PDHA1 PDHB

Gene overlap in member pathways for Regulation of pyruvate metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DLAT	Dihydrolipoamide S-Acetyltransferase	Protein Coding	5
2	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	5
3	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	5
4	PDHB	Pyruvate Dehydrogenase E1 Subunit Beta	Protein Coding	5
5	PDHA2	Pyruvate Dehydrogenase E1 Subunit Alpha 2	Protein Coding	4
6	PDHX	Pyruvate Dehydrogenase Complex Component X	Protein Coding	4
7	SIRT4	Sirtuin 4	Protein Coding	3
8	GSTZ1	Glutathione S-Transferase Zeta 1	Protein Coding	3
9	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	3
10	PDK2	Pyruvate Dehydrogenase Kinase 2	Protein Coding	3
11	PDK3	Pyruvate Dehydrogenase Kinase 3	Protein Coding	3
12	PDK4	Pyruvate Dehydrogenase Kinase 4	Protein Coding	3
13	PDP1	Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 1	Protein Coding	3
14	PDPR	Pyruvate Dehydrogenase Phosphatase Regulatory Subunit	Protein Coding	3
15	PDP2	Pyruvate Dehydrogenase Phosphatase Catalytic Subunit 2	Protein Coding	3
16	RANBP9	RAN Binding Protein 9	Protein Coding	2
17	MAEA	Macrophage Erythroblast Attacher, E3 Ubiquitin Ligase	Protein Coding	2
18	PGAM5	PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase	Protein Coding	2
19	ARMC8	Armadillo Repeat Containing 8	Protein Coding	2
20	LDHA	Lactate Dehydrogenase A	Protein Coding	2
21	ME1	Malic Enzyme 1	Protein Coding	2
22	MKLN1	Muskelin 1	Protein Coding	2
23	NEK1	NIMA Related Kinase 1	Protein Coding	2
24	PKM	Pyruvate Kinase M1/2	Protein Coding	2
25	GID8	GID Complex Subunit 8 Homolog	Protein Coding	2
26	RPS27A	Ribosomal Protein S27a	Protein Coding	2
27	RMND5B	Required For Meiotic Nuclear Division 5 Homolog B	Protein Coding	2
28	RMND5A	Required For Meiotic Nuclear Division 5 Homolog A	Protein Coding	2
29	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
30	UBB	Ubiquitin B	Protein Coding	2
31	UBC	Ubiquitin C	Protein Coding	2
32	GID4	GID Complex Subunit 4 Homolog	Protein Coding	2
33	WDR26	WD Repeat Domain 26	Protein Coding	2
34	ME3	Malic Enzyme 3	Protein Coding	1
35	LDHAL6A	Lactate Dehydrogenase A Like 6A	Protein Coding	1
36	MPC2	Mitochondrial Pyruvate Carrier 2	Protein Coding	1
37	GLO1	Glyoxalase I	Protein Coding	1
38	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	1
39	HAGH	Hydroxyacylglutathione Hydrolase	Protein Coding	1
40	MPC1L	Mitochondrial Pyruvate Carrier 1 Like	Protein Coding	1
41	LDHB	Lactate Dehydrogenase B	Protein Coding	1
42	LDHC	Lactate Dehydrogenase C	Protein Coding	1
43	ME2	Malic Enzyme 2	Protein Coding	1
44	PC	Pyruvate Carboxylase	Protein Coding	1
45	MPC1	Mitochondrial Pyruvate Carrier 1	Protein Coding	1
46	PKLR	Pyruvate Kinase L/R	Protein Coding	1
47	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	1
48	FAHD1	Fumarylacetoacetate Hydrolase Domain Containing 1	Protein Coding	1
49	LDHAL6B	Lactate Dehydrogenase A Like 6B	Protein Coding	1

Disorders associated with Regulation of pyruvate metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1, PDHX	6.01
2	Spermatogenic failure 70	Enrichment	PDHA2	3.35
3	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	3.23
4	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	3.23
5	Pyruvate dehydrogenase e2 deficiency	Enrichment	DLAT	3.23
6	Pyruvate dehydrogenase e1-beta deficiency	Enrichment	PDHB	3.23
7	Pyruvate dehydrogenase e3-binding protein deficiency	Enrichment	PDHX	3.05
8	Charcot-marie-tooth disease, x-linked dominant, 6	Enrichment	PDK3	2.96
9	Pyruvate dehydrogenase phosphatase deficiency	Enrichment	PDP1	2.96
10	Maleylacetoacetate isomerase deficiency	Enrichment	GSTZ1	2.96
11	Spermatogenic failure 1	Enrichment	PDHA2	2.75
12	Azoospermia	Enrichment	FAHD1, PDHA2	2.63
13	Amyotrophic lateral sclerosis 24	Enrichment	NEK1	2.61
14	Renu syndrome	Enrichment	SIRT4	2.48
15	Lactic acidosis	Enrichment	DLD	2.45
16	Adenosine triphosphate, elevated, of erythrocytes	Enrichment	PKLR	2.44
17	Anemia, congenital, nonspherocytic hemolytic, 2	Enrichment	PKLR	2.44
18	Hydroxyacyl glutathione hydrolase deficiency	Enrichment	HAGH	2.44
19	Lactate dehydrogenase b deficiency	Enrichment	LDHB	2.44
20	Mitochondrial pyruvate carrier deficiency	Enrichment	MPC1	2.44
21	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	MAEA	2.31
22	Fanconi-bickel syndrome	Enrichment	LDHA	2.31
23	Orofaciodigital syndrome ii	Enrichment	NEK1	2.31
24	Dyskeratosis congenita, autosomal recessive 2	Enrichment	RMND5B	2.31
25	Skraban-deardorff syndrome	Enrichment	WDR26	2.31
26	Submucosal cleft palate	Enrichment	UBB	2.31
27	Cleft hard palate	Enrichment	UBB	2.31
28	Sudden infant death syndrome	Enrichment	PDHA1	2.30
29	Spermatogenic failure 22	Enrichment	FAHD1	2.14
30	Premature ovarian failure 23	Enrichment	FAHD1	2.14
31	Uvula, bifid	Enrichment	UBB	2.14
32	Cleft soft palate	Enrichment	UBB	2.14
33	Pyruvate carboxylase deficiency	Enrichment	PC	1.97
34	Short rib-polydactyly syndrome	Enrichment	NEK1	1.84
35	Motor neuron disease	Enrichment	NEK1	1.77
36	Short-rib thoracic dysplasia 12	Enrichment	NEK1	1.71
37	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PDHA2	1.61
38	Hemolytic anemia	Enrichment	PKLR	1.60
39	Short-rib thoracic dysplasia 6 with or without polydactyly	Enrichment	NEK1	1.54
40	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	NEK1	1.54
41	Mitochondrial disease	Enrichment	PDHX	1.42
42	Connective tissue disease	Enrichment	NEK1	1.12
43	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	NEK1	0.88

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of pyruvate metabolism

Pathway Network for Regulation of pyruvate metabolism

Pathway network for the Regulation of pyruvate metabolism SuperPath

Member Pathways for Regulation of pyruvate metabolism

Pathways in the Regulation of pyruvate metabolism SuperPath

Gene overlap in member pathways for Regulation of pyruvate metabolism SuperPath

Associated Genes for Regulation of pyruvate metabolism

Associated Disorders for Regulation of pyruvate metabolism

Disorders associated with Regulation of pyruvate metabolism SuperPath

STRING Interaction Network for Regulation of pyruvate metabolism

Sources for Regulation of pyruvate metabolism