Regulation of RAC1 activity

No Pathway Network information available for Regulation of RAC1 activity

Pathways in the Regulation of RAC1 activity SuperPath

#	Name	Source	Genes
1	Regulation of RAC1 activity	PubChem	ABI1 ABR ARHGAP1 ARHGAP17 ARHGAP32 ARHGAP9 ARHGDIA ARHGEF2 ARHGEF25 ARHGEF6 ARHGEF7 BCR CHN1 CHN2 DEF6 DOCK1 DOCK2 DOCK6 ELMO1 EPS8 KALRN MCF2 NGEF PREX1 PREX2 RAC1 RACGAP1 RALBP1 RAP1GDS1 RASGRF1 RASGRF2 SOS1 SPATA13 TIAM1 TIAM2 TRIO VAV1 VAV2 VAV3 (see all 39) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DOCK6	Dedicator Of Cytokinesis 6	Protein Coding	1
2	ARHGEF25	Rho Guanine Nucleotide Exchange Factor 25	Protein Coding	1
3	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	1
4	ARHGAP9	Rho GTPase Activating Protein 9	Protein Coding	1
5	DEF6	DEF6 Guanine Nucleotide Exchange Factor	Protein Coding	1
6	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	1
7	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	1
8	CHN1	Chimerin 1	Protein Coding	1
9	SPATA13	Spermatogenesis Associated 13	Protein Coding	1
10	ARHGAP17	Rho GTPase Activating Protein 17	Protein Coding	1
11	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
12	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	1
13	EPS8	EGFR Pathway Substrate 8, Signaling Adaptor	Protein Coding	1
14	ABI1	Abl Interactor 1	Protein Coding	1
15	CHN2	Chimerin 2	Protein Coding	1
16	RAP1GDS1	Rap1 GTPase-GDP Dissociation Stimulator 1	Protein Coding	1
17	ELMO1	Engulfment And Cell Motility 1	Protein Coding	1
18	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	1
19	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
20	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	1
21	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
22	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	1
23	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
24	PREX2	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2	Protein Coding	1
25	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
26	TIAM2	TIAM Rac1 Associated GEF 2	Protein Coding	1
27	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	1
28	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
29	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
30	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
31	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	1
32	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	1
33	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
34	KALRN	Kalirin RhoGEF Kinase	Protein Coding	1
35	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
36	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
37	RAC1	Rac Family Small GTPase 1	Protein Coding	1
38	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
39	RALBP1	RalA Binding Protein 1	Protein Coding	1

Disorders associated with Regulation of RAC1 activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 4	Enrichment	SOS1	2.54
2	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.54
3	Immunodeficiency 87 and autoimmunity	Enrichment	DEF6	2.54
4	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.54
5	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.54
6	Immunodeficiency 40	Enrichment	DOCK2	2.54
7	Deafness, autosomal recessive 102	Enrichment	EPS8	2.54
8	Alfadhel syndrome	Enrichment	RAP1GDS1	2.54
9	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.54
10	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	2.54
11	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.54
12	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.54
13	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.54
14	Temporomandibular joint anomaly	Enrichment	DOCK1	2.54
15	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	2.24
16	Fibromatosis, gingival, 1	Enrichment	SOS1	2.24
17	Pulmonic stenosis	Enrichment	SOS1	2.24
18	Deafness, autosomal recessive 28	Enrichment	TRIO	2.24
19	Duane retraction syndrome 2	Enrichment	CHN1	2.24
20	Adams-oliver syndrome 2	Enrichment	DOCK6	2.24
21	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.24
22	Spastic paraplegia 70, autosomal recessive	Enrichment	ARHGAP9	2.24
23	Paget's disease of bone	Enrichment	DOCK6	2.24
24	Nuchal bleb, familial	Enrichment	SOS1	2.07
25	Hypercholanemia, familial 1	Enrichment	DOCK6	2.07
26	Adams-oliver syndrome 1	Enrichment	DOCK6	2.07
27	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	2.07
28	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	2.07
29	Duane retraction syndrome	Enrichment	CHN1	2.07
30	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	1.94
31	Gingival fibromatosis	Enrichment	SOS1	1.94
32	Moebius syndrome	Enrichment	CHN1	1.84
33	Robinow syndrome, autosomal dominant 2	Enrichment	CHN1	1.84
34	Leukemia, chronic myeloid	Enrichment	BCR	1.70
35	Noonan syndrome 3	Enrichment	SOS1	1.70
36	Adams-oliver syndrome	Enrichment	DOCK6	1.70
37	Moyamoya angiopathy	Enrichment	ARHGEF25	1.70
38	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.70
39	Coronary heart disease 5	Enrichment	KALRN	1.59
40	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.59
41	Aortic valve disease 1	Enrichment	SOS1	1.43
42	Hypercholesterolemia, familial, 1	Enrichment	DOCK6	1.43
43	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.40
44	Familial hypercholesterolemia	Enrichment	DOCK6	1.37
45	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.37
46	Syndromic intellectual disability	Enrichment	TRIO	1.32
47	Arteriovenous malformations of the brain	Enrichment	PREX2	1.27
48	Noonan syndrome 1	Enrichment	SOS1	1.19
49	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	1.19
50	Rasopathy	Enrichment	SOS1	1.14
51	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	1.03
52	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	1.01
53	Deafness, autosomal recessive	Enrichment	EPS8	0.78
54	Autosomal recessive nonsyndromic deafness	Enrichment	EPS8	0.77
55	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	EPS8	0.64
56	Microcephaly	Enrichment	TRIO	0.52
57	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of RAC1 activity

Pathway Network for Regulation of RAC1 activity

Member Pathways for Regulation of RAC1 activity

Pathways in the Regulation of RAC1 activity SuperPath

Associated Genes for Regulation of RAC1 activity

Associated Disorders for Regulation of RAC1 activity

Disorders associated with Regulation of RAC1 activity SuperPath

STRING Interaction Network for Regulation of RAC1 activity

Sources for Regulation of RAC1 activity