Regulation of Ras family activation

No Pathway Network information available for Regulation of Ras family activation

Pathways in the Regulation of Ras family activation SuperPath

#	Name	Source	Genes
1	Regulation of Ras family activation	PubChem	CAMK2B DAB2IP GRB2 HRAS KRAS LGALS1 LGALS3 NF1 NRAS PLCE1 PRRT2 RABGEF1 RASA1 RASA2 RASA4 RASAL1 RASGRF1 RASGRF2 RASGRP1 RASGRP2 RASGRP3 RASGRP4 RIN1 RRAS SOS1 SOS2 SYNGAP1 (see all 27) (see less)
2	Activation of RAS in B cells	Reactome	HRAS KRAS NRAS RASGRP1 RASGRP3

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	2
2	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	2
3	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
4	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
5	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
6	RASGRP4	RAS Guanyl Releasing Protein 4	Protein Coding	1
7	RASA2	RAS P21 Protein Activator 2	Protein Coding	1
8	RASA4	RAS P21 Protein Activator 4	Protein Coding	1
9	RASAL1	RAS Protein Activator Like 1	Protein Coding	1
10	SYNGAP1	Synaptic Ras GTPase Activating Protein 1	Protein Coding	1
11	DAB2IP	DAB2 Interacting Protein	Protein Coding	1
12	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
13	LGALS1	Galectin 1	Protein Coding	1
14	RIN1	Ras And Rab Interactor 1	Protein Coding	1
15	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
16	LGALS3	Galectin 3	Protein Coding	1
17	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	1
18	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
19	NF1	Neurofibromin 1	Protein Coding	1
20	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
21	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
22	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
23	RRAS	RAS Related	Protein Coding	1
24	RABGEF1	RAB Guanine Nucleotide Exchange Factor 1	Protein Coding	1
25	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
26	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
27	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1

Disorders associated with Regulation of Ras family activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, KRAS, NF1, NRAS, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, RASA2, RRAS, SOS1, SOS2	10.64
3	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	9.91
4	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	9.06
5	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	8.40
6	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NF1, NRAS, RRAS	8.21
7	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	7.96
8	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	7.06
9	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.96
10	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	6.61
11	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	6.49
12	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	6.19
13	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	5.64
14	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	5.64
15	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	5.64
16	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	5.52
17	Pilocytic astrocytoma	Enrichment	KRAS, NF1	4.64
18	Bladder cancer	Enrichment	HRAS, KRAS, NF1	4.61
19	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	4.30
20	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, RASA1	4.10
21	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	4.07
22	Arteriovenous malformation	Enrichment	HRAS, RASA1	3.87
23	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, RASA1	3.77
24	Oculoectodermal syndrome	Enrichment	KRAS	3.43
25	Melanosis, neurocutaneous	Enrichment	NRAS	3.43
26	Noonan syndrome 6	Enrichment	NRAS	3.43
27	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	3.43
28	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.43
29	Congenital pulmonary airway malformation	Enrichment	KRAS	3.43
30	Immunodeficiency 64	Enrichment	RASGRP1	3.43
31	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	3.43
32	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.43
33	Neurocutaneous melanocytosis	Enrichment	NRAS	3.43
34	Rhabdomyosarcoma	Enrichment	HRAS, NF1	3.35
35	Costello syndrome	Enrichment	HRAS	3.13
36	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	3.13
37	Wooly hair nevus	Enrichment	HRAS	3.13
38	Langerhans cell histiocytosis	Enrichment	NRAS	2.96
39	Spermatocytoma	Enrichment	HRAS	2.96
40	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.83
41	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.83
42	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.83
43	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.83
44	Epidermolytic nevus	Enrichment	HRAS	2.83
45	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.70
46	Noonan syndrome 4	Enrichment	SOS1	2.70
47	Noonan syndrome 9	Enrichment	SOS2	2.70
48	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.70
49	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.70
50	Plexiform neurofibroma	Enrichment	NF1	2.70
51	Neurofibroma	Enrichment	NF1	2.70
52	Neurofibromatosis	Enrichment	NF1	2.70
53	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.70
54	Optic nerve glioma	Enrichment	NF1	2.70
55	Gorham's disease	Enrichment	RASA1	2.70
56	Breast adenocarcinoma	Enrichment	KRAS	2.66
57	Lung squamous cell carcinoma	Enrichment	KRAS	2.66
58	Gallbladder cancer	Enrichment	KRAS	2.59
59	Pilomyxoid astrocytoma	Enrichment	KRAS	2.59
60	Gastric cancer	Enrichment	KRAS, NF1	2.48
61	Cafe-au-lait spots, multiple	Enrichment	NF1	2.40
62	Fibromatosis, gingival, 1	Enrichment	SOS1	2.40
63	Pulmonic stenosis	Enrichment	SOS1	2.40
64	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.40
65	Intellectual developmental disorder, autosomal recessive 5	Enrichment	SYNGAP1	2.40
66	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	2.40
67	Bardet-biedl syndrome 9	Enrichment	NF1	2.40
68	Prrt2-related disorder	Enrichment	PRRT2	2.40
69	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	2.40
70	Lip and oral cavity carcinoma	Enrichment	HRAS	2.35
71	Protein-deficiency anemia	Enrichment	NRAS	2.32
72	Lung cancer susceptibility 3	Enrichment	KRAS	2.29
73	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, NF1	2.27
74	Myeloma, multiple	Enrichment	KRAS, NF1	2.26
75	Lynch syndrome	Enrichment	KRAS	2.26
76	Watson syndrome	Enrichment	NF1	2.22
77	Nuchal bleb, familial	Enrichment	SOS1	2.22
78	Glut1 deficiency syndrome 2	Enrichment	PRRT2	2.22
79	Intellectual developmental disorder, autosomal dominant 5	Enrichment	SYNGAP1	2.22
80	Nephrotic syndrome, type 3	Enrichment	PLCE1	2.22
81	Neurofibromatosis, familial spinal	Enrichment	NF1	2.22
82	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	2.22
83	Wieacker-wolff syndrome	Enrichment	RASA1	2.22
84	Brain cancer	Enrichment	NF1	2.22
85	Arteriovenous malformations of the brain	Enrichment	KRAS	2.16
86	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	2.10
87	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	2.10
88	Neurofibromatosis-noonan syndrome	Enrichment	NF1	2.10
89	Embryonal rhabdomyosarcoma	Enrichment	NF1	2.10
90	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	2.10
91	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	2.10
92	Middle aortic syndrome	Enrichment	NF1	2.10
93	Gingival fibromatosis	Enrichment	SOS1	2.10
94	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.10
95	Pancreatic cancer	Enrichment	KRAS	2.04
96	Hydrops fetalis, nonimmune	Enrichment	HRAS	2.02
97	Capillary malformations, congenital	Enrichment	RASA1	2.00
98	Rhabdomyosarcoma 2	Enrichment	NF1	2.00
99	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	2.00
100	Self-limited infantile epilepsy	Enrichment	PRRT2	2.00
101	Lung cancer	Enrichment	KRAS	1.93
102	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.92
103	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.92
104	Hemangioma, capillary infantile	Enrichment	RASA1	1.92
105	Basal cell carcinoma 1	Enrichment	RASA1	1.92
106	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.86
107	Ewing sarcoma	Enrichment	NF1	1.80
108	Hereditary breast carcinoma	Enrichment	KRAS	1.79
109	Neurofibromatosis, type i	Enrichment	NF1	1.75
110	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.75
111	Leukemia, acute lymphoblastic 3	Enrichment	NF1	1.75
112	Myoclonic-atonic epilepsy	Enrichment	SYNGAP1	1.75
113	Microcephaly	Enrichment	CAMK2B, SYNGAP1	1.61
114	Aortic valve disease 1	Enrichment	SOS1	1.59
115	Stereotypic movement disorder	Enrichment	SYNGAP1	1.59
116	Breast cancer	Enrichment	KRAS	1.56
117	Pheochromocytoma	Enrichment	NF1	1.56
118	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.56
119	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.56
120	Colorectal cancer	Enrichment	NRAS	1.50
121	Ovarian cancer	Enrichment	KRAS	1.44
122	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.41
123	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	1.39
124	Skin disease	Enrichment	NF1	1.37
125	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	1.18
126	Dystonia	Enrichment	CAMK2B	1.17
127	Nephrotic syndrome	Enrichment	PLCE1	1.08
128	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2B	1.02
129	Congenital nervous system abnormality	Enrichment	CAMK2B	0.72
130	Nervous system disease	Enrichment	CAMK2B	0.72
131	Autism spectrum disorder	Enrichment	NF1	0.71
132	Complex neurodevelopmental disorder	Enrichment	SYNGAP1	0.66
133	Inherited cancer-predisposing syndrome	Enrichment	NF1	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of Ras family activation

Pathway Network for Regulation of Ras family activation

Member Pathways for Regulation of Ras family activation

Pathways in the Regulation of Ras family activation SuperPath

Associated Genes for Regulation of Ras family activation

Associated Disorders for Regulation of Ras family activation

Disorders associated with Regulation of Ras family activation SuperPath

STRING Interaction Network for Regulation of Ras family activation

Sources for Regulation of Ras family activation