Regulation of retinoblastoma protein

No Pathway Network information available for Regulation of retinoblastoma protein

Pathways in the Regulation of retinoblastoma protein SuperPath

#	Name	Source	Genes
1	Regulation of retinoblastoma protein	PubChem	AATF ABL1 ATF2 ATF7 BGLAP BRD2 CBX4 CCNA2 CCNE1 CDK2 CDK4 CDKN1A CDKN1B CDKN2A CEBPB CKM CSF2 CTBP1 DNMT1 E2F1 E2F4 ELF1 GSC HDAC1 HDAC3 ID2 JUN MAPK14 MAPK9 MDM2 MEF2C MET MITF MYL1 MYOD1 PAX3 PPARG PPP2CA PPP2R3B RAF1 RB1 RBBP4 RBP2 RUNX2 SFTPD SIRT1 SKP2 SMARCA4 SMARCB1 SPI1 SUV39H1 TAF1 TBP TFDP1 TGFB2 UBTF (see all 56) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MYL1	Myosin Light Chain 1	Protein Coding	1
2	ATF7	Activating Transcription Factor 7	Protein Coding	1
3	TAF1	TATA-Box Binding Protein Associated Factor 1	Protein Coding	1
4	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
5	MYOD1	Myogenic Differentiation 1	Protein Coding	1
6	ID2	Inhibitor Of DNA Binding 2	Protein Coding	1
7	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
8	GSC	Goosecoid Homeobox	Protein Coding	1
9	SUV39H1	SUV39H1 Histone Lysine Methyltransferase	Protein Coding	1
10	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
11	ELF1	E74 Like ETS Transcription Factor 1	Protein Coding	1
12	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
13	TFDP1	Transcription Factor Dp-1	Protein Coding	1
14	CSF2	Colony Stimulating Factor 2	Protein Coding	1
15	BRD2	Bromodomain Containing 2	Protein Coding	1
16	UBTF	Upstream Binding Transcription Factor	Protein Coding	1
17	SMARCB1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1	Protein Coding	1
18	PAX3	Paired Box 3	Protein Coding	1
19	SFTPD	Surfactant Protein D	Protein Coding	1
20	DNMT1	DNA Methyltransferase 1	Protein Coding	1
21	CBX4	Chromobox 4	Protein Coding	1
22	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	1
23	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
24	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	1
25	CCNE1	Cyclin E1	Protein Coding	1
26	E2F4	E2F Transcription Factor 4	Protein Coding	1
27	CCNA2	Cyclin A2	Protein Coding	1
28	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
29	AATF	Apoptosis Antagonizing Transcription Factor	Protein Coding	1
30	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
31	TBP	TATA-Box Binding Protein	Protein Coding	1
32	E2F1	E2F Transcription Factor 1	Protein Coding	1
33	CKM	Creatine Kinase, M-Type	Protein Coding	1
34	RBP2	Retinol Binding Protein 2	Protein Coding	1
35	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
36	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
37	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
38	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
39	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
40	SIRT1	Sirtuin 1	Protein Coding	1
41	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
42	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
43	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
44	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
45	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
46	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
47	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
48	HDAC3	Histone Deacetylase 3	Protein Coding	1
49	ATF2	Activating Transcription Factor 2	Protein Coding	1
50	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
51	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	1
52	HDAC1	Histone Deacetylase 1	Protein Coding	1
53	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
54	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
55	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
56	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	1

Disorders associated with Regulation of retinoblastoma protein SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inherited cancer-predisposing syndrome	Enrichment	CDK4, CDKN1B, CDKN2A, MET, MITF, RB1, SMARCA4, SMARCB1	7.21
2	Lip and oral cavity carcinoma	Enrichment	ABL1, CDKN2A, RB1	4.85
3	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4, SMARCB1	4.78
4	Papillary renal cell carcinoma	Enrichment	MET, MITF	4.78
5	Melanoma, cutaneous malignant 1	Enrichment	CDK4, CDKN2A, MITF	4.36
6	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	4.30
7	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	4.30
8	Ovarian cancer	Enrichment	CDKN1B, CDKN2A, MET, RB1, SMARCB1	4.23
9	Bladder cancer	Enrichment	CDKN1A, CDKN2A, RB1	3.65
10	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2	3.60
11	Waardenburg syndrome	Enrichment	MITF, PAX3	3.60
12	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	3.46
13	Waardenburg syndrome, type 1	Enrichment	MITF, PAX3	3.46
14	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, CDKN2A	3.46
15	Melanoma	Enrichment	CDKN2A, MITF	3.13
16	Coffin-siris syndrome 1	Enrichment	SMARCA4, SMARCB1	2.77
17	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, CDKN2A	2.40
18	Craniofacial-deafness-hand syndrome	Enrichment	PAX3	2.38
19	Waardenburg syndrome, type 3	Enrichment	PAX3	2.38
20	Intellectual developmental disorder, x-linked, syndromic 33	Enrichment	TAF1	2.38
21	Short stature, auditory canal atresia, mandibular hypoplasia, and skeletal abnormalities	Enrichment	GSC	2.38
22	Dystonia 3, torsion, x-linked	Enrichment	TAF1	2.38
23	Noonan syndrome 5	Enrichment	RAF1	2.38
24	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.38
25	Heterochromia iridis	Enrichment	MITF	2.38
26	Tietz albinism-deafness syndrome	Enrichment	MITF	2.38
27	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.38
28	Accelerated tumor formation	Enrichment	MDM2	2.38
29	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.38
30	Lessel-kubisch syndrome	Enrichment	MDM2	2.38
31	Osteofibrous dysplasia	Enrichment	MET	2.38
32	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.38
33	Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness	Enrichment	MITF	2.38
34	Deafness, autosomal recessive 97	Enrichment	MET	2.38
35	Camurati-engelmann disease 2	Enrichment	TGFB2	2.38
36	Rhabdoid tumor predisposition syndrome 1	Enrichment	SMARCB1	2.38
37	Neuroendocrine tumor	Enrichment	CDKN1B	2.38
38	Autism 9	Enrichment	MET	2.38
39	Leopard syndrome 2	Enrichment	RAF1	2.38
40	Congenital myopathy 17	Enrichment	MYOD1	2.38
41	Neurilemmoma	Enrichment	SMARCB1	2.38
42	Coffin-siris syndrome 3	Enrichment	SMARCB1	2.38
43	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.38
44	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.38
45	Congenital myopathy 14	Enrichment	MYL1	2.38
46	Trigonitis	Enrichment	RAF1	2.38
47	Trilateral retinoblastoma	Enrichment	RB1	2.38
48	Arthrogryposis, distal, type 11	Enrichment	MET	2.38
49	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.38
50	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.38
51	X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome	Enrichment	TAF1	2.38
52	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.38
53	Agammaglobulinemia	Enrichment	SPI1	2.38
54	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.38
55	Mef2c-related disorder	Enrichment	MEF2C	2.38
56	Lung oat cell carcinoma	Enrichment	RB1	2.38
57	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.08
58	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.08
59	Carotid intimal medial thickness 1	Enrichment	PPARG	2.08
60	Spinocerebellar ataxia 17	Enrichment	TBP	2.08
61	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	2.08
62	Schwannomatosis 1	Enrichment	SMARCB1	2.08
63	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.08
64	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.08
65	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.08
66	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.08
67	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.08
68	Melanoma, cutaneous malignant 8	Enrichment	MITF	2.08
69	Childhood hepatocellular carcinoma	Enrichment	MET	2.08
70	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	2.08
71	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.08
72	Loeys-dietz syndrome 4	Enrichment	TGFB2	2.08
73	Otosclerosis 12	Enrichment	SMARCA4	2.08
74	Coffin-siris syndrome 4	Enrichment	SMARCA4	2.08
75	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.08
76	Familial partial lipodystrophy	Enrichment	PPARG	2.08
77	Familial retinoblastoma	Enrichment	RB1	2.08
78	Cleidocranial dysplasia 1	Enrichment	RUNX2	1.91
79	Retinoblastoma	Enrichment	RB1	1.91
80	Waardenburg syndrome, type 2a	Enrichment	MITF	1.91
81	Osteogenic sarcoma	Enrichment	RB1	1.91
82	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.91
83	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	1.91
84	Hypotrichosis 8	Enrichment	RB1	1.91
85	Atypical teratoid rhabdoid tumor	Enrichment	SMARCB1	1.91
86	Cleidocranial dysplasia	Enrichment	RUNX2	1.91
87	Squamous cell carcinoma	Enrichment	RB1	1.91
88	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.91
89	Bone osteosarcoma	Enrichment	RB1	1.91
90	Neurodegeneration, childhood-onset, with brain atrophy	Enrichment	UBTF	1.91
91	Schwannomatosis	Enrichment	SMARCB1	1.91
92	Renal cell carcinoma	Enrichment	MET	1.91
93	Gastric cancer	Enrichment	CDK4, CDKN2A	1.87
94	Small cell cancer of the lung	Enrichment	RB1	1.78
95	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.78
96	Leptin deficiency or dysfunction	Enrichment	PPARG	1.78
97	Lynch syndrome 4	Enrichment	RB1	1.78
98	Congenital generalized lipodystrophy	Enrichment	PPARG	1.78
99	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.78
100	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.78
101	Primary hyperparathyroidism	Enrichment	CDKN1B	1.78
102	Full schwannomatosis	Enrichment	SMARCB1	1.78
103	Clear cell papillary renal cell carcinoma	Enrichment	MITF	1.78
104	Rhabdomyosarcoma 2	Enrichment	PAX3	1.69
105	Rare syndromic intellectual disability	Enrichment	UBTF	1.69
106	Atrial septal defect 1	Enrichment	TGFB2	1.61
107	Myopathy, centronuclear, 1	Enrichment	MYOD1	1.61
108	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.61
109	Waardenburg syndrome, type 4a	Enrichment	MITF	1.61
110	Adrenocortical carcinoma	Enrichment	CDKN2A	1.61
111	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.61
112	Waardenburg syndrome, type 2e	Enrichment	MITF	1.54
113	Leukemia, chronic myeloid	Enrichment	ABL1	1.54
114	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.54
115	Noonan syndrome 3	Enrichment	RAF1	1.54
116	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	1.54
117	Pilomyxoid astrocytoma	Enrichment	RAF1	1.54
118	Moyamoya angiopathy	Enrichment	ABL1	1.54
119	Arthrogryposis, distal, type 1a	Enrichment	MET	1.49
120	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.49
121	Neuroblastoma	Enrichment	SMARCA4	1.49
122	Loeys-dietz syndrome	Enrichment	TGFB2	1.44
123	Ventricular septal defect	Enrichment	SMARCA4	1.44
124	Marfan syndrome	Enrichment	TGFB2	1.39
125	Autosomal non-syndromic agammaglobulinemia	Enrichment	SPI1	1.39
126	Rare genetic deafness	Enrichment	MITF, PAX3	1.38
127	Meningioma, familial	Enrichment	SMARCB1	1.35
128	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.35
129	Atrial heart septal defect	Enrichment	SMARCA4	1.35
130	Interatrial communication	Enrichment	SMARCA4	1.35
131	Meningioma	Enrichment	SMARCB1	1.31
132	Colorectal cancer	Enrichment	MET, PPARG	1.30
133	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.28
134	Nk-cell enteropathy	Enrichment	SMARCB1	1.28
135	Lung cancer susceptibility 3	Enrichment	RB1	1.25
136	Heart disease	Enrichment	ABL1	1.25
137	Pituitary stalk interruption syndrome	Enrichment	DNMT1	1.25
138	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.22
139	Familial hypercholesterolemia	Enrichment	SMARCA4	1.22
140	Noonan syndrome and noonan-related syndrome	Enrichment	RAF1	1.22
141	Gliosarcoma	Enrichment	PPARG	1.19
142	Cleft palate, isolated	Enrichment	SMARCA4	1.17
143	Giant cell glioblastoma	Enrichment	PPARG	1.17
144	Autism spectrum disorder	Enrichment	MEF2C, SMARCB1	1.13
145	Ehlers-danlos syndrome	Enrichment	TGFB2	1.12
146	Parkinson's disease	Enrichment	TBP	1.12
147	Hepatocellular carcinoma	Enrichment	MET	1.06
148	Noonan syndrome 1	Enrichment	RAF1	1.04
149	Ear malformation	Enrichment	MITF	1.02
150	Parkinson disease, late-onset	Enrichment	TBP	1.02
151	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.02
152	Pancreatic cancer	Enrichment	CDKN2A	1.01
153	Rasopathy	Enrichment	RAF1	0.99
154	Differentiated thyroid carcinoma	Enrichment	PPARG	0.95
155	Lung cancer	Enrichment	MET	0.91
156	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.89
157	Left ventricular noncompaction	Enrichment	RAF1	0.87
158	Non-syndromic genetic deafness	Enrichment	MITF	0.86
159	Fetal akinesia deformation sequence 1	Enrichment	MYOD1	0.85
160	Cerebral palsy	Enrichment	SMARCA4	0.83
161	Type 2 diabetes mellitus	Enrichment	PPARG	0.80
162	Distal arthrogryposis	Enrichment	MYOD1	0.80
163	Nonsyndromic hearing loss	Enrichment	MITF	0.80
164	Nephrotic syndrome	Enrichment	RUNX2	0.79
165	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFB2	0.78
166	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.73
167	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MITF	0.71
168	Spastic ataxia	Enrichment	DNMT1	0.71
169	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.71
170	Hereditary breast ovarian cancer syndrome	Enrichment	MITF	0.69
171	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.67
172	Breast cancer	Enrichment	JUN	0.57
173	Dilated cardiomyopathy	Enrichment	RAF1	0.55
174	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.51
175	Microcephaly	Enrichment	ABL1	0.40
176	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of retinoblastoma protein

Pathway Network for Regulation of retinoblastoma protein

Member Pathways for Regulation of retinoblastoma protein

Pathways in the Regulation of retinoblastoma protein SuperPath

Associated Genes for Regulation of retinoblastoma protein

Associated Disorders for Regulation of retinoblastoma protein

Disorders associated with Regulation of retinoblastoma protein SuperPath

STRING Interaction Network for Regulation of retinoblastoma protein

Sources for Regulation of retinoblastoma protein