Regulation of RhoA activity

No Pathway Network information available for Regulation of RhoA activity

Pathways in the Regulation of RhoA activity SuperPath

#	Name	Source	Genes
1	Regulation of RhoA activity	PubChem	ABR AKAP13 ARAP1 ARAP3 ARHGAP32 ARHGAP35 ARHGAP4 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF5 BCR CDKN1B DEF6 DLC1 ECT2 FARP1 MCF2 MCF2L MYO9B NET1 NGEF OPHN1 PLEKHG6 RAP1GDS1 RHOA SRGAP1 TRIO VAV1 VAV2 VAV3 (see all 47) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARHGAP4	Rho GTPase Activating Protein 4	Protein Coding	1
2	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	1
3	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	1
4	ARAP3	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3	Protein Coding	1
5	ARHGAP6	Rho GTPase Activating Protein 6	Protein Coding	1
6	OPHN1	Oligophrenin 1	Protein Coding	1
7	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	1
8	ECT2	Epithelial Cell Transforming 2	Protein Coding	1
9	DLC1	DLC1 Rho GTPase Activating Protein	Protein Coding	1
10	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	1
11	FARP1	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1	Protein Coding	1
12	ARHGEF10L	Rho Guanine Nucleotide Exchange Factor 10 Like	Protein Coding	1
13	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
14	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	1
15	PLEKHG6	Pleckstrin Homology And RhoGEF Domain Containing G6	Protein Coding	1
16	ARHGEF17	Rho Guanine Nucleotide Exchange Factor 17	Protein Coding	1
17	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	1
18	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	1
19	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
20	ARHGEF25	Rho Guanine Nucleotide Exchange Factor 25	Protein Coding	1
21	ARHGAP9	Rho GTPase Activating Protein 9	Protein Coding	1
22	DEF6	DEF6 Guanine Nucleotide Exchange Factor	Protein Coding	1
23	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	1
24	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
25	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	1
26	ARHGAP8	Rho GTPase Activating Protein 8	Protein Coding	1
27	SRGAP1	SLIT-ROBO Rho GTPase Activating Protein 1	Protein Coding	1
28	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
29	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	1
30	RAP1GDS1	Rap1 GTPase-GDP Dissociation Stimulator 1	Protein Coding	1
31	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
32	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	1
33	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
34	ARAP1	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	1
35	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1
36	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
37	ARHGEF18	Rho/Rac Guanine Nucleotide Exchange Factor 18	Protein Coding	1
38	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
39	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
40	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	1
41	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	1
42	ARHGEF28	Rho Guanine Nucleotide Exchange Factor 28	Protein Coding	1
43	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
44	MYO9B	Myosin IXB	Protein Coding	1
45	RHOA	Ras Homolog Family Member A	Protein Coding	1
46	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	1
47	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1

Disorders associated with Regulation of RhoA activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Martsolf syndrome 1	Enrichment	ARHGAP35, ARHGAP5	3.93
2	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.46
3	Immunodeficiency 62	Enrichment	ARHGEF1	2.46
4	Immunodeficiency 87 and autoimmunity	Enrichment	DEF6	2.46
5	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.46
6	Retinitis pigmentosa 78	Enrichment	ARHGEF18	2.46
7	Intellectual developmental disorder, x-linked, syndromic, billuart type	Enrichment	OPHN1	2.46
8	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	2.46
9	Celiac disease 4	Enrichment	MYO9B	2.46
10	Neuroendocrine tumor	Enrichment	CDKN1B	2.46
11	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	2.46
12	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.46
13	Alfadhel syndrome	Enrichment	RAP1GDS1	2.46
14	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	2.46
15	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.46
16	Deafness, autosomal recessive 28	Enrichment	TRIO	2.16
17	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.16
18	Spastic paraplegia 70, autosomal recessive	Enrichment	ARHGAP9	2.16
19	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	1.98
20	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.98
21	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	1.86
22	Oligohydramnios	Enrichment	OPHN1	1.86
23	Primary hyperparathyroidism	Enrichment	CDKN1B	1.86
24	Hemihyperplasia, isolated	Enrichment	RHOA	1.69
25	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.69
26	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.62
27	Thyroid cancer, nonmedullary, 2	Enrichment	SRGAP1	1.62
28	Leukemia, chronic myeloid	Enrichment	BCR	1.62
29	Follicular thyroid carcinoma	Enrichment	SRGAP1	1.62
30	Moyamoya angiopathy	Enrichment	ARHGEF25	1.62
31	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.62
32	Peters-plus syndrome	Enrichment	ARHGAP35	1.47
33	Amelogenesis imperfecta, type ie	Enrichment	ARHGAP6	1.47
34	Neural tube defects	Enrichment	DLC1	1.36
35	Amelogenesis imperfecta	Enrichment	ARHGAP6	1.36
36	Syndromic intellectual disability	Enrichment	TRIO	1.24
37	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	1.11
38	Cakut	Enrichment	SRGAP1	0.95
39	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	0.95
40	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.93
41	Charcot-marie-tooth disease	Enrichment	ARHGEF10	0.88
42	Colorectal cancer	Enrichment	DLC1	0.58
43	Ovarian cancer	Enrichment	CDKN1B	0.53
44	Congenital nervous system abnormality	Enrichment	OPHN1	0.51
45	Nervous system disease	Enrichment	OPHN1	0.51
46	Microcephaly	Enrichment	TRIO	0.46
47	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B	0.43
48	Retinitis pigmentosa	Enrichment	ARHGEF18	0.28
49	Hereditary retinal dystrophy	Enrichment	ARHGEF18	0.19
50	Fundus dystrophy	Enrichment	ARHGEF18	0.19

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of RhoA activity

Pathway Network for Regulation of RhoA activity

Member Pathways for Regulation of RhoA activity

Pathways in the Regulation of RhoA activity SuperPath

Associated Genes for Regulation of RhoA activity

Associated Disorders for Regulation of RhoA activity

Disorders associated with Regulation of RhoA activity SuperPath

STRING Interaction Network for Regulation of RhoA activity

Sources for Regulation of RhoA activity