Regulation of RUNX1 Expression and Activity

No Pathway Network information available for Regulation of RUNX1 Expression and Activity

Pathways in the Regulation of RUNX1 Expression and Activity SuperPath

#	Name	Source	Genes
1	Regulation of RUNX1 Expression and Activity	Reactome	AGO1 AGO2 AGO3 AGO4 CBFB CCND1 CCND2 CCND3 CDK6 MOV10 PML PTPN11 RUNX1 SRC TNRC6A TNRC6B TNRC6C (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDK6	Cyclin Dependent Kinase 6	Protein Coding	1
2	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	1
3	AGO4	Argonaute RISC Component 4	Protein Coding	1
4	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	1
5	AGO1	Argonaute RISC Component 1	Protein Coding	1
6	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	1
7	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	1
8	MOV10	Mov10 RNA Helicase	Protein Coding	1
9	PML	PML Nuclear Body Scaffold	Protein Coding	1
10	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	1
11	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
12	CCND1	Cyclin D1	Protein Coding	1
13	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
14	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	1
15	CBFB	Core-Binding Factor Subunit Beta	Protein Coding	1
16	CCND2	Cyclin D2	Protein Coding	1
17	CCND3	Cyclin D3	Protein Coding	1

Disorders associated with Regulation of RUNX1 Expression and Activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Thrombocytopenia	Enrichment	PTPN11, RUNX1, SRC	4.56
2	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, TNRC6B	3.34
3	Metachondromatosis	Enrichment	PTPN11	2.90
4	Leopard syndrome 1	Enrichment	PTPN11	2.90
5	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.90
6	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.90
7	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.90
8	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.90
9	Thrombocytopenia 6	Enrichment	SRC	2.90
10	Malignant astrocytoma	Enrichment	PTPN11	2.90
11	Storage pool platelet disease	Enrichment	RUNX1	2.60
12	Premature ovarian failure 3	Enrichment	AGO2	2.60
13	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	2.60
14	Werner syndrome	Enrichment	PTPN11	2.60
15	Cleidocranial dysplasia 2	Enrichment	CBFB	2.60
16	Tafro syndrome	Enrichment	RUNX1	2.60
17	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	RUNX1	2.43
18	Lessel-kreienkamp syndrome	Enrichment	AGO2	2.43
19	Tricuspid valve insufficiency	Enrichment	PTPN11	2.43
20	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	RUNX1	2.43
21	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	2.30
22	Mantle cell lymphoma	Enrichment	CCND1	2.30
23	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.30
24	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.30
25	Blood platelet disease	Enrichment	RUNX1	2.30
26	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	CBFB	2.30
27	Colorectal cancer	Enrichment	CCND1, SRC	2.28
28	Von hippel-lindau syndrome	Enrichment	CCND1	2.20
29	Lymphoma	Enrichment	PTPN11	2.20
30	Aggressive systemic mastocytosis	Enrichment	RUNX1	2.20
31	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	RUNX1	2.20
32	Pancytopenia	Enrichment	RUNX1	2.13
33	Patent ductus arteriosus	Enrichment	PTPN11	2.13
34	Autism spectrum disorder	Enrichment	PTPN11, TNRC6B	2.09
35	Myelofibrosis	Enrichment	SRC	2.06
36	Leukemia, chronic myeloid	Enrichment	RUNX1	2.06
37	Noonan syndrome 3	Enrichment	PTPN11	2.06
38	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.95
39	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	RUNX1	1.95
40	Inherited cancer-predisposing syndrome	Enrichment	PTPN11, RUNX1	1.93
41	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.90
42	Pectus excavatum	Enrichment	PTPN11	1.86
43	Specific learning disability	Enrichment	PTPN11	1.86
44	Epicanthus	Enrichment	PTPN11	1.83
45	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.83
46	Congenital long qt syndrome	Enrichment	PTPN11	1.83
47	Acute promyelocytic leukemia	Enrichment	PML	1.79
48	Osteoporosis	Enrichment	SRC	1.76
49	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.73
50	Patent foramen ovale	Enrichment	PTPN11	1.65
51	Noonan syndrome 1	Enrichment	PTPN11	1.55
52	Scoliosis	Enrichment	PTPN11	1.53
53	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.49
54	Rasopathy	Enrichment	PTPN11	1.49
55	Strabismus	Enrichment	PTPN11	1.48
56	Long qt syndrome 1	Enrichment	PTPN11	1.43
57	Non-immune hydrops fetalis	Enrichment	PTPN11	1.42
58	Primary autosomal recessive microcephaly	Enrichment	CDK6	1.40
59	Leukemia, acute myeloid	Enrichment	RUNX1	1.31
60	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.28
61	Myeloma, multiple	Enrichment	CCND1	1.17
62	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.17
63	Microcephaly	Enrichment	PTPN11	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of RUNX1 Expression and Activity

Pathway Network for Regulation of RUNX1 Expression and Activity

Member Pathways for Regulation of RUNX1 Expression and Activity

Pathways in the Regulation of RUNX1 Expression and Activity SuperPath

Associated Genes for Regulation of RUNX1 Expression and Activity

Associated Disorders for Regulation of RUNX1 Expression and Activity

Disorders associated with Regulation of RUNX1 Expression and Activity SuperPath

STRING Interaction Network for Regulation of RUNX1 Expression and Activity

Sources for Regulation of RUNX1 Expression and Activity