Regulation of T cell activation by CD28 family

Pathway network for the Regulation of T cell activation by CD28 family SuperPath

Sources:

Reactome
QIAGEN

Pathways in the Regulation of T cell activation by CD28 family SuperPath

#	Name	Source	Genes
1	Regulation of T cell activation by CD28 family	Reactome	AKT1 AKT2 AKT3 BTLA CD247 CD274 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CDC42 CSK CTLA4 FYN GRAP2 GRB2 HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DQB2 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ICOS ICOSLG LCK LYN MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PAK1 PAK2 PAK3 PDCD1 PDCD1LG2 PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRR5 PTPN11 PTPN6 RAC1 RICTOR SRC THEM4 TNFRSF14 TRIB3 VAV1 YES1 (see all 74) (see less)
2	CTLA4 Signaling	QIAGEN	AKT1 AKT2 AKT3 AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CD247 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CD8A CLTA CLTB CLTC CTLA4 FYN GNAL GRAP2 GRB2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 LAT LCK LCP2 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5E PTPA PTPN22 SYK TRAT1 ZAP70 (see all 71) (see less)
3	Co-stimulation by CD28	Reactome	AKT1 AKT2 AKT3 CD28 CD80 CD86 CDC42 CTLA4 FYN GRAP2 GRB2 LCK LYN MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PAK1 PAK2 PAK3 PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRR5 RAC1 RICTOR SRC THEM4 TRIB3 VAV1 YES1 (see all 48) (see less)
4	CD28 dependent PI3K/Akt signaling	Reactome	AKT1 AKT2 AKT3 CD28 CD80 CD86 FYN LCK MAP3K14 MAP3K8 MAPKAP1 MLST8 MTOR PDPK1 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PRR5 RICTOR THEM4 TRIB3 (see all 27) (see less)
5	Co-inhibition by CTLA4	Reactome	AKT1 AKT2 AKT3 CD80 CD86 CTLA4 FYN LCK LYN PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPN11 SRC YES1 (see all 21) (see less)
6	CD28 dependent Vav1 pathway	Reactome	CD28 CD80 CD86 CDC42 FYN GRB2 LCK PAK1 PAK2 PAK3 RAC1 VAV1 (see all 12) (see less)
7	Co-stimulation by ICOS	Reactome	ICOS ICOSLG PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 (see all 11) (see less)
8	Co-inhibition by BTLA	Reactome	BTLA GRB2 PTPN11 PTPN6 TNFRSF14
9	Activation of AKT2	Reactome	AKT2 PDPK1 THEM4 TRIB3

Gene overlap in member pathways for Regulation of T cell activation by CD28 family SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	6
2	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6
3	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6
4	CD80	CD80 Molecule	Protein Coding	6
5	CD86	CD86 Molecule	Protein Coding	6
6	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	5
7	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	5
8	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	5
9	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	5
10	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	5
11	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	5
12	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	5
13	CD28	CD28 Molecule	Protein Coding	5
14	THEM4	Thioesterase Superfamily Member 4	Protein Coding	4
15	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	4
16	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	4
17	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	4
18	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	4
19	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	4
20	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	4
21	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	4
22	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	4
23	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	4
24	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	4
25	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	4
26	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	4
27	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	4
28	TRIB3	Tribbles Pseudokinase 3	Protein Coding	4
29	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	3
30	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	3
31	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	3
32	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
33	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	3
34	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	3
35	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	3
36	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	3
37	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	3
38	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	3
39	PRR5	Proline Rich 5	Protein Coding	3
40	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	3
41	RAC1	Rac Family Small GTPase 1	Protein Coding	3
42	MLST8	MTOR Associated Protein MLST8	Protein Coding	3
43	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
44	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	3
45	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	3
46	MAPKAP1	MAPK Associated Protein 1	Protein Coding	3
47	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	3
48	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	3
49	CDC42	Cell Division Cycle 42	Protein Coding	3
50	BTLA	B And T Lymphocyte Associated	Protein Coding	2
51	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	2
52	ICOS	Inducible T Cell Costimulator	Protein Coding	2
53	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	2
54	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	2
55	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	2
56	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	2
57	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	2
58	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	2
59	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	2
60	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	2
61	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	2
62	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	2
63	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	2
64	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	2
65	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	2
66	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	2
67	CD247	CD247 Molecule	Protein Coding	2
68	CD4	CD4 Molecule	Protein Coding	2
69	CSK	C-Terminal Src Kinase	Protein Coding	1
70	CD274	CD274 Molecule	Protein Coding	1
71	HLA-DPB1	Major Histocompatibility Complex, Class II, DP Beta 1	Protein Coding	1
72	HLA-DQB2	Major Histocompatibility Complex, Class II, DQ Beta 2	Protein Coding	1
73	PDCD1	Programmed Cell Death 1	Protein Coding	1
74	PDCD1LG2	Programmed Cell Death 1 Ligand 2	Protein Coding	1
75	AP1B1	Adaptor Related Protein Complex 1 Subunit Beta 1	Protein Coding	1
76	AP1G1	Adaptor Related Protein Complex 1 Subunit Gamma 1	Protein Coding	1
77	AP1G2	Adaptor Related Protein Complex 1 Subunit Gamma 2	Protein Coding	1
78	AP1M1	Adaptor Related Protein Complex 1 Subunit Mu 1	Protein Coding	1
79	AP1M2	Adaptor Related Protein Complex 1 Subunit Mu 2	Protein Coding	1
80	AP1S1	Adaptor Related Protein Complex 1 Subunit Sigma 1	Protein Coding	1
81	AP1S2	Adaptor Related Protein Complex 1 Subunit Sigma 2	Protein Coding	1
82	AP1S3	Adaptor Related Protein Complex 1 Subunit Sigma 3	Protein Coding	1
83	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	1
84	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	1
85	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	1
86	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	1
87	AP2S1	Adaptor Related Protein Complex 2 Subunit Sigma 1	Protein Coding	1
88	CD8A	CD8 Subunit Alpha	Protein Coding	1
89	CLTA	Clathrin Light Chain A	Protein Coding	1
90	CLTB	Clathrin Light Chain B	Protein Coding	1
91	CLTC	Clathrin Heavy Chain	Protein Coding	1
92	GNAL	G Protein Subunit Alpha L	Protein Coding	1
93	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	1
94	HLA-DMB	Major Histocompatibility Complex, Class II, DM Beta	Protein Coding	1
95	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	1
96	HLA-DOB	Major Histocompatibility Complex, Class II, DO Beta	Protein Coding	1
97	LAT	Linker For Activation Of T Cells	Protein Coding	1
98	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
99	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
100	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
101	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
102	PPP2R2B	Protein Phosphatase 2 Regulatory Subunit Bbeta	Protein Coding	1
103	PPP2R2C	Protein Phosphatase 2 Regulatory Subunit Bgamma	Protein Coding	1
104	PPP2R3A	Protein Phosphatase 2 Regulatory Subunit B''''Alpha	Protein Coding	1
105	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
106	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	1
107	PTPN22	Protein Tyrosine Phosphatase Non-Receptor Type 22	Protein Coding	1
108	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
109	TRAT1	T Cell Receptor Associated Transmembrane Adaptor 1	Protein Coding	1
110	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1

Disorders associated with Regulation of T cell activation by CD28 family SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, LCK, ZAP70	7.78
2	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	7.55
3	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA	7.15
4	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	6.86
5	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.75
6	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	5.75
7	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	5.75
8	Granulomatosis with polyangiitis	Enrichment	CTLA4, HLA-DPA1, PTPN22	5.57
9	Immune system disease	Enrichment	CDC42, PIK3CD	4.91
10	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.64
11	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	4.57
12	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	4.57
13	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	4.57
14	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	4.57
15	Mycosis fungoides	Enrichment	CD28, CTLA4	4.44
16	Saczary syndrome	Enrichment	CD28, CTLA4	4.44
17	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.24
18	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	4.10
19	Mednik syndrome	Enrichment	AP1B1, AP1S1	4.09
20	Adult-onset myasthenia gravis	Enrichment	CTLA4, HLA-DQA1	4.09
21	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1, PTPN22	4.09
22	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.87
23	Temporal arteritis	Enrichment	HLA-DRB1, PTPN22	3.79
24	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	3.79
25	Immunodeficiency, common variable, 1	Enrichment	CTLA4, ICOS	3.76
26	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, PTPN11	3.76
27	Lung cancer	Enrichment	MAP3K8, PIK3CA, PPP2R1B	3.72
28	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SRC	3.61
29	Meningioma	Enrichment	AKT1, PIK3CA	3.60
30	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	3.57
31	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	3.53
32	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	3.53
33	Metachondromatosis	Enrichment	PTPN11	3.43
34	Leopard syndrome 1	Enrichment	PTPN11	3.43
35	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	3.43
36	Bullous pyoderma gangrenosum	Enrichment	PTPN6	3.43
37	Pustular pyoderma gangrenosum	Enrichment	PTPN6	3.43
38	Classic pyoderma gangrenosum	Enrichment	PTPN6	3.43
39	Malignant astrocytoma	Enrichment	PTPN11	3.43
40	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, PTPN22	3.25
41	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, PTPN22	3.25
42	Werner syndrome	Enrichment	PTPN11	3.13
43	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	3.13
44	Macrodactyly	Enrichment	PIK3CA	3.09
45	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	3.09
46	Cowden syndrome 5	Enrichment	PIK3CA	3.09
47	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	3.09
48	Cerebral cavernous malformations 4	Enrichment	PIK3CA	3.09
49	Short syndrome	Enrichment	PIK3R1	3.09
50	Immunodeficiency 119	Enrichment	ICOSLG	3.09
51	Hemifacial myohyperplasia	Enrichment	PIK3CA	3.09
52	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	3.09
53	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	3.09
54	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	3.09
55	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	3.09
56	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	3.09
57	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	3.09
58	Hypospadias	Enrichment	PIK3CA	3.09
59	Rare venous malformation	Enrichment	PIK3CA	3.09
60	Diaphragmatic eventration	Enrichment	PIK3CA	3.09
61	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	3.09
62	Rare combined vascular malformation	Enrichment	PIK3CA	3.09
63	Cavernous lymphangioma	Enrichment	PIK3CA	3.09
64	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	3.09
65	Late-onset combined immunodeficiency due to icosl deficiency	Enrichment	ICOSLG	3.09
66	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	3.09
67	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	3.09
68	Macrodactyly of toe	Enrichment	PIK3CA	3.09
69	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	3.05
70	Knobloch syndrome 2	Enrichment	PAK2	3.05
71	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	3.05
72	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	3.05
73	Immunodeficiency 22	Enrichment	LCK	3.05
74	Takenouchi-kosaki syndrome	Enrichment	CDC42	3.05
75	Nocarh syndrome	Enrichment	CDC42	3.05
76	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.05
77	Systemic lupus erythematosus	Enrichment	CTLA4, HLA-DRB1, PTPN22	2.96
78	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.96
79	Tricuspid valve insufficiency	Enrichment	PTPN11	2.96
80	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.83
81	Proteus syndrome	Enrichment	AKT1	2.81
82	Celiac disease 3	Enrichment	CTLA4	2.81
83	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.81
84	Type 1 diabetes mellitus 12	Enrichment	CTLA4	2.81
85	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.81
86	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.81
87	Cowden syndrome 6	Enrichment	AKT1	2.81
88	Thrombocytopenia 6	Enrichment	SRC	2.81
89	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.81
90	Capillary hemangioma	Enrichment	AKT3	2.81
91	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.81
92	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.79
93	Keratosis, seborrheic	Enrichment	PIK3CA	2.79
94	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.79
95	Noonan syndrome 8	Enrichment	PIK3CA	2.79
96	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.79
97	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.75
98	Lymphoma	Enrichment	PTPN11	2.73
99	Immunodeficiency 112	Enrichment	MAP3K14	2.70
100	Nik deficiency	Enrichment	MAP3K14	2.70
101	Patent ductus arteriosus	Enrichment	PTPN11	2.66
102	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	2.63
103	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.61
104	Keratoacanthoma	Enrichment	PIK3CA	2.61
105	Thrombocytopenia	Enrichment	PTPN11, SRC	2.61
106	Noonan syndrome 3	Enrichment	PTPN11	2.59
107	Hashimoto thyroiditis	Enrichment	CTLA4	2.51
108	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.51
109	Senior-loken syndrome 7	Enrichment	AKT3	2.51
110	Bardet-biedl syndrome 16	Enrichment	AKT3	2.51
111	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.51
112	Cerebrovascular disease	Enrichment	PIK3CA	2.49
113	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.49
114	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.46
115	Knobloch syndrome	Enrichment	PAK2	2.45
116	Cebalid syndrome	Enrichment	MTOR	2.40
117	Smith-kingsmore syndrome	Enrichment	MTOR	2.40
118	Capillary malformations, congenital	Enrichment	PIK3CA	2.39
119	Pectus excavatum	Enrichment	PTPN11	2.39
120	Specific learning disability	Enrichment	PTPN11	2.39
121	Knobloch syndrome 1	Enrichment	PAK2	2.35
122	Epicanthus	Enrichment	PTPN11	2.35
123	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.35
124	Congenital long qt syndrome	Enrichment	PTPN11	2.35
125	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	2.33
126	Asparagine synthetase deficiency	Enrichment	CTLA4	2.33
127	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	2.33
128	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.31
129	Cowden syndrome 1	Enrichment	PIK3CA	2.31
130	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.31
131	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.31
132	Keratitis-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	AP1B1	2.28
133	Hypocalciuric hypercalcemia, familial, type iii	Enrichment	AP2S1	2.28
134	Spinocerebellar ataxia 12	Enrichment	PPP2R2B	2.28
135	Immunodeficiency 116	Enrichment	CD8A	2.28
136	Immunodeficiency 81	Enrichment	LCP2	2.28
137	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.28
138	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.28
139	Immunodeficiency 48	Enrichment	ZAP70	2.28
140	Okt4 epitope deficiency	Enrichment	CD4	2.28
141	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.28
142	Immunodeficiency 18	Enrichment	CD3E	2.28
143	Usmani-riazuddin syndrome, autosomal recessive	Enrichment	AP1G1	2.28
144	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.28
145	Immunodeficiency 25	Enrichment	CD247	2.28
146	Dystonia 25	Enrichment	GNAL	2.28
147	Psoriasis 15, pustular	Enrichment	AP1S3	2.28
148	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.28
149	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.28
150	Usmani-riazuddin syndrome, autosomal dominant	Enrichment	AP1G1	2.28
151	Immunodeficiency 79	Enrichment	CD4	2.28
152	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.28
153	Colitis	Enrichment	SYK	2.28
154	Immunodeficiency 19	Enrichment	CD3D	2.28
155	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.28
156	Autoimmune disease, multisystem, infantile-onset, 4	Enrichment	PDCD1	2.26
157	Systemic lupus erythematosus 2	Enrichment	PDCD1	2.26
158	Berylliosis	Enrichment	HLA-DPB1	2.26
159	Autoimmune disease, multisystem, infantile-onset, 5	Enrichment	CD274	2.26
160	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	2.26
161	Nevus, epidermal	Enrichment	PIK3CA	2.25
162	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.25
163	Gallbladder cancer	Enrichment	PIK3CA	2.25
164	Patent foramen ovale	Enrichment	PTPN11	2.18
165	Arteriovenous malformation	Enrichment	PIK3CA	2.14
166	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.14
167	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.10
168	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.10
169	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.10
170	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	2.09
171	Noonan syndrome 1	Enrichment	PTPN11	2.07
172	Scoliosis	Enrichment	PTPN11	2.05
173	Combined immunodeficiency	Enrichment	ICOSLG	2.05
174	Lung non-small cell carcinoma	Enrichment	PIK3CA	2.05
175	Combined t cell and b cell immunodeficiency	Enrichment	ICOSLG	2.05
176	Combined t and b cell immunodeficiency	Enrichment	ICOSLG	2.05
177	Hydrops fetalis, nonimmune	Enrichment	PTPN11	2.02
178	Rasopathy	Enrichment	PTPN11	2.02
179	Breast cancer	Enrichment	AKT1, PIK3CA	2.01
180	Lip and oral cavity carcinoma	Enrichment	PIK3CA	2.01
181	Strabismus	Enrichment	PTPN11	2.00
182	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	1.98
183	Sarcoidosis 1	Enrichment	HLA-DRB1	1.98
184	Psoriasis 14, pustular	Enrichment	AP1S3	1.98
185	Pettigrew syndrome	Enrichment	AP1S2	1.98
186	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	1.98
187	Immunodeficiency 17	Enrichment	CD3G	1.98
188	Immunodeficiency 52	Enrichment	LAT	1.98
189	Arthritis	Enrichment	SYK	1.98
190	Nk-cell enteropathy	Enrichment	PIK3CB	1.98
191	Myelofibrosis	Enrichment	SRC	1.97
192	Megacolon	Enrichment	AKT3	1.97
193	Long qt syndrome 1	Enrichment	PTPN11	1.96
194	Non-immune hydrops fetalis	Enrichment	PTPN11	1.94
195	Lynch syndrome	Enrichment	PIK3CA	1.92
196	Type 2 diabetes mellitus	Enrichment	AKT2	1.91
197	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.86
198	Polymicrogyria	Enrichment	AKT3	1.81
199	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	1.81
200	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.80
201	Endometrial cancer	Enrichment	PIK3CA	1.77
202	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.77
203	Hepatocellular carcinoma	Enrichment	PIK3CA	1.75
204	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.69
205	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.68
206	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.68
207	Osteoporosis	Enrichment	SRC	1.67
208	Bladder cancer	Enrichment	PIK3CA	1.63
209	Prostate cancer	Enrichment	PIK3CA	1.63
210	Follicular lymphoma	Enrichment	HLA-DRB1	1.59
211	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.59
212	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.53
213	Rare genetic intellectual disability	Enrichment	MTOR	1.53
214	Inflammatory myofibroblastic tumor	Enrichment	CLTC	1.51
215	Limited scleroderma	Enrichment	HLA-DRB1	1.51
216	Gastric cancer	Enrichment	PIK3CA	1.46
217	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.44
218	Autism spectrum disorder	Enrichment	PTPN11	1.40
219	Hypertelorism	Enrichment	PIK3CA	1.38
220	Myeloma, multiple	Enrichment	PIK3R2	1.35
221	Microcephaly	Enrichment	PTPN11	1.35
222	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	AP1G2	1.34
223	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.34
224	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	1.32
225	Isolated tracheo-esophageal fistula	Enrichment	AP1G2	1.29
226	Immune deficiency disease	Enrichment	SYK	1.25
227	Complex neurodevelopmental disorder	Enrichment	PAK3, PPP2CA	1.15
228	Esophageal atresia/tracheoesophageal fistula	Enrichment	AP1G2	1.02
229	Primary ovarian insufficiency	Enrichment	RICTOR	0.95
230	Severe covid-19	Enrichment	HLA-DQB1	0.85
231	Dystonia	Enrichment	GNAL	0.77
232	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	0.64
233	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of T cell activation by CD28 family

Pathway Network for Regulation of T cell activation by CD28 family

Pathway network for the Regulation of T cell activation by CD28 family SuperPath

Member Pathways for Regulation of T cell activation by CD28 family

Pathways in the Regulation of T cell activation by CD28 family SuperPath

Gene overlap in member pathways for Regulation of T cell activation by CD28 family SuperPath

Associated Genes for Regulation of T cell activation by CD28 family

Associated Disorders for Regulation of T cell activation by CD28 family

Disorders associated with Regulation of T cell activation by CD28 family SuperPath

STRING Interaction Network for Regulation of T cell activation by CD28 family

Sources for Regulation of T cell activation by CD28 family