Regulation of Telomerase

No Pathway Network information available for Regulation of Telomerase

Pathways in the Regulation of Telomerase SuperPath

#	Name	Source	Genes
1	Regulation of Telomerase	PubChem	ABL1 ACD AKT1 ATM BLM CCND1 CDKN1B DCLRE1B DKC1 E2F1 EGF EGFR ESR1 FOS HDAC1 HDAC2 HNRNPC HSP90AA1 HUS1 IFNAR2 IFNG IL2 IRF1 JUN MAPK3 MAX MRE11 MTOR MXD1 MYC NBN NCL NFKB1 NR2F2 PARP2 PINX1 POT1 PRKCA PTGES3 RAD1 RAD50 RAD9A RBBP4 RBBP7 RPS6KB1 SAP18 SAP30 SIN3A SIN3B SMAD3 SMG5 SMG6 SP1 SP3 TERF1 TERF2 TERF2IP TERT TGFB1 TINF2 TNKS UBE3A WRN WT1 XRCC5 XRCC6 YWHAE ZNFX1 (see all 68) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PINX1	PIN2 (TERF1) Interacting Telomerase Inhibitor 1	Protein Coding	1
2	SIN3B	SIN3 Transcription Regulator Family Member B	Protein Coding	1
3	ZNFX1	Zinc Finger NFX1-Type Containing 1	Protein Coding	1
4	MXD1	MAX Dimerization Protein 1	Protein Coding	1
5	PARP2	Poly(ADP-Ribose) Polymerase 2	Protein Coding	1
6	TNKS	Tankyrase	Protein Coding	1
7	DCLRE1B	DNA Cross-Link Repair 1B	Protein Coding	1
8	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	1
9	UBE3A	Ubiquitin Protein Ligase E3A	Protein Coding	1
10	NCL	Nucleolin	Protein Coding	1
11	SMG6	SMG6 Nonsense Mediated MRNA Decay Factor	Protein Coding	1
12	SMG5	SMG5 Nonsense Mediated MRNA Decay Factor	Protein Coding	1
13	SAP30	Sin3A Associated Protein 30	Protein Coding	1
14	SAP18	Sin3A Associated Protein 18	Protein Coding	1
15	IFNG	Interferon Gamma	Protein Coding	1
16	IL2	Interleukin 2	Protein Coding	1
17	HNRNPC	Heterogeneous Nuclear Ribonucleoprotein C	Protein Coding	1
18	SP3	Sp3 Transcription Factor	Protein Coding	1
19	DKC1	Dyskerin Pseudouridine Synthase 1	Protein Coding	1
20	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
21	TERF1	Telomeric Repeat Binding Factor 1	Protein Coding	1
22	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	1
23	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	1
24	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
25	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
26	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
27	CCND1	Cyclin D1	Protein Coding	1
28	EGF	Epidermal Growth Factor	Protein Coding	1
29	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	1
30	XRCC6	X-Ray Repair Cross Complementing 6	Protein Coding	1
31	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	1
32	RAD1	RAD1 Checkpoint DNA Exonuclease	Protein Coding	1
33	WRN	WRN RecQ Like Helicase	Protein Coding	1
34	E2F1	E2F Transcription Factor 1	Protein Coding	1
35	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
36	TINF2	TERF1 Interacting Nuclear Factor 2	Protein Coding	1
37	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	1
38	TERF2IP	TERF2 Interacting Protein	Protein Coding	1
39	POT1	Protection Of Telomeres 1	Protein Coding	1
40	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	1
41	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
42	BLM	BLM RecQ Like Helicase	Protein Coding	1
43	NBN	Nibrin	Protein Coding	1
44	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
45	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	1
46	WT1	WT1 Transcription Factor	Protein Coding	1
47	SP1	Sp1 Transcription Factor	Protein Coding	1
48	HDAC2	Histone Deacetylase 2	Protein Coding	1
49	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
50	NR2F2	Nuclear Receptor Subfamily 2 Group F Member 2	Protein Coding	1
51	SMAD3	SMAD Family Member 3	Protein Coding	1
52	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
53	PRKCA	Protein Kinase C Alpha	Protein Coding	1
54	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
55	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
56	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
57	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
58	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
59	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	1
60	PTGES3	Prostaglandin E Synthase 3	Protein Coding	1
61	HDAC1	Histone Deacetylase 1	Protein Coding	1
62	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
63	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
64	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
65	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
66	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
67	ESR1	Estrogen Receptor 1	Protein Coding	1
68	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1

Disorders associated with Regulation of Telomerase SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ovarian cancer	Enrichment	AKT1, ATM, BLM, CDKN1B, EGFR, MRE11, NBN, RAD50, WRN, WT1	10.14
2	Breast cancer	Enrichment	AKT1, ATM, BLM, ESR1, IL2, JUN, MRE11, NBN, RAD50	9.98
3	Inherited cancer-predisposing syndrome	Enrichment	ATM, BLM, CDKN1B, EGFR, MAX, MRE11, NBN, POT1, RAD50, WT1	9.00
4	Hoyeraal-hreidarsson syndrome	Enrichment	ACD, DKC1, TERT, TINF2	8.06
5	Hereditary breast carcinoma	Enrichment	AKT1, ATM, BLM, ESR1, NBN, RAD50	7.11
6	Melanoma, cutaneous malignant 1	Enrichment	ACD, POT1, TERF2IP, TERT	5.88
7	Dyskeratosis congenita	Enrichment	DKC1, POT1, TERT, TINF2	5.67
8	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BLM, MRE11, NBN, RAD50	5.11
9	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, POT1	4.85
10	Aplastic anemia	Enrichment	IFNG, NBN, TERT	4.85
11	Witteveen-kolk syndrome	Enrichment	SIN3A, SIN3B	4.61
12	Mantle cell lymphoma	Enrichment	ATM, CCND1	3.83
13	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	3.83
14	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TERT	3.76
15	Idiopathic aplastic anemia	Enrichment	IFNG, TERT	3.61
16	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT, TINF2	3.44
17	Kidney clear cell sarcoma	Enrichment	TERT, YWHAE	3.44
18	Bladder cancer	Enrichment	ATM, EGFR, TERT	3.40
19	Renal cell carcinoma, papillary, 1	Enrichment	ATM, MTOR	3.29
20	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT, TINF2	3.29
21	Colonic benign neoplasm	Enrichment	ATM, MRE11	3.06
22	Colorectal cancer	Enrichment	AKT1, ATM, BLM, CCND1	3.03
23	Gastric cancer	Enrichment	ATM, IRF1, NBN	2.89
24	Lung non-small cell carcinoma	Enrichment	EGFR, IRF1	2.88
25	Meningioma	Enrichment	AKT1, TERT	2.80
26	Lip and oral cavity carcinoma	Enrichment	ABL1, EGFR	2.80
27	Breast-ovarian cancer, familial 1	Enrichment	ATM, NBN	2.73
28	Heart disease	Enrichment	ABL1, NR2F2	2.66
29	Renal cell carcinoma, nonpapillary	Enrichment	ATM, MTOR	2.60
30	Gliosarcoma	Enrichment	ATM, EGFR	2.55
31	Giant cell glioblastoma	Enrichment	ATM, EGFR	2.49
32	Endometrial cancer	Enrichment	ATM, BLM	2.31
33	Proteus syndrome	Enrichment	AKT1	2.30
34	Bloom syndrome	Enrichment	BLM	2.30
35	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.30
36	Hypomagnesemia 4, renal	Enrichment	EGF	2.30
37	Tumor predisposition syndrome 3	Enrichment	POT1	2.30
38	Immunodeficiency 69	Enrichment	IFNG	2.30
39	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8	Enrichment	POT1	2.30
40	46,xx sex reversal 5	Enrichment	NR2F2	2.30
41	Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 1	Enrichment	DKC1	2.30
42	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.30
43	Neuroendocrine tumor	Enrichment	CDKN1B	2.30
44	Meacham syndrome	Enrichment	WT1	2.30
45	High-grade astrocytoma with piloid features	Enrichment	POT1	2.30
46	Dyskeratosis congenita, autosomal recessive 8	Enrichment	DCLRE1B	2.30
47	Cerebroretinal microangiopathy with calcifications and cysts 3	Enrichment	POT1	2.30
48	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.30
49	Cowden syndrome 6	Enrichment	AKT1	2.30
50	Endometrial serous adenocarcinoma	Enrichment	ATM	2.30
51	Immunodeficiency 91 and hyperinflammation	Enrichment	ZNFX1	2.30
52	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.30
53	Intellectual developmental disorder, autosomal dominant 74	Enrichment	HNRNPC	2.30
54	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.30
55	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.30
56	15q11q13 microduplication syndrome	Enrichment	UBE3A	2.30
57	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.30
58	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.30
59	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, MYC	2.23
60	Pancreatic cancer	Enrichment	ATM, NBN	2.16
61	Prostate cancer	Enrichment	ATM, NBN	2.04
62	Burkitt lymphoma	Enrichment	MYC	2.00
63	Camurati-engelmann disease 1	Enrichment	TGFB1	2.00
64	Denys-drash syndrome	Enrichment	WT1	2.00
65	Revesz syndrome	Enrichment	TINF2	2.00
66	Nephrotic syndrome, type 4	Enrichment	WT1	2.00
67	Frasier syndrome	Enrichment	WT1	2.00
68	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	2.00
69	Immunodeficiency 45	Enrichment	IFNAR2	2.00
70	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.00
71	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.00
72	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.00
73	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.00
74	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.00
75	Werner syndrome	Enrichment	WRN	2.00
76	Cebalid syndrome	Enrichment	MTOR	2.00
77	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.00
78	Dyskeratosis congenita, autosomal dominant 3	Enrichment	TINF2	2.00
79	Oligodendroglioma	Enrichment	POT1	2.00
80	Camurati-engelmann disease	Enrichment	TGFB1	2.00
81	High grade glioma	Enrichment	ATM	2.00
82	Melanoma, cutaneous malignant 9	Enrichment	TERT	2.00
83	T-cell prolymphocytic leukemia	Enrichment	ATM	2.00
84	Smith-kingsmore syndrome	Enrichment	MTOR	2.00
85	Idiopathic interstitial pneumonia	Enrichment	TERT	2.00
86	Anaplastic oligodendroglioma	Enrichment	POT1	2.00
87	Immunodeficiency 117	Enrichment	IRF1	2.00
88	Angelman syndrome due to maternal 15q11q13 deletion	Enrichment	UBE3A	2.00
89	Common variable immunodeficiency 12	Enrichment	NFKB1	2.00
90	Desmoplastic small round cell tumor	Enrichment	WT1	2.00
91	Lung cancer	Enrichment	EGFR, IRF1	1.95
92	Mesothelioma, malignant	Enrichment	WT1	1.82
93	Ataxia-telangiectasia	Enrichment	ATM	1.82
94	Nijmegen breakage syndrome	Enrichment	NBN	1.82
95	Polycythemia vera	Enrichment	ATM	1.82
96	Tuberous sclerosis 1	Enrichment	IFNG	1.82
97	Dyskeratosis congenita, x-linked	Enrichment	DKC1	1.82
98	Hepatitis c virus	Enrichment	IFNG	1.82
99	Estrogen resistance	Enrichment	ESR1	1.82
100	Tuberous sclerosis 2	Enrichment	IFNG	1.82
101	Dyskeratosis congenita, autosomal dominant 6	Enrichment	ACD	1.82
102	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.82
103	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.82
104	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.82
105	Koolen-de vries syndrome	Enrichment	ATM	1.82
106	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.82
107	Interstitial lung disease	Enrichment	TERT	1.82
108	Macrocytic anemia	Enrichment	TERT	1.82
109	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.82
110	Adenocarcinoma	Enrichment	ATM	1.82
111	Migraine without aura	Enrichment	ESR1	1.82
112	Immunodeficiency 44	Enrichment	IFNAR2	1.82
113	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.82
114	Angelman syndrome due to imprinting defect in 15q11-q13	Enrichment	UBE3A	1.82
115	Aniridia 1	Enrichment	WT1	1.70
116	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.70
117	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.70
118	Spastic paraplegia 47, autosomal recessive	Enrichment	DCLRE1B	1.70
119	Congenital generalized lipodystrophy	Enrichment	FOS	1.70
120	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.70
121	Lung sarcomatoid carcinoma	Enrichment	TERT	1.70
122	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.70
123	Hepatitis b	Enrichment	IFNAR2	1.70
124	Aortic aneurysm	Enrichment	SMAD3	1.70
125	Primary hyperparathyroidism	Enrichment	CDKN1B	1.70
126	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.70
127	Oculomotor apraxia	Enrichment	ATM	1.70
128	Von hippel-lindau syndrome	Enrichment	CCND1	1.61
129	Leber congenital amaurosis 10	Enrichment	WT1	1.61
130	Congenital heart defects, multiple types, 4	Enrichment	NR2F2	1.61
131	Glioblastoma	Enrichment	ATM	1.61
132	Histiocytoid hemangioma	Enrichment	FOS	1.61
133	Hemimegalencephaly	Enrichment	MTOR	1.61
134	Endometrial stromal sarcoma	Enrichment	YWHAE	1.61
135	Angelman syndrome	Enrichment	UBE3A	1.53
136	Cowden syndrome 1	Enrichment	EGFR	1.53
137	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	WT1	1.53
138	Wilms tumor 5	Enrichment	WT1	1.53
139	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.53
140	Pulmonary fibrosis	Enrichment	TERT	1.53
141	Adrenocortical carcinoma	Enrichment	TERT	1.53
142	Clear cell renal cell carcinoma	Enrichment	ATM	1.53
143	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.53
144	Breast adenocarcinoma	Enrichment	AKT1	1.53
145	Lung squamous cell carcinoma	Enrichment	EGFR	1.53
146	46,xy disorder of sex development	Enrichment	NR2F2	1.53
147	Myeloma, multiple	Enrichment	ATM, CCND1	1.49
148	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.46
149	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.46
150	Leukemia, chronic myeloid	Enrichment	ABL1	1.46
151	Common variable immunodeficiency	Enrichment	NFKB1	1.46
152	Overgrowth syndrome	Enrichment	MTOR	1.46
153	Moyamoya angiopathy	Enrichment	ABL1	1.46
154	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.46
155	Primary ovarian insufficiency	Enrichment	NBN, WT1	1.45
156	Fanconi anemia, complementation group c	Enrichment	DCLRE1B	1.40
157	Difference of sex development	Enrichment	WT1	1.40
158	Leukemia, acute lymphoblastic 3	Enrichment	WT1	1.35
159	Loeys-dietz syndrome	Enrichment	SMAD3	1.35
160	Adult hepatocellular carcinoma	Enrichment	EGF	1.35
161	Cowden syndrome	Enrichment	AKT1	1.35
162	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.35
163	Lynch syndrome 1	Enrichment	ATM	1.31
164	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.31
165	Migraine with or without aura 1	Enrichment	ESR1	1.27
166	Immune deficiency disease	Enrichment	ATM	1.27
167	Leukemia, acute lymphoblastic	Enrichment	NBN	1.27
168	46,xy complete gonadal dysgenesis	Enrichment	WT1	1.27
169	Uterine corpus cancer	Enrichment	ATM	1.27
170	Familial colorectal cancer type x	Enrichment	ATM	1.27
171	Premature menopause	Enrichment	NBN	1.20
172	Medulloblastoma	Enrichment	WRN	1.17
173	Pheochromocytoma	Enrichment	MAX	1.17
174	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.17
175	Lung cancer susceptibility 3	Enrichment	EGFR	1.17
176	Cataract	Enrichment	WRN	1.17
177	46,xy partial gonadal dysgenesis	Enrichment	WT1	1.17
178	Wilms tumor 1	Enrichment	WT1	1.14
179	Kidney disease	Enrichment	WT1	1.14
180	Rare genetic intellectual disability	Enrichment	MTOR	1.14
181	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	DKC1	1.11
182	Interstitial lung disease 2	Enrichment	TERT	1.09
183	Human immunodeficiency virus type 1	Enrichment	IFNG	1.06
184	Arteriovenous malformations of the brain	Enrichment	EGFR	1.04
185	Diffuse large b-cell lymphoma	Enrichment	NBN	1.04
186	Ehlers-danlos syndrome	Enrichment	SMAD3	1.04
187	Focal segmental glomerulosclerosis	Enrichment	WT1	1.02
188	Lissencephaly	Enrichment	NBN	1.00
189	Hepatoblastoma	Enrichment	TERT	1.00
190	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	1.00
191	Myocardial infarction	Enrichment	ESR1	0.98
192	Multisystem inflammatory syndrome in children	Enrichment	IFNAR2	0.98
193	Microcephaly	Enrichment	ABL1, NBN	0.90
194	Differentiated thyroid carcinoma	Enrichment	TERT	0.87
195	Cystic fibrosis	Enrichment	TGFB1	0.83
196	Connective tissue disease	Enrichment	SMAD3	0.83
197	Genetic steroid-resistant nephrotic syndrome	Enrichment	WT1	0.80
198	Leukemia, acute myeloid	Enrichment	TERT	0.74
199	Type 2 diabetes mellitus	Enrichment	WRN	0.72
200	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3	0.70
201	Complex neurodevelopmental disorder	Enrichment	HNRNPC	0.33

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of Telomerase

Pathway Network for Regulation of Telomerase

Member Pathways for Regulation of Telomerase

Pathways in the Regulation of Telomerase SuperPath

Associated Genes for Regulation of Telomerase

Associated Disorders for Regulation of Telomerase

Disorders associated with Regulation of Telomerase SuperPath

STRING Interaction Network for Regulation of Telomerase

Sources for Regulation of Telomerase