Regulation of TP53 Activity

Pathway network for the Regulation of TP53 Activity SuperPath

Sources:

Reactome

Pathways in the Regulation of TP53 Activity SuperPath

#	Name	Source	Genes
1	Regulation of TP53 Activity	Reactome	AKT1 AKT2 AKT3 ATM ATR ATRIP AURKA AURKB BANP BARD1 BLM BRCA1 BRD1 BRD7 BRIP1 BRPF1 BRPF3 CCNA1 CCNA2 CCNG1 CDK1 CDK2 CDK5 CDK5R1 CDKN2A CHD3 CHD4 CHEK1 CHEK2 CSNK2A1 CSNK2A2 CSNK2B DAXX DNA2 DYRK2 EHMT1 EHMT2 EP300 EXO1 GATAD2A GATAD2B HDAC1 HDAC2 HIPK1 HIPK2 HUS1 ING2 ING5 JMY KAT5 KAT6A KMT5A L3MBTL1 MAP2K6 MAPK11 MAPK14 MAPKAP1 MAPKAPK5 MBD3 MDM2 MDM4 MEAF6 MLST8 MRE11 MTA2 MTOR NBN NOC2L NUAK1 PDPK1 PHF20 PIN1 PIP4K2A PIP4K2B PIP4K2C PIP4P1 PLK3 PML POU4F1 POU4F2 PPP1R13L PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5C PRDM1 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRMT5 PRR5 RAD1 RAD17 RAD50 RAD9A RAD9B RBBP4 RBBP7 RBBP8 RFC2 RFC3 RFC4 RFC5 RFFL RHNO1 RICTOR RMI1 RMI2 RNF34 RPA1 RPA2 RPA3 RPS27A SETD9 SGK1 SMYD2 SSRP1 STK11 SUPT16H TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TBP TOP3A TOPBP1 TP53 TP53INP1 TP53RK TPX2 TTC5 UBA52 UBB UBC USP7 WRN ZNF385A (see all 155) (see less)
2	Transcriptional Regulation by TP53	Reactome	AGO1 AGO2 AGO3 AGO4 AIFM2 AKT1 AKT2 AKT3 ARID3A ATF2 ATM ATR ATRIP AURKA AURKB BANP BARD1 BBC3 BCL2L14 BCL6 BIRC5 BLM BNIP3L BRCA1 BRD1 BRD7 BRIP1 BRPF1 BRPF3 BTG2 CARM1 CASP1 CASP10 CASP2 CCNA1 CCNA2 CCNB1 CCNE1 CCNE2 CCNG1 CCNH CCNK CCNT1 CCNT2 CDC25C CDK1 CDK12 CDK13 CDK2 CDK5 CDK5R1 CDK7 CDK9 CDKN1A CDKN1B CDKN2A CHD3 CHD4 CHEK1 CHEK2 CHM CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 COX4I1 COX4I2 COX5A COX5B COX6A1 COX6A2 COX6B1 COX6B2 COX6C COX7A1 COX7A2 COX7A2L COX7B COX7C COX8A COX8C COXFA4 CPAP CRADD CREBBP CSNK2A1 CSNK2A2 CSNK2B CTDP1 DAXX DDB2 DDIT4 DNA2 DYRK2 E2F1 E2F4 E2F7 E2F8 EHMT1 EHMT2 ELL ELOA ELOA2 ELOB ELOC EP300 ERCC2 ERCC3 EXO1 FANCC FANCD2 FANCI FOS G6PD GADD45A GATAD2A GATAD2B GLS GLS2 GPI GPX2 GSR GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 HDAC1 HDAC2 HIGD1C HIPK1 HIPK2 HUS1 IGFBP3 ING2 ING5 JMY JUN KAT5 KAT6A KMT5A L3MBTL1 LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MAP2K6 MAPK11 MAPK14 MAPKAP1 MAPKAPK5 MBD3 MDC1 MDM2 MDM4 MEAF6 MLH1 MLST8 MNAT1 MOV10 MRE11 MSH2 MT-CO1 MT-CO2 MT-CO3 MTA2 MTOR NBN NDRG1 NELFA NELFB NELFCD NELFE NLRC4 NOC2L NPM1 NUAK1 PCBP4 PCNA PDPK1 PERP PHF20 PIDD1 PIN1 PIP4K2A PIP4K2B PIP4K2C PIP4P1 PLAGL1 PLK2 PLK3 PMAIP1 PML PMS2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POU4F1 POU4F2 PPP1R13L PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5C PRDM1 PRDX1 PRDX2 PRDX5 PRELID1 PRELID3A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRMT1 PRMT5 PRR5 PTEN RABGGTA RABGGTB RAD1 RAD17 RAD50 RAD51D RAD9A RAD9B RBBP4 RBBP7 RBBP8 RBL1 RBL2 RFC2 RFC3 RFC4 RFC5 RFFL RGCC RHEB RHNO1 RICTOR RMI1 RMI2 RNF34 RPA1 RPA2 RPA3 RPS27A RPTOR RRAGA RRAGB RRAGC RRAGD RRM2B SCO2 SESN1 SESN2 SESN3 SETD9 SFN SGK1 SLC38A9 SMYD2 SSRP1 STEAP3 STK11 SUPT16H SUPT4H1 SUPT5H TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TBP TCEA1 TFDP1 TFDP2 TIGAR TMEM219 TNFRSF10C TNFRSF10D TNKS1BP1 TNRC6A TNRC6B TNRC6C TOP3A TOPBP1 TP53 TP53AIP1 TP53I3 TP53INP1 TP53RK TPX2 TRIAP1 TSC1 TSC2 TTC5 TXN TXNRD1 UBA52 UBB UBC USP7 WRN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZNF385A ZNF420 (see all 347) (see less)
3	Regulation of TP53 Activity through Phosphorylation	Reactome	ATM ATR ATRIP AURKA AURKB BARD1 BLM BRCA1 BRIP1 CCNA1 CCNA2 CDK2 CDK5 CDK5R1 CHEK1 CHEK2 CSNK2A1 CSNK2A2 CSNK2B DNA2 DYRK2 EXO1 HIPK1 HIPK2 HUS1 KAT5 MAPK11 MAPK14 MAPKAPK5 MDM2 MDM4 MRE11 NBN NOC2L NUAK1 PIN1 PLK3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RAD1 RAD17 RAD50 RAD9A RAD9B RBBP8 RFC2 RFC3 RFC4 RFC5 RHNO1 RMI1 RMI2 RPA1 RPA2 RPA3 RPS27A SSRP1 STK11 SUPT16H TAF1 TAF10 TAF11 TAF12 TAF13 TAF15 TAF1L TAF2 TAF3 TAF4 TAF4B TAF5 TAF6 TAF7 TAF7L TAF9 TAF9B TBP TOP3A TOPBP1 TP53 TP53INP1 TP53RK TPX2 UBA52 UBB UBC WRN (see all 92) (see less)
4	Regulation of TP53 Activity through Methylation	Reactome	ATM CHEK2 EHMT1 EHMT2 EP300 JMY KMT5A L3MBTL1 MDM2 MDM4 PRMT5 RPS27A SETD9 SMYD2 TP53 TTC5 UBA52 UBB UBC (see all 19) (see less)
5	Regulation of TP53 Activity through Association with Co-factors	Reactome	AKT1 AKT2 AKT3 BANP PHF20 POU4F1 POU4F2 PPP1R13L TP53 ZNF385A (see all 10) (see less)

Gene overlap in member pathways for Regulation of TP53 Activity SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TP53	Tumor Protein P53	Protein Coding	5
2	CHEK2	Checkpoint Kinase 2	Protein Coding	4
3	MDM2	MDM2 Proto-Oncogene	Protein Coding	4
4	MDM4	MDM4 Regulator Of P53	Protein Coding	4
5	ATM	ATM Serine/Threonine Kinase	Protein Coding	4
6	RPS27A	Ribosomal Protein S27a	Protein Coding	4
7	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	4
8	UBB	Ubiquitin B	Protein Coding	4
9	UBC	Ubiquitin C	Protein Coding	4
10	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	3
11	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	3
12	CDK2	Cyclin Dependent Kinase 2	Protein Coding	3
13	CDK5	Cyclin Dependent Kinase 5	Protein Coding	3
14	PRMT5	Protein Arginine Methyltransferase 5	Protein Coding	3
15	KAT5	Lysine Acetyltransferase 5	Protein Coding	3
16	PPP1R13L	Protein Phosphatase 1 Regulatory Subunit 13 Like	Protein Coding	3
17	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	3
18	TOPBP1	DNA Topoisomerase II Binding Protein 1	Protein Coding	3
19	CHEK1	Checkpoint Kinase 1	Protein Coding	3
20	SUPT16H	SPT16 Homolog, Facilitates Chromatin Remodeling Subunit	Protein Coding	3
21	TP53RK	TP53 Regulating Kinase	Protein Coding	3
22	RMI2	RecQ Mediated Genome Instability 2	Protein Coding	3
23	PLK3	Polo Like Kinase 3	Protein Coding	3
24	SETD9	SET Domain Containing 9	Protein Coding	3
25	JMY	Junction Mediating And Regulatory Protein, P53 Cofactor	Protein Coding	3
26	TAF1L	TATA-Box Binding Protein Associated Factor 1 Like	Protein Coding	3
27	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3
28	RAD9B	RAD9 Checkpoint Clamp Component B	Protein Coding	3
29	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	3
30	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	3
31	CSNK2B	Casein Kinase 2 Beta	Protein Coding	3
32	DNA2	DNA Replication Helicase/Nuclease 2	Protein Coding	3
33	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
34	HIPK1	Homeodomain Interacting Protein Kinase 1	Protein Coding	3
35	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
36	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
37	TPX2	TPX2 Microtubule Nucleation Factor	Protein Coding	3
38	ZNF385A	Zinc Finger Protein 385A	Protein Coding	3
39	L3MBTL1	L3MBTL Histone Methyl-Lysine Binding Protein 1	Protein Coding	3
40	NOC2L	NOC2 Like Nucleolar Associated Transcriptional Repressor	Protein Coding	3
41	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	3
42	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	3
43	KMT5A	Lysine Methyltransferase 5A	Protein Coding	3
44	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	3
45	NBN	Nibrin	Protein Coding	3
46	PHF20	PHD Finger Protein 20	Protein Coding	3
47	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	3
48	TAF9B	TATA-Box Binding Protein Associated Factor 9b	Protein Coding	3
49	PIN1	Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1	Protein Coding	3
50	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	3
51	TAF7L	TATA-Box Binding Protein Associated Factor 7 Like	Protein Coding	3
52	ATR	ATR Checkpoint Kinase	Protein Coding	3
53	POU4F1	POU Class 4 Homeobox 1	Protein Coding	3
54	POU4F2	POU Class 4 Homeobox 2	Protein Coding	3
55	BANP	BTG3 Associated Nuclear Protein	Protein Coding	3
56	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	3
57	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	3
58	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	3
59	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	3
60	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	3
61	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	3
62	SMYD2	SET And MYND Domain Containing 2	Protein Coding	3
63	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	3
64	RAD1	RAD1 Checkpoint DNA Exonuclease	Protein Coding	3
65	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	3
66	RAD17	RAD17 Checkpoint Clamp Loader Component	Protein Coding	3
67	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	3
68	RFC2	Replication Factor C Subunit 2	Protein Coding	3
69	RFC3	Replication Factor C Subunit 3	Protein Coding	3
70	RFC4	Replication Factor C Subunit 4	Protein Coding	3
71	RFC5	Replication Factor C Subunit 5	Protein Coding	3
72	RPA1	Replication Protein A1	Protein Coding	3
73	RPA2	Replication Protein A2	Protein Coding	3
74	RPA3	Replication Protein A3	Protein Coding	3
75	BLM	BLM RecQ Like Helicase	Protein Coding	3
76	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	3
77	SSRP1	Structure Specific Recognition Protein 1	Protein Coding	3
78	AURKA	Aurora Kinase A	Protein Coding	3
79	STK11	Serine/Threonine Kinase 11	Protein Coding	3
80	TAF1	TATA-Box Binding Protein Associated Factor 1	Protein Coding	3
81	TAF2	TATA-Box Binding Protein Associated Factor 2	Protein Coding	3
82	TAF4	TATA-Box Binding Protein Associated Factor 4	Protein Coding	3
83	TAF4B	TATA-Box Binding Protein Associated Factor 4b	Protein Coding	3
84	TAF5	TATA-Box Binding Protein Associated Factor 5	Protein Coding	3
85	TAF6	TATA-Box Binding Protein Associated Factor 6	Protein Coding	3
86	TAF7	TATA-Box Binding Protein Associated Factor 7	Protein Coding	3
87	TAF9	TATA-Box Binding Protein Associated Factor 9	Protein Coding	3
88	TAF10	TATA-Box Binding Protein Associated Factor 10	Protein Coding	3
89	TAF11	TATA-Box Binding Protein Associated Factor 11	Protein Coding	3
90	TAF12	TATA-Box Binding Protein Associated Factor 12	Protein Coding	3
91	TAF13	TATA-Box Binding Protein Associated Factor 13	Protein Coding	3
92	TBP	TATA-Box Binding Protein	Protein Coding	3
93	TOP3A	DNA Topoisomerase III Alpha	Protein Coding	3
94	WRN	WRN RecQ Like Helicase	Protein Coding	3
95	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	3
96	RMI1	RecQ Mediated Genome Instability 1	Protein Coding	3
97	TAF15	TATA-Box Binding Protein Associated Factor 15	Protein Coding	3
98	RHNO1	RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1	Protein Coding	3
99	TAF3	TATA-Box Binding Protein Associated Factor 3	Protein Coding	3
100	BRIP1	BRCA1 Interacting DNA Helicase 1	Protein Coding	3
101	ATRIP	ATR Interacting Protein	Protein Coding	3
102	DYRK2	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2	Protein Coding	3
103	MAPKAPK5	MAPK Activated Protein Kinase 5	Protein Coding	3
104	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	3
105	CCNA2	Cyclin A2	Protein Coding	3
106	CCNA1	Cyclin A1	Protein Coding	3
107	EXO1	Exonuclease 1	Protein Coding	3
108	TTC5	Tetratricopeptide Repeat Domain 5	Protein Coding	3
109	AURKB	Aurora Kinase B	Protein Coding	3
110	TP53INP1	Tumor Protein P53 Inducible Nuclear Protein 1	Protein Coding	3
111	NUAK1	NUAK Family Kinase 1	Protein Coding	3
112	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	2
113	CHD3	Chromodomain Helicase DNA Binding Protein 3	Protein Coding	2
114	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	2
115	RFFL	Ring Finger And FYVE Like Domain Containing E3 Ubiquitin Protein Ligase	Protein Coding	2
116	DAXX	Death Domain Associated Protein	Protein Coding	2
117	BRD1	Bromodomain Containing 1	Protein Coding	2
118	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	2
119	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	2
120	BRPF3	Bromodomain And PHD Finger Containing 3	Protein Coding	2
121	BRD7	Bromodomain Containing 7	Protein Coding	2
122	HDAC1	Histone Deacetylase 1	Protein Coding	2
123	HDAC2	Histone Deacetylase 2	Protein Coding	2
124	ING2	Inhibitor Of Growth Family Member 2	Protein Coding	2
125	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
126	PIP4K2A	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Alpha	Protein Coding	2
127	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	2
128	PML	PML Nuclear Body Scaffold	Protein Coding	2
129	GATAD2A	GATA Zinc Finger Domain Containing 2A	Protein Coding	2
130	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
131	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
132	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
133	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
134	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	2
135	PRR5	Proline Rich 5	Protein Coding	2
136	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
137	GATAD2B	GATA Zinc Finger Domain Containing 2B	Protein Coding	2
138	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
139	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	2
140	PRDM1	PR/SET Domain 1	Protein Coding	2
141	MLST8	MTOR Associated Protein MLST8	Protein Coding	2
142	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	2
143	MEAF6	MYST/Esa1 Associated Factor 6	Protein Coding	2
144	BRPF1	Bromodomain And PHD Finger Containing 1	Protein Coding	2
145	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	2
146	MAPKAP1	MAPK Associated Protein 1	Protein Coding	2
147	PIP4K2C	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma	Protein Coding	2
148	KAT6A	Lysine Acetyltransferase 6A	Protein Coding	2
149	RNF34	Ring Finger Protein 34	Protein Coding	2
150	PIP4K2B	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta	Protein Coding	2
151	ING5	Inhibitor Of Growth Family Member 5	Protein Coding	2
152	CCNG1	Cyclin G1	Protein Coding	2
153	PIP4P1	Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 1	Protein Coding	2
154	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	2
155	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2
156	CDK7	Cyclin Dependent Kinase 7	Protein Coding	1
157	CDK9	Cyclin Dependent Kinase 9	Protein Coding	1
158	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
159	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
160	RRAGB	Ras Related GTP Binding B	Protein Coding	1
161	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	1
162	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	1
163	LAMTOR5	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5	Protein Coding	1
164	PRELID3A	PRELI Domain Containing 3A	Protein Coding	1
165	RRAGA	Ras Related GTP Binding A	Protein Coding	1
166	PLK2	Polo Like Kinase 2	Protein Coding	1
167	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
168	CHM	CHM Rab Escort Protein	Protein Coding	1
169	TMEM219	Transmembrane Protein 219	Protein Coding	1
170	COX6B2	Cytochrome C Oxidase Subunit 6B2	Protein Coding	1
171	COX4I1	Cytochrome C Oxidase Subunit 4I1	Protein Coding	1
172	COX5B	Cytochrome C Oxidase Subunit 5B	Protein Coding	1
173	COX6A1	Cytochrome C Oxidase Subunit 6A1	Protein Coding	1
174	COX6A2	Cytochrome C Oxidase Subunit 6A2	Protein Coding	1
175	COX6B1	Cytochrome C Oxidase Subunit 6B1	Protein Coding	1
176	COX6C	Cytochrome C Oxidase Subunit 6C	Protein Coding	1
177	COX7A1	Cytochrome C Oxidase Subunit 7A1	Protein Coding	1
178	COX7A2	Cytochrome C Oxidase Subunit 7A2	Protein Coding	1
179	COX7B	Cytochrome C Oxidase Subunit 7B	Protein Coding	1
180	COX7C	Cytochrome C Oxidase Subunit 7C	Protein Coding	1
181	COX8A	Cytochrome C Oxidase Subunit 8A	Protein Coding	1
182	ATF2	Activating Transcription Factor 2	Protein Coding	1
183	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
184	SESN3	Sestrin 3	Protein Coding	1
185	E2F7	E2F Transcription Factor 7	Protein Coding	1
186	ZNF420	Zinc Finger Protein 420	Protein Coding	1
187	SLC38A9	Solute Carrier Family 38 Member 9	Protein Coding	1
188	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	1
189	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
190	ARID3A	AT-Rich Interaction Domain 3A	Protein Coding	1
191	E2F1	E2F Transcription Factor 1	Protein Coding	1
192	E2F4	E2F Transcription Factor 4	Protein Coding	1
193	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	1
194	AGO4	Argonaute RISC Component 4	Protein Coding	1
195	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	1
196	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	1
197	FANCC	FA Complementation Group C	Protein Coding	1
198	FANCD2	FA Complementation Group D2	Protein Coding	1
199	CNOT1	CCR4-NOT Transcription Complex Subunit 1	Protein Coding	1
200	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	1
201	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
202	CNOT6L	CCR4-NOT Transcription Complex Subunit 6 Like	Protein Coding	1
203	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	1
204	PRDX5	Peroxiredoxin 5	Protein Coding	1
205	CNOT10	CCR4-NOT Transcription Complex Subunit 10	Protein Coding	1
206	NELFB	Negative Elongation Factor Complex Member B	Protein Coding	1
207	AGO1	Argonaute RISC Component 1	Protein Coding	1
208	BBC3	BCL2 Binding Component 3	Protein Coding	1
209	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	1
210	GLS2	Glutaminase 2	Protein Coding	1
211	PRELID1	PRELI Domain Containing 1	Protein Coding	1
212	SESN1	Sestrin 1	Protein Coding	1
213	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	1
214	GLS	Glutaminase	Protein Coding	1
215	SFN	Stratifin	Protein Coding	1
216	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	1
217	GPX2	Glutathione Peroxidase 2	Protein Coding	1
218	LAMTOR2	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 2	Protein Coding	1
219	RGCC	Regulator Of Cell Cycle	Protein Coding	1
220	GSR	Glutathione-Disulfide Reductase	Protein Coding	1
221	GTF2F1	General Transcription Factor IIF Subunit 1	Protein Coding	1
222	GTF2F2	General Transcription Factor IIF Subunit 2	Protein Coding	1
223	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	1
224	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	1
225	GTF2H3	General Transcription Factor IIH Subunit 3	Protein Coding	1
226	GTF2H4	General Transcription Factor IIH Subunit 4	Protein Coding	1
227	CNOT7	CCR4-NOT Transcription Complex Subunit 7	Protein Coding	1
228	PRMT1	Protein Arginine Methyltransferase 1	Protein Coding	1
229	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
230	COX8C	Cytochrome C Oxidase Subunit 8C	Protein Coding	1
231	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	1
232	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
233	LAMTOR4	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4	Protein Coding	1
234	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	1
235	MLH1	MutL Homolog 1	Protein Coding	1
236	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	1
237	MOV10	Mov10 RNA Helicase	Protein Coding	1
238	MSH2	MutS Homolog 2	Protein Coding	1
239	MT-CO1	Mitochondrially Encoded Cytochrome C Oxidase I	Protein Coding	1
240	MT-CO2	Mitochondrially Encoded Cytochrome C Oxidase II	Protein Coding	1
241	MT-CO3	Mitochondrially Encoded Cytochrome C Oxidase III	Protein Coding	1
242	COXFA4	Cytochrome C Oxidase Associated Subunit FA4	Protein Coding	1
243	CNOT2	CCR4-NOT Transcription Complex Subunit 2	Protein Coding	1
244	CNOT3	CCR4-NOT Transcription Complex Subunit 3	Protein Coding	1
245	CNOT4	CCR4-NOT Transcription Complex Subunit 4	Protein Coding	1
246	NPM1	Nucleophosmin 1	Protein Coding	1
247	RRM2B	Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B	Protein Coding	1
248	PRDX1	Peroxiredoxin 1	Protein Coding	1
249	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
250	ELOA2	Elongin A2	Protein Coding	1
251	NELFCD	Negative Elongation Factor Complex Member C/D	Protein Coding	1
252	TRIAP1	TP53 Regulated Inhibitor Of Apoptosis 1	Protein Coding	1
253	CDK12	Cyclin Dependent Kinase 12	Protein Coding	1
254	PLAGL1	PLAG1 Like Zinc Finger 1	Protein Coding	1
255	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
256	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	1
257	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
258	POLR2B	RNA Polymerase II Subunit B	Protein Coding	1
259	POLR2C	RNA Polymerase II Subunit C	Protein Coding	1
260	POLR2D	RNA Polymerase II Subunit D	Protein Coding	1
261	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	1
262	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	1
263	POLR2G	RNA Polymerase II Subunit G	Protein Coding	1
264	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	1
265	POLR2I	RNA Polymerase II Subunit I	Protein Coding	1
266	POLR2J	RNA Polymerase II Subunit J	Protein Coding	1
267	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	1
268	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	1
269	DDIT4	DNA Damage Inducible Transcript 4	Protein Coding	1
270	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	1
271	FANCI	FA Complementation Group I	Protein Coding	1
272	STEAP3	STEAP3 Metalloreductase	Protein Coding	1
273	PIDD1	P53-Induced Death Domain Protein 1	Protein Coding	1
274	CNOT11	CCR4-NOT Transcription Complex Subunit 11	Protein Coding	1
275	CPAP	Centrosome Assembly And Centriole Elongation Protein	Protein Coding	1
276	PCBP4	Poly(RC) Binding Protein 4	Protein Coding	1
277	TIGAR	TP53 Induced Glycolysis Regulatory Phosphatase	Protein Coding	1
278	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
279	CNOT6	CCR4-NOT Transcription Complex Subunit 6	Protein Coding	1
280	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
281	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	1
282	NLRC4	NLR Family CARD Domain Containing 4	Protein Coding	1
283	RRAGD	Ras Related GTP Binding D	Protein Coding	1
284	RABGGTA	Rab Geranylgeranyltransferase Subunit Alpha	Protein Coding	1
285	RABGGTB	Rab Geranylgeranyltransferase Subunit Beta	Protein Coding	1
286	RAD51D	RAD51 Paralog D	Protein Coding	1
287	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	1
288	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	1
289	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
290	BCL6	BCL6 Transcription Repressor	Protein Coding	1
291	HIGD1C	HIG1 Hypoxia Inducible Domain Family Member 1C	Protein Coding	1
292	TP53AIP1	Tumor Protein P53 Regulated Apoptosis Inducing Protein 1	Protein Coding	1
293	PERP	P53 Apoptosis Effector Related To PMP22	Protein Coding	1
294	RRAGC	Ras Related GTP Binding C	Protein Coding	1
295	BNIP3L	BCL2 Interacting Protein 3 Like	Protein Coding	1
296	SUPT4H1	SPT4 Homolog, DSIF Elongation Factor Subunit	Protein Coding	1
297	SUPT5H	SPT5 Homolog, DSIF Elongation Factor Subunit	Protein Coding	1
298	TCEA1	Transcription Elongation Factor A1	Protein Coding	1
299	ELOC	Elongin C	Protein Coding	1
300	ELOB	Elongin B	Protein Coding	1
301	ELOA	Elongin A	Protein Coding	1
302	PRDX2	Peroxiredoxin 2	Protein Coding	1
303	TFDP1	Transcription Factor Dp-1	Protein Coding	1
304	TFDP2	Transcription Factor Dp-2	Protein Coding	1
305	TSC1	TSC Complex Subunit 1	Protein Coding	1
306	TSC2	TSC Complex Subunit 2	Protein Coding	1
307	TXN	Thioredoxin	Protein Coding	1
308	TXNRD1	Thioredoxin Reductase 1	Protein Coding	1
309	NELFA	Negative Elongation Factor Complex Member A	Protein Coding	1
310	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
311	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
312	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
313	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
314	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
315	BTG2	BTG Anti-Proliferation Factor 2	Protein Coding	1
316	NELFE	Negative Elongation Factor Complex Member E	Protein Coding	1
317	BCL2L14	BCL2 Like 14	Protein Coding	1
318	E2F8	E2F Transcription Factor 8	Protein Coding	1
319	ELL	Elongation Factor For RNA Polymerase II	Protein Coding	1
320	CASP1	Caspase 1	Protein Coding	1
321	CASP2	Caspase 2	Protein Coding	1
322	SESN2	Sestrin 2	Protein Coding	1
323	CASP10	Caspase 10	Protein Coding	1
324	COX4I2	Cytochrome C Oxidase Subunit 4I2	Protein Coding	1
325	AIFM2	AIF Family Member 2	Protein Coding	1
326	TNKS1BP1	Tankyrase 1 Binding Protein 1	Protein Coding	1
327	CDK13	Cyclin Dependent Kinase 13	Protein Coding	1
328	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	1
329	CRADD	CARD And Death Domain Containing Adaptor Protein	Protein Coding	1
330	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	1
331	TNFRSF10C	TNF Receptor Superfamily Member 10c	Protein Coding	1
332	CCNK	Cyclin K	Protein Coding	1
333	CCNB1	Cyclin B1	Protein Coding	1
334	CCNE1	Cyclin E1	Protein Coding	1
335	CCNH	Cyclin H	Protein Coding	1
336	CCNT1	Cyclin T1	Protein Coding	1
337	CCNT2	Cyclin T2	Protein Coding	1
338	CNOT9	CCR4-NOT Transcription Complex Subunit 9	Protein Coding	1
339	CCNE2	Cyclin E2	Protein Coding	1
340	CTDP1	CTD Phosphatase Subunit 1	Protein Coding	1
341	COX7A2L	Cytochrome C Oxidase Subunit 7A2 Like	Protein Coding	1
342	CNOT8	CCR4-NOT Transcription Complex Subunit 8	Protein Coding	1
343	COX5A	Cytochrome C Oxidase Subunit 5A	Protein Coding	1
344	TP53I3	Tumor Protein P53 Inducible Protein 3	Protein Coding	1
345	MDC1	Mediator Of DNA Damage Checkpoint 1	Protein Coding	1
346	CDC25C	Cell Division Cycle 25C	Protein Coding	1
347	SCO2	Synthesis Of Cytochrome C Oxidase 2	Protein Coding	1

Disorders associated with Regulation of TP53 Activity SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pancreatic cancer	Enrichment	ATM, BRCA1, BRIP1, CDKN2A, CHEK2, NBN, RBBP8, STK11, TP53	16.00
2	Breast cancer	Enrichment	AKT1, ATM, BARD1, BLM, BRCA1, BRIP1, CHEK2, FANCC, JUN, MLH1, MRE11, MSH2, NBN, PMS2, PTEN, RAD50, RAD51D, TP53	16.00
3	Ovarian cancer	Enrichment	AKT1, ATM, BARD1, BLM, BRCA1, BRIP1, CDKN1B, CDKN2A, CHEK2, ERCC2, ERCC3, FANCC, FANCD2, MRE11, MSH2, NBN, PMS2, PTEN, RAD50, RAD51D, TP53, TSC2, WRN	16.00
4	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, BRIP1, CHEK2, MLH1, MRE11, MSH2, NBN, PLK2, PMS2, PTEN, RAD50, RAD51D, TP53	11.36
5	Hereditary breast carcinoma	Enrichment	ATM, BARD1, BLM, BRCA1, BRIP1, CHEK2, NBN, RAD50, TP53	10.96
6	Gastric cancer	Enrichment	ATM, BARD1, BRCA1, BRIP1, CASP10, CDKN2A, CHEK2, FANCI, MLH1, MSH2, NBN, PMS2, PTEN, RAD51D, STK11, TP53	10.91
7	Inherited cancer-predisposing syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, BRIP1, CDKN1B, CDKN2A, CHEK2, ERCC3, FANCC, MLH1, MRE11, MSH2, NBN, PMS2, PTEN, RAD50, RAD51D, STK11, TP53, TSC1, TSC2	10.72
8	Colorectal cancer	Enrichment	AKT1, ATM, AURKA, BLM, BRCA1, BRIP1, CHEK2, EP300, FANCC, FANCI, MLH1, MSH2, MT-CO1, PMS2, RAD51D, RMI1, TP53	10.18
9	Cox deficiency, benign infantile mitochondrial myopathy	Enrichment	COX4I1, COX5A, COX6A2, COX6B1, COX8A, MT-CO1, MT-CO2, MT-CO3	9.36
10	Endometrial cancer	Enrichment	ATM, BARD1, BLM, BRCA1, CHEK2, MLH1, MSH2, PMS2, PTEN	9.02
11	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRIP1, CHEK2, MSH2, NBN, RAD51D	7.99
12	Li-fraumeni syndrome	Enrichment	CHEK2, MDM2, TP53	7.33
13	Lynch syndrome 1	Enrichment	ATM, CHEK2, MLH1, MSH2, PMS2, RAD51D	7.29
14	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRIP1, CHEK2, MSH2, PTEN	6.95
15	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	6.38
16	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	6.38
17	Bladder cancer	Enrichment	ATM, BRCA1, CDKN1A, CDKN2A, ERCC2, PTEN, TP53, TSC1	6.34
18	Prostate cancer	Enrichment	ATM, BRCA1, CHEK2, NBN, TP53	5.87
19	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	5.73
20	Sarcoma	Enrichment	CHEK2, TP53	5.73
21	Seckel syndrome	Enrichment	ATR, ATRIP, DNA2, RBBP8	5.73
22	Hemimegalencephaly	Enrichment	AKT3, MTOR, PTEN, RHEB	5.69
23	Familial colorectal cancer	Enrichment	MLH1, MSH2, MT-CO1, MT-CO2, TP53	5.62
24	Diffuse large b-cell lymphoma	Enrichment	CHEK2, CREBBP, NBN, PMS2, PTEN, TP53	5.26
25	Osteogenic sarcoma	Enrichment	CHEK2, TP53	5.25
26	Adenocarcinoma	Enrichment	ATM, TP53	5.25
27	Bone osteosarcoma	Enrichment	CHEK2, TP53	5.25
28	Breast adenocarcinoma	Enrichment	AKT1, TP53	5.14
29	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	COX4I1, COX6B1, COX8A, MT-CO1, MT-CO2, MT-CO3	4.85
30	Colonic benign neoplasm	Enrichment	ATM, CHEK2, MRE11	4.61
31	Rhabdomyosarcoma	Enrichment	BRCA1, MSH2, PMS2, PTEN, TP53	4.43
32	Microcephaly, growth restriction, and increased sister chromatid exchange 2	Enrichment	RMI2, TOP3A	4.34
33	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2, PMS2	4.19
34	Melanoma	Enrichment	CDKN2A, CHEK2, PTEN, STK11	4.11
35	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	4.08
36	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	3.99
37	Gliosarcoma	Enrichment	ATM, TP53	3.66
38	Giant cell glioblastoma	Enrichment	ATM, TP53	3.60
39	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	3.57
40	Lip and oral cavity carcinoma	Enrichment	CDKN2A, STK11, TP53	3.53
41	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TP53	3.37
42	Myeloma, multiple	Enrichment	ATM, AURKA, BARD1, SGK1, TP53	3.36
43	Lynch syndrome	Enrichment	CHEK2, MLH1, MSH2, PMS2	3.34
44	Muir-torre syndrome	Enrichment	MLH1, MSH2	3.19
45	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	3.19
46	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP, KAT6A	3.19
47	Proteus syndrome	Enrichment	AKT1	3.13
48	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	3.13
49	Arrhythmogenic cardiomyopathy with variable ectodermal abnormalities	Enrichment	PPP1R13L	3.13
50	Bone marrow failure syndrome 5	Enrichment	TP53	3.13
51	Papilloma of choroid plexus	Enrichment	TP53	3.13
52	Basal cell carcinoma 7	Enrichment	TP53	3.13
53	Anaplastic thyroid carcinoma	Enrichment	TP53	3.13
54	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	3.13
55	Cowden syndrome 6	Enrichment	AKT1	3.13
56	Ductal carcinoma in situ	Enrichment	TP53	3.13
57	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.13
58	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.13
59	Capillary hemangioma	Enrichment	AKT3	3.13
60	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.13
61	Choroid plexus cancer	Enrichment	TP53	3.13
62	Multiple congenital anomalies/dysmorphic syndrome	Enrichment	PPP1R13L	3.13
63	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.13
64	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	3.13
65	Mitochondrial myopathy, infantile, transient	Enrichment	MT-CO1, MT-CO2, MT-CO3	2.91
66	Adult hepatocellular carcinoma	Enrichment	TP53, TSC1, TSC2	2.91
67	Trichothiodystrophy	Enrichment	ERCC2, ERCC3, GTF2H5	2.91
68	Accelerated tumor formation	Enrichment	MDM2	2.85
69	Lessel-kubisch syndrome	Enrichment	MDM2	2.85
70	Bone marrow failure syndrome 6	Enrichment	MDM4	2.85
71	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.85
72	Endometrial serous adenocarcinoma	Enrichment	ATM	2.85
73	Leiomyosarcoma	Enrichment	CHEK2	2.85
74	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.85
75	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.83
76	Cervical cancer	Enrichment	TP53	2.83
77	Lymphoma, hodgkin, classic	Enrichment	TP53	2.83
78	Ataxia, intention tremor, and hypotonia syndrome, childhood-onset	Enrichment	POU4F1	2.83
79	Senior-loken syndrome 7	Enrichment	AKT3	2.83
80	Congenital fibrosarcoma	Enrichment	TP53	2.83
81	Cervix carcinoma	Enrichment	TP53	2.83
82	Hodgkin's lymphoma	Enrichment	TP53	2.83
83	Bardet-biedl syndrome 16	Enrichment	AKT3	2.83
84	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.83
85	Mitochondrial myopathy with reversible cytochrome c oxidase deficiency	Enrichment	MT-CO1, MT-CO2, MT-CO3	2.76
86	Hepatoblastoma	Enrichment	BARD1, ERCC2, MSH2, TP53	2.75
87	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRIP1, FANCC, FANCD2, FANCI	2.74
88	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	2.72
89	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	2.72
90	Hamartoma	Enrichment	TSC1, TSC2	2.72
91	Nasopharyngeal carcinoma	Enrichment	TP53	2.66
92	Cerebellar dysfunction with variable cognitive and behavioral abnormalities	Enrichment	POU4F1	2.66
93	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.66
94	Anaplastic astrocytoma	Enrichment	TP53	2.66
95	Squamous cell carcinoma	Enrichment	TP53	2.66
96	Xeroderma pigmentosum, variant type	Enrichment	DDB2, ERCC2, ERCC3	2.63
97	Renal cell carcinoma, papillary, 1	Enrichment	ATM, MTOR	2.58
98	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	2.58
99	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.55
100	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.55
101	Menke-hennekam syndrome 2	Enrichment	EP300	2.55
102	Kleefstra syndrome	Enrichment	EHMT1	2.55
103	High grade glioma	Enrichment	ATM	2.55
104	T-cell prolymphocytic leukemia	Enrichment	ATM	2.55
105	Kleefstra syndrome due to a point mutation	Enrichment	EHMT1	2.55
106	Submucosal cleft palate	Enrichment	UBB	2.55
107	Cleft hard palate	Enrichment	UBB	2.55
108	Small cell cancer of the lung	Enrichment	TP53	2.53
109	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.53
110	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.53
111	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.53
112	Lung sarcomatoid carcinoma	Enrichment	TP53	2.53
113	Orofacial cleft	Enrichment	PPP1R13L	2.53
114	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.53
115	Noonan syndrome with multiple lentigines	Enrichment	PPP1R13L	2.53
116	Orofacial clefting syndrome	Enrichment	PPP1R13L	2.53
117	Nk-cell enteropathy	Enrichment	AURKB, CHEK2	2.47
118	Rhabdomyosarcoma 2	Enrichment	TP53	2.43
119	Lymphoma	Enrichment	TP53	2.43
120	Acute megakaryocytic leukemia	Enrichment	TP53	2.43
121	Lynch syndrome 4	Enrichment	MSH2, PMS2	2.42
122	Tuberous sclerosis	Enrichment	TSC1, TSC2	2.42
123	Hereditary recurrent myoglobinuria	Enrichment	MT-CO1, MT-CO3	2.42
124	Ataxia-telangiectasia	Enrichment	ATM	2.38
125	Polycythemia vera	Enrichment	ATM	2.38
126	Uvula, bifid	Enrichment	UBB	2.38
127	Cleft soft palate	Enrichment	UBB	2.38
128	Neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism	Enrichment	TTC5	2.38
129	Koolen-de vries syndrome	Enrichment	ATM	2.38
130	Dedifferentiated liposarcoma	Enrichment	MDM2	2.38
131	Well-differentiated liposarcoma	Enrichment	MDM2	2.38
132	Esophageal cancer	Enrichment	TP53	2.29
133	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.29
134	Essential thrombocythemia	Enrichment	TP53	2.29
135	Gallbladder cancer	Enrichment	TP53	2.29
136	Megacolon	Enrichment	AKT3	2.29
137	Polymicrogyria	Enrichment	AKT3, EHMT1	2.26
138	Mantle cell lymphoma	Enrichment	ATM	2.25
139	Hemoglobin c disease	Enrichment	CHEK2	2.25
140	Oculomotor apraxia	Enrichment	ATM	2.25
141	Lung cancer	Enrichment	BRCA1, CHEK2, PPP2R1B	2.24
142	Glioma susceptibility 1	Enrichment	TP53	2.23
143	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.23
144	Rare genetic intellectual disability	Enrichment	CREBBP, EP300, MTOR	2.22
145	Fanconi anemia, complementation group d2	Enrichment	BRIP1, FANCD2	2.21
146	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, PMS2	2.21
147	Glioblastoma	Enrichment	ATM, MSH2	2.21
148	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2, ERCC3	2.21
149	Primary hyperaldosteronism	Enrichment	TP53	2.18
150	Cowden syndrome	Enrichment	AKT1	2.18
151	Leukemia, acute lymphoblastic	Enrichment	CDKN2A, NBN	2.18
152	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.17
153	Bloom syndrome	Enrichment	BLM	2.17
154	Intellectual developmental disorder, x-linked, syndromic 33	Enrichment	TAF1	2.17
155	Dystonia 3, torsion, x-linked	Enrichment	TAF1	2.17
156	Seckel syndrome 2	Enrichment	RBBP8	2.17
157	Fanconi anemia, complementation group j	Enrichment	BRIP1	2.17
158	Seckel syndrome 1	Enrichment	ATR	2.17
159	Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity	Enrichment	TAF2	2.17
160	Seckel syndrome 8	Enrichment	DNA2	2.17
161	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.17
162	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.17
163	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 6	Enrichment	DNA2	2.17
164	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.17
165	Infant-type hemispheric glioma	Enrichment	BRCA1	2.17
166	Jawad syndrome	Enrichment	RBBP8	2.17
167	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.17
168	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.17
169	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.17
170	Spermatogenic failure 13	Enrichment	TAF4B	2.17
171	Neurocardiofaciodigital syndrome	Enrichment	MAPKAPK5	2.17
172	Alazami-yuan syndrome	Enrichment	TAF6	2.17
173	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.17
174	Intellectual developmental disorder, autosomal recessive 60	Enrichment	TAF13	2.17
175	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.17
176	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 5	Enrichment	TOP3A	2.17
177	Neurodevelopmental disorder with dysmorphic facies and thin corpus callosum	Enrichment	SUPT16H	2.17
178	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.17
179	Rothmund-thomson syndrome, type 4	Enrichment	DNA2	2.17
180	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.17
181	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.17
182	X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome	Enrichment	TAF1	2.17
183	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.17
184	Intestinal polyposis syndrome	Enrichment	STK11	2.17
185	Primary peritoneal carcinoma	Enrichment	BRCA1	2.17
186	Autism spectrum disorder	Enrichment	CDK13, CSNK2A1, CSNK2B, EHMT1, KAT6A, PTEN, TNRC6B, TSC2	2.16
187	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.16
188	Myelodysplastic syndrome	Enrichment	TP53	2.09
189	Rubinstein-taybi syndrome 1	Enrichment	EP300	2.08
190	Wilms tumor 5	Enrichment	CHEK2	2.08
191	Kleefstra syndrome 1	Enrichment	EHMT1	2.08
192	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	2.08
193	Clear cell renal cell carcinoma	Enrichment	ATM	2.08
194	Meningioma	Enrichment	AKT1	2.05
195	Lung cancer susceptibility 3	Enrichment	TP53	1.99
196	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	1.94
197	Gand syndrome	Enrichment	GATAD2B	1.94
198	Intellectual developmental disorder with dysmorphic facies and ptosis	Enrichment	BRPF1	1.94
199	Houge-janssens syndrome 4	Enrichment	PPP2R5C	1.94
200	Houge-janssens syndrome 2	Enrichment	PPP2R1A	1.94
201	Arboleda-tham syndrome	Enrichment	KAT6A	1.94
202	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	Enrichment	GATAD2B	1.94
203	Cdkn2a cancer predisposition	Enrichment	CDKN2A	1.94
204	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	1.94
205	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRIP1, GLS, POLR2B	1.93
206	Renal cell carcinoma, nonpapillary	Enrichment	ATM, MTOR	1.91
207	Charge syndrome	Enrichment	EP300	1.90
208	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B	1.90
209	Peutz-jeghers syndrome	Enrichment	STK11	1.87
210	Rothmund-thomson syndrome, type 2	Enrichment	DNA2	1.87
211	Spinocerebellar ataxia 17	Enrichment	TBP	1.87
212	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.87
213	Intellectual developmental disorder, autosomal dominant 73	Enrichment	TAF4	1.87
214	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.87
215	Werner syndrome	Enrichment	WRN	1.87
216	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	1.87
217	Pancreatic cancer 4	Enrichment	BRCA1	1.87
218	Ovarian cancer 1	Enrichment	BRIP1	1.87
219	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRIP1	1.87
220	14q11.2 microduplication syndrome	Enrichment	SUPT16H	1.87
221	Inflammatory breast carcinoma	Enrichment	BRCA1	1.87
222	Peritoneum cancer	Enrichment	BRCA1	1.87
223	Bilateral breast cancer	Enrichment	BRCA1	1.87
224	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, CNOT1, CNOT3, CSNK2A1, PPP2CA, TAF4, TNRC6B	1.84
225	Immune deficiency disease	Enrichment	ATM	1.82
226	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A, STK11	1.80
227	Syndromic intellectual disability	Enrichment	KAT6A, TAF6	1.80
228	Diamond-blackfan anemia 1	Enrichment	TP53	1.77
229	Prognathism, mandibular	Enrichment	CSNK2B	1.69
230	Vasculopathy, retinal, with cerebral leukoencephalopathy and systemic manifestations	Enrichment	ATRIP	1.69
231	Nijmegen breakage syndrome	Enrichment	NBN	1.69
232	Chilblain lupus 1	Enrichment	ATRIP	1.69
233	Galloway-mowat syndrome 4	Enrichment	TP53RK	1.69
234	Chilblain lupus	Enrichment	ATRIP	1.69
235	Testicular germ cell cancer	Enrichment	STK11	1.69
236	Childhood apraxia of speech	Enrichment	RFC3	1.69
237	Testicular cancer	Enrichment	STK11	1.69
238	Apc-associated polyposis conditions	Enrichment	STK11	1.69
239	Polydactyly, postaxial, type a1	Enrichment	EP300	1.68
240	Wilms tumor 1	Enrichment	CHEK2	1.68
241	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	RRM2B, SCO2	1.68
242	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.64
243	Neutrophilia, hereditary	Enrichment	PIP4K2B	1.64
244	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.64
245	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	1.64
246	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	PIP4K2B	1.64
247	Snijders blok-campeau syndrome	Enrichment	CHD3	1.64
248	Cebalid syndrome	Enrichment	MTOR	1.64
249	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.64
250	Severe congenital neutropenia 7	Enrichment	PIP4K2B	1.64
251	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	PIP4K2A	1.64
252	Hao-fountain syndrome	Enrichment	USP7	1.64
253	Smith-kingsmore syndrome	Enrichment	MTOR	1.64
254	3p25.3 microdeletion syndrome	Enrichment	BRPF1	1.64
255	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.64
256	Malignant granular cell myoblastoma	Enrichment	BRD7	1.64
257	Granular cell carcinoma	Enrichment	BRD7	1.64
258	Linear skin defects with multiple congenital anomalies 2	Enrichment	COX7B	1.59
259	Vacterl association with hydrocephalus	Enrichment	PTEN	1.59
260	Immunodeficiency due to defect in mapbp-interacting protein	Enrichment	LAMTOR2	1.59
261	Myoglobinuria, recurrent	Enrichment	MT-CO1	1.59
262	Xeroderma pigmentosum, complementation group b	Enrichment	ERCC3	1.59
263	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	1.59
264	Holoprosencephaly 12 with or without pancreatic agenesis	Enrichment	CNOT1	1.59
265	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	1.59
266	Mitochondrial complex iv deficiency, nuclear type 18	Enrichment	COX6A2	1.59
267	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	1.59
268	Casgid syndrome	Enrichment	GLS	1.59
269	Lynch syndrome 2	Enrichment	MLH1	1.59
270	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	1.59
271	Familial cold autoinflammatory syndrome 4	Enrichment	NLRC4	1.59
272	Mitochondrial dna depletion syndrome 8b	Enrichment	RRM2B	1.59
273	Papillary tumor of the pineal region	Enrichment	PTEN	1.59
274	Autoinflammation with infantile enterocolitis	Enrichment	NLRC4	1.59
275	Trichothiodystrophy 2, photosensitive	Enrichment	ERCC3	1.59
276	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	1.59
277	Xeroderma pigmentosum group b	Enrichment	ERCC3	1.59
278	Developmental and epileptic encephalopathy 71	Enrichment	GLS	1.59
279	Neuroendocrine tumor	Enrichment	CDKN1B	1.59
280	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	1.59
281	Intellectual developmental disorder, autosomal recessive 34, with variant lissencephaly	Enrichment	CRADD	1.59
282	Olmsted syndrome 2	Enrichment	PERP	1.59
283	Trichothiodystrophy 3, photosensitive	Enrichment	GTF2H5	1.59
284	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	1.59
285	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	1.59
286	Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis	Enrichment	COX4I2	1.59
287	Glioma susceptibility 2	Enrichment	PTEN	1.59
288	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	1.59
289	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	1.59
290	Mismatch repair cancer syndrome 2	Enrichment	MSH2	1.59
291	Vissers-bodmer syndrome	Enrichment	CNOT1	1.59
292	Mitochondrial complex iv deficiency, nuclear type 7	Enrichment	COX6B1	1.59
293	Mitochondrial complex iv deficiency, nuclear type 20	Enrichment	COX5A	1.59
294	Mismatch repair cancer syndrome 4	Enrichment	PMS2	1.59
295	Intellectual developmental disorder with hypertelorism and distinctive facies	Enrichment	CCNK	1.59
296	Menke-hennekam syndrome 1	Enrichment	CREBBP	1.59
297	Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies	Enrichment	CNOT2	1.59
298	Mitochondrial complex iv deficiency, nuclear type 16	Enrichment	COX4I1	1.59
299	Mitochondrial complex iv deficiency, nuclear type 21	Enrichment	COXFA4	1.59
300	Erythrokeratodermia variabilis et progressiva 7	Enrichment	PERP	1.59
301	Mitochondrial complex iv deficiency, nuclear type 15	Enrichment	COX8A	1.59
302	Rectal benign neoplasm	Enrichment	MSH2	1.59
303	Charcot-marie-tooth disease, recessive intermediate d	Enrichment	COX6A1	1.59
304	Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly	Enrichment	CASP2	1.59
305	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	1.59
306	Pituitary cancer	Enrichment	PMS2	1.59
307	Ascending colon cancer	Enrichment	MSH2	1.59
308	Autosomal recessive axonal charcot-marie-tooth disease due to copper metabolism defect	Enrichment	SCO2	1.59
309	Pancreatic insufficiency-anemia-hyperostosis syndrome	Enrichment	COX4I2	1.59
310	Spastic ataxia-dysarthria due to glutaminase deficiency	Enrichment	GLS	1.59
311	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	1.59
312	Ovarian cyst	Enrichment	MSH2	1.59
313	Congenital nonspherocytic hemolytic anemia	Enrichment	G6PD	1.59
314	Autosomal dominant spastic ataxia	Enrichment	MT-CO3	1.59
315	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	1.59
316	Xeroderma pigmentosum group d	Enrichment	ERCC2	1.59
317	Menke-hennekam syndrome	Enrichment	CREBBP	1.59
318	Intellectual developmental disorder, autosomal recessive 75, with neuropsychiatric features and variant lissencephaly	Enrichment	PIDD1	1.59
319	Pancreatic agenesis-holoprosencephaly syndrome	Enrichment	CNOT1	1.59
320	Primary immunodeficiency syndrome due to p14 deficiency	Enrichment	LAMTOR2	1.59
321	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	1.59
322	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	1.59
323	Rrm2b mitochondrial dna maintenance defects	Enrichment	RRM2B	1.59
324	Tubular renal disease-cardiomyopathy syndrome	Enrichment	RRAGD	1.59
325	Periodic fever-infantile enterocolitis-autoinflammatory syndrome	Enrichment	NLRC4	1.59
326	Diamond-blackfan anemia	Enrichment	TP53	1.58
327	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.57
328	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.57
329	Cholangiocarcinoma	Enrichment	BRCA1	1.57
330	Aicardi-goutieres syndrome 1	Enrichment	ATRIP	1.57
331	Enophthalmos	Enrichment	CSNK2B	1.57
332	Syndactyly	Enrichment	CSNK2B	1.57
333	Thrombotic microangiopathy	Enrichment	ATRIP	1.57
334	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.57
335	Tetralogy of fallot	Enrichment	MT-CO1, MT-CO2, MT-CO3	1.55
336	Mitochondrial complex v deficiency, mitochondrial type 1	Enrichment	MT-CO1, MT-CO2, MT-CO3	1.55
337	Neuropathy, ataxia, and retinitis pigmentosa	Enrichment	MT-CO1, MT-CO2, MT-CO3	1.55
338	Striatonigral degeneration, infantile, mitochondrial	Enrichment	MT-CO1, MT-CO2, MT-CO3	1.55
339	Camptodactyly of fingers	Enrichment	MT-CO1, MT-CO2, MT-CO3	1.55
340	Leukemia, acute myeloid	Enrichment	TP53	1.54
341	Primary ovarian insufficiency	Enrichment	CHEK2, NBN, RICTOR	1.52
342	Type 2 diabetes mellitus	Enrichment	AKT2	1.52
343	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	ATRIP	1.48
344	Chondrosarcoma, extraskeletal myxoid	Enrichment	TAF15	1.48
345	Familial adenomatous polyposis 1	Enrichment	STK11	1.48
346	Vascular dementia	Enrichment	ATRIP	1.48
347	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	1.48
348	Testicular germ cell tumor	Enrichment	STK11	1.40
349	Acute promyelocytic leukemia	Enrichment	NPM1, PML	1.37
350	Fanconi renotubular syndrome 1	Enrichment	RRM2B	1.30
351	Burkitt lymphoma	Enrichment	PMS2	1.30
352	Thumb deformity	Enrichment	CREBBP	1.30
353	Rod-cone dystrophy, sensorineural deafness, and fanconi-type renal dysfunction	Enrichment	RRM2B	1.30
354	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	1.30
355	Fanconi anemia, complementation group i	Enrichment	FANCI	1.30
356	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 5	Enrichment	RRM2B	1.30
357	Waardenburg syndrome, type 4c	Enrichment	POLR2F	1.30
358	Premature ovarian failure 3	Enrichment	AGO2	1.30
359	Congenital cataracts, facial dysmorphism, and neuropathy	Enrichment	CTDP1	1.30
360	Microcephaly 6, primary, autosomal recessive	Enrichment	CPAP	1.30
361	Seckel syndrome 4	Enrichment	CPAP	1.30
362	Mitochondrial dna depletion syndrome 8a	Enrichment	RRM2B	1.30
363	Anemia, hypochromic microcytic, with iron overload 2	Enrichment	STEAP3	1.30
364	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 2	Enrichment	RRM2B	1.30
365	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.30
366	Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder	Enrichment	CDK13	1.30
367	Global developmental delay, progressive ataxia, and elevated glutamine	Enrichment	GLS	1.30
368	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	1.30
369	Hypomagnesemia 7, renal, with or without dilated cardiomyopathy	Enrichment	RRAGD	1.30
370	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	1.30
371	Intravascular large b-cell lymphoma	Enrichment	BCL6	1.30
372	Myopia 6	Enrichment	SCO2	1.30
373	Alopecia-intellectual disability syndrome 4	Enrichment	CNOT1	1.30
374	Lissencephaly 3	Enrichment	CPAP	1.30
375	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	1.30
376	Congenital hemolytic anemia	Enrichment	G6PD	1.30
377	Glucosephosphate dehydrogenase deficiency	Enrichment	G6PD	1.30
378	Acute myeloid leukemia without maturation	Enrichment	NPM1	1.30
379	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	1.30
380	Lymphomatoid papulosis	Enrichment	NPM1	1.30
381	Long-olsen-distelmaier syndrome	Enrichment	RRAGC	1.30
382	Vacterl with hydrocephalus	Enrichment	PTEN	1.30
383	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.30
384	Juvenile polyposis of infancy	Enrichment	PTEN	1.30
385	Xeroderma pigmentosum group e	Enrichment	DDB2	1.30
386	Paternal uniparental disomy of chromosome 6	Enrichment	PLAGL1	1.30
387	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	1.30
388	Isolated growth hormone deficiency, type ia	Enrichment	DNA2	1.28
389	Corpus callosum, agenesis of	Enrichment	CREBBP, ERCC2	1.26
390	Isolated corpus callosum agenesis	Enrichment	CREBBP, ERCC2	1.26
391	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP, ERCC2	1.26
392	Dilated cardiomyopathy	Enrichment	PPP1R13L	1.24
393	Cornelia de lange syndrome 1	Enrichment	TAF6	1.23
394	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRIP1	1.23
395	Cornelia de lange syndrome	Enrichment	TAF6	1.23
396	Aplastic anemia	Enrichment	NBN	1.18
397	Aicardi-goutieres syndrome	Enrichment	ATRIP	1.18
398	Galloway-mowat syndrome	Enrichment	TP53RK	1.18
399	Isolated tracheo-esophageal fistula	Enrichment	BRIP1	1.18
400	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.18
401	Leber hereditary optic neuropathy, modifier of	Enrichment	MT-CO1, MT-CO2, MT-CO3	1.17
402	Mitochondrial disease	Enrichment	MT-CO1, MT-CO2, MT-CO3, RRM2B, TOP3A	1.14
403	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	MT-CO1, MT-CO2, MT-CO3	1.14
404	Keratoderma, palmoplantar, with deafness	Enrichment	MT-CO1	1.13
405	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.13
406	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	1.13
407	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.13
408	Linear skin defects with multiple congenital anomalies 1	Enrichment	COX7B	1.13
409	Mitochondrial complex iv deficiency, nuclear type 2	Enrichment	SCO2	1.13
410	Tuberous sclerosis 2	Enrichment	TSC2	1.13
411	Seckel syndrome 5	Enrichment	CPAP	1.13
412	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.13
413	Breast-ovarian cancer, familial 4	Enrichment	RAD51D	1.13
414	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.13
415	Tethered spinal cord syndrome	Enrichment	CREBBP	1.13
416	Wieacker-wolff syndrome	Enrichment	CCNH	1.13
417	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	1.13
418	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	PERP	1.13
419	Xanthinuria, type ii	Enrichment	TSC2	1.13
420	Cellular ependymoma	Enrichment	MSH2	1.13
421	Tanycytic ependymoma	Enrichment	MSH2	1.13
422	Papillary ependymoma	Enrichment	MSH2	1.13
423	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.13
424	Hereditary site-specific ovarian cancer syndrome	Enrichment	RAD51D	1.13
425	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.13
426	Lessel-kreienkamp syndrome	Enrichment	AGO2	1.13
427	Idiopathic camptocormia	Enrichment	RRM2B	1.13
428	Clear cell ependymoma	Enrichment	MSH2	1.13
429	Myelodysplastic syndrome with ring sideroblasts	Enrichment	MT-CO1	1.13
430	Overgrowth syndrome	Enrichment	MTOR	1.11
431	Autosomal recessive non-syndromic intellectual disability	Enrichment	TTC5	1.11
432	Schizophrenia	Enrichment	EHMT1	1.10
433	Neural tube defects	Enrichment	RAD9B	1.07
434	Premature menopause	Enrichment	NBN	1.07
435	Medulloblastoma	Enrichment	WRN	1.04
436	Periventricular nodular heterotopia	Enrichment	BRCA1	1.04
437	Cataract	Enrichment	WRN	1.04
438	Erythrocytosis, familial, 2	Enrichment	FANCD2	1.01
439	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10	1.01
440	Choroideremia	Enrichment	CHM	1.01
441	Congenital generalized lipodystrophy	Enrichment	FOS	1.01
442	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.01
443	Intellectual developmental disorder with speech delay, autism, and dysmorphic facies	Enrichment	CNOT3	1.01
444	Craniopharyngioma	Enrichment	ERCC2	1.01
445	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.01
446	Primary hyperparathyroidism	Enrichment	CDKN1B	1.01
447	Glioma	Enrichment	PTEN	1.01
448	Benign ependymoma	Enrichment	MSH2	1.01
449	Lissencephaly	Enrichment	CPAP, NBN	1.00
450	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	0.99
451	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A, CNOT3	0.93
452	Parkinson's disease	Enrichment	TBP	0.92
453	Capillary malformations, congenital	Enrichment	CCNH	0.92
454	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	CPAP	0.92
455	Von hippel-lindau syndrome	Enrichment	FANCD2	0.92
456	Microcephaly 1, primary, autosomal recessive	Enrichment	CPAP	0.92
457	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	G6PD	0.92
458	Kearns-sayre syndrome	Enrichment	RRM2B	0.92
459	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	0.92
460	Macrocephaly/autism syndrome	Enrichment	PTEN	0.92
461	Cox deficiency, infantile mitochondrial myopathy	Enrichment	SCO2	0.92
462	Follicular lymphoma	Enrichment	BCL6	0.92
463	Acute myeloid leukemia with maturation	Enrichment	NPM1	0.92
464	Transient neonatal diabetes mellitus	Enrichment	PLAGL1	0.92
465	Night blindness	Enrichment	CHM	0.92
466	Hemangioma	Enrichment	PTEN	0.92
467	Histiocytoid hemangioma	Enrichment	FOS	0.92
468	Rare isolated myopia	Enrichment	SCO2	0.92
469	Endometrial stromal sarcoma	Enrichment	YWHAE	0.92
470	Williams-beuren syndrome	Enrichment	RFC2	0.90
471	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	0.84
472	Cowden syndrome 1	Enrichment	PTEN	0.84
473	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC2	0.84
474	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	RRM2B	0.84
475	Wolf-hirschhorn syndrome	Enrichment	NELFA	0.84
476	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	0.84
477	Waardenburg syndrome, type 4a	Enrichment	POLR2F	0.84
478	Hemangioma, capillary infantile	Enrichment	CCNH	0.84
479	Deafness, nonsyndromic sensorineural, mitochondrial	Enrichment	MT-CO1	0.84
480	Mitochondrial dna depletion syndrome 1	Enrichment	SCO2	0.84
481	Basal cell carcinoma 1	Enrichment	CCNH	0.84
482	Keratoconus	Enrichment	TSC1	0.84
483	Hereditary spherocytosis	Enrichment	GPI	0.84
484	Hypertrichosis	Enrichment	CREBBP	0.84
485	Waardenburg syndrome	Enrichment	POLR2F	0.84
486	Kidney clear cell sarcoma	Enrichment	YWHAE	0.84
487	Hypertelorism	Enrichment	MT-CO1, MT-CO2, MT-CO3	0.83
488	Parkinson disease, late-onset	Enrichment	TBP	0.82
489	Microcephaly	Enrichment	EP300	0.80
490	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	0.78
491	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	0.78
492	Waardenburg syndrome, type 1	Enrichment	POLR2F	0.78
493	Mitochondrial dna depletion syndrome 4a	Enrichment	FANCI	0.78
494	Waardenburg syndrome, type 2e	Enrichment	POLR2F	0.78
495	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	0.78
496	Polycystic kidney disease 1	Enrichment	TSC2	0.78
497	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	0.78
498	Follicular thyroid carcinoma	Enrichment	PTEN	0.78
499	Hemolytic anemia	Enrichment	GPI	0.78
500	Fanconi anemia, complementation group c	Enrichment	FANCC	0.73
501	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	PRDX1	0.73
502	Mitochondrial dna depletion syndrome 4b	Enrichment	SCO2	0.73
503	Primary autosomal recessive microcephaly	Enrichment	TAF13	0.71
504	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.70
505	Craniosynostosis	Enrichment	KAT6A	0.69
506	Inflammatory bowel disease 1	Enrichment	ERCC2	0.68
507	Coronary heart disease 5	Enrichment	G6PD	0.68
508	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	0.68
509	Arteriovenous malformation	Enrichment	CCNH	0.68
510	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	CRADD	0.68
511	Hypotrichosis simplex	Enrichment	ERCC2	0.68
512	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	0.64
513	Rare mitochondrial non-syndromic sensorineural deafness	Enrichment	MT-CO1	0.64
514	Systemic lupus erythematosus	Enrichment	ATRIP	0.63
515	Meningioma, familial	Enrichment	PTEN	0.61
516	Cardiomyopathy, familial hypertrophic, 9	Enrichment	PMS2	0.61
517	Specific learning disability	Enrichment	YWHAG	0.61
518	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.60
519	Leigh syndrome, nuclear	Enrichment	MT-CO1, MT-CO2, MT-CO3	0.59
520	Charcot-marie-tooth disease	Enrichment	CTDP1, NDRG1	0.55
521	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	0.54
522	Heart disease	Enrichment	CREBBP	0.52
523	Leigh disease	Enrichment	MT-CO1, MT-CO2, MT-CO3	0.51
524	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	TAF4B	0.50
525	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	0.49
526	Kidney disease	Enrichment	TSC1	0.49
527	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TAF15	0.49
528	Isolated congenital microcephaly	Enrichment	CPAP	0.47
529	Heart, malformation of	Enrichment	CDK13	0.43
530	Charcot-marie-tooth disease type 4	Enrichment	NDRG1	0.43
531	Dyskeratosis congenita	Enrichment	NPM1	0.41
532	Leukodystrophy	Enrichment	ERCC2	0.39
533	Cardiomyopathy, dilated, 1g	Enrichment	PMS2	0.36
534	Leber plus disease	Enrichment	MT-CO1, MT-CO2, MT-CO3	0.36
535	Malaria	Enrichment	G6PD	0.35
536	Kallmann syndrome	Enrichment	POLR2F	0.35
537	Autoinflammatory disease	Enrichment	NLRC4	0.33
538	Scoliosis	Enrichment	CREBBP	0.33
539	Congenital nervous system abnormality	Enrichment	CREBBP, PTEN, TSC2	0.29
540	Nervous system disease	Enrichment	CREBBP, PTEN, TSC2	0.29
541	Hirschsprung disease 1	Enrichment	POLR2F	0.28
542	Severe covid-19	Enrichment	CASP10	0.28
543	Peripheral nervous system disease	Enrichment	COX6A1	0.25
544	Neuropathy	Enrichment	COX6A1	0.25
545	Eye disease	Enrichment	CHM	0.22
546	Retinitis pigmentosa	Enrichment	CHM, MT-CO1, MT-CO2, MT-CO3, RRM2B	0.20
547	Epilepsy	Enrichment	MT-CO3	0.19
548	West syndrome	Enrichment	TSC2	0.17
549	Sensorineural hearing loss	Enrichment	RRM2B	0.15
550	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	0.12
551	Autism	Enrichment	CREBBP	0.07
552	Hereditary retinal dystrophy	Enrichment	ATRIP	0.06
553	Fundus dystrophy	Enrichment	ATRIP	0.06
554	Rare genetic deafness	Enrichment	POLR2F	0.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of TP53 Activity

Pathway Network for Regulation of TP53 Activity

Pathway network for the Regulation of TP53 Activity SuperPath

Member Pathways for Regulation of TP53 Activity

Pathways in the Regulation of TP53 Activity SuperPath

Gene overlap in member pathways for Regulation of TP53 Activity SuperPath

Associated Genes for Regulation of TP53 Activity

Associated Disorders for Regulation of TP53 Activity

Disorders associated with Regulation of TP53 Activity SuperPath

STRING Interaction Network for Regulation of TP53 Activity

Sources for Regulation of TP53 Activity