Regulation of TP53 Activity through Acetylation

Pathway network for the Regulation of TP53 Activity through Acetylation SuperPath

Sources:

Reactome

Pathways in the Regulation of TP53 Activity through Acetylation SuperPath

#	Name	Source	Genes
1	Regulation of TP53 Activity through Acetylation	Reactome	AKT1 AKT2 AKT3 BRD1 BRD7 BRPF1 BRPF3 CHD3 CHD4 EP300 GATAD2A GATAD2B HDAC1 HDAC2 ING2 ING5 KAT6A MAP2K6 MBD3 MEAF6 MTA2 PIN1 PIP4K2A PIP4K2B PIP4K2C PIP4P1 PML RBBP4 RBBP7 TP53 (see all 30) (see less)
2	PI5P Regulates TP53 Acetylation	Reactome	EP300 ING2 MAP2K6 PIN1 PIP4K2A PIP4K2B PIP4K2C PIP4P1 TP53 (see all 9) (see less)
3	Synthesis of PIPs in the nucleus	Reactome	PIP4K2A PIP4K2B PIP4K2C PIP4P1

Gene overlap in member pathways for Regulation of TP53 Activity through Acetylation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIP4K2A	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Alpha	Protein Coding	3
2	PIP4K2C	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma	Protein Coding	3
3	PIP4K2B	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta	Protein Coding	3
4	PIP4P1	Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 1	Protein Coding	3
5	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
6	ING2	Inhibitor Of Growth Family Member 2	Protein Coding	2
7	PIN1	Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1	Protein Coding	2
8	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
9	TP53	Tumor Protein P53	Protein Coding	2
10	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
11	CHD3	Chromodomain Helicase DNA Binding Protein 3	Protein Coding	1
12	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	1
13	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
14	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
15	BRD1	Bromodomain Containing 1	Protein Coding	1
16	BRPF3	Bromodomain And PHD Finger Containing 3	Protein Coding	1
17	BRD7	Bromodomain Containing 7	Protein Coding	1
18	HDAC1	Histone Deacetylase 1	Protein Coding	1
19	HDAC2	Histone Deacetylase 2	Protein Coding	1
20	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	1
21	PML	PML Nuclear Body Scaffold	Protein Coding	1
22	GATAD2A	GATA Zinc Finger Domain Containing 2A	Protein Coding	1
23	GATAD2B	GATA Zinc Finger Domain Containing 2B	Protein Coding	1
24	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
25	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	1
26	MEAF6	MYST/Esa1 Associated Factor 6	Protein Coding	1
27	BRPF1	Bromodomain And PHD Finger Containing 1	Protein Coding	1
28	KAT6A	Lysine Acetyltransferase 6A	Protein Coding	1
29	ING5	Inhibitor Of Growth Family Member 5	Protein Coding	1
30	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	1

Disorders associated with Regulation of TP53 Activity through Acetylation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast adenocarcinoma	Enrichment	AKT1, TP53	4.15
2	Neutrophilia, hereditary	Enrichment	PIP4K2B	3.23
3	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	PIP4K2B	3.23
4	Severe congenital neutropenia 7	Enrichment	PIP4K2B	3.23
5	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	PIP4K2A	3.23
6	Bone marrow failure syndrome 5	Enrichment	TP53	3.18
7	Papilloma of choroid plexus	Enrichment	TP53	3.18
8	Basal cell carcinoma 7	Enrichment	TP53	3.18
9	Anaplastic thyroid carcinoma	Enrichment	TP53	3.18
10	Ductal carcinoma in situ	Enrichment	TP53	3.18
11	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.18
12	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.18
13	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.18
14	Choroid plexus cancer	Enrichment	TP53	3.18
15	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.18
16	Colorectal cancer	Enrichment	AKT1, EP300, TP53	3.04
17	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.88
18	Cervical cancer	Enrichment	TP53	2.88
19	Lymphoma, hodgkin, classic	Enrichment	TP53	2.88
20	Menke-hennekam syndrome 2	Enrichment	EP300	2.88
21	Congenital fibrosarcoma	Enrichment	TP53	2.88
22	Li-fraumeni syndrome 1	Enrichment	TP53	2.88
23	Sarcoma	Enrichment	TP53	2.88
24	Cervix carcinoma	Enrichment	TP53	2.88
25	Hodgkin's lymphoma	Enrichment	TP53	2.88
26	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.88
27	Osteogenic sarcoma	Enrichment	TP53	2.70
28	Nasopharyngeal carcinoma	Enrichment	TP53	2.70
29	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.70
30	Anaplastic astrocytoma	Enrichment	TP53	2.70
31	Squamous cell carcinoma	Enrichment	TP53	2.70
32	Adenocarcinoma	Enrichment	TP53	2.70
33	Bone osteosarcoma	Enrichment	TP53	2.70
34	Proteus syndrome	Enrichment	AKT1	2.66
35	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.66
36	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.66
37	Gand syndrome	Enrichment	GATAD2B	2.66
38	Intellectual developmental disorder with dysmorphic facies and ptosis	Enrichment	BRPF1	2.66
39	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.66
40	Cowden syndrome 6	Enrichment	AKT1	2.66
41	Arboleda-tham syndrome	Enrichment	KAT6A	2.66
42	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	Enrichment	GATAD2B	2.66
43	Capillary hemangioma	Enrichment	AKT3	2.66
44	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.66
45	Small cell cancer of the lung	Enrichment	TP53	2.58
46	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.58
47	Lung sarcomatoid carcinoma	Enrichment	TP53	2.58
48	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.58
49	Rhabdomyosarcoma 2	Enrichment	TP53	2.48
50	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.48
51	Lymphoma	Enrichment	TP53	2.48
52	Acute megakaryocytic leukemia	Enrichment	TP53	2.48
53	Li-fraumeni syndrome	Enrichment	TP53	2.40
54	Rubinstein-taybi syndrome 1	Enrichment	EP300	2.40
55	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	2.40
56	Adrenocortical carcinoma	Enrichment	TP53	2.40
57	Hereditary breast carcinoma	Enrichment	AKT1, TP53	2.37
58	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	2.35
59	Snijders blok-campeau syndrome	Enrichment	CHD3	2.35
60	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	KAT6A	2.35
61	Senior-loken syndrome 7	Enrichment	AKT3	2.35
62	Bardet-biedl syndrome 16	Enrichment	AKT3	2.35
63	3p25.3 microdeletion syndrome	Enrichment	BRPF1	2.35
64	Malignant granular cell myoblastoma	Enrichment	BRD7	2.35
65	Granular cell carcinoma	Enrichment	BRD7	2.35
66	Esophageal cancer	Enrichment	TP53	2.33
67	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.33
68	Essential thrombocythemia	Enrichment	TP53	2.33
69	Gallbladder cancer	Enrichment	TP53	2.33
70	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.33
71	Glioma susceptibility 1	Enrichment	TP53	2.28
72	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.28
73	Charge syndrome	Enrichment	EP300	2.22
74	Adult hepatocellular carcinoma	Enrichment	TP53	2.22
75	Primary hyperaldosteronism	Enrichment	TP53	2.22
76	Leukemia, chronic lymphocytic	Enrichment	TP53	2.18
77	Familial colorectal cancer	Enrichment	TP53	2.18
78	Myelodysplastic syndrome	Enrichment	TP53	2.14
79	Lip and oral cavity carcinoma	Enrichment	TP53	2.10
80	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.05
81	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.05
82	Lung cancer susceptibility 3	Enrichment	TP53	2.03
83	Polydactyly, postaxial, type a1	Enrichment	EP300	2.00
84	Rare genetic intellectual disability	Enrichment	EP300	2.00
85	Rhabdomyosarcoma	Enrichment	TP53	1.98
86	Gliosarcoma	Enrichment	TP53	1.98
87	Hemimegalencephaly	Enrichment	AKT3	1.96
88	Giant cell glioblastoma	Enrichment	TP53	1.95
89	Breast cancer	Enrichment	AKT1, TP53	1.93
90	Diffuse large b-cell lymphoma	Enrichment	TP53	1.90
91	Hepatoblastoma	Enrichment	TP53	1.86
92	Hepatocellular carcinoma	Enrichment	TP53	1.84
93	Diamond-blackfan anemia 1	Enrichment	TP53	1.82
94	Megacolon	Enrichment	AKT3	1.81
95	Pancreatic cancer	Enrichment	TP53	1.78
96	Bladder cancer	Enrichment	TP53	1.72
97	Prostate cancer	Enrichment	TP53	1.72
98	Cowden syndrome	Enrichment	AKT1	1.70
99	Ovarian cancer	Enrichment	AKT1, TP53	1.68
100	Polymicrogyria	Enrichment	AKT3	1.66
101	Diamond-blackfan anemia	Enrichment	TP53	1.63
102	Meningioma	Enrichment	AKT1	1.58
103	Leukemia, acute myeloid	Enrichment	TP53	1.58
104	Gastric cancer	Enrichment	TP53	1.55
105	Acute promyelocytic leukemia	Enrichment	PML	1.55
106	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.44
107	Myeloma, multiple	Enrichment	TP53	1.44
108	Syndromic intellectual disability	Enrichment	KAT6A	1.43
109	Craniosynostosis	Enrichment	KAT6A	1.36
110	Microcephaly	Enrichment	EP300	1.10
111	Inherited cancer-predisposing syndrome	Enrichment	TP53	1.07
112	Type 2 diabetes mellitus	Enrichment	AKT2	1.05
113	Autism spectrum disorder	Enrichment	KAT6A	0.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of TP53 Activity through Acetylation

Pathway Network for Regulation of TP53 Activity through Acetylation

Pathway network for the Regulation of TP53 Activity through Acetylation SuperPath

Member Pathways for Regulation of TP53 Activity through Acetylation

Pathways in the Regulation of TP53 Activity through Acetylation SuperPath

Gene overlap in member pathways for Regulation of TP53 Activity through Acetylation SuperPath

Associated Genes for Regulation of TP53 Activity through Acetylation

Associated Disorders for Regulation of TP53 Activity through Acetylation

Disorders associated with Regulation of TP53 Activity through Acetylation SuperPath

STRING Interaction Network for Regulation of TP53 Activity through Acetylation

Sources for Regulation of TP53 Activity through Acetylation