Regulation of Wnt / B-catenin signaling by small molecule compounds

No Pathway Network information available for Regulation of Wnt / B-catenin signaling by small molecule compounds

Pathways in the Regulation of Wnt / B-catenin signaling by small molecule compounds SuperPath

#	Name	Source	Genes
1	Regulation of Wnt / B-catenin signaling by small molecule compounds	WikiPathways	APC AXIN1 CSNK1A1 CTNNB1 DKK3 DVL2 FZD7 FZD8 GSK3B LEF1 LRP1 MBOAT1 SFRP4 TCF4 TNKS WNT1 (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TNKS	Tankyrase	Protein Coding	1
2	FZD8	Frizzled Class Receptor 8	Protein Coding	1
3	AXIN1	Axin 1	Protein Coding	1
4	WNT1	Wnt Family Member 1	Protein Coding	1
5	TCF4	Transcription Factor 4	Protein Coding	1
6	SFRP4	Secreted Frizzled Related Protein 4	Protein Coding	1
7	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
8	LRP1	LDL Receptor Related Protein 1	Protein Coding	1
9	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
10	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
11	MBOAT1	Membrane Bound Glycerophospholipid O-Acyltransferase 1	Protein Coding	1
12	CTNNB1	Catenin Beta 1	Protein Coding	1
13	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
14	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
15	FZD7	Frizzled Class Receptor 7	Protein Coding	1
16	DKK3	Dickkopf Wnt Signaling Pathway Inhibitor 3	Protein Coding	1

Disorders associated with Regulation of Wnt / B-catenin signaling by small molecule compounds SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1	5.69
2	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	5.41
3	Desmoid tumor	Enrichment	APC, CTNNB1	5.41
4	Craniopharyngioma	Enrichment	APC, CTNNB1	5.11
5	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	4.33
6	Medulloblastoma	Enrichment	APC, CTNNB1	3.93
7	Polycystic liver disease	Enrichment	CTNNB1, DKK3	3.76
8	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, DKK3	3.76
9	Hepatoblastoma	Enrichment	APC, CTNNB1	3.57
10	Atrophoderma vermiculata	Enrichment	LRP1	2.93
11	Keratosis pilaris atrophicans	Enrichment	LRP1	2.93
12	Caudal duplication anomaly	Enrichment	AXIN1	2.93
13	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.93
14	Pyle disease	Enrichment	SFRP4	2.93
15	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.93
16	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	2.93
17	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.93
18	Adenoid ameloblastoma	Enrichment	CTNNB1	2.93
19	Familial adenomatous polyposis	Enrichment	APC	2.93
20	Gardner syndrome	Enrichment	APC	2.93
21	5q22 microdeletion syndrome	Enrichment	APC	2.93
22	Attenuated familial adenomatous polyposis	Enrichment	APC	2.93
23	Microcystic stromal tumor	Enrichment	CTNNB1	2.93
24	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.63
25	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.63
26	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.63
27	Developmental dysplasia of the hip 3	Enrichment	LRP1	2.63
28	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.63
29	Split hand-foot malformation	Enrichment	LEF1	2.63
30	Periampullary adenoma	Enrichment	APC	2.63
31	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.63
32	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.63
33	Teratoma	Enrichment	CTNNB1	2.63
34	Osteoporosis, juvenile	Enrichment	WNT1	2.45
35	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.45
36	Cenani-lenz syndactyly syndrome	Enrichment	APC	2.45
37	Anus, imperforate	Enrichment	CTNNB1	2.45
38	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.45
39	Keratosis follicularis spinulosa decalvans	Enrichment	LRP1	2.45
40	Colon adenocarcinoma	Enrichment	APC	2.45
41	Apc-associated polyposis conditions	Enrichment	APC	2.45
42	Colorectal cancer	Enrichment	APC, CTNNB1	2.34
43	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	2.33
44	Pitt-hopkins syndrome	Enrichment	TCF4	2.33
45	Pilomatrixoma	Enrichment	CTNNB1	2.33
46	Alazami syndrome	Enrichment	CTNNB1	2.33
47	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.23
48	Familial adenomatous polyposis 1	Enrichment	APC	2.23
49	Cholangitis, primary sclerosing	Enrichment	TCF4	2.23
50	Fuchs' endothelial dystrophy	Enrichment	TCF4	2.23
51	Ovarian cancer	Enrichment	APC, CTNNB1	2.21
52	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.15
53	Split-hand/foot malformation 1	Enrichment	LEF1	2.15
54	Adrenocortical carcinoma	Enrichment	CTNNB1	2.15
55	Gallbladder cancer	Enrichment	CTNNB1	2.08
56	Microcephaly	Enrichment	CTNNB1, TCF4	2.05
57	Spastic paraplegia 4, autosomal dominant	Enrichment	TCF4	2.03
58	Exudative vitreoretinopathy	Enrichment	CTNNB1	2.03
59	Colonic benign neoplasm	Enrichment	APC	1.98
60	Epicanthus	Enrichment	TCF4	1.85
61	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.82
62	Stereotypic movement disorder	Enrichment	TCF4	1.82
63	Osteoporosis	Enrichment	WNT1	1.79
64	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.76
65	Brittle bone disorder	Enrichment	WNT1	1.57
66	Bladder cancer	Enrichment	CTNNB1	1.47
67	Gastric cancer	Enrichment	APC	1.30
68	Hereditary breast carcinoma	Enrichment	APC	1.30
69	Autosomal dominant non-syndromic intellectual disability	Enrichment	TCF4	1.24
70	Breast cancer	Enrichment	APC	1.07
71	Congenital nervous system abnormality	Enrichment	CTNNB1	0.93
72	Nervous system disease	Enrichment	CTNNB1	0.93
73	Autism spectrum disorder	Enrichment	TCF4	0.92
74	Inherited cancer-predisposing syndrome	Enrichment	APC	0.84

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulation of Wnt / B-catenin signaling by small molecule compounds

Pathway Network for Regulation of Wnt / B-catenin signaling by small molecule compounds

Member Pathways for Regulation of Wnt / B-catenin signaling by small molecule compounds

Pathways in the Regulation of Wnt / B-catenin signaling by small molecule compounds SuperPath

Associated Genes for Regulation of Wnt / B-catenin signaling by small molecule compounds

Associated Disorders for Regulation of Wnt / B-catenin signaling by small molecule compounds

Disorders associated with Regulation of Wnt / B-catenin signaling by small molecule compounds SuperPath

STRING Interaction Network for Regulation of Wnt / B-catenin signaling by small molecule compounds

Sources for Regulation of Wnt / B-catenin signaling by small molecule compounds