Regulatory circuits of the STAT3 signaling pathway

No Pathway Network information available for Regulatory circuits of the STAT3 signaling pathway

Pathways in the Regulatory circuits of the STAT3 signaling pathway SuperPath

#	Name	Source	Genes
1	Regulatory circuits of the STAT3 signaling pathway	WikiPathways	CNTFR CSF3R EGFR GHR IL21R IL27RA IL6R IL9R LIFR MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MPL OSMR PIAS3 PTPRT SOCS3 STAT3 (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CNTFR	Ciliary Neurotrophic Factor Receptor	Protein Coding	1
2	IL27RA	Interleukin 27 Receptor Subunit Alpha	Protein Coding	1
3	OSMR	Oncostatin M Receptor	Protein Coding	1
4	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
5	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
6	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
7	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
8	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
9	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
10	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
11	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
12	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
13	IL21R	Interleukin 21 Receptor	Protein Coding	1
14	MPL	MPL Proto-Oncogene, Thrombopoietin Receptor	Protein Coding	1
15	LIFR	LIF Receptor Subunit Alpha	Protein Coding	1
16	IL9R	Interleukin 9 Receptor	Protein Coding	1
17	IL6R	Interleukin 6 Receptor	Protein Coding	1
18	GHR	Growth Hormone Receptor	Protein Coding	1
19	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
20	CSF3R	Colony Stimulating Factor 3 Receptor	Protein Coding	1
21	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
22	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
23	PTPRT	Protein Tyrosine Phosphatase Receptor Type T	Protein Coding	1
24	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1

Disorders associated with Regulatory circuits of the STAT3 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Specific learning disability	Enrichment	GHR, MAPK1	3.79
2	Amyloidosis, primary localized cutaneous, 1	Enrichment	OSMR	2.75
3	Thrombocythemia 2	Enrichment	MPL	2.75
4	Dermatitis, atopic, 4	Enrichment	SOCS3	2.75
5	Amegakaryocytic thrombocytopenia, congenital, 1	Enrichment	MPL	2.75
6	Noonan syndrome 13	Enrichment	MAPK1	2.75
7	Laron syndrome	Enrichment	GHR	2.75
8	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.75
9	Growth hormone insensitivity, partial	Enrichment	GHR	2.75
10	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.75
11	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.75
12	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.75
13	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.75
14	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.75
15	Chronic neutrophilic leukemia	Enrichment	CSF3R	2.75
16	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.75
17	Neutrophilia, hereditary	Enrichment	CSF3R	2.45
18	Growth hormone deficiency, isolated partial	Enrichment	GHR	2.45
19	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	CSF3R	2.45
20	Immunodeficiency 31c	Enrichment	IL21R	2.45
21	Primary cutaneous amyloidosis	Enrichment	OSMR	2.45
22	Immunodeficiency 56	Enrichment	IL21R	2.45
23	Severe congenital neutropenia 7	Enrichment	CSF3R	2.45
24	Congenital amegakaryocytic thrombocytopenia	Enrichment	MPL	2.45
25	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.28
26	Stuve-wiedemann syndrome 1	Enrichment	LIFR	2.28
27	Dyskeratosis congenita, autosomal dominant 6	Enrichment	MPL	2.28
28	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.28
29	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.28
30	Hyper ige syndrome	Enrichment	STAT3	2.28
31	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.28
32	Stüve-wiedemann syndrome	Enrichment	LIFR	2.28
33	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.15
34	Cowden syndrome 1	Enrichment	EGFR	1.98
35	Lung squamous cell carcinoma	Enrichment	EGFR	1.98
36	Myelofibrosis	Enrichment	MPL	1.91
37	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.91
38	Essential thrombocythemia	Enrichment	MPL	1.91
39	Lennox-gastaut syndrome	Enrichment	MAPK10	1.85
40	Severe congenital neutropenia	Enrichment	CSF3R	1.85
41	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.85
42	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	CSF3R	1.80
43	Lung non-small cell carcinoma	Enrichment	EGFR	1.71
44	Lip and oral cavity carcinoma	Enrichment	EGFR	1.68
45	Hypercholesterolemia, familial, 1	Enrichment	GHR	1.64
46	Acute promyelocytic leukemia	Enrichment	STAT3	1.64
47	Lung cancer susceptibility 3	Enrichment	EGFR	1.61
48	Familial hypercholesterolemia	Enrichment	GHR	1.58
49	Gliosarcoma	Enrichment	EGFR	1.55
50	Giant cell glioblastoma	Enrichment	EGFR	1.53
51	Heart, malformation of	Enrichment	MAPK1	1.50
52	Arteriovenous malformations of the brain	Enrichment	EGFR	1.48
53	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.48
54	Bladder cancer	Enrichment	EGFR	1.30
55	Lung cancer	Enrichment	EGFR	1.26
56	Cakut	Enrichment	LIFR	1.23
57	Thrombocytopenia	Enrichment	MPL	1.09
58	Schizophrenia	Enrichment	PTPRT	1.00
59	Autism	Enrichment	PTPRT	0.92
60	Ovarian cancer	Enrichment	EGFR	0.78
61	Microcephaly	Enrichment	MAPK1	0.71
62	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.68

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Regulatory circuits of the STAT3 signaling pathway

Pathway Network for Regulatory circuits of the STAT3 signaling pathway

Member Pathways for Regulatory circuits of the STAT3 signaling pathway

Pathways in the Regulatory circuits of the STAT3 signaling pathway SuperPath

Associated Genes for Regulatory circuits of the STAT3 signaling pathway

Associated Disorders for Regulatory circuits of the STAT3 signaling pathway

Disorders associated with Regulatory circuits of the STAT3 signaling pathway SuperPath

STRING Interaction Network for Regulatory circuits of the STAT3 signaling pathway

Sources for Regulatory circuits of the STAT3 signaling pathway