Relationship between inflammation, COX-2 and EGFR

No Pathway Network information available for Relationship between inflammation, COX-2 and EGFR

Pathways in the Relationship between inflammation, COX-2 and EGFR SuperPath

#	Name	Source	Genes
1	Relationship between inflammation, COX-2 and EGFR	WikiPathways	BRAF CYP19A1 EGFR MMP1 PIK3CA PLA1A PTGER4 PTGES2 PTGS2 SRC (see all 10) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLA1A	Phospholipase A1 Member A	Protein Coding	1
2	PTGES2	Prostaglandin E Synthase 2	Protein Coding	1
3	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
4	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
5	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
6	PTGER4	Prostaglandin E Receptor 4	Protein Coding	1
7	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
8	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
9	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
10	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	1

Disorders associated with Relationship between inflammation, COX-2 and EGFR SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, PIK3CA	7.32
2	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR, PIK3CA	7.20
3	Lung cancer	Enrichment	BRAF, EGFR, PIK3CA	5.85
4	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	5.14
5	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	5.14
6	Gallbladder cancer	Enrichment	BRAF, PIK3CA	4.99
7	Colorectal cancer	Enrichment	BRAF, PIK3CA, SRC	4.53
8	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR	4.35
9	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR	4.08
10	Bladder cancer	Enrichment	EGFR, PIK3CA	3.71
11	Macrodactyly	Enrichment	PIK3CA	3.13
12	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	3.13
13	Noonan syndrome 7	Enrichment	BRAF	3.13
14	Leopard syndrome 3	Enrichment	BRAF	3.13
15	Cowden syndrome 5	Enrichment	PIK3CA	3.13
16	Cerebral cavernous malformations 4	Enrichment	PIK3CA	3.13
17	Lymphangioma	Enrichment	BRAF	3.13
18	Hemifacial myohyperplasia	Enrichment	PIK3CA	3.13
19	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	3.13
20	Phace association	Enrichment	BRAF	3.13
21	Thrombocytopenia 6	Enrichment	SRC	3.13
22	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	3.13
23	Hypospadias	Enrichment	PIK3CA	3.13
24	Rare venous malformation	Enrichment	PIK3CA	3.13
25	Diaphragmatic eventration	Enrichment	PIK3CA	3.13
26	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	3.13
27	Syringocystadenoma papilliferum	Enrichment	BRAF	3.13
28	Rare combined vascular malformation	Enrichment	PIK3CA	3.13
29	Ganglioglioma	Enrichment	BRAF	3.13
30	Cavernous lymphangioma	Enrichment	PIK3CA	3.13
31	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	3.13
32	Nongerminomatous germ cell tumor	Enrichment	BRAF	3.13
33	Phace syndrome	Enrichment	BRAF	3.13
34	Classic hairy cell leukemia	Enrichment	BRAF	3.13
35	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	3.13
36	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	3.13
37	Macrodactyly of toe	Enrichment	PIK3CA	3.13
38	Pulmonic stenosis	Enrichment	BRAF	2.83
39	Keratosis, seborrheic	Enrichment	PIK3CA	2.83
40	Noonan syndrome 8	Enrichment	PIK3CA	2.83
41	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	2.83
42	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.83
43	Ataxia-telangiectasia	Enrichment	BRAF	2.66
44	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.66
45	Langerhans cell histiocytosis	Enrichment	BRAF	2.66
46	Aromatase excess syndrome	Enrichment	CYP19A1	2.66
47	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.66
48	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.66
49	Tethered spinal cord syndrome	Enrichment	BRAF	2.66
50	Aromatase deficiency	Enrichment	CYP19A1	2.66
51	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.66
52	Keratoacanthoma	Enrichment	PIK3CA	2.66
53	Ovarian cancer	Enrichment	EGFR, PIK3CA	2.62
54	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF	2.53
55	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.53
56	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.53
57	Cardiofaciocutaneous syndrome	Enrichment	BRAF	2.53
58	Cerebrovascular disease	Enrichment	PIK3CA	2.53
59	Craniopharyngioma	Enrichment	BRAF	2.53
60	Noonan syndrome with multiple lentigines	Enrichment	BRAF	2.53
61	Newborn respiratory distress syndrome	Enrichment	BRAF	2.53
62	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.53
63	Capillary malformations, congenital	Enrichment	PIK3CA	2.43
64	Hemimegalencephaly	Enrichment	PIK3CA	2.43
65	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.35
66	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.35
67	Wilms tumor 5	Enrichment	BRAF	2.35
68	Breast adenocarcinoma	Enrichment	PIK3CA	2.35
69	Nevus, epidermal	Enrichment	PIK3CA	2.29
70	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	2.29
71	Myelofibrosis	Enrichment	SRC	2.29
72	Squamous cell carcinoma, head and neck	Enrichment	EGFR	2.29
73	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.29
74	Pilomyxoid astrocytoma	Enrichment	BRAF	2.29
75	Follicular thyroid carcinoma	Enrichment	BRAF	2.29
76	Melanocytic nevus syndrome, congenital	Enrichment	BRAF	2.23
77	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	2.23
78	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	2.18
79	Arteriovenous malformation	Enrichment	PIK3CA	2.18
80	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.18
81	Primary hyperaldosteronism	Enrichment	BRAF	2.18
82	Ventricular septal defect	Enrichment	BRAF	2.18
83	Cowden syndrome	Enrichment	PIK3CA	2.18
84	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	2.13
85	Melanoma	Enrichment	BRAF	2.13
86	Meningioma	Enrichment	PIK3CA	2.05
87	Osteoporosis	Enrichment	SRC	1.99
88	Wilms tumor 1	Enrichment	BRAF	1.96
89	Lynch syndrome	Enrichment	PIK3CA	1.96
90	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF	1.96
91	Gliosarcoma	Enrichment	EGFR	1.93
92	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.90
93	Dandy-walker syndrome	Enrichment	BRAF	1.90
94	Giant cell glioblastoma	Enrichment	EGFR	1.90
95	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.86
96	Endometrial cancer	Enrichment	PIK3CA	1.81
97	Hepatocellular carcinoma	Enrichment	PIK3CA	1.79
98	Noonan syndrome 1	Enrichment	BRAF	1.77
99	Rasopathy	Enrichment	BRAF	1.72
100	Prostate cancer	Enrichment	PIK3CA	1.67
101	Differentiated thyroid carcinoma	Enrichment	BRAF	1.67
102	Gastric cancer	Enrichment	PIK3CA	1.50
103	Hereditary breast carcinoma	Enrichment	PIK3CA	1.50
104	Thrombocytopenia	Enrichment	SRC	1.46
105	Hypertelorism	Enrichment	PIK3CA	1.42
106	Myeloma, multiple	Enrichment	BRAF	1.39
107	Primary ovarian insufficiency	Enrichment	CYP19A1	1.37
108	Breast cancer	Enrichment	PIK3CA	1.27
109	Dilated cardiomyopathy	Enrichment	BRAF	1.24
110	Inherited cancer-predisposing syndrome	Enrichment	EGFR	1.03

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Relationship between inflammation, COX-2 and EGFR

Pathway Network for Relationship between inflammation, COX-2 and EGFR

Member Pathways for Relationship between inflammation, COX-2 and EGFR

Pathways in the Relationship between inflammation, COX-2 and EGFR SuperPath

Associated Genes for Relationship between inflammation, COX-2 and EGFR

Associated Disorders for Relationship between inflammation, COX-2 and EGFR

Disorders associated with Relationship between inflammation, COX-2 and EGFR SuperPath

STRING Interaction Network for Relationship between inflammation, COX-2 and EGFR

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