Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Pathway network for the Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SuperPath

Sources:

Reactome

Pathways in the Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SuperPath

#	Name	Source	Genes
1	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	Reactome	ATM BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 KAT5 MRE11 NBN PALB2 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RBBP8 RMI1 RMI2 RTEL1 SEM1 TOP3A WRN XRCC2 XRCC3 (see all 27) (see less)
2	Resolution of D-Loop Structures	Reactome	ATM BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EME1 EME2 EXO1 FIGNL1 FIRRM GEN1 KAT5 MRE11 MUS81 NBN PALB2 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RBBP8 RMI1 RMI2 RTEL1 SEM1 SLX1A SLX1B SLX4 SPIDR TOP3A WRN XRCC2 XRCC3 (see all 37) (see less)
3	Resolution of D-loop Structures through Holliday Junction Intermediates	Reactome	ATM BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EME1 EME2 EXO1 FIGNL1 FIRRM GEN1 KAT5 MRE11 MUS81 NBN PALB2 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RBBP8 RMI1 RMI2 SEM1 SLX1A SLX1B SLX4 SPIDR TOP3A WRN XRCC2 XRCC3 (see all 36) (see less)
4	Defective homologous recombination repair (HRR) due to PALB2 loss of function	Reactome	ATM BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 KAT5 MRE11 NBN PALB2 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RBBP8 RMI1 RMI2 SEM1 TOP3A WRN XRCC2 (see all 25) (see less)
5	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Reactome	ATM BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 KAT5 MRE11 NBN PALB2 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RBBP8 RMI1 RMI2 SEM1 TOP3A WRN XRCC2 (see all 25) (see less)
6	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function	Reactome	ATM BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 KAT5 MRE11 NBN PALB2 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RBBP8 RMI1 RMI2 SEM1 TOP3A WRN XRCC2 (see all 25) (see less)
7	Defective homologous recombination repair (HRR) due to BRCA1 loss of function	Reactome	ATM BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 KAT5 MRE11 NBN PALB2 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RBBP8 RMI1 RMI2 SEM1 TOP3A WRN XRCC2 (see all 25) (see less)
8	Impaired BRCA2 binding to PALB2	Reactome	ATM BARD1 BLM BRCA1 BRCA2 BRIP1 DNA2 EXO1 KAT5 MRE11 NBN PALB2 RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD51D RBBP8 RMI1 RMI2 TOP3A WRN XRCC2 (see all 24) (see less)

Gene overlap in member pathways for Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	8
2	KAT5	Lysine Acetyltransferase 5	Protein Coding	8
3	RAD51AP1	RAD51 Associated Protein 1	Protein Coding	8
4	RMI2	RecQ Mediated Genome Instability 2	Protein Coding	8
5	DNA2	DNA Replication Helicase/Nuclease 2	Protein Coding	8
6	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	8
7	NBN	Nibrin	Protein Coding	8
8	ATM	ATM Serine/Threonine Kinase	Protein Coding	8
9	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	8
10	RAD51	RAD51 Recombinase	Protein Coding	8
11	RAD51C	RAD51 Paralog C	Protein Coding	8
12	RAD51B	RAD51 Paralog B	Protein Coding	8
13	RAD51D	RAD51 Paralog D	Protein Coding	8
14	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	8
15	BLM	BLM RecQ Like Helicase	Protein Coding	8
16	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	8
17	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	8
18	TOP3A	DNA Topoisomerase III Alpha	Protein Coding	8
19	WRN	WRN RecQ Like Helicase	Protein Coding	8
20	XRCC2	X-Ray Repair Cross Complementing 2	Protein Coding	8
21	PALB2	Partner And Localizer Of BRCA2	Protein Coding	8
22	RMI1	RecQ Mediated Genome Instability 1	Protein Coding	8
23	BRIP1	BRCA1 Interacting DNA Helicase 1	Protein Coding	8
24	EXO1	Exonuclease 1	Protein Coding	8
25	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	7
26	XRCC3	X-Ray Repair Cross Complementing 3	Protein Coding	3
27	RTEL1	Regulator Of Telomere Elongation Helicase 1	Protein Coding	2
28	EME1	Essential Meiotic Structure-Specific Endonuclease 1	Protein Coding	2
29	EME2	Essential Meiotic Structure-Specific Endonuclease Subunit 2	Protein Coding	2
30	SPIDR	Scaffold Protein Involved In DNA Repair	Protein Coding	2
31	GEN1	GEN1 Holliday Junction 5'' Flap Endonuclease	Protein Coding	2
32	SLX1A	Structure-Specific Endonuclease Subunit SLX1A	Protein Coding	2
33	FIRRM	FIGNL1 Interacting Regulator Of Recombination And Mitosis	Protein Coding	2
34	FIGNL1	Fidgetin Like 1	Protein Coding	2
35	SLX1B	Structure-Specific Endonuclease Subunit SLX1B	Protein Coding	2
36	MUS81	MUS81 Structure-Specific Endonuclease Subunit	Protein Coding	2
37	SLX4	SLX4 Structure-Specific Endonuclease Subunit	Protein Coding	2

Disorders associated with Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MRE11, NBN, PALB2, RAD50, RAD51, RAD51C, RAD51D, XRCC2, XRCC3	16.00
2	Ovarian cancer	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MRE11, NBN, PALB2, RAD50, RAD51C, RAD51D, WRN	16.00
3	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, NBN, PALB2, RBBP8	16.00
4	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MRE11, NBN, PALB2, RAD50, RAD51, RAD51B, RAD51C, RAD51D, XRCC2	16.00
5	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2, BRIP1, PALB2, RAD51, RAD51C, SLX4, XRCC2	16.00
6	Gastric cancer	Enrichment	ATM, BARD1, BRCA1, BRCA2, BRIP1, NBN, PALB2, RAD51C, RAD51D	16.00
7	Hereditary breast carcinoma	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, NBN, PALB2, RAD50, RAD51, RAD51D	16.00
8	Colorectal cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, BRIP1, PALB2, RAD51D, RMI1	16.00
9	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2, BRIP1, NBN, PALB2, RAD51C, RAD51D	11.52
10	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRCA2, BRIP1, PALB2, RAD51C	11.39
11	Inherited cancer-predisposing syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, BRIP1, MRE11, NBN, PALB2, RAD50, RAD51B, RAD51C, RAD51D, XRCC2	11.36
12	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, NBN, PALB2, RAD51D	11.14
13	Endometrial cancer	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, RAD51C	10.96
14	Colonic benign neoplasm	Enrichment	ATM, MRE11, PALB2	6.39
15	Lynch syndrome 1	Enrichment	ATM, PALB2, RAD51D	6.24
16	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2, BRIP1	5.52
17	Microcephaly, growth restriction, and increased sister chromatid exchange 2	Enrichment	RMI2, TOP3A	5.52
18	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	5.52
19	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	5.52
20	Neuroendocrine tumor of pancreas	Enrichment	BRCA2, PALB2	5.52
21	Hereditary site-specific ovarian cancer syndrome	Enrichment	RAD51C, RAD51D	5.05
22	Bladder cancer	Enrichment	ATM, BRCA1, BRCA2	4.76
23	Chordoma	Enrichment	BRCA2, PALB2	4.75
24	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	4.75
25	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	4.75
26	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	4.75
27	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2	4.52
28	Glioblastoma	Enrichment	ATM, SLX4	4.17
29	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2, DNA2	4.08
30	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2, BRIP1	3.97
31	Myeloma, multiple	Enrichment	ATM, BARD1, BRCA2	3.90
32	Isolated tracheo-esophageal fistula	Enrichment	BRCA2, BRIP1	3.87
33	Familial colorectal cancer type x	Enrichment	ATM, BRCA2	3.79
34	Medulloblastoma	Enrichment	BRCA2, WRN	3.57
35	Seckel syndrome	Enrichment	DNA2, RBBP8	3.57
36	Rhabdomyosarcoma	Enrichment	BRCA1, BRCA2	3.45
37	Diffuse large b-cell lymphoma	Enrichment	BRCA2, NBN	3.30
38	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2, BRIP1	3.30
39	Hepatoblastoma	Enrichment	BARD1, BRCA2	3.21
40	Hepatocellular carcinoma	Enrichment	NBN, RAD50	3.17
41	Lung cancer	Enrichment	BRCA1, PALB2	2.84
42	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.75
43	Bloom syndrome	Enrichment	BLM	2.75
44	Seckel syndrome 2	Enrichment	RBBP8	2.75
45	Fanconi anemia, complementation group j	Enrichment	BRIP1	2.75
46	Glioma susceptibility 3	Enrichment	BRCA2	2.75
47	Mirror movements 2	Enrichment	RAD51	2.75
48	Seckel syndrome 8	Enrichment	DNA2	2.75
49	Fanconi anemia, complementation group r	Enrichment	RAD51	2.75
50	Fanconi anemia, complementation group u	Enrichment	XRCC2	2.75
51	Premature ovarian failure 17	Enrichment	XRCC2	2.75
52	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 6	Enrichment	DNA2	2.75
53	Spermatogenic failure 50	Enrichment	XRCC2	2.75
54	Infant-type hemispheric glioma	Enrichment	BRCA1	2.75
55	Pancreatic cancer 2	Enrichment	BRCA2	2.75
56	Jawad syndrome	Enrichment	RBBP8	2.75
57	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.75
58	Endometrial serous adenocarcinoma	Enrichment	ATM	2.75
59	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 5	Enrichment	TOP3A	2.75
60	Rothmund-thomson syndrome, type 4	Enrichment	DNA2	2.75
61	Basal cell carcinoma	Enrichment	PALB2	2.75
62	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.75
63	Primary peritoneal carcinoma	Enrichment	BRCA1	2.75
64	Fanconi anemia, complementation group p	Enrichment	SLX4	2.58
65	Ovarian dysgenesis 9	Enrichment	SPIDR	2.58
66	Rothmund-thomson syndrome, type 2	Enrichment	DNA2	2.45
67	Fanconi anemia, complementation group n	Enrichment	PALB2	2.45
68	Pancreatic cancer 3	Enrichment	PALB2	2.45
69	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	2.45
70	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.45
71	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.45
72	Werner syndrome	Enrichment	WRN	2.45
73	Pancreatic cancer 4	Enrichment	BRCA1	2.45
74	Ovarian cancer 1	Enrichment	BRIP1	2.45
75	Short stature, microcephaly, and endocrine dysfunction	Enrichment	XRCC2	2.45
76	High grade glioma	Enrichment	ATM	2.45
77	Fanconi anemia, complementation group d1	Enrichment	BRCA2	2.45
78	T-cell prolymphocytic leukemia	Enrichment	ATM	2.45
79	Peritoneum cancer	Enrichment	BRCA1	2.45
80	Melanoma, cutaneous malignant 6	Enrichment	XRCC3	2.40
81	Dyskeratosis congenita, autosomal recessive 5	Enrichment	RTEL1	2.40
82	Autosomal dominant dyskeratosis congenita 4	Enrichment	RTEL1	2.40
83	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 3	Enrichment	RTEL1	2.40
84	Primary ovarian insufficiency	Enrichment	NBN, RAD51C	2.32
85	Ataxia-telangiectasia	Enrichment	ATM	2.28
86	Nijmegen breakage syndrome	Enrichment	NBN	2.28
87	Polycythemia vera	Enrichment	ATM	2.28
88	Breast-ovarian cancer, familial 3	Enrichment	RAD51C	2.28
89	Breast-ovarian cancer, familial 4	Enrichment	RAD51D	2.28
90	Tumor predisposition syndrome 1	Enrichment	BRCA2	2.28
91	Fanconi anemia, complementation group o	Enrichment	RAD51C	2.28
92	Breast-ovarian cancer, familial 5	Enrichment	PALB2	2.28
93	Koolen-de vries syndrome	Enrichment	ATM	2.28
94	Adenocarcinoma	Enrichment	ATM	2.28
95	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	2.28
96	Dyskeratosis congenita, x-linked	Enrichment	RTEL1	2.22
97	Mirror movements 1	Enrichment	RAD51	2.15
98	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	2.15
99	Mantle cell lymphoma	Enrichment	ATM	2.15
100	Oculomotor apraxia	Enrichment	ATM	2.15
101	Epilepsy, progressive myoclonic, 4, with or without renal failure	Enrichment	RTEL1	2.10
102	Combined oxidative phosphorylation deficiency 24	Enrichment	RTEL1	2.10
103	Cutis laxa, autosomal recessive, type ib	Enrichment	MUS81	2.10
104	Fanconi anemia, complementation group d2	Enrichment	BRIP1	2.05
105	Kabuki syndrome 1	Enrichment	BRCA2	1.98
106	Clear cell renal cell carcinoma	Enrichment	ATM	1.98
107	Combined oxidative phosphorylation deficiency 32	Enrichment	EME2	1.98
108	Pulmonary fibrosis	Enrichment	RTEL1	1.92
109	Hoyeraal-hreidarsson syndrome	Enrichment	RTEL1	1.92
110	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.91
111	Isolated split hand-split foot malformation	Enrichment	SEM1	1.83
112	Polydactyly	Enrichment	BRCA2	1.80
113	Leukemia, acute lymphoblastic 3	Enrichment	PALB2	1.80
114	Leukemia, chronic lymphocytic	Enrichment	ATM	1.76
115	Aplastic anemia	Enrichment	NBN	1.76
116	Immune deficiency disease	Enrichment	ATM	1.71
117	Leukemia, acute lymphoblastic	Enrichment	NBN	1.71
118	Premature menopause	Enrichment	NBN	1.64
119	Periventricular nodular heterotopia	Enrichment	BRCA1	1.61
120	Cataract	Enrichment	WRN	1.61
121	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.58
122	Wilms tumor 1	Enrichment	BRCA2	1.58
123	Gliosarcoma	Enrichment	ATM	1.55
124	Giant cell glioblastoma	Enrichment	ATM	1.53
125	46 xx gonadal dysgenesis	Enrichment	SPIDR	1.50
126	Interstitial lung disease 2	Enrichment	RTEL1	1.48
127	Lissencephaly	Enrichment	NBN	1.44
128	Dyskeratosis congenita	Enrichment	RTEL1	1.43
129	Cerebral palsy	Enrichment	BRCA2	1.18
130	Type 2 diabetes mellitus	Enrichment	WRN	1.14
131	Leukemia, acute myeloid	Enrichment	RTEL1	1.12
132	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	XRCC2	1.02
133	Mitochondrial disease	Enrichment	TOP3A	0.84
134	Leigh syndrome, nuclear	Enrichment	EME2	0.77
135	Leigh disease	Enrichment	EME2	0.74
136	Microcephaly	Enrichment	NBN	0.71

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² PubChem

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⁸ Cell Signaling Technology

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¹¹ MalaCards

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Pathway Network for Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Pathway network for the Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SuperPath

Member Pathways for Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Pathways in the Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SuperPath

Gene overlap in member pathways for Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SuperPath

Associated Genes for Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Associated Disorders for Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Disorders associated with Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) SuperPath

STRING Interaction Network for Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Sources for Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)