Response of EIF2AK1 (HRI) to heme deficiency

No Pathway Network information available for Response of EIF2AK1 (HRI) to heme deficiency

#	Name	Source	Genes
1	Response of EIF2AK1 (HRI) to heme deficiency	Reactome	ASNS ATF3 ATF4 ATF5 CEBPB CEBPG CHAC1 DDIT3 EIF2AK1 EIF2S1 EIF2S2 EIF2S3 GRB10 PPP1R15A TRIB3 (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
2	CEBPG	CCAAT Enhancer Binding Protein Gamma	Protein Coding	1
3	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
4	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
5	EIF2S3	Eukaryotic Translation Initiation Factor 2 Subunit Gamma	Protein Coding	1
6	ATF5	Activating Transcription Factor 5	Protein Coding	1
7	PPP1R15A	Protein Phosphatase 1 Regulatory Subunit 15A	Protein Coding	1
8	EIF2AK1	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1	Protein Coding	1
9	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
10	ASNS	Asparagine Synthetase (Glutamine-Hydrolyzing)	Protein Coding	1
11	ATF3	Activating Transcription Factor 3	Protein Coding	1
12	ATF4	Activating Transcription Factor 4	Protein Coding	1
13	TRIB3	Tribbles Pseudokinase 3	Protein Coding	1
14	CHAC1	ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1	Protein Coding	1
15	EIF2S2	Eukaryotic Translation Initiation Factor 2 Subunit Beta	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mehmo syndrome	Enrichment	EIF2S3	2.96
2	Leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome	Enrichment	EIF2AK1	2.96
3	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.96
4	Leukodystrophy, hypomyelinating, 17	Enrichment	EIF2AK1	2.66
5	Asparagine synthetase deficiency	Enrichment	ASNS	2.48
6	Myxoid liposarcoma	Enrichment	DDIT3	2.48
7	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	ASNS	2.48
8	Spinocerebellar ataxia, autosomal recessive 29	Enrichment	ASNS	2.48

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Response of EIF2AK1 (HRI) to heme deficiency