Response of endothelial cells to shear stress

Pathway network for the Response of endothelial cells to shear stress SuperPath

Sources:

Reactome

Pathways in the Response of endothelial cells to shear stress SuperPath

#	Name	Source	Genes
1	Response of endothelial cells to shear stress	Reactome	ABL1 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADM AKT1 ANXA2 CALCRL CALM1 CALM2 CALM3 CAPN2 CAPNS1 CAPNS2 CDH5 CHUK CTNNB1 FLT4 FN1 FYN GNA11 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IKBKB IKBKE IKBKG ITGA5 ITGAV ITGB1 ITGB3 KDR MAPKAP1 MLST8 MMP14 MTOR NFKB1 NFKBIA NOS3 P2RY2 PANX1 PDE4D PDPK1 PECAM1 PIEZO1 PIK3CA PIK3CB PIK3CD PIK3R2 PKN2 PPP2CA PPP2R1A PPP2R1B PPP2R2A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRR5 PTK2 PTPN1 RAMP2 RELA RICTOR STAT1 TLN1 TRPV4 VCL YAP1 (see all 94) (see less)
2	Cellular responses to mechanical stimuli	Reactome	ABL1 ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADM AKT1 ANXA2 CACNA1H CACNA2D1 CACNB1 CACNB2 CACNB3 CACNG7 CALCRL CALM1 CALM2 CALM3 CAPN2 CAPNS1 CAPNS2 CDH5 CHUK CTNNB1 FLT4 FN1 FYN GJA1 GNA11 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HSPG2 IKBKB IKBKE IKBKG ITGA5 ITGAV ITGB1 ITGB3 KDR MAPKAP1 MLST8 MMP14 MTOR NFKB1 NFKBIA NOS3 P2RX7 P2RY2 PANX1 PDE4D PDPK1 PECAM1 PIEZO1 PIK3CA PIK3CB PIK3CD PIK3R2 PKN2 PPP2CA PPP2R1A PPP2R1B PPP2R2A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRR5 PTK2 PTPN1 RAMP2 RELA RICTOR SPP1 STAT1 TLN1 TRPV4 VCL YAP1 (see all 104) (see less)
3	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADM AKT1 CALCRL CALM1 CALM2 CALM3 CAPN2 CAPNS1 CAPNS2 CDH5 CTNNB1 FLT4 FYN GNA11 GNAQ GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 KDR MAPKAP1 MLST8 MMP14 MTOR NOS3 P2RY2 PANX1 PDPK1 PECAM1 PIEZO1 PIK3CA PIK3CB PIK3CD PIK3R2 PKN2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRR5 RAMP2 RICTOR TLN1 TRPV4 VCL (see all 71) (see less)
4	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Reactome	ABL1 ANXA2 CAPN2 CAPNS1 CAPNS2 CHUK FN1 GNA11 GNAQ IKBKB IKBKE IKBKG ITGA5 ITGAV ITGB1 ITGB3 NFKB1 NFKBIA PDE4D PIEZO1 PPP2CA PPP2R1A PPP2R1B PPP2R2A PTK2 PTPN1 RELA STAT1 VCL YAP1 (see all 30) (see less)
5	Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Reactome	AKT1 CACNA1H CACNA2D1 CACNB1 CACNB2 CACNB3 CACNG7 GJA1 HSPG2 ITGA5 ITGAV ITGB1 ITGB3 P2RX7 PANX1 PIEZO1 SPP1 (see all 17) (see less)

Gene overlap in member pathways for Response of endothelial cells to shear stress SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIEZO1	Piezo Type Mechanosensitive Ion Channel Component 1 (Er Blood Group)	Protein Coding	5
2	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	4
3	PANX1	Pannexin 1	Protein Coding	4
4	GNA11	G Protein Subunit Alpha 11	Protein Coding	4
5	GNAQ	G Protein Subunit Alpha Q	Protein Coding	4
6	ITGA5	Integrin Subunit Alpha 5	Protein Coding	4
7	ITGAV	Integrin Subunit Alpha V	Protein Coding	4
8	ITGB1	Integrin Subunit Beta 1	Protein Coding	4
9	ITGB3	Integrin Subunit Beta 3	Protein Coding	4
10	VCL	Vinculin	Protein Coding	4
11	CAPN2	Calpain 2	Protein Coding	4
12	CAPNS1	Calpain Small Subunit 1	Protein Coding	4
13	CAPNS2	Calpain Small Subunit 2	Protein Coding	4
14	CDH5	Cadherin 5	Protein Coding	3
15	CALCRL	Calcitonin Receptor Like Receptor	Protein Coding	3
16	RAMP2	Receptor Activity Modifying Protein 2	Protein Coding	3
17	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	3
18	GNB5	G Protein Subunit Beta 5	Protein Coding	3
19	ADCY1	Adenylate Cyclase 1	Protein Coding	3
20	ADCY2	Adenylate Cyclase 2	Protein Coding	3
21	ADCY3	Adenylate Cyclase 3	Protein Coding	3
22	ADCY5	Adenylate Cyclase 5	Protein Coding	3
23	ADCY6	Adenylate Cyclase 6	Protein Coding	3
24	ADCY7	Adenylate Cyclase 7	Protein Coding	3
25	ADCY8	Adenylate Cyclase 8	Protein Coding	3
26	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	3
27	ADCY9	Adenylate Cyclase 9	Protein Coding	3
28	ADM	Adrenomedullin	Protein Coding	3
29	CTNNB1	Catenin Beta 1	Protein Coding	3
30	ADCY4	Adenylate Cyclase 4	Protein Coding	3
31	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	3
32	FN1	Fibronectin 1	Protein Coding	3
33	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	3
34	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	3
35	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	3
36	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
37	GNAS	GNAS Complex Locus	Protein Coding	3
38	GNB1	G Protein Subunit Beta 1	Protein Coding	3
39	GNB2	G Protein Subunit Beta 2	Protein Coding	3
40	GNB3	G Protein Subunit Beta 3	Protein Coding	3
41	GNG3	G Protein Subunit Gamma 3	Protein Coding	3
42	GNG4	G Protein Subunit Gamma 4	Protein Coding	3
43	GNG5	G Protein Subunit Gamma 5	Protein Coding	3
44	GNG7	G Protein Subunit Gamma 7	Protein Coding	3
45	GNG10	G Protein Subunit Gamma 10	Protein Coding	3
46	GNG11	G Protein Subunit Gamma 11	Protein Coding	3
47	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	3
48	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	3
49	ANXA2	Annexin A2	Protein Coding	3
50	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
51	KDR	Kinase Insert Domain Receptor	Protein Coding	3
52	MMP14	Matrix Metallopeptidase 14	Protein Coding	3
53	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
54	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
55	NOS3	Nitric Oxide Synthase 3	Protein Coding	3
56	P2RY2	Purinergic Receptor P2Y2	Protein Coding	3
57	PDE4D	Phosphodiesterase 4D	Protein Coding	3
58	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	3
59	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	3
60	GNG13	G Protein Subunit Gamma 13	Protein Coding	3
61	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
62	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
63	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	3
64	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
65	GNG2	G Protein Subunit Gamma 2	Protein Coding	3
66	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	3
67	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	3
68	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	3
69	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	3
70	PRR5	Proline Rich 5	Protein Coding	3
71	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	3
72	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	3
73	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	3
74	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	3
75	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	3
76	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	3
77	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	3
78	PKN2	Protein Kinase N2	Protein Coding	3
79	GNG12	G Protein Subunit Gamma 12	Protein Coding	3
80	PTK2	Protein Tyrosine Kinase 2	Protein Coding	3
81	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	3
82	TRPV4	Transient Receptor Potential Cation Channel Subfamily V Member 4	Protein Coding	3
83	GNB4	G Protein Subunit Beta 4	Protein Coding	3
84	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
85	MLST8	MTOR Associated Protein MLST8	Protein Coding	3
86	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	3
87	TLN1	Talin 1	Protein Coding	3
88	MAPKAP1	MAPK Associated Protein 1	Protein Coding	3
89	CALM1	Calmodulin 1	Protein Coding	3
90	CALM2	Calmodulin 2	Protein Coding	3
91	CALM3	Calmodulin 3	Protein Coding	3
92	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
93	GNG8	G Protein Subunit Gamma 8	Protein Coding	3
94	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	3
95	GJA1	Gap Junction Protein Alpha 1	Protein Coding	2
96	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	2
97	P2RX7	Purinergic Receptor P2X 7	Protein Coding	2
98	CACNG7	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7	Protein Coding	2
99	SPP1	Secreted Phosphoprotein 1	Protein Coding	2
100	CACNA2D1	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1	Protein Coding	2
101	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	2
102	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	2
103	CACNB3	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3	Protein Coding	2
104	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	2

Disorders associated with Response of endothelial cells to shear stress SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Capillary malformations, congenital	Enrichment	GNA11, GNAQ, PIK3CA	5.87
2	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.33
3	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	5.33
4	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.12
5	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	4.85
6	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	4.57
7	Acrodysostosis	Enrichment	PDE4D, PRKAR1A	4.32
8	Melanoma, uveal	Enrichment	GNA11, GNAQ	4.15
9	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3CA	4.09
10	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.79
11	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	3.57
12	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ, PIK3CA	3.40
13	Hemangioma, capillary infantile	Enrichment	FLT4, KDR	3.40
14	Adrenocortical carcinoma	Enrichment	CTNNB1, PRKAR1A	3.40
15	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.40
16	Brugada syndrome	Enrichment	CACNA2D1, CACNB2	3.33
17	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	3.30
18	Non-immune hydrops fetalis	Enrichment	CALCRL, FLT4, PIEZO1	3.25
19	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA	3.25
20	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.02
21	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	3.02
22	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.02
23	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	2.90
24	Proteus syndrome	Enrichment	AKT1	2.90
25	Hypoplastic left heart syndrome 1	Enrichment	GJA1	2.90
26	Brugada syndrome 4	Enrichment	CACNB2	2.90
27	Oculodentodigital dysplasia	Enrichment	GJA1	2.90
28	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	2.90
29	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	2.90
30	Epilepsy, childhood absence 6	Enrichment	CACNA1H	2.90
31	Cowden syndrome 6	Enrichment	AKT1	2.90
32	Developmental and epileptic encephalopathy 110	Enrichment	CACNA2D1	2.90
33	Blood group, er	Enrichment	PIEZO1	2.90
34	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	2.90
35	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	2.90
36	Conn's syndrome	Enrichment	CACNA1H	2.90
37	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.90
38	Diffuse lymphatic malformation	Enrichment	PIEZO1	2.90
39	Meningioma	Enrichment	AKT1, PIK3CA	2.76
40	Primary hyperaldosteronism	Enrichment	CACNA1H, GNAS	2.69
41	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.66
42	Incontinentia pigmenti	Enrichment	IKBKG	2.66
43	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.66
44	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.66
45	Fetal encasement syndrome	Enrichment	CHUK	2.66
46	Sturge-weber syndrome	Enrichment	GNAQ	2.66
47	Immunodeficiency 15b	Enrichment	IKBKB	2.66
48	Immunodeficiency 15a	Enrichment	IKBKB	2.66
49	Pulmonary hypertension, primary, 6	Enrichment	CAPNS1	2.66
50	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.66
51	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.66
52	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.66
53	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.66
54	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.66
55	Immunodeficiency 31a	Enrichment	STAT1	2.66
56	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.66
57	Acrodysostosis 2 with or without hormone resistance	Enrichment	PDE4D	2.66
58	Immunodeficiency 31b	Enrichment	STAT1	2.66
59	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.66
60	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.66
61	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.66
62	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.66
63	Hallermann-streiff syndrome	Enrichment	GJA1	2.60
64	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	2.60
65	Syndactyly, type iii	Enrichment	GJA1	2.60
66	Syndactyly, type v	Enrichment	GJA1	2.60
67	Oocyte/zygote/embryo maturation arrest 7	Enrichment	PANX1	2.60
68	Craniometaphyseal dysplasia	Enrichment	GJA1	2.60
69	Lymphatic malformation 6	Enrichment	PIEZO1	2.60
70	Breast cancer	Enrichment	AKT1, CACNA2D1, GNG3, PIK3CA	2.58
71	Lip and oral cavity carcinoma	Enrichment	ABL1, PIK3CA	2.52
72	Hypertension, essential	Enrichment	GNB3, NOS3	2.46
73	Primary ovarian insufficiency	Enrichment	KDR, NOS3, RICTOR	2.44
74	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.43
75	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.43
76	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	2.43
77	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.43
78	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.35
79	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.35
80	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.35
81	Immunodeficiency 33	Enrichment	IKBKG	2.35
82	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.35
83	Chromosome 5q12 deletion syndrome	Enrichment	PDE4D	2.35
84	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.35
85	Immunodeficiency 31c	Enrichment	STAT1	2.35
86	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.35
87	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.35
88	Rela fusion-positive ependymoma	Enrichment	RELA	2.35
89	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.35
90	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.35
91	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.35
92	Common variable immunodeficiency 12	Enrichment	NFKB1	2.35
93	Dehydrated hereditary stomatocytosis 1 with or without pseudohyperkalemia and/or perinatal edema	Enrichment	PIEZO1	2.30
94	Pediatric systemic lupus erythematosus	Enrichment	SPP1	2.30
95	Metatropic dysplasia	Enrichment	TRPV4	2.28
96	Macrodactyly	Enrichment	PIK3CA	2.28
97	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.28
98	Parastremmatic dwarfism	Enrichment	TRPV4	2.28
99	Spondylometaphyseal dysplasia, kozlowski type	Enrichment	TRPV4	2.28
100	Neuronopathy, distal hereditary motor, autosomal dominant 8	Enrichment	TRPV4	2.28
101	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.28
102	Carney complex, type 1	Enrichment	PRKAR1A	2.28
103	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.28
104	Osseous heteroplasia, progressive	Enrichment	GNAS	2.28
105	Brachyolmia type 3	Enrichment	TRPV4	2.28
106	Sodium serum level quantitative trait locus 1	Enrichment	TRPV4	2.28
107	Cowden syndrome 5	Enrichment	PIK3CA	2.28
108	Spondyloepiphyseal dysplasia, maroteaux type	Enrichment	TRPV4	2.28
109	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.28
110	Scapuloperoneal spinal muscular atrophy	Enrichment	TRPV4	2.28
111	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.28
112	Avascular necrosis of femoral head, primary, 2	Enrichment	TRPV4	2.28
113	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.28
114	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.28
115	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.28
116	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.28
117	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.28
118	Winchester syndrome	Enrichment	MMP14	2.28
119	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.28
120	Myxoma, intracardiac	Enrichment	PRKAR1A	2.28
121	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.28
122	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.28
123	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.28
124	Skeletal dysplasia and progressive central nervous system degeneration, lethal	Enrichment	TRPV4	2.28
125	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.28
126	Digital arthropathy-brachydactyly, familial	Enrichment	TRPV4	2.28
127	Long qt syndrome 16	Enrichment	CALM3	2.28
128	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.28
129	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.28
130	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.28
131	Disorders of gnas inactivation	Enrichment	GNAS	2.28
132	Congenital heart defects, multiple types, 7	Enrichment	FLT4	2.28
133	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.28
134	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.28
135	Sick sinus syndrome 4	Enrichment	GNB2	2.28
136	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.28
137	Tufted angioma of skin	Enrichment	KDR	2.28
138	Adenoid ameloblastoma	Enrichment	CTNNB1	2.28
139	Long qt syndrome 15	Enrichment	CALM2	2.28
140	Hypospadias	Enrichment	PIK3CA	2.28
141	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.28
142	Rare venous malformation	Enrichment	PIK3CA	2.28
143	Diaphragmatic eventration	Enrichment	PIK3CA	2.28
144	Capillary leak syndrome	Enrichment	TLN1	2.28
145	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.28
146	Rare combined vascular malformation	Enrichment	PIK3CA	2.28
147	Cavernous lymphangioma	Enrichment	PIK3CA	2.28
148	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.28
149	Monostotic fibrous dysplasia	Enrichment	GNAS	2.28
150	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.28
151	Mazabraud syndrome	Enrichment	GNAS	2.28
152	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.28
153	Macrodactyly of toe	Enrichment	PIK3CA	2.28
154	Microcystic stromal tumor	Enrichment	CTNNB1	2.28
155	Trpv4-related bone disorder	Enrichment	TRPV4	2.28
156	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	2.23
157	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.20
158	Cardiac arrest	Enrichment	CACNA2D1	2.20
159	Cleft upper lip	Enrichment	GJA1	2.20
160	Female infertility due to oocyte meiotic arrest	Enrichment	PANX1	2.20
161	Congenital short qt syndrome	Enrichment	CACNA2D1	2.20
162	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.18
163	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.18
164	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.18
165	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	2.13
166	Childhood absence epilepsy	Enrichment	CACNA1H	2.13
167	Tetralogy of fallot	Enrichment	FLT4, KDR	2.09
168	Hydrops fetalis, nonimmune	Enrichment	FLT4, PIEZO1	2.09
169	Brugada syndrome 1	Enrichment	CACNA2D1	2.06
170	Glanzmann thrombasthenia 1	Enrichment	ITGB3	2.06
171	Malignant epithelioid hemangioendothelioma	Enrichment	YAP1	2.05
172	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.05
173	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	2.00
174	Hypoplastic left heart syndrome	Enrichment	GJA1	2.00
175	Bladder cancer	Enrichment	CTNNB1, PIK3CA	2.00
176	Lymphatic malformation 1	Enrichment	FLT4	1.98
177	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.98
178	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.98
179	Intracranial hypertension, idiopathic	Enrichment	FLT4	1.98
180	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.98
181	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.98
182	Hereditary motor and sensory neuropathy, type iic	Enrichment	TRPV4	1.98
183	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.98
184	Keratosis, seborrheic	Enrichment	PIK3CA	1.98
185	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.98
186	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	1.98
187	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.98
188	Angioma, tufted	Enrichment	KDR	1.98
189	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.98
190	Noonan syndrome 8	Enrichment	PIK3CA	1.98
191	Long qt syndrome 14	Enrichment	CALM1	1.98
192	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.98
193	Cebalid syndrome	Enrichment	MTOR	1.98
194	Usher syndrome, type iv	Enrichment	PRKAR1A	1.98
195	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.98
196	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.98
197	Pseudohypoparathyroidism	Enrichment	GNAS	1.98
198	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.98
199	Fibrolamellar carcinoma	Enrichment	PRKACA	1.98
200	Lymphatic malformation 8	Enrichment	CALCRL	1.98
201	Familial avascular necrosis of the femoral head	Enrichment	TRPV4	1.98
202	Immune system disease	Enrichment	PIK3CD	1.98
203	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.98
204	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.98
205	Smith-kingsmore syndrome	Enrichment	MTOR	1.98
206	Hereditary lymphedema i	Enrichment	FLT4	1.98
207	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.98
208	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.98
209	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.98
210	Teratoma	Enrichment	CTNNB1	1.98
211	Cerebral visual impairment	Enrichment	GNB1	1.98
212	Colorectal cancer	Enrichment	AKT1, CTNNB1, PIK3CA	1.97
213	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.96
214	Hydrops fetalis	Enrichment	PIEZO1	1.95
215	Long qt syndrome	Enrichment	CALM1, CALM2	1.94
216	Leukemia, chronic lymphocytic	Enrichment	P2RX7	1.90
217	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.90
218	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.88
219	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	1.86
220	Leukemia, chronic myeloid	Enrichment	ABL1	1.81
221	Common variable immunodeficiency	Enrichment	NFKB1	1.81
222	Moyamoya angiopathy	Enrichment	ABL1	1.81
223	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.81
224	Desmoid disease, hereditary	Enrichment	CTNNB1	1.81
225	Mccune-albright syndrome	Enrichment	GNAS	1.81
226	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.81
227	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP14	1.81
228	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.81
229	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	1.81
230	Anus, imperforate	Enrichment	CTNNB1	1.81
231	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.81
232	Desmoid tumor	Enrichment	CTNNB1	1.81
233	Immunodeficiency 14	Enrichment	PIK3CD	1.81
234	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.81
235	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.81
236	Keratoacanthoma	Enrichment	PIK3CA	1.81
237	Ovarian cancer	Enrichment	AKT1, CTNNB1, PIK3CA	1.80
238	Neural tube defects	Enrichment	ITGB1	1.79
239	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2	1.79
240	Coronary heart disease 5	Enrichment	IKBKG	1.70
241	Lung cancer	Enrichment	PIK3CA, PPP2R1B	1.69
242	Chorea, benign hereditary	Enrichment	ADCY5	1.68
243	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.68
244	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.68
245	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.68
246	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.68
247	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.68
248	Pilomatrixoma	Enrichment	CTNNB1	1.68
249	Carney complex variant	Enrichment	PRKAR1A	1.68
250	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.68
251	Alazami syndrome	Enrichment	CTNNB1	1.68
252	Cerebrovascular disease	Enrichment	PIK3CA	1.68
253	Craniopharyngioma	Enrichment	CTNNB1	1.68
254	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.68
255	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.68
256	Familial sick sinus syndrome	Enrichment	GNB2	1.68
257	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.66
258	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.65
259	Alzheimer disease 2	Enrichment	NOS3	1.59
260	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.59
261	Pre-eclampsia	Enrichment	NOS3	1.59
262	Genetic motor neuron disease	Enrichment	TRPV4	1.59
263	Myocardial infarction	Enrichment	ITGB3	1.56
264	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.55
265	Microphthalmia/coloboma 12	Enrichment	YAP1	1.55
266	Heart disease	Enrichment	ABL1	1.52
267	Cowden syndrome 1	Enrichment	PIK3CA	1.51
268	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.51
269	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.51
270	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.51
271	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.51
272	Coloboma of macula	Enrichment	YAP1	1.49
273	Gliosarcoma	Enrichment	NFKBIA	1.46
274	Severe covid-19	Enrichment	ITGAV	1.45
275	Nevus, epidermal	Enrichment	PIK3CA	1.44
276	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.44
277	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.44
278	Brachydactyly	Enrichment	GNAS	1.44
279	Overgrowth syndrome	Enrichment	MTOR	1.44
280	Giant cell glioblastoma	Enrichment	NFKBIA	1.43
281	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.39
282	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.39
283	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.39
284	Hypothyroidism	Enrichment	GNB1	1.39
285	Arteriovenous malformation	Enrichment	PIK3CA	1.34
286	Systemic lupus erythematosus	Enrichment	SPP1	1.32
287	Malaria	Enrichment	IKBKG	1.30
288	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.30
289	Stroke, ischemic	Enrichment	NOS3	1.29
290	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.29
291	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.29
292	Primary bone dysplasia	Enrichment	TRPV4	1.29
293	Microcephaly	Enrichment	ABL1, CTNNB1, GNB1	1.27
294	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.25
295	Myelodysplastic syndrome	Enrichment	GNB1	1.25
296	Osteochondrodysplasia	Enrichment	TRPV4	1.25
297	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.25
298	Myeloma, multiple	Enrichment	PIK3R2, YAP1	1.24
299	Thrombocytopenia	Enrichment	ITGB3	1.23
300	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	TRPV4	1.18
301	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.18
302	Clubfoot	Enrichment	TRPV4	1.18
303	Nk-cell enteropathy	Enrichment	PIK3CB	1.18
304	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA2D1	1.17
305	Severe combined immunodeficiency	Enrichment	IKBKB	1.15
306	Medulloblastoma	Enrichment	CTNNB1	1.15
307	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.12
308	Lynch syndrome	Enrichment	PIK3CA	1.12
309	Rare genetic intellectual disability	Enrichment	MTOR	1.12
310	Alzheimer disease, familial, 1	Enrichment	NOS3	1.07
311	Cleft palate, isolated	Enrichment	GNB1	1.07
312	Sudden infant death syndrome	Enrichment	CALM2	1.07
313	Polycystic liver disease	Enrichment	CTNNB1	1.07
314	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.07
315	Type 2 diabetes mellitus	Enrichment	PTPN1	1.05
316	Beckwith-wiedemann syndrome	Enrichment	TRPV4	1.04
317	Neuromuscular disease	Enrichment	TRPV4	1.04
318	Nephrotic syndrome	Enrichment	FN1	1.04
319	Endometrial cancer	Enrichment	PIK3CA	0.98
320	Hepatoblastoma	Enrichment	CTNNB1	0.98
321	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1	0.97
322	Congenital nervous system abnormality	Enrichment	CTNNB1, GNB5	0.97
323	Nervous system disease	Enrichment	CTNNB1, GNB5	0.97
324	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.96
325	Familial isolated dilated cardiomyopathy	Enrichment	VCL	0.95
326	Congenital stationary night blindness	Enrichment	GNB3	0.94
327	Strabismus	Enrichment	GNB1	0.88
328	Prostate cancer	Enrichment	PIK3CA	0.85
329	Connective tissue disease	Enrichment	TRPV4	0.81
330	Dilated cardiomyopathy	Enrichment	VCL	0.79
331	Dystonia	Enrichment	GNB1	0.77
332	Cerebral palsy	Enrichment	GNB1	0.73
333	Charcot-marie-tooth disease	Enrichment	TRPV4	0.71
334	Gastric cancer	Enrichment	PIK3CA	0.69
335	Complex neurodevelopmental disorder	Enrichment	GNB2, PPP2CA	0.67
336	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	0.64
337	Hypertelorism	Enrichment	PIK3CA	0.62
338	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.48
339	Autism spectrum disorder	Enrichment	GNB1	0.36
340	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.30

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Response of endothelial cells to shear stress

Pathway Network for Response of endothelial cells to shear stress

Pathway network for the Response of endothelial cells to shear stress SuperPath

Member Pathways for Response of endothelial cells to shear stress

Pathways in the Response of endothelial cells to shear stress SuperPath

Gene overlap in member pathways for Response of endothelial cells to shear stress SuperPath

Associated Genes for Response of endothelial cells to shear stress

Associated Disorders for Response of endothelial cells to shear stress

Disorders associated with Response of endothelial cells to shear stress SuperPath

STRING Interaction Network for Response of endothelial cells to shear stress

Sources for Response of endothelial cells to shear stress