RET signaling

No Pathway Network information available for RET signaling

Pathways in the RET signaling SuperPath

#	Name	Source	Genes
1	RET signaling	Reactome	ARTN DOK1 DOK2 DOK4 DOK5 DOK6 FRS2 GAB1 GAB2 GDNF GFRA1 GFRA2 GFRA3 GFRA4 GRB10 GRB2 GRB7 IRS2 MAPK7 NRTN PDLIM7 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PRKACA PRKACB PRKACG PRKCA PSPN PTPN11 RAP1GAP RET SHC1 SHC3 SOS1 SRC (see all 40) (see less)
2	Signaling events regulated by Ret tyrosine kinase	PubChem	BCAR1 CREB1 CRK DOK1 DOK4 DOK5 DOK6 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 HRAS IRS1 IRS2 JUN MAPK3 MAPK8 NCK1 PDLIM7 PIK3CA PIK3R1 PRKACA PRKCA PTK2 PTPN11 PXN RAC1 RAP1A RASA1 RET RHOA SHANK3 SHC1 SOS1 SRC (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	2
2	DOK1	Docking Protein 1	Protein Coding	2
3	DOK6	Docking Protein 6	Protein Coding	2
4	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	2
5	GDNF	Glial Cell Derived Neurotrophic Factor	Protein Coding	2
6	GFRA1	GDNF Family Receptor Alpha 1	Protein Coding	2
7	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
8	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	2
9	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	2
10	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
11	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
12	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
13	DOK4	Docking Protein 4	Protein Coding	2
14	PRKCA	Protein Kinase C Alpha	Protein Coding	2
15	DOK5	Docking Protein 5	Protein Coding	2
16	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
17	RET	Ret Proto-Oncogene	Protein Coding	2
18	SHC1	SHC Adaptor Protein 1	Protein Coding	2
19	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
20	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
21	IRS2	Insulin Receptor Substrate 2	Protein Coding	2
22	PDLIM7	PDZ And LIM Domain 7	Protein Coding	2
23	GFRA2	GDNF Family Receptor Alpha 2	Protein Coding	1
24	GFRA3	GDNF Family Receptor Alpha 3	Protein Coding	1
25	NRTN	Neurturin	Protein Coding	1
26	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
27	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
28	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
29	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
30	SHC3	SHC Adaptor Protein 3	Protein Coding	1
31	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
32	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
33	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
34	PSPN	Persephin	Protein Coding	1
35	RAP1GAP	RAP1 GTPase Activating Protein	Protein Coding	1
36	GFRA4	GDNF Family Receptor Alpha 4	Protein Coding	1
37	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
38	DOK2	Docking Protein 2	Protein Coding	1
39	ARTN	Artemin	Protein Coding	1
40	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
41	SHANK3	SH3 And Multiple Ankyrin Repeat Domains 3	Protein Coding	1
42	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
43	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
44	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
45	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
46	PXN	Paxillin	Protein Coding	1
47	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
48	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
49	NCK1	NCK Adaptor Protein 1	Protein Coding	1
50	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
51	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
52	RHOA	Ras Homolog Family Member A	Protein Coding	1
53	RAC1	Rac Family Small GTPase 1	Protein Coding	1
54	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
55	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
56	IRS1	Insulin Receptor Substrate 1	Protein Coding	1

Disorders associated with RET signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 3	Enrichment	HRAS, PTPN11, SOS1	6.15
2	Arteriovenous malformation	Enrichment	HRAS, PIK3CA, RASA1	5.77
3	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA, RASA1	5.62
4	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, PTPN11, SOS1	5.04
5	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.64
6	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.60
7	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.60
8	Noonan syndrome 1	Enrichment	HRAS, PTPN11, SOS1	4.46
9	Rasopathy	Enrichment	HRAS, PTPN11, SOS1	4.30
10	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.30
11	Breast cancer	Enrichment	JUN, PIK3CA, RET, SHC1	4.26
12	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	4.12
13	Hirschsprung disease 1	Enrichment	GDNF, NRTN, RET	4.08
14	Colorectal cancer	Enrichment	PIK3CA, PIK3R1, RET, SRC	4.01
15	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.94
16	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.94
17	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.80
18	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA, RASA1	3.80
19	Congenital central hypoventilation syndrome	Enrichment	GDNF, RET	3.57
20	Renal agenesis, bilateral	Enrichment	GFRA1, RET	3.57
21	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.52
22	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.42
23	Lung non-small cell carcinoma	Enrichment	HRAS, PIK3CA	3.38
24	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.30
25	Hepatocellular carcinoma	Enrichment	PIK3CA, RET	2.77
26	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.62
27	Multiple endocrine neoplasia, type iib	Enrichment	RET	2.55
28	Macrodactyly	Enrichment	PIK3CA	2.55
29	Metachondromatosis	Enrichment	PTPN11	2.55
30	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.55
31	Deafness, autosomal recessive 26	Enrichment	GAB1	2.55
32	Noonan syndrome 4	Enrichment	SOS1	2.55
33	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.55
34	Leopard syndrome 1	Enrichment	PTPN11	2.55
35	Cowden syndrome 5	Enrichment	PIK3CA	2.55
36	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.55
37	Short syndrome	Enrichment	PIK3R1	2.55
38	Renal hypodysplasia/aplasia 4	Enrichment	GFRA1	2.55
39	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.55
40	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.55
41	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.55
42	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.55
43	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.55
44	Hirschsprung disease 3	Enrichment	GDNF	2.55
45	Schizophrenia 15	Enrichment	SHANK3	2.55
46	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.55
47	Thrombocytopenia 6	Enrichment	SRC	2.55
48	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.55
49	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.55
50	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.55
51	Hypospadias	Enrichment	PIK3CA	2.55
52	Thyroid cancer	Enrichment	RET	2.55
53	Mutism	Enrichment	SHANK3	2.55
54	Rare venous malformation	Enrichment	PIK3CA	2.55
55	Gorham's disease	Enrichment	RASA1	2.55
56	Diaphragmatic eventration	Enrichment	PIK3CA	2.55
57	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.55
58	Rare combined vascular malformation	Enrichment	PIK3CA	2.55
59	Cavernous lymphangioma	Enrichment	PIK3CA	2.55
60	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.55
61	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.55
62	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.55
63	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.55
64	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.55
65	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.55
66	Macrodactyly of toe	Enrichment	PIK3CA	2.55
67	Gastrointestinal system disease	Enrichment	RET	2.55
68	Malignant astrocytoma	Enrichment	PTPN11	2.55
69	Multiple endocrine neoplasia	Enrichment	RET	2.55
70	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.53
71	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.53
72	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.53
73	Bladder cancer	Enrichment	HRAS, PIK3CA	2.53
74	Differentiated thyroid carcinoma	Enrichment	HRAS, RET	2.53
75	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.47
76	Fibromatosis, gingival, 1	Enrichment	SOS1	2.25
77	Costello syndrome	Enrichment	HRAS	2.25
78	Pulmonic stenosis	Enrichment	SOS1	2.25
79	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.25
80	Keratosis, seborrheic	Enrichment	PIK3CA	2.25
81	Noonan syndrome 8	Enrichment	PIK3CA	2.25
82	Myopia 28, autosomal recessive	Enrichment	DOK1	2.25
83	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.25
84	Werner syndrome	Enrichment	PTPN11	2.25
85	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.25
86	Phelan-mcdermid syndrome	Enrichment	SHANK3	2.25
87	Medullary thyroid carcinoma	Enrichment	RET	2.25
88	Fibrolamellar carcinoma	Enrichment	PRKACA	2.25
89	Psychotic disorder	Enrichment	SHANK3	2.25
90	Wooly hair nevus	Enrichment	HRAS	2.25
91	Scoliosis, isolated 1	Enrichment	MAPK7	2.23
92	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.23
93	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.23
94	Immune system disease	Enrichment	PIK3CD	2.23
95	Type 2 diabetes mellitus	Enrichment	IRS1, IRS2	2.21
96	Hereditary breast carcinoma	Enrichment	PIK3CA, RET	2.17
97	Thrombocytopenia	Enrichment	PTPN11, SRC	2.10
98	Thyroid carcinoma, familial medullary	Enrichment	RET	2.08
99	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.08
100	Nuchal bleb, familial	Enrichment	SOS1	2.08
101	Large congenital melanocytic nevus	Enrichment	HRAS	2.08
102	Wieacker-wolff syndrome	Enrichment	RASA1	2.08
103	Gingival overgrowth	Enrichment	RET	2.08
104	Spermatocytoma	Enrichment	HRAS	2.08
105	Melanoma of soft tissue	Enrichment	CREB1	2.08
106	Tricuspid valve insufficiency	Enrichment	PTPN11	2.08
107	Keratoacanthoma	Enrichment	PIK3CA	2.08
108	Hypertelorism	Enrichment	PIK3CA, RET	2.03
109	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.95
110	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	1.95
111	Cerebrovascular disease	Enrichment	PIK3CA	1.95
112	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.95
113	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.95
114	Epidermolytic nevus	Enrichment	HRAS	1.95
115	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.95
116	Haddad syndrome	Enrichment	RET	1.95
117	Gingival fibromatosis	Enrichment	SOS1	1.95
118	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.93
119	Multiple endocrine neoplasia, type iia	Enrichment	RET	1.86
120	Lymphoma	Enrichment	PTPN11	1.86
121	Hemimegalencephaly	Enrichment	PIK3CA	1.86
122	Cowden syndrome 1	Enrichment	PIK3CA	1.78
123	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.78
124	Hemangioma, capillary infantile	Enrichment	RASA1	1.78
125	Basal cell carcinoma 1	Enrichment	RASA1	1.78
126	Patent ductus arteriosus	Enrichment	PTPN11	1.78
127	Breast adenocarcinoma	Enrichment	PIK3CA	1.78
128	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.78
129	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	1.78
130	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.71
131	Myelofibrosis	Enrichment	SRC	1.71
132	Gallbladder cancer	Enrichment	PIK3CA	1.71
133	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.71
134	Follicular thyroid carcinoma	Enrichment	HRAS	1.71
135	Overgrowth syndrome	Enrichment	PIK3R1	1.71
136	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.65
137	Renal hypodysplasia/aplasia 1	Enrichment	RET	1.65
138	Hypothyroidism	Enrichment	RET	1.65
139	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.60
140	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.60
141	Cowden syndrome	Enrichment	PIK3CA	1.60
142	Pectus excavatum	Enrichment	PTPN11	1.52
143	Specific learning disability	Enrichment	PTPN11	1.52
144	Ovarian cancer	Enrichment	PIK3CA, RET	1.49
145	Epicanthus	Enrichment	PTPN11	1.48
146	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.48
147	Renal hypodysplasia/aplasia 3	Enrichment	RET	1.48
148	Meningioma	Enrichment	PIK3CA	1.48
149	Congenital long qt syndrome	Enrichment	PTPN11	1.48
150	Aortic valve disease 1	Enrichment	SOS1	1.45
151	Autism spectrum disorder	Enrichment	PTPN11, SHANK3	1.43
152	Nk-cell enteropathy	Enrichment	PIK3CB	1.42
153	Osteoporosis	Enrichment	SRC	1.41
154	Pheochromocytoma	Enrichment	RET	1.41
155	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.41
156	Lynch syndrome	Enrichment	PIK3CA	1.38
157	Rhabdomyosarcoma	Enrichment	HRAS	1.36
158	Patent foramen ovale	Enrichment	PTPN11	1.31
159	Inherited cancer-predisposing syndrome	Enrichment	PTPN11, RET	1.28
160	Endometrial cancer	Enrichment	PIK3CA	1.24
161	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	1.24
162	Scoliosis	Enrichment	PTPN11	1.19
163	Tetralogy of fallot	Enrichment	RET	1.15
164	Strabismus	Enrichment	PTPN11	1.14
165	Prostate cancer	Enrichment	PIK3CA	1.11
166	Long qt syndrome 1	Enrichment	PTPN11	1.09
167	Lung cancer	Enrichment	PIK3CA	1.07
168	Gastric cancer	Enrichment	PIK3CA	0.94
169	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.94
170	Sensorineural hearing loss	Enrichment	RET	0.90
171	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.84
172	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.84
173	Myeloma, multiple	Enrichment	PIK3R2	0.82
174	Microcephaly	Enrichment	PTPN11	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RET signaling

Pathway Network for RET signaling

Member Pathways for RET signaling

Pathways in the RET signaling SuperPath

Associated Genes for RET signaling

Associated Disorders for RET signaling

Disorders associated with RET signaling SuperPath

STRING Interaction Network for RET signaling

Sources for RET signaling