Retinoblastoma gene in cancer

No Pathway Network information available for Retinoblastoma gene in cancer

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Retinoblastoma gene in cancer SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Meier-gorlin syndrome 1EnrichmentCDC45, CDT1, MCM7, ORC16.51
2Inherited cancer-predisposing syndromeEnrichmentBARD1, CDK4, CDKN1B, DHFR, MSH6, POLE, RB1, TP535.74
3Ovarian cancerEnrichmentBARD1, CDKN1B, FANCG, MSH6, RB1, TP534.37
4Lip and oral cavity carcinomaEnrichmentABL1, RB1, TP534.28
5Pituitary stalk interruption syndromeEnrichmentDNMT1, FANCG, SMARCA24.07
6Osteogenic sarcomaEnrichmentRB1, TP533.93
7Dedifferentiated liposarcomaEnrichmentCDK4, MDM23.93
8Squamous cell carcinomaEnrichmentRB1, TP533.93
9Bone osteosarcomaEnrichmentRB1, TP533.93
10Well-differentiated liposarcomaEnrichmentCDK4, MDM23.93
11Gastric cancerEnrichmentBARD1, CDK4, MSH6, TP533.81
12Small cell cancer of the lungEnrichmentRB1, TP533.63
13Lynch syndrome 4EnrichmentMSH6, RB13.63
14Endometrial cancerEnrichmentBARD1, DHFR, MSH63.52
15Li-fraumeni syndromeEnrichmentMDM2, TP533.23
16Wiedemann-steiner syndromeEnrichmentSMC1A, SMC33.23
17Bladder cancerEnrichmentCDKN1A, RB1, TP533.10
18Multiple endocrine neoplasia, type iEnrichmentCDKN1A, CDKN1B3.09
19B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentABL1, TP533.09
20Cornelia de lange syndrome 1EnrichmentSMC1A, SMC32.86
21Cornelia de lange syndromeEnrichmentSMC1A, SMC32.86
22Leukemia, chronic lymphocyticEnrichmentCCND1, TP532.76
23Familial colorectal cancer type xEnrichmentNPAT, POLE2.68
24Colorectal cancerEnrichmentCCND1, MSH6, POLE, TP532.65
25Hereditary breast carcinomaEnrichmentBARD1, MSH6, TP532.57
26Lung cancer susceptibility 3EnrichmentRB1, TP532.46
27Seckel syndromeEnrichmentPLK4, PRIM12.46
28RhabdomyosarcomaEnrichmentMSH6, TP532.35
29Hereditary breast ovarian cancer syndromeEnrichmentBARD1, MSH6, TP532.29
30Myeloma, multipleEnrichmentBARD1, CCND1, TP532.27
31Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual developmentEnrichmentPOLE2.20
32Developmental and epileptic encephalopathy 85 with or without midline brain defectsEnrichmentSMC1A2.20
33Van esch-o'driscoll syndromeEnrichmentPOLA12.20
34Spermatogenic failure, x-linked, 9EnrichmentRBBP72.20
35Intellectual developmental disorder, x-linked 100EnrichmentKIF4A2.20
36Taurodontism, microdontia, and dens invaginatusEnrichmentKIF4A2.20
37Cornelia de lange syndrome 3 with or without midline brain defectsEnrichmentSMC32.20
38Noonan syndrome 5EnrichmentRAF12.20
39Melanoma, cutaneous malignant 3EnrichmentCDK42.20
40Brachyphalangy, polydactyly, and tibial aplasia/hypoplasiaEnrichmentHMGB12.20
41Cardiomyopathy, dilated, 1nnEnrichmentRAF12.20
42Lactose intolerance, adult typeEnrichmentMCM62.20
43Microcephaly 12, primary, autosomal recessiveEnrichmentCDK62.20
44Microcephaly and chorioretinopathy, autosomal recessive, 2EnrichmentPLK42.20
45Focal segmental glomerulosclerosis 8EnrichmentANLN2.20
46Accelerated tumor formationEnrichmentMDM22.20
47Fanconi anemia, complementation group gEnrichmentFANCG2.20
48Colorectal cancer 12EnrichmentPOLE2.20
49Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6EnrichmentRPA12.20
50Pigmentary disorder, reticulate, with systemic manifestations, x-linkedEnrichmentPOLA12.20
51Lessel-kubisch syndromeEnrichmentMDM22.20
52Bone marrow failure syndrome 5EnrichmentTP532.20
53Meier-gorlin syndrome 4EnrichmentCDT12.20
54Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6EnrichmentRRM12.20
55Papilloma of choroid plexusEnrichmentTP532.20
56AnisometropiaEnrichmentMCM72.20
57Basal cell carcinoma 7EnrichmentTP532.20
58Anaplastic thyroid carcinomaEnrichmentTP532.20
59Immunodeficiency 54EnrichmentMCM42.20
60Neuroendocrine tumorEnrichmentCDKN1B2.20
61Leopard syndrome 2EnrichmentRAF12.20
62Immunodeficiency 26 with or without neurologic abnormalitiesEnrichmentPRKDC2.20
63Ataxia-telangiectasia-like disorder 2EnrichmentPCNA2.20
64Microcephaly and chorioretinopathy 2EnrichmentPLK42.20
65Megaloblastic anemia due to dihydrofolate reductase deficiencyEnrichmentDHFR2.20
66Ductal carcinoma in situEnrichmentTP532.20
67Meier-gorlin syndrome 7EnrichmentCDC452.20
68Blepharophimosis-impaired intellectual development syndromeEnrichmentSMARCA22.20
69TrigonitisEnrichmentRAF12.20
70Thyroid gland undifferentiated carcinomaEnrichmentTP532.20
71Trilateral retinoblastomaEnrichmentRB12.20
72Small-cell carcinoma of the ovary of hypercalcemic typeEnrichmentTP532.20
73Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtypeEnrichmentTP532.20
74Morimoto-ryu-malicdan neuromuscular syndromeEnrichmentRFC42.20
75Chromosome 15q24 deletion syndromeEnrichmentSIN3A2.20
76Oocyte/zygote/embryo maturation arrest 21EnrichmentCHEK12.20
77Immunodeficiency 122EnrichmentPOLD32.20
78Choroid plexus cancerEnrichmentTP532.20
79Pleomorphic xanthoastrocytomaEnrichmentTP532.20
80Lung oat cell carcinomaEnrichmentRB12.20
81HepatoblastomaEnrichmentBARD1, TP532.11
82Precursor t-cell acute lymphoblastic leukemiaEnrichmentABL1, MYC2.04
83Pancreatic cancerEnrichmentFANCG, TP531.96
84Breast cancerEnrichmentBARD1, MSH6, TP531.92
85Burkitt lymphomaEnrichmentMYC1.90
86Adrenocortical carcinoma, hereditaryEnrichmentTP531.90
87Cervical cancerEnrichmentTP531.90
88Cornelia de lange syndrome 2EnrichmentSMC1A1.90
89Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomaliesEnrichmentPOLE1.90
90Chromosome 13q14 deletion syndromeEnrichmentRB11.90
91Lymphoma, hodgkin, classicEnrichmentTP531.90
92Multiple endocrine neoplasia, type ivEnrichmentCDKN1B1.90
93Congenital heart defects and skeletal malformations syndromeEnrichmentABL11.90
94Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiencyEnrichmentPOLE1.90
95Cerebellar ataxia, deafness, and narcolepsy, autosomal dominantEnrichmentDNMT11.90
96Primordial dwarfism-immunodeficiency-lipodystrophy syndromeEnrichmentPRIM11.90
97Congenital fibrosarcomaEnrichmentTP531.90
98Li-fraumeni syndrome 1EnrichmentTP531.90
99SarcomaEnrichmentTP531.90
100Witteveen-kolk syndromeEnrichmentSIN3A1.90
101Facial dysmorphism, immunodeficiency, livedo, and short statureEnrichmentPOLE1.90
102Cervix carcinomaEnrichmentTP531.90
103Hodgkin's lymphomaEnrichmentTP531.90
104Blepharophimosis - intellectual disability syndromeEnrichmentSMARCA21.90
105Dyskeratosis congenita, digenicEnrichmentTYMS1.90
106Mismatch repair cancer syndrome 3EnrichmentMSH61.90
107Familial retinoblastomaEnrichmentRB11.90
108Pleomorphic rhabdomyosarcomaEnrichmentTP531.90
109Prostate cancerEnrichmentMSH6, TP531.84
110Primary autosomal recessive microcephalyEnrichmentCDK6, MCM71.76
111RetinoblastomaEnrichmentRB11.72
112Partington syndromeEnrichmentPOLA11.72
113Nasopharyngeal carcinomaEnrichmentTP531.72
114Woolly hair, autosomal recessive 3EnrichmentRB11.72
115Neuropathy, hereditary sensory, type ieEnrichmentDNMT11.72
116Lynch syndrome 5EnrichmentMSH61.72
117Familial adenomatous polyposis 4EnrichmentDHFR1.72
118Hypotrichosis 8EnrichmentRB11.72
119High-grade b-cell lymphoma double-hit/triple-hitEnrichmentMYC1.72
120Atypical teratoid rhabdoid tumorEnrichmentTP531.72
121Anaplastic astrocytomaEnrichmentTP531.72
122T-cell acute lymphoblastic leukemiaEnrichmentABL11.72
123AdenocarcinomaEnrichmentTP531.72
124Childhood apraxia of speechEnrichmentRFC31.72
125Intellectual developmental disorder with dysmorphic facies and behavioral abnormalitiesEnrichmentMSH61.72
126Colon adenocarcinomaEnrichmentMSH61.72
127Polymerase proofreading-related polyposisEnrichmentPOLE1.72
128Gaucher disease, type iEnrichmentMSH61.60
129Thyroid cancer, nonmedullary, 1EnrichmentTP531.60
130Mismatch repair cancer syndrome 1EnrichmentMSH61.60
131AstigmatismEnrichmentMCM71.60
132Nicolaides-baraitser syndromeEnrichmentSMARCA21.60
133Mantle cell lymphomaEnrichmentCCND11.60
134BlepharophimosisEnrichmentSMARCA21.60
135EnophthalmosEnrichmentMCM71.60
136Lung sarcomatoid carcinomaEnrichmentTP531.60
137Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentABL11.60
138Embryonal rhabdomyosarcomaEnrichmentTP531.60
139Noonan syndrome with multiple lentiginesEnrichmentRAF11.60
140Smarca2-related nicolaides-baraitser syndromeEnrichmentSMARCA21.60
141Autosomal recessive chorioretinopathy-microcephaly syndromeEnrichmentPLK41.60
142Primary hyperparathyroidismEnrichmentCDKN1B1.60
143Male infertility due to gonadal dysgenesis or sperm disorderEnrichmentCHEK11.60
144Von hippel-lindau syndromeEnrichmentCCND11.50
145Rhabdomyosarcoma 2EnrichmentTP531.50
146LymphomaEnrichmentTP531.50
147Acute megakaryocytic leukemiaEnrichmentTP531.50
148FarsightednessEnrichmentMCM71.50
149Adrenocortical carcinomaEnrichmentTP531.43
150Breast adenocarcinomaEnrichmentTP531.43
151Multicystic kidney dysplasiaEnrichmentKIF4A1.43
152Multicystic dysplastic kidneyEnrichmentKIF4A1.43
153MicrocephalyEnrichmentABL1, MCM7, SMC1A1.36
154Esophageal cancerEnrichmentTP531.36
155Squamous cell carcinoma, head and neckEnrichmentTP531.36
156Leukemia, chronic myeloidEnrichmentABL11.36
157Noonan syndrome 3EnrichmentRAF11.36
158Hereditary sensory and autonomic neuropathy type 1EnrichmentDNMT11.36
159Essential thrombocythemiaEnrichmentTP531.36
160Gallbladder cancerEnrichmentTP531.36
161Pilomyxoid astrocytomaEnrichmentRAF11.36
162Moyamoya angiopathyEnrichmentABL11.36
163Melanocytic nevus syndrome, congenitalEnrichmentRAF11.30
164Glioma susceptibility 1EnrichmentTP531.30
165Lymphoma, non-hodgkin, familialEnrichmentTP531.30
166Rett syndrome, congenital variantEnrichmentSMC1A1.30
167Adult hepatocellular carcinomaEnrichmentTP531.25
168Primary hyperaldosteronismEnrichmentTP531.25
169Lynch syndrome 1EnrichmentMSH61.21
170Familial colorectal cancerEnrichmentTP531.21
171Myelodysplastic syndromeEnrichmentTP531.17
172Uterine corpus cancerEnrichmentMSH61.17
173Heart diseaseEnrichmentABL11.07
174HydrocephalusEnrichmentKIF4A1.04
175Lynch syndromeEnrichmentMSH61.04
176Noonan syndrome and noonan-related syndromeEnrichmentRAF11.04
177Hydrocephalus, congenital, 1EnrichmentKIF4A1.01
178GliosarcomaEnrichmentTP531.01
179Melanoma, cutaneous malignant 1EnrichmentCDK40.99
180Polycystic liver diseaseEnrichmentCDC25A0.99
181Giant cell glioblastomaEnrichmentTP530.99
182Autosomal dominant polycystic liver diseaseEnrichmentCDC25A0.99
183Semilobar holoprosencephalyEnrichmentSMC1A0.97
184Diffuse large b-cell lymphomaEnrichmentTP530.94
185Dyskeratosis congenitaEnrichmentTYMS0.94
186Hepatocellular carcinomaEnrichmentTP530.88
187MicrophthalmiaEnrichmentMCM70.88
188Diamond-blackfan anemia 1EnrichmentTP530.87
189Noonan syndrome 1EnrichmentRAF10.87
190Cardiomyopathy, familial hypertrophic, 1EnrichmentRAF10.85
191RasopathyEnrichmentRAF10.82
192Differentiated thyroid carcinomaEnrichmentCCDC60.77
193Familial hypertrophic cardiomyopathyEnrichmentRAF10.72
194Genetic steroid-resistant nephrotic syndromeEnrichmentANLN0.71
195Fanconi anemia, complementation group aEnrichmentFANCG0.70
196Left ventricular noncompactionEnrichmentRAF10.70
197Diamond-blackfan anemiaEnrichmentTP530.69
198Leukemia, acute myeloidEnrichmentTP530.65
199Spastic ataxiaEnrichmentDNMT10.54
200Familial isolated dilated cardiomyopathyEnrichmentRAF10.54
201Dilated cardiomyopathyEnrichmentRAF10.40
202Congenital nervous system abnormalityEnrichmentSMC1A0.31
203Nervous system diseaseEnrichmentSMC1A0.31
204Autism spectrum disorderEnrichmentSMC30.30

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