Retinoid cycle disease events

Pathway network for the Retinoid cycle disease events SuperPath

Sources:

Reactome

Pathways in the Retinoid cycle disease events SuperPath

#	Name	Source	Genes
1	Retinoid cycle disease events	Reactome	ABCA4 LRAT NAPEPLD OPN1LW OPN1MW OPN1MW3 OPN1SW RBP1 RBP4 RDH12 RDH5 RLBP1 STRA6 TTR (see all 14) (see less)
2	The canonical retinoid cycle in rods (twilight vision)	Reactome	ABCA4 CYP4V2 DHRS9 HSD17B1 HSD17B6 LRAT MYO7A RBP1 RBP3 RBP4 RDH10 RDH11 RDH12 RDH16 RDH5 RDH8 RHO RLBP1 RPE65 SDR9C7 STRA6 TTR (see all 22) (see less)
3	Diseases of the neuronal system	Reactome	ABCA4 LRAT NAPEPLD OPN1LW OPN1MW OPN1MW3 OPN1SW RBP1 RBP4 RDH12 RDH5 RLBP1 STRA6 TTR (see all 14) (see less)
4	Diseases associated with visual transduction	Reactome	ABCA4 LRAT NAPEPLD OPN1LW OPN1MW OPN1MW3 OPN1SW RBP1 RBP4 RDH12 RDH5 RLBP1 STRA6 TTR (see all 14) (see less)
5	Defective visual phototransduction due to STRA6 loss of function	Reactome	RBP4 STRA6 TTR
6	Biosynthesis of A2E, implicated in retinal degradation	Reactome	NAPEPLD
7	Defective visual phototransduction due to ABCA4 loss of function	Reactome	ABCA4

Gene overlap in member pathways for Retinoid cycle disease events SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABCA4	ATP Binding Cassette Subfamily A Member 4	Protein Coding	5
2	RBP4	Retinol Binding Protein 4	Protein Coding	5
3	STRA6	Signaling Receptor And Transporter Of Retinol STRA6	Protein Coding	5
4	TTR	Transthyretin	Protein Coding	5
5	RDH12	Retinol Dehydrogenase 12	Protein Coding	4
6	NAPEPLD	N-Acyl Phosphatidylethanolamine Phospholipase D	Protein Coding	4
7	RBP1	Retinol Binding Protein 1	Protein Coding	4
8	RDH5	Retinol Dehydrogenase 5	Protein Coding	4
9	RLBP1	Retinaldehyde Binding Protein 1	Protein Coding	4
10	LRAT	Lecithin Retinol Acyltransferase	Protein Coding	4
11	OPN1MW3	Opsin 1, Medium Wave Sensitive 3	Protein Coding	3
12	OPN1MW	Opsin 1, Medium Wave Sensitive	Protein Coding	3
13	OPN1LW	Opsin 1, Long Wave Sensitive	Protein Coding	3
14	OPN1SW	Opsin 1, Short Wave Sensitive	Protein Coding	3
15	DHRS9	Dehydrogenase/Reductase 9	Protein Coding	1
16	SDR9C7	Short Chain Dehydrogenase/Reductase Family 9C Member 7	Protein Coding	1
17	RDH10	Retinol Dehydrogenase 10	Protein Coding	1
18	CYP4V2	Cytochrome P450 Family 4 Subfamily V Member 2	Protein Coding	1
19	HSD17B1	Hydroxysteroid 17-Beta Dehydrogenase 1	Protein Coding	1
20	MYO7A	Myosin VIIA	Protein Coding	1
21	RDH8	Retinol Dehydrogenase 8	Protein Coding	1
22	RDH11	Retinol Dehydrogenase 11	Protein Coding	1
23	RBP3	Retinol Binding Protein 3	Protein Coding	1
24	RHO	Rhodopsin	Protein Coding	1
25	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	1
26	RDH16	Retinol Dehydrogenase 16	Protein Coding	1
27	HSD17B6	Hydroxysteroid 17-Beta Dehydrogenase 6	Protein Coding	1

Disorders associated with Retinoid cycle disease events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Retinal disease	Direct
2	Nervous system disease	Direct
3	Microphthalmia	Direct
4	Dystrophies primarily involving the retinal pigment epithelium	Direct
5	Macular degeneration	Direct
6	Hereditary retinal dystrophy	Enrichment	ABCA4, CYP4V2, LRAT, MYO7A, RBP3, RBP4, RDH11, RDH12, RDH5, RHO, RLBP1, RPE65	10.73
7	Fundus dystrophy	Enrichment	ABCA4, CYP4V2, LRAT, MYO7A, RBP3, RBP4, RDH11, RDH12, RDH5, RHO, RLBP1, RPE65	10.73
8	Retinitis pigmentosa	Enrichment	ABCA4, CYP4V2, LRAT, MYO7A, RBP3, RDH12, RDH5, RHO, RLBP1, RPE65	10.70
9	Eye disease	Enrichment	ABCA4, LRAT, RBP4, RDH12, RLBP1, RPE65	10.49
10	Congenital stationary night blindness	Enrichment	ABCA4, RBP3, RDH5, RHO	7.35
11	Fundus albipunctatus	Enrichment	RDH5, RHO, RLBP1	6.89
12	Stargardt disease 1	Enrichment	ABCA4, LRAT, RDH12, RPE65	6.86
13	Leber congenital amaurosis 14	Enrichment	ABCA4, LRAT	5.60
14	Cone-rod dystrophy 2	Enrichment	ABCA4, RBP3, RDH12, RHO	5.40
15	Bietti crystalline corneoretinal dystrophy	Enrichment	ABCA4, CYP4V2	5.12
16	Leber plus disease	Enrichment	ABCA4, LRAT, RDH12, RPE65	4.82
17	Optic atrophy plus syndrome	Enrichment	ABCA4, CYP4V2, RDH5	4.33
18	Macs syndrome	Enrichment	RBP4, STRA6	3.33
19	Carpal tunnel syndrome 1	Enrichment	TTR	2.79
20	Hyperthyroxinemia, dystransthyretinemic	Enrichment	TTR	2.79
21	Deafness, autosomal recessive 2	Enrichment	MYO7A	2.79
22	Night blindness, congenital stationary, autosomal dominant 1	Enrichment	RHO	2.79
23	Bothnia retinal dystrophy	Enrichment	RLBP1	2.79
24	Amyloidosis, hereditary systemic 1	Enrichment	TTR	2.79
25	Mandibulofacial dysostosis with impaired intellectual development	Enrichment	ABCA4	2.79
26	Newfoundland rod-cone dystrophy	Enrichment	RLBP1	2.79
27	Retinitis pigmentosa 66	Enrichment	RBP3	2.79
28	Microphthalmia/coloboma 10	Enrichment	RBP4	2.79
29	Leber congenital amaurosis 2	Enrichment	RPE65	2.79
30	Retinitis pigmentosa 87 with choroidal involvement	Enrichment	RPE65	2.79
31	Deafness, autosomal dominant 11	Enrichment	MYO7A	2.79
32	Retinitis pigmentosa 4	Enrichment	RHO	2.79
33	Retinitis pigmentosa 20	Enrichment	RPE65	2.79
34	Ichthyosis, congenital, autosomal recessive 13	Enrichment	SDR9C7	2.79
35	Amyloidosis	Enrichment	TTR	2.79
36	Usher syndrome type 1b	Enrichment	MYO7A	2.79
37	Stargardt disease 5	Enrichment	RDH8	2.79
38	Hereditary amyloidosis	Enrichment	TTR	2.79
39	Attrv30m amyloidosis	Enrichment	TTR	2.79
40	Attrv122i amyloidosis	Enrichment	TTR	2.79
41	Stargardt disease 3	Enrichment	ABCA4	2.49
42	Mononeuropathy of the median nerve, mild	Enrichment	TTR	2.49
43	Retinal dystrophy, juvenile cataracts, and short stature syndrome	Enrichment	RDH11	2.49
44	Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	Enrichment	RBP4	2.49
45	Acth deficiency, isolated	Enrichment	RPE65	2.49
46	Neuropathy, congenital hypomyelinating, 2	Enrichment	RHO	2.49
47	Optic disk drusen	Enrichment	RHO	2.49
48	Cone-rod dystrophy 3	Enrichment	ABCA4	2.49
49	Progressive retinal dystrophy due to retinol transport defect	Enrichment	RBP4	2.49
50	Congenital isolated adrenocorticotropic hormone deficiency	Enrichment	RPE65	2.49
51	Macular degeneration, age-related, 2	Enrichment	ABCA4	2.31
52	Retinitis pigmentosa 1	Enrichment	ABCA4	2.31
53	Microphthalmia, syndromic 9	Enrichment	STRA6	2.31
54	Retinitis pigmentosa 19	Enrichment	ABCA4	2.31
55	Leber congenital amaurosis 13	Enrichment	RDH12	2.31
56	Microcephaly 17, primary, autosomal recessive	Enrichment	RHO	2.31
57	Age related macular degeneration	Enrichment	ABCA4	2.31
58	Retinitis pigmentosa 91	Enrichment	ABCA4	2.19
59	Choroideremia	Enrichment	CYP4V2	2.19
60	Macular dystrophy with or without cone dysfunction	Enrichment	RDH12	2.19
61	Vitreoretinopathy	Enrichment	ABCA4	2.19
62	Retinal detachment	Enrichment	RHO	2.09
63	Night blindness	Enrichment	RHO	2.09
64	Syndromic rod-cone dystrophy	Enrichment	ABCA4	2.01
65	Meniere disease	Enrichment	MYO7A	1.95
66	Mitochondrial dna depletion syndrome 4a	Enrichment	RLBP1	1.95
67	Coats disease	Enrichment	RHO	1.95
68	Retinal degeneration	Enrichment	RPE65	1.95
69	Leber congenital amaurosis 1	Enrichment	LRAT	1.89
70	Congenital nonbullous ichthyosiform erythroderma	Enrichment	SDR9C7	1.79
71	Usher syndrome type 2	Enrichment	MYO7A	1.75
72	Microphthalmia/coloboma 12	Enrichment	RBP4	1.68
73	Cone-rod dystrophy 6	Enrichment	ABCA4	1.65
74	Cataract	Enrichment	RHO	1.65
75	Isolated macular dystrophy	Enrichment	ABCA4	1.65
76	Coloboma of macula	Enrichment	RBP4	1.62
77	Usher syndrome, type i	Enrichment	MYO7A	1.62
78	Anterior segment dysgenesis	Enrichment	RBP4	1.62
79	Autosomal recessive congenital ichthyosis	Enrichment	SDR9C7	1.62
80	Ear malformation	Enrichment	MYO7A	1.42
81	Cone dystrophy	Enrichment	ABCA4	1.42
82	Auditory neuropathy	Enrichment	MYO7A	1.38
83	Usher syndrome	Enrichment	MYO7A	1.28
84	Non-syndromic genetic deafness	Enrichment	MYO7A	1.25
85	Charcot-marie-tooth disease	Enrichment	TTR	1.19
86	Nonsyndromic hearing loss	Enrichment	MYO7A	1.18
87	Sensorineural hearing loss	Enrichment	MYO7A	1.12
88	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYO7A	1.09
89	Hereditary breast ovarian cancer syndrome	Enrichment	MYO7A	1.07
90	Deafness, autosomal recessive	Enrichment	MYO7A	1.01
91	Autosomal recessive nonsyndromic deafness	Enrichment	MYO7A	1.00
92	Autism	Enrichment	RPE65	0.96
93	Rare genetic deafness	Enrichment	MYO7A	0.92
94	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYO7A	0.87

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Retinoid cycle disease events

Pathway Network for Retinoid cycle disease events

Pathway network for the Retinoid cycle disease events SuperPath

Member Pathways for Retinoid cycle disease events

Pathways in the Retinoid cycle disease events SuperPath

Gene overlap in member pathways for Retinoid cycle disease events SuperPath

Associated Genes for Retinoid cycle disease events

Associated Disorders for Retinoid cycle disease events

Disorders associated with Retinoid cycle disease events SuperPath

STRING Interaction Network for Retinoid cycle disease events

Sources for Retinoid cycle disease events