Retinol metabolism (TR)

No Pathway Network information available for Retinol metabolism (TR)

Pathways in the Retinol metabolism (TR) SuperPath

#	Name	Source	Genes
1	Retinol metabolism	GeneGo (Thomson Reuters)	ADHFE1 ALDH1A1 ALDH1A2 ALDH1A3 ALDH2 ALDH9A1 BCO1 BCO2 CRABP1 CYP1A1 CYP1A2 CYP1B1 CYP2A6 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 CYP3A5 CYP3A7 CYP4A11 DGAT1 DHRS3 DHRS4 LRAT RDH11 RDH12 RDH14 RDH5 RHO RPE65 UGT1A3 UGT1A8 UGT2B7 XDH (see all 38) (see less)
2	Ifosfamide Pathway, Pharmacokinetics	PharmGKB	ALDH1A1 CYP2A6 CYP2B6 CYP2C8 CYP2C9 CYP3A4 CYP3A5 (see all 7) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	2
2	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	2
3	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	2
4	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	2
5	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	2
6	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	2
7	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	2
8	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	1
9	ALDH1A3	Aldehyde Dehydrogenase 1 Family Member A3	Protein Coding	1
10	ALDH9A1	Aldehyde Dehydrogenase 9 Family Member A1	Protein Coding	1
11	CRABP1	Cellular Retinoic Acid Binding Protein 1	Protein Coding	1
12	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
13	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
14	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	1
15	CYP3A7	Cytochrome P450 Family 3 Subfamily A Member 7	Protein Coding	1
16	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	1
17	CYP2C18	Cytochrome P450 Family 2 Subfamily C Member 18	Protein Coding	1
18	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	1
19	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
20	CYP4A11	Cytochrome P450 Family 4 Subfamily A Member 11	Protein Coding	1
21	RDH5	Retinol Dehydrogenase 5	Protein Coding	1
22	RHO	Rhodopsin	Protein Coding	1
23	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	1
24	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	1
25	XDH	Xanthine Dehydrogenase	Protein Coding	1
26	DGAT1	Diacylglycerol O-Acyltransferase 1	Protein Coding	1
27	ALDH1A2	Aldehyde Dehydrogenase 1 Family Member A2	Protein Coding	1
28	LRAT	Lecithin Retinol Acyltransferase	Protein Coding	1
29	DHRS3	Dehydrogenase/Reductase 3	Protein Coding	1
30	DHRS4	Dehydrogenase/Reductase 4	Protein Coding	1
31	RDH11	Retinol Dehydrogenase 11	Protein Coding	1
32	BCO1	Beta-Carotene Oxygenase 1	Protein Coding	1
33	UGT1A8	UDP Glucuronosyltransferase Family 1 Member A8	Protein Coding	1
34	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	1
35	RDH14	Retinol Dehydrogenase 14	Protein Coding	1
36	BCO2	Beta-Carotene Oxygenase 2	Protein Coding	1
37	ADHFE1	Alcohol Dehydrogenase Iron Containing 1	Protein Coding	1
38	RDH12	Retinol Dehydrogenase 12	Protein Coding	1

Disorders associated with Retinol metabolism (TR) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Coumarin resistance	Enrichment	CYP2A6, CYP2C9	6.16
2	Stargardt disease 1	Enrichment	LRAT, RDH12, RPE65	4.11
3	Eye disease	Enrichment	LRAT, RDH12, RPE65	3.90
4	Hereditary retinal dystrophy	Enrichment	LRAT, RDH11, RDH12, RDH5, RHO, RPE65	3.85
5	Fundus dystrophy	Enrichment	LRAT, RDH11, RDH12, RDH5, RHO, RPE65	3.85
6	Fundus albipunctatus	Enrichment	RDH5, RHO	3.80
7	Retinitis pigmentosa	Enrichment	LRAT, RDH12, RDH5, RHO, RPE65	3.53
8	Crigler-najjar syndrome, type i	Enrichment	UGT1A3, UGT1A8	3.47
9	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A3, UGT1A8	3.47
10	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A3, UGT1A8	3.47
11	Crigler-najjar syndrome, type ii	Enrichment	UGT1A3, UGT1A8	3.47
12	Gilbert syndrome	Enrichment	UGT1A3, UGT1A8	3.38
13	Bilirubin metabolic disorder	Enrichment	UGT1A3, UGT1A8	3.38
14	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.29
15	Efavirenz, poor metabolism of	Enrichment	CYP2B6	3.29
16	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.29
17	Letrozole toxicity	Enrichment	CYP2A6	3.29
18	Congenital stationary night blindness	Enrichment	RDH5, RHO	2.73
19	Tobacco addiction	Enrichment	CYP2A6	2.69
20	Leber plus disease	Enrichment	LRAT, RDH12, RPE65	2.63
21	Hypercarotenemia and vitamin a deficiency, autosomal dominant	Enrichment	BCO1	2.55
22	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.55
23	Night blindness, congenital stationary, autosomal dominant 1	Enrichment	RHO	2.55
24	Leber congenital amaurosis 2	Enrichment	RPE65	2.55
25	Retinitis pigmentosa 87 with choroidal involvement	Enrichment	RPE65	2.55
26	Alcohol sensitivity, acute	Enrichment	ALDH2	2.55
27	Diaphragmatic hernia 4, with cardiovascular defects	Enrichment	ALDH1A2	2.55
28	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	2.55
29	Retinitis pigmentosa 4	Enrichment	RHO	2.55
30	Retinitis pigmentosa 20	Enrichment	RPE65	2.55
31	Hereditary hypercarotenemia and vitamin a deficiency	Enrichment	BCO1	2.55
32	Glaucoma 1, open angle, a	Enrichment	CYP1B1	2.25
33	Xanthinuria, type i	Enrichment	XDH	2.25
34	Retinal dystrophy, juvenile cataracts, and short stature syndrome	Enrichment	RDH11	2.25
35	Anterior segment dysgenesis 6	Enrichment	CYP1B1	2.25
36	Acth deficiency, isolated	Enrichment	RPE65	2.25
37	Amed syndrome, digenic	Enrichment	ALDH2	2.25
38	Neuropathy, congenital hypomyelinating, 2	Enrichment	RHO	2.25
39	Microphthalmia, isolated 8	Enrichment	ALDH1A3	2.25
40	Optic disk drusen	Enrichment	RHO	2.25
41	Leber congenital amaurosis 14	Enrichment	LRAT	2.25
42	Primary congenital glaucoma	Enrichment	CYP1B1	2.25
43	Congenital isolated adrenocorticotropic hormone deficiency	Enrichment	RPE65	2.25
44	Leber congenital amaurosis 13	Enrichment	RDH12	2.08
45	Xanthinuria, type ii	Enrichment	XDH	2.08
46	Microcephaly 17, primary, autosomal recessive	Enrichment	RHO	2.08
47	Isolated anophthalmia-microphthalmia syndrome	Enrichment	ALDH1A3	2.08
48	Hypertension, essential	Enrichment	CYP3A5	2.06
49	Glaucoma 3, primary infantile, b	Enrichment	CYP1B1	1.95
50	Diarrhea 7, protein-losing enteropathy type	Enrichment	DGAT1	1.95
51	Macular dystrophy with or without cone dysfunction	Enrichment	RDH12	1.95
52	Retinal detachment	Enrichment	RHO	1.86
53	Congenital diarrhea 7 with exudative enteropathy	Enrichment	DGAT1	1.86
54	Night blindness	Enrichment	RHO	1.86
55	Juvenile glaucoma	Enrichment	CYP1B1	1.86
56	Cone-rod dystrophy 2	Enrichment	RDH12, RHO	1.81
57	Lung cancer	Enrichment	CYP2A6	1.79
58	Glaucoma, primary open angle	Enrichment	CYP1B1	1.78
59	Alcohol dependence	Enrichment	ALDH2	1.78
60	Anterior segment dysgenesis 5	Enrichment	CYP1B1	1.78
61	Diarrhea	Enrichment	DGAT1	1.78
62	Autism	Enrichment	ALDH1A3, RPE65	1.76
63	Glaucoma 3, primary congenital, a	Enrichment	CYP1B1	1.71
64	Coats disease	Enrichment	RHO	1.71
65	Retinal degeneration	Enrichment	RPE65	1.71
66	Leber congenital amaurosis 1	Enrichment	LRAT	1.65
67	Peters-plus syndrome	Enrichment	CYP1B1	1.56
68	Nanophthalmos	Enrichment	ALDH1A3	1.52
69	Cataract	Enrichment	RHO	1.41
70	Anterior segment dysgenesis	Enrichment	CYP1B1	1.38
71	Macs syndrome	Enrichment	ALDH1A3	1.26
72	Microphthalmia	Enrichment	ALDH1A3	1.22
73	Optic atrophy plus syndrome	Enrichment	RDH5	0.93

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Retinol metabolism (TR)

Pathway Network for Retinol metabolism (TR)

Member Pathways for Retinol metabolism (TR)

Pathways in the Retinol metabolism (TR) SuperPath

Associated Genes for Retinol metabolism (TR)

Associated Disorders for Retinol metabolism (TR)

Disorders associated with Retinol metabolism (TR) SuperPath

STRING Interaction Network for Retinol metabolism (TR)

Sources for Retinol metabolism (TR)