Retinol metabolism (WikiPathways)

No Pathway Network information available for Retinol metabolism (WikiPathways)

#	Name	Source	Genes
1	Retinol metabolism	WikiPathways	ADH1A ALDH1A1 AOX1 AWAT2 BCO1 CYP1A1 CYP2A6 CYP2W1 CYP3A7 CYP3A7-CYP3A51P DHRS4 DHRS9 LRAT PNPLA4 RDH12 RDH13 RPE65 SDR16C5 (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SDR16C5	Short Chain Dehydrogenase/Reductase Family 16C Member 5	Protein Coding	1
2	CYP2W1	Cytochrome P450 Family 2 Subfamily W Member 1	Protein Coding	1
3	DHRS4	Dehydrogenase/Reductase 4	Protein Coding	1
4	DHRS9	Dehydrogenase/Reductase 9	Protein Coding	1
5	AOX1	Aldehyde Oxidase 1	Protein Coding	1
6	RDH13	Retinol Dehydrogenase 13	Protein Coding	1
7	RDH12	Retinol Dehydrogenase 12	Protein Coding	1
8	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	1
9	ADH1A	Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide	Protein Coding	1
10	BCO1	Beta-Carotene Oxygenase 1	Protein Coding	1
11	LRAT	Lecithin Retinol Acyltransferase	Protein Coding	1
12	AWAT2	Acyl-CoA Wax Alcohol Acyltransferase 2	Protein Coding	1
13	PNPLA4	Patatin Like Domain 4, Phospholipase And Triacylglycerol Lipase	Protein Coding	1
14	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	1
15	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
16	CYP3A7-CYP3A51P	CYP3A7-CYP3A51P Readthrough	Protein Coding	1
17	CYP3A7	Cytochrome P450 Family 3 Subfamily A Member 7	Protein Coding	1
18	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Stargardt disease 1	Enrichment	LRAT, RDH12, RPE65	5.11
2	Eye disease	Enrichment	LRAT, RDH12, RPE65	4.90
3	Leber plus disease	Enrichment	LRAT, RDH12, RPE65	3.60
4	Hypercarotenemia and vitamin a deficiency, autosomal dominant	Enrichment	BCO1	2.88
5	Leber congenital amaurosis 2	Enrichment	RPE65	2.88
6	Retinitis pigmentosa 87 with choroidal involvement	Enrichment	RPE65	2.88
7	Retinitis pigmentosa 20	Enrichment	RPE65	2.88
8	Hereditary hypercarotenemia and vitamin a deficiency	Enrichment	BCO1	2.88
9	Letrozole toxicity	Enrichment	CYP2A6	2.88
10	Retinitis pigmentosa	Enrichment	LRAT, RDH12, RPE65	2.59
11	Acth deficiency, isolated	Enrichment	RPE65	2.58
12	Leber congenital amaurosis 14	Enrichment	LRAT	2.58
13	Congenital isolated adrenocorticotropic hormone deficiency	Enrichment	RPE65	2.58
14	Leber congenital amaurosis 13	Enrichment	RDH12	2.40
15	Coumarin resistance	Enrichment	CYP2A6	2.40
16	Tobacco addiction	Enrichment	CYP2A6	2.28
17	Macular dystrophy with or without cone dysfunction	Enrichment	RDH12	2.28
18	Hereditary retinal dystrophy	Enrichment	LRAT, RDH12, RPE65	2.21
19	Fundus dystrophy	Enrichment	LRAT, RDH12, RPE65	2.21
20	Retinal degeneration	Enrichment	RPE65	2.03
21	Leber congenital amaurosis 1	Enrichment	LRAT	1.98
22	Lung cancer	Enrichment	CYP2A6	1.38
23	Cone-rod dystrophy 2	Enrichment	RDH12	1.06
24	Autism	Enrichment	RPE65	1.04

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Retinol metabolism (WikiPathways)