RHO GTPases Activate NADPH Oxidases

No Pathway Network information available for RHO GTPases Activate NADPH Oxidases

Pathways in the RHO GTPases Activate NADPH Oxidases SuperPath

#	Name	Source	Genes
1	RHO GTPases Activate NADPH Oxidases	Reactome	CYBA CYBB MAPK1 MAPK11 MAPK14 MAPK3 NCF1 NCF2 NCF4 NOX1 NOX3 NOXA1 NOXO1 PIK3C3 PIK3R4 PIN1 PRKCA PRKCB PRKCD PRKCZ RAC1 RAC2 S100A8 S100A9 (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOXA1	NADPH Oxidase Activator 1	Protein Coding	1
2	NOXO1	NADPH Oxidase Organizer 1	Protein Coding	1
3	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
4	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	1
5	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	1
6	NOX1	NADPH Oxidase 1	Protein Coding	1
7	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
8	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	1
9	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	1
10	NOX3	NADPH Oxidase 3	Protein Coding	1
11	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
12	PIN1	Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1	Protein Coding	1
13	PRKCA	Protein Kinase C Alpha	Protein Coding	1
14	PRKCB	Protein Kinase C Beta	Protein Coding	1
15	PRKCD	Protein Kinase C Delta	Protein Coding	1
16	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
17	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
18	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
19	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
20	RAC1	Rac Family Small GTPase 1	Protein Coding	1
21	RAC2	Rac Family Small GTPase 2	Protein Coding	1
22	S100A8	S100 Calcium Binding Protein A8	Protein Coding	1
23	S100A9	S100 Calcium Binding Protein A9	Protein Coding	1
24	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	1

Disorders associated with RHO GTPases Activate NADPH Oxidases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2, NCF4	10.48
2	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	5.05
3	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	4.75
4	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	2.75
5	Immunodeficiency 34	Enrichment	CYBB	2.75
6	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.75
7	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.75
8	Noonan syndrome 13	Enrichment	MAPK1	2.75
9	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.75
10	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.75
11	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.75
12	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.75
13	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.75
14	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.75
15	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	2.45
16	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	2.45
17	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.45
18	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	2.28
19	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	2.28
20	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.15
21	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.80
22	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.80
23	Specific learning disability	Enrichment	MAPK1	1.71
24	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.64
25	Heart, malformation of	Enrichment	MAPK1	1.50
26	Williams-beuren syndrome	Enrichment	NCF1	1.46
27	Microcephaly	Enrichment	MAPK1	0.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RHO GTPases Activate NADPH Oxidases

Pathway Network for RHO GTPases Activate NADPH Oxidases

Member Pathways for RHO GTPases Activate NADPH Oxidases

Pathways in the RHO GTPases Activate NADPH Oxidases SuperPath

Associated Genes for RHO GTPases Activate NADPH Oxidases

Associated Disorders for RHO GTPases Activate NADPH Oxidases

Disorders associated with RHO GTPases Activate NADPH Oxidases SuperPath

STRING Interaction Network for RHO GTPases Activate NADPH Oxidases

Sources for RHO GTPases Activate NADPH Oxidases