RhoA signaling pathway

No Pathway Network information available for RhoA signaling pathway

Pathways in the RhoA signaling pathway SuperPath

#	Name	Source	Genes
1	RhoA signaling pathway	PubChem	ACTA1 ATF2 CCN1 CDC42 CDKN1B CFL1 CIT DIAPH1 ETV5 F2RL2 FOS ITGB1 JUN LIMK1 MAP2K3 MAP2K4 MAPK12 MAPK8 MRTFA MYL2 PARD6A PKN1 PKN2 PLD1 PPP1R12A PRKCZ PTEN RHOA ROCK1 SCAI SH3GL2 SLC9A1 SLC9A3 SRF TLN1 VCL (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
2	ETV5	ETS Variant Transcription Factor 5	Protein Coding	1
3	CCN1	Cellular Communication Network Factor 1	Protein Coding	1
4	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	1
5	MYL2	Myosin Light Chain 2	Protein Coding	1
6	PLD1	Phospholipase D1	Protein Coding	1
7	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
8	PKN2	Protein Kinase N2	Protein Coding	1
9	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
10	SCAI	Suppressor Of Cancer Cell Invasion	Protein Coding	1
11	MRTFA	Myocardin Related Transcription Factor A	Protein Coding	1
12	CIT	Citron Rho-Interacting Serine/Threonine Kinase	Protein Coding	1
13	PKN1	Protein Kinase N1	Protein Coding	1
14	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
15	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
16	SRF	Serum Response Factor	Protein Coding	1
17	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
18	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	1
19	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
20	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
21	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
22	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
23	SLC9A1	Solute Carrier Family 9 Member A1	Protein Coding	1
24	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
25	VCL	Vinculin	Protein Coding	1
26	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
27	CDC42	Cell Division Cycle 42	Protein Coding	1
28	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
29	CFL1	Cofilin 1	Protein Coding	1
30	LIMK1	LIM Domain Kinase 1	Protein Coding	1
31	TLN1	Talin 1	Protein Coding	1
32	RHOA	Ras Homolog Family Member A	Protein Coding	1
33	ATF2	Activating Transcription Factor 2	Protein Coding	1
34	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	1
35	SLC9A3	Solute Carrier Family 9 Member A3	Protein Coding	1
36	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1

Disorders associated with RhoA signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1, MYL2	3.15
2	Dilated cardiomyopathy	Enrichment	ACTA1, MYL2, VCL	2.91
3	Vacterl association with hydrocephalus	Enrichment	PTEN	2.58
4	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.58
5	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.58
6	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.58
7	Lichtenstein-knorr syndrome	Enrichment	SLC9A1	2.58
8	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.58
9	Papillary tumor of the pineal region	Enrichment	PTEN	2.58
10	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.58
11	Neuroendocrine tumor	Enrichment	CDKN1B	2.58
12	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.58
13	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.58
14	Glioma susceptibility 2	Enrichment	PTEN	2.58
15	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.58
16	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.58
17	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.58
18	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.58
19	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.58
20	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.58
21	Zebra body myopathy	Enrichment	ACTA1	2.58
22	Capillary leak syndrome	Enrichment	TLN1	2.58
23	Nocarh syndrome	Enrichment	CDC42	2.58
24	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.58
25	Actin-accumulation myopathy	Enrichment	ACTA1	2.58
26	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.28
27	Diarrhea 8, secretory sodium, congenital	Enrichment	SLC9A3	2.28
28	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	2.28
29	Immunodeficiency 66	Enrichment	MRTFA	2.28
30	Cardiomyopathy, familial hypertrophic, 10	Enrichment	MYL2	2.28
31	Immune system disease	Enrichment	CDC42	2.28
32	Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy	Enrichment	MYL2	2.28
33	Vacterl with hydrocephalus	Enrichment	PTEN	2.28
34	Juvenile polyposis of infancy	Enrichment	PTEN	2.28
35	Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)	Enrichment	MRTFA	2.28
36	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	SLC9A3	2.10
37	Microcephaly 17, primary, autosomal recessive	Enrichment	CIT	2.10
38	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.10
39	Nemaline myopathy 2	Enrichment	ACTA1	1.98
40	Congenital generalized lipodystrophy	Enrichment	FOS	1.98
41	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.98
42	Primary hyperparathyroidism	Enrichment	CDKN1B	1.98
43	Intermediate nemaline myopathy	Enrichment	ACTA1	1.98
44	Glioma	Enrichment	PTEN	1.98
45	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.88
46	Macrocephaly/autism syndrome	Enrichment	PTEN	1.88
47	Hemangioma	Enrichment	PTEN	1.88
48	Histiocytoid hemangioma	Enrichment	FOS	1.88
49	Acute megakaryocytic leukemia	Enrichment	PTEN	1.88
50	Hemimegalencephaly	Enrichment	PTEN	1.88
51	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.88
52	Cowden syndrome 1	Enrichment	PTEN	1.80
53	Hemihyperplasia, isolated	Enrichment	RHOA	1.80
54	Moyamoya disease 1	Enrichment	DIAPH1	1.80
55	Pendred syndrome	Enrichment	DIAPH1	1.80
56	Typical nemaline myopathy	Enrichment	ACTA1	1.80
57	Breast cancer	Enrichment	JUN, PTEN	1.77
58	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.73
59	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.73
60	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.73
61	Follicular thyroid carcinoma	Enrichment	PTEN	1.73
62	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.73
63	Familial isolated restrictive cardiomyopathy	Enrichment	MYL2	1.73
64	Cowden syndrome	Enrichment	PTEN	1.63
65	Nemaline myopathy	Enrichment	ACTA1	1.58
66	Melanoma	Enrichment	PTEN	1.58
67	Meningioma, familial	Enrichment	PTEN	1.54
68	Uterine corpus cancer	Enrichment	PTEN	1.54
69	Ovarian cancer	Enrichment	CDKN1B, PTEN	1.53
70	Meningioma	Enrichment	PTEN	1.50
71	Neural tube defects	Enrichment	ITGB1	1.47
72	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.47
73	Heart disease	Enrichment	MYL2	1.44
74	Rhabdomyosarcoma	Enrichment	PTEN	1.38
75	Cardiomyopathy, dilated, 1e	Enrichment	MYL2	1.35
76	Neuromuscular disease	Enrichment	ACTA1	1.33
77	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, PTEN	1.32
78	Diffuse large b-cell lymphoma	Enrichment	PTEN	1.31
79	Congenital myopathy	Enrichment	ACTA1	1.31
80	Williams-beuren syndrome	Enrichment	LIMK1	1.29
81	Endometrial cancer	Enrichment	PTEN	1.27
82	Centronuclear myopathy	Enrichment	ACTA1	1.27
83	Hydrops fetalis, nonimmune	Enrichment	ACTA1	1.18
84	Auditory neuropathy	Enrichment	DIAPH1	1.18
85	Bladder cancer	Enrichment	PTEN	1.13
86	Prostate cancer	Enrichment	PTEN	1.13
87	Non-immune hydrops fetalis	Enrichment	ACTA1	1.10
88	Cystic fibrosis	Enrichment	SLC9A3	1.09
89	Primary autosomal recessive microcephaly	Enrichment	CIT	1.09
90	Familial hypertrophic cardiomyopathy	Enrichment	MYL2	1.08
91	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	1.03
92	Epilepsy	Enrichment	DIAPH1	1.00
93	Myopathy	Enrichment	ACTA1	1.00
94	Distal arthrogryposis	Enrichment	ACTA1	0.98
95	Gastric cancer	Enrichment	PTEN	0.97
96	Hypertrophic cardiomyopathy	Enrichment	MYL2	0.97
97	Hereditary breast carcinoma	Enrichment	PTEN	0.96
98	Familial isolated dilated cardiomyopathy	Enrichment	VCL	0.88
99	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.87
100	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	0.86
101	Rare genetic deafness	Enrichment	DIAPH1	0.72
102	Congenital nervous system abnormality	Enrichment	PTEN	0.61
103	Nervous system disease	Enrichment	PTEN	0.61
104	Autism spectrum disorder	Enrichment	PTEN	0.60
105	Microcephaly	Enrichment	DIAPH1	0.55

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RhoA signaling pathway

Pathway Network for RhoA signaling pathway

Member Pathways for RhoA signaling pathway

Pathways in the RhoA signaling pathway SuperPath

Associated Genes for RhoA signaling pathway

Associated Disorders for RhoA signaling pathway

Disorders associated with RhoA signaling pathway SuperPath

STRING Interaction Network for RhoA signaling pathway

Sources for RhoA signaling pathway