RHOBTB GTPase Cycle

Pathway network for the RHOBTB GTPase Cycle SuperPath

Sources:

Reactome

Pathways in the RHOBTB GTPase Cycle SuperPath

#	Name	Source	Genes
1	RHOBTB GTPase Cycle	Reactome	ACTG1 ACTN1 CCT2 CCT6A CCT7 CDC37 COPS2 COPS4 CPSF7 CUL3 DBN1 DDX39B GPS1 HNRNPC HSP90AA1 HSP90AB1 MSI2 MYO6 PDE5A PHIP RBBP6 RBMX RHOBTB1 RHOBTB2 RNF20 ROCK1 ROCK2 SPEN SRRM1 STK38 TMOD3 TRA2B TWF1 TXNL1 VIM (see all 35) (see less)
2	RHOBTB2 GTPase cycle	Reactome	ACTG1 ACTN1 CCT2 CCT6A CCT7 CDC37 CUL3 DBN1 DDX39B HNRNPC HSP90AA1 HSP90AB1 MSI2 MYO6 PHIP RBMX RHOBTB2 SRRM1 STK38 TMOD3 TRA2B TWF1 TXNL1 (see all 23) (see less)
3	RHOBTB1 GTPase cycle	Reactome	CCT2 CCT7 COPS2 COPS4 CPSF7 CUL3 DBN1 GPS1 HNRNPC MYO6 PDE5A RBBP6 RBMX RHOBTB1 RNF20 ROCK1 ROCK2 SPEN SRRM1 STK38 TRA2B TXNL1 VIM (see all 23) (see less)

Gene overlap in member pathways for RHOBTB GTPase Cycle SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SRRM1	Serine And Arginine Repetitive Matrix 1	Protein Coding	3
2	CCT7	Chaperonin Containing TCP1 Subunit 7	Protein Coding	3
3	CCT2	Chaperonin Containing TCP1 Subunit 2	Protein Coding	3
4	STK38	Serine/Threonine Kinase 38	Protein Coding	3
5	DBN1	Drebrin 1	Protein Coding	3
6	RBMX	RNA Binding Motif Protein X-Linked	Protein Coding	3
7	HNRNPC	Heterogeneous Nuclear Ribonucleoprotein C	Protein Coding	3
8	MYO6	Myosin VI	Protein Coding	3
9	TRA2B	Transformer 2 Beta Homolog	Protein Coding	3
10	CUL3	Cullin 3	Protein Coding	3
11	TXNL1	Thioredoxin Like 1	Protein Coding	3
12	CDC37	Cell Division Cycle 37, HSP90 Cochaperone	Protein Coding	2
13	MSI2	Musashi RNA Binding Protein 2	Protein Coding	2
14	SPEN	Spen Family Transcriptional Repressor	Protein Coding	2
15	RHOBTB2	Rho Related BTB Domain Containing 2	Protein Coding	2
16	GPS1	G Protein Pathway Suppressor 1	Protein Coding	2
17	TMOD3	Tropomodulin 3	Protein Coding	2
18	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
19	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	2
20	COPS4	COP9 Signalosome Subunit 4	Protein Coding	2
21	PHIP	PHIP Subunit Of CUL4-Ring Ligase Complex	Protein Coding	2
22	RNF20	Ring Finger Protein 20	Protein Coding	2
23	TWF1	Twinfilin Actin Binding Protein 1	Protein Coding	2
24	RBBP6	RB Binding Protein 6, Ubiquitin Ligase	Protein Coding	2
25	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	2
26	ACTG1	Actin Gamma 1	Protein Coding	2
27	VIM	Vimentin	Protein Coding	2
28	DDX39B	DExD-Box Helicase 39B	Protein Coding	2
29	CPSF7	Cleavage And Polyadenylation Specific Factor 7	Protein Coding	2
30	PDE5A	Phosphodiesterase 5A	Protein Coding	2
31	ACTN1	Actinin Alpha 1	Protein Coding	2
32	CCT6A	Chaperonin Containing TCP1 Subunit 6A	Protein Coding	2
33	COPS2	COP9 Signalosome Subunit 2	Protein Coding	2
34	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	2
35	RHOBTB1	Rho Related BTB Domain Containing 1	Protein Coding	2

Disorders associated with RHOBTB GTPase Cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Non-syndromic genetic deafness	Enrichment	ACTG1, MYO6	2.78
2	Intellectual developmental disorder, x-linked, syndromic, gustavson type	Enrichment	RBMX	2.77
3	Deafness, autosomal dominant 22	Enrichment	MYO6	2.77
4	Pseudohypoaldosteronism, type iie	Enrichment	CUL3	2.77
5	Deafness, autosomal recessive 37	Enrichment	MYO6	2.77
6	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.77
7	Neurodevelopmental disorder with or without autism or seizures	Enrichment	CUL3	2.77
8	Developmental and epileptic encephalopathy 64	Enrichment	RHOBTB2	2.77
9	Intellectual developmental disorder, autosomal dominant 74	Enrichment	HNRNPC	2.77
10	Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome	Enrichment	MYO6	2.77
11	Autosomal dominant nonsyndromic hearing loss 22	Enrichment	MYO6	2.77
12	Radio-tartaglia syndrome	Enrichment	SPEN	2.77
13	Premature aging	Enrichment	VIM	2.77
14	Nonsyndromic hearing loss	Enrichment	ACTG1, MYO6	2.64
15	Intellectual developmental disorder, x-linked, syndromic, shashi type	Enrichment	RBMX	2.47
16	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	CUL3	2.47
17	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.47
18	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.47
19	Syndromic x-linked intellectual disability shashi type	Enrichment	RBMX	2.47
20	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTG1	2.47
21	Cataract 30	Enrichment	VIM	2.47
22	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, MYO6	2.46
23	Pseudohypoaldosteronism, type iia	Enrichment	CUL3	2.29
24	Chung-jansen syndrome	Enrichment	PHIP	2.29
25	Rare genetic deafness	Enrichment	ACTG1, MYO6	2.11
26	Coloboma of choroid and retina	Enrichment	ACTG1	2.07
27	Histiocytoid hemangioma	Enrichment	VIM	2.07
28	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	MYO6	1.99
29	Rett syndrome	Enrichment	RHOBTB2	1.93
30	Alternating hemiplegia of childhood	Enrichment	RHOBTB2	1.87
31	Choreatic disease	Enrichment	RHOBTB2	1.87
32	Autism spectrum disorder	Enrichment	CUL3, SPEN	1.84
33	Cat eye syndrome	Enrichment	ACTG1	1.77
34	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	1.77
35	Cataract 30, multiple types	Enrichment	VIM	1.77
36	Complex neurodevelopmental disorder	Enrichment	CUL3, HNRNPC	1.73
37	Nk-cell enteropathy	Enrichment	CUL3	1.66
38	Chromosome 1p36 deletion syndrome	Enrichment	SPEN	1.66
39	Syndromic intellectual disability	Enrichment	PHIP	1.55
40	Lissencephaly	Enrichment	ACTG1	1.46
41	Myocardial infarction	Enrichment	CCT7	1.44
42	Ear malformation	Enrichment	MYO6	1.40
43	Cakut	Enrichment	ACTG1	1.25
44	Dystonia	Enrichment	RHOBTB2	1.24
45	Thrombocytopenia	Enrichment	ACTN1	1.11
46	Schizophrenia	Enrichment	PHIP	1.02
47	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYO6	0.85
48	Leber plus disease	Enrichment	CCT2	0.83
49	Microcephaly	Enrichment	ACTG1	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RHOBTB GTPase Cycle

Pathway Network for RHOBTB GTPase Cycle

Pathway network for the RHOBTB GTPase Cycle SuperPath

Member Pathways for RHOBTB GTPase Cycle

Pathways in the RHOBTB GTPase Cycle SuperPath

Gene overlap in member pathways for RHOBTB GTPase Cycle SuperPath

Associated Genes for RHOBTB GTPase Cycle

Associated Disorders for RHOBTB GTPase Cycle

Disorders associated with RHOBTB GTPase Cycle SuperPath

STRING Interaction Network for RHOBTB GTPase Cycle

Sources for RHOBTB GTPase Cycle