RHOC GTPase cycle

Pathway network for the RHOC GTPase cycle SuperPath

Sources:

Reactome

Pathways in the RHOC GTPase cycle SuperPath

#	Name	Source	Genes
1	RHOC GTPase cycle	Reactome	ABCD3 ABR ACBD5 AKAP13 ANLN ARHGAP1 ARHGAP18 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 ARHGDIA ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF17 ARHGEF25 ARHGEF28 ARHGEF40 ARHGEF5 BCR C1QBP CAV1 CAVIN1 CCDC187 CIT DAAM1 DEPDC1B DIAPH1 DIAPH3 DLC1 ERBIN FMNL2 FMNL3 IQGAP1 IQGAP3 JUP LBR LMAN1 MACO1 MCAM MCF2 MCF2L MYO9B OPHN1 PIK3R1 PKN1 PKN2 PKN3 PREX1 RACGAP1 RHOA RHOC ROCK1 ROCK2 RTKN SLK STARD13 STK10 STOM STX5 TFRC TJP2 TMPO VAMP3 VANGL1 VAPB VAV2 (see all 72) (see less)
2	RHOA GTPase cycle	Reactome	AAAS ABCD3 ABR ACBD5 ACTC1 AKAP13 ANLN ARAP1 ARAP2 ARAP3 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP18 ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP26 ARHGAP28 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP6 ARHGAP8 ARHGAP9 ARHGDIA ARHGDIB ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARHGEF40 ARHGEF5 ARHGEF7 ATP6AP1 BCAP31 BCR C1QBP CAV1 CAVIN1 CIT DAAM1 DDRGK1 DEF6 DEPDC1B DIAPH1 DIAPH3 DLC1 DOCK2 ECT2 EMC3 ERBIN FAF2 FAM13A FARP1 FMNL3 GMIP HMOX2 IQGAP1 IQGAP3 JUP KALRN KTN1 LBR LMAN1 MACO1 MCAM MCF2 MCF2L MYO9A MYO9B NET1 NGEF OPHN1 PCDH7 PGRMC2 PIK3R1 PIK3R2 PKN1 PKN2 PKN3 PLD1 PLEKHG3 PLEKHG4 PLEKHG5 PLEKHG6 PREX1 PREX2 RACGAP1 RASGRF2 RHOA RHPN1 RHPN2 ROCK1 ROCK2 RTKN SCFD1 SLK SNAP23 SOWAHC SRGAP1 STARD13 STARD8 STBD1 STK10 STOM STX5 TAGAP TEX2 TFRC TIAM1 TJP2 TMEM87A TMPO TRIO VAMP3 VANGL1 VAPB VAV1 VAV2 VAV3 VMA22 YKT6 (see all 146) (see less)
3	RHOB GTPase cycle	Reactome	ABR ACTC1 AKAP13 ANLN ARHGAP1 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 ARHGDIG ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF17 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF5 BCR CAV1 CAVIN1 CIT DAAM1 DEPDC1B DIAPH1 DIAPH3 DLC1 ECT2 ERBIN IQGAP3 JUP MCAM MCF2 MCF2L MYO9A MYO9B NET1 OPHN1 PCDH7 PIK3R1 PIK3R2 PKN1 PKN2 PKN3 PREX1 RACGAP1 RHOB RHPN2 ROCK1 ROCK2 RTKN SLK SNAP23 SOWAHC STARD13 STARD8 STK10 STOM TFRC TJP2 VAMP3 VANGL1 VAV2 (see all 68) (see less)

Gene overlap in member pathways for RHOC GTPase cycle SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DLC1	DLC1 Rho GTPase Activating Protein	Protein Coding	3
2	CIT	Citron Rho-Interacting Serine/Threonine Kinase	Protein Coding	3
3	AKAP13	A-Kinase Anchoring Protein 13	Protein Coding	3
4	ARHGEF25	Rho Guanine Nucleotide Exchange Factor 25	Protein Coding	3
5	IQGAP3	IQ Motif Containing GTPase Activating Protein 3	Protein Coding	3
6	DIAPH1	Diaphanous Related Formin 1	Protein Coding	3
7	STOM	Stomatin	Protein Coding	3
8	DAAM1	Dishevelled Associated Activator Of Morphogenesis 1	Protein Coding	3
9	ARHGAP26	Rho GTPase Activating Protein 26	Protein Coding	3
10	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	3
11	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	3
12	CAVIN1	Caveolae Associated Protein 1	Protein Coding	3
13	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	3
14	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	3
15	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	3
16	PKN3	Protein Kinase N3	Protein Coding	3
17	JUP	Junction Plakoglobin	Protein Coding	3
18	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	3
19	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	3
20	MCAM	Melanoma Cell Adhesion Molecule	Protein Coding	3
21	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	3
22	MYO9B	Myosin IXB	Protein Coding	3
23	OPHN1	Oligophrenin 1	Protein Coding	3
24	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
25	ANLN	Anillin, Actin Binding Protein	Protein Coding	3
26	ARHGEF10L	Rho Guanine Nucleotide Exchange Factor 10 Like	Protein Coding	3
27	DEPDC1B	DEP Domain Containing 1B	Protein Coding	3
28	PKN1	Protein Kinase N1	Protein Coding	3
29	PKN2	Protein Kinase N2	Protein Coding	3
30	ERBIN	Erbb2 Interacting Protein	Protein Coding	3
31	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	3
32	ARHGAP21	Rho GTPase Activating Protein 21	Protein Coding	3
33	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	3
34	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	3
35	RTKN	Rhotekin	Protein Coding	3
36	ARHGEF28	Rho Guanine Nucleotide Exchange Factor 28	Protein Coding	3
37	STK10	Serine/Threonine Kinase 10	Protein Coding	3
38	TFRC	Transferrin Receptor	Protein Coding	3
39	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	3
40	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	3
41	ARHGAP39	Rho GTPase Activating Protein 39	Protein Coding	3
42	DIAPH3	Diaphanous Related Formin 3	Protein Coding	3
43	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	3
44	CAV1	Caveolin 1	Protein Coding	3
45	STARD13	StAR Related Lipid Transfer Domain Containing 13	Protein Coding	3
46	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	3
47	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	3
48	TJP2	Tight Junction Protein 2	Protein Coding	3
49	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	3
50	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	3
51	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	3
52	SLK	STE20 Like Kinase	Protein Coding	3
53	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	3
54	ARHGEF17	Rho Guanine Nucleotide Exchange Factor 17	Protein Coding	3
55	RHOA	Ras Homolog Family Member A	Protein Coding	2
56	LBR	Lamin B Receptor	Protein Coding	2
57	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	2
58	LMAN1	Lectin, Mannose Binding 1	Protein Coding	2
59	MACO1	Macoilin 1	Protein Coding	2
60	ARHGEF40	Rho Guanine Nucleotide Exchange Factor 40	Protein Coding	2
61	ABCD3	ATP Binding Cassette Subfamily D Member 3	Protein Coding	2
62	STX5	Syntaxin 5	Protein Coding	2
63	C1QBP	Complement C1q Binding Protein	Protein Coding	2
64	TMPO	Thymopoietin	Protein Coding	2
65	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	2
66	FMNL3	Formin Like 3	Protein Coding	2
67	ACBD5	Acyl-CoA Binding Domain Containing 5	Protein Coding	2
68	VAPB	VAMP Associated Protein B And C	Protein Coding	2
69	ARHGAP18	Rho GTPase Activating Protein 18	Protein Coding	2
70	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	2
71	ECT2	Epithelial Cell Transforming 2	Protein Coding	2
72	MYO9A	Myosin IXA	Protein Coding	2
73	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	2
74	PCDH7	Protocadherin 7	Protein Coding	2
75	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
76	SOWAHC	Sosondowah Ankyrin Repeat Domain Family Member C	Protein Coding	2
77	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	2
78	RHPN2	Rhophilin Rho GTPase Binding Protein 2	Protein Coding	2
79	SNAP23	Synaptosome Associated Protein 23	Protein Coding	2
80	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	2
81	STARD8	StAR Related Lipid Transfer Domain Containing 8	Protein Coding	2
82	FMNL2	Formin Like 2	Protein Coding	1
83	RHOC	Ras Homolog Family Member C	Protein Coding	1
84	CCDC187	Coiled-Coil Domain Containing 187	Protein Coding	1
85	BCAP31	B Cell Receptor Associated Protein 31	Protein Coding	1
86	FAM13A	Family With Sequence Similarity 13 Member A	Protein Coding	1
87	FARP1	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1	Protein Coding	1
88	PGRMC2	Progesterone Receptor Membrane Component 2	Protein Coding	1
89	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
90	YKT6	YKT6 Vesicular SNARE Protein	Protein Coding	1
91	RHPN1	Rhophilin Rho GTPase Binding Protein 1	Protein Coding	1
92	ARAP2	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2	Protein Coding	1
93	ARAP1	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	1
94	TAGAP	T Cell Activation RhoGTPase Activating Protein	Protein Coding	1
95	ARHGEF19	Rho Guanine Nucleotide Exchange Factor 19	Protein Coding	1
96	ARHGAP42	Rho GTPase Activating Protein 42	Protein Coding	1
97	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	1
98	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	1
99	FAF2	Fas Associated Factor Family Member 2	Protein Coding	1
100	SCFD1	Sec1 Family Domain Containing 1	Protein Coding	1
101	ARHGEF18	Rho/Rac Guanine Nucleotide Exchange Factor 18	Protein Coding	1
102	ARHGAP45	Rho GTPase Activating Protein 45	Protein Coding	1
103	ARHGAP8	Rho GTPase Activating Protein 8	Protein Coding	1
104	ARHGAP30	Rho GTPase Activating Protein 30	Protein Coding	1
105	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	1
106	PLEKHG4	Pleckstrin Homology And RhoGEF Domain Containing G4	Protein Coding	1
107	TMEM87A	Transmembrane Protein 87A	Protein Coding	1
108	PLEKHG3	Pleckstrin Homology And RhoGEF Domain Containing G3	Protein Coding	1
109	HMOX2	Heme Oxygenase 2	Protein Coding	1
110	ARHGAP40	Rho GTPase Activating Protein 40	Protein Coding	1
111	KTN1	Kinectin 1	Protein Coding	1
112	ARHGAP4	Rho GTPase Activating Protein 4	Protein Coding	1
113	ARHGAP6	Rho GTPase Activating Protein 6	Protein Coding	1
114	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
115	DEF6	DEF6 Guanine Nucleotide Exchange Factor	Protein Coding	1
116	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	1
117	GMIP	GEM Interacting Protein	Protein Coding	1
118	PLD1	Phospholipase D1	Protein Coding	1
119	ATP6AP1	ATPase H+ Transporting Accessory Protein 1	Protein Coding	1
120	PLEKHG6	Pleckstrin Homology And RhoGEF Domain Containing G6	Protein Coding	1
121	EMC3	ER Membrane Protein Complex Subunit 3	Protein Coding	1
122	TEX2	Testis Expressed 2	Protein Coding	1
123	PLEKHG5	Pleckstrin Homology And RhoGEF Domain Containing G5	Protein Coding	1
124	ARHGAP31	Rho GTPase Activating Protein 31	Protein Coding	1
125	SRGAP1	SLIT-ROBO Rho GTPase Activating Protein 1	Protein Coding	1
126	ARHGAP20	Rho GTPase Activating Protein 20	Protein Coding	1
127	ARHGAP23	Rho GTPase Activating Protein 23	Protein Coding	1
128	ARHGAP22	Rho GTPase Activating Protein 22	Protein Coding	1
129	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	1
130	ARHGAP9	Rho GTPase Activating Protein 9	Protein Coding	1
131	ARAP3	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3	Protein Coding	1
132	DDRGK1	DDRGK Domain Containing 1	Protein Coding	1
133	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
134	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	1
135	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
136	ARHGAP10	Rho GTPase Activating Protein 10	Protein Coding	1
137	ARHGAP28	Rho GTPase Activating Protein 28	Protein Coding	1
138	PREX2	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2	Protein Coding	1
139	AAAS	Aladin WD Repeat Nucleoporin	Protein Coding	1
140	ARHGAP24	Rho GTPase Activating Protein 24	Protein Coding	1
141	VMA22	Vacuolar ATPase Assembly Factor VMA22	Protein Coding	1
142	ARHGAP19	Rho GTPase Activating Protein 19	Protein Coding	1
143	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
144	ARHGAP11B	Rho GTPase Activating Protein 11B	Protein Coding	1
145	STBD1	Starch Binding Domain 1	Protein Coding	1
146	KALRN	Kalirin RhoGEF Kinase	Protein Coding	1
147	ARHGAP29	Rho GTPase Activating Protein 29	Protein Coding	1
148	ARHGAP11A	Rho GTPase Activating Protein 11A	Protein Coding	1
149	ARHGAP44	Rho GTPase Activating Protein 44	Protein Coding	1
150	RHOB	Ras Homolog Family Member B	Protein Coding	1
151	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1

Disorders associated with RHOC GTPase cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Martsolf syndrome 1	Enrichment	ARHGAP35, ARHGAP5	3.61
2	Neural tube defects	Enrichment	DLC1, VANGL1	2.73
3	Immunodeficiency 47	Enrichment	ATP6AP1, VMA22	2.51
4	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.30
5	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.30
6	Deafness, autosomal dominant 51	Enrichment	TJP2	2.30
7	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.30
8	Focal segmental glomerulosclerosis 8	Enrichment	ANLN	2.30
9	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.30
10	Immunodeficiency 62	Enrichment	ARHGEF1	2.30
11	Naxos disease	Enrichment	JUP	2.30
12	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.30
13	Intellectual developmental disorder, x-linked, syndromic, billuart type	Enrichment	OPHN1	2.30
14	Short syndrome	Enrichment	PIK3R1	2.30
15	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.30
16	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	2.30
17	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	2.30
18	Celiac disease 4	Enrichment	MYO9B	2.30
19	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.30
20	Immunodeficiency 46	Enrichment	TFRC	2.30
21	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.30
22	Lipodystrophy, congenital generalized, type 4	Enrichment	CAVIN1	2.30
23	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.30
24	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.30
25	Myasthenic syndrome, congenital, 24, presynaptic	Enrichment	MYO9A	2.30
26	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.30
27	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.30
28	Autosomal dominant combined immunodeficiency due to erbin deficiency	Enrichment	ERBIN	2.30
29	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.28
30	Greenberg dysplasia	Enrichment	LBR	2.28
31	Pelger-huet anomaly	Enrichment	LBR	2.28
32	Spinal muscular atrophy, late-onset, finkel type	Enrichment	VAPB	2.28
33	Retinal dystrophy with leukodystrophy	Enrichment	ACBD5	2.28
34	Rhizomelic skeletal dysplasia with or without pelger-huet anomaly	Enrichment	LBR	2.28
35	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	2.28
36	Amyotrophic lateral sclerosis 8	Enrichment	VAPB	2.28
37	Congenital disorder of glycosylation, type iiaa	Enrichment	STX5	2.28
38	Reynolds syndrome	Enrichment	LBR	2.28
39	Bile acid synthesis defect, congenital, 5	Enrichment	ABCD3	2.28
40	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.28
41	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.28
42	Autosomal dominant adult-onset proximal spinal muscular atrophy	Enrichment	VAPB	2.28
43	Genetic steroid-resistant nephrotic syndrome	Enrichment	ANLN, ARHGAP24, ARHGDIA	2.24
44	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	2.00
45	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.00
46	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.00
47	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	2.00
48	Atrial septal defect 5	Enrichment	ACTC1	2.00
49	Combined deficiency of factor v and factor viii	Enrichment	LMAN1	1.98
50	Crohn's disease	Enrichment	FMNL2	1.98
51	Type 1 diabetes mellitus 21	Enrichment	TAGAP	1.97
52	Cardiac valvular dysplasia 1	Enrichment	PLD1	1.97
53	Spinal muscular atrophy, facioscapulohumeral type	Enrichment	PLEKHG5	1.97
54	Immunodeficiency 87 and autoimmunity	Enrichment	DEF6	1.97
55	Retinitis pigmentosa 78	Enrichment	ARHGEF18	1.97
56	Deafness, dystonia, and cerebral hypomyelination	Enrichment	BCAP31	1.97
57	Spondyloepimetaphyseal dysplasia, shohat type	Enrichment	DDRGK1	1.97
58	Immunodeficiency 40	Enrichment	DOCK2	1.97
59	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	1.97
60	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	1.97
61	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	1.97
62	Hypercholanemia, familial 1	Enrichment	TJP2	1.82
63	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.82
64	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.82
65	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	1.82
66	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.82
67	Immunodeficiency 14	Enrichment	PIK3R1	1.82
68	Microcephaly 17, primary, autosomal recessive	Enrichment	CIT	1.82
69	Factor v and factor viii, combined deficiency of, 1	Enrichment	LMAN1	1.80
70	Sacral defect with anterior meningocele	Enrichment	VANGL1	1.70
71	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.70
72	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	1.70
73	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.70
74	Congenital generalized lipodystrophy	Enrichment	CAVIN1	1.70
75	Oligohydramnios	Enrichment	OPHN1	1.70
76	Deafness, autosomal recessive 28	Enrichment	TRIO	1.67
77	Neuronopathy, distal hereditary motor, autosomal recessive 4	Enrichment	PLEKHG5	1.67
78	Charcot-marie-tooth disease, recessive intermediate c	Enrichment	PLEKHG5	1.67
79	Spastic paraplegia 70, autosomal recessive	Enrichment	ARHGAP9	1.67
80	Congenital disorder of glycosylation, type iio	Enrichment	VMA22	1.67
81	Cadds	Enrichment	BCAP31	1.67
82	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.61
83	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIAPH3, TJP2	1.55
84	Branchiootorenal syndrome 1	Enrichment	TJP2	1.53
85	Moyamoya disease 1	Enrichment	DIAPH1	1.53
86	Testicular germ cell tumor	Enrichment	STK10	1.53
87	Pendred syndrome	Enrichment	DIAPH1	1.53
88	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.53
89	Limited scleroderma	Enrichment	CAV1	1.53
90	Familial hypercholanemia	Enrichment	TJP2	1.53
91	Hemihyperplasia, isolated	Enrichment	RHOA	1.50
92	Alagille syndrome 1	Enrichment	FAM13A	1.50
93	Spinocerebellar ataxia 4	Enrichment	PLEKHG4	1.50
94	Adams-oliver syndrome 1	Enrichment	ARHGAP31	1.50
95	Polycystic kidney disease 2 with or without polycystic liver disease	Enrichment	FAM13A	1.50
96	Polycystic kidney disease 2	Enrichment	FAM13A	1.50
97	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.50
98	Squamous cell carcinoma	Enrichment	FAM13A	1.50
99	Leukemia, chronic myeloid	Enrichment	BCR	1.46
100	Branchiootorenal syndrome	Enrichment	TJP2	1.46
101	Overgrowth syndrome	Enrichment	PIK3R1	1.46
102	Moyamoya angiopathy	Enrichment	ARHGEF25	1.46
103	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.46
104	Oculopharyngodistal myopathy 1	Enrichment	ABCD3	1.44
105	Achalasia-addisonianism-alacrima syndrome	Enrichment	AAAS	1.37
106	Primary biliary cholangitis	Enrichment	TJP2	1.35
107	Inflammatory bowel disease 1	Enrichment	FMNL2	1.33
108	Peters-plus syndrome	Enrichment	ARHGAP35	1.31
109	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.31
110	Combined immunodeficiency	Enrichment	TFRC	1.27
111	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.27
112	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.27
113	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.27
114	Presynaptic congenital myasthenic syndromes	Enrichment	MYO9A	1.27
115	Juvenile myelomonocytic leukemia	Enrichment	ARHGAP26	1.23
116	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.23
117	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.23
118	Dilated cardiomyopathy	Enrichment	ACTC1, JUP	1.22
119	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.17
120	Colorectal cancer	Enrichment	DLC1, PIK3R1	1.15
121	Thyroid cancer, nonmedullary, 2	Enrichment	SRGAP1	1.14
122	Adams-oliver syndrome	Enrichment	ARHGAP31	1.14
123	Follicular thyroid carcinoma	Enrichment	SRGAP1	1.14
124	Wolff-parkinson-white syndrome	Enrichment	JUP	1.11
125	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	1.11
126	Patent foramen ovale	Enrichment	ACTC1	1.06
127	Coronary heart disease 5	Enrichment	KALRN	1.03
128	Juvenile amyotrophic lateral sclerosis	Enrichment	PLEKHG5	1.03
129	Amelogenesis imperfecta, type ie	Enrichment	ARHGAP6	0.99
130	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	0.96
131	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1, TMPO	0.95
132	Auditory neuropathy	Enrichment	DIAPH1	0.91
133	Jeune thoracic dystrophy	Enrichment	LBR	0.90
134	Amelogenesis imperfecta	Enrichment	ARHGAP6	0.88
135	Asphyxiating thoracic dystrophy	Enrichment	LBR	0.86
136	Cleft lip/palate	Enrichment	ARHGAP29	0.85
137	Primary autosomal recessive microcephaly	Enrichment	CIT	0.83
138	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	0.82
139	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	LBR	0.79
140	Left ventricular noncompaction	Enrichment	ACTC1	0.79
141	Interstitial lung disease 2	Enrichment	FAM13A	0.77
142	Syndromic intellectual disability	Enrichment	TRIO	0.77
143	Epilepsy	Enrichment	DIAPH1	0.74
144	Arteriovenous malformations of the brain	Enrichment	PREX2	0.73
145	Charcot-marie-tooth disease	Enrichment	ARHGEF10	0.73
146	Distal arthrogryposis	Enrichment	ACTC1	0.72
147	Hypertrophic cardiomyopathy	Enrichment	ACTC1	0.71
148	Myeloma, multiple	Enrichment	PIK3R2	0.61
149	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VAPB	0.58
150	Cakut	Enrichment	SRGAP1	0.51
151	Congenital nervous system abnormality	Enrichment	AAAS, OPHN1	0.50
152	Nervous system disease	Enrichment	AAAS, OPHN1	0.50
153	Non-syndromic x-linked intellectual disability	Enrichment	ATP6AP1	0.49
154	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.49
155	Rare genetic deafness	Enrichment	DIAPH1	0.48
156	Cerebral palsy	Enrichment	ARHGAP31	0.46
157	Hereditary spastic paraplegia	Enrichment	PLEKHG5	0.44
158	Mitochondrial disease	Enrichment	C1QBP	0.43
159	Microcephaly	Enrichment	DIAPH1, TRIO	0.42
160	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.13
161	Retinitis pigmentosa	Enrichment	ARHGEF18	0.05
162	Hereditary retinal dystrophy	Enrichment	ARHGEF18	0.02
163	Fundus dystrophy	Enrichment	ARHGEF18	0.02

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RHOC GTPase cycle

Pathway Network for RHOC GTPase cycle

Pathway network for the RHOC GTPase cycle SuperPath

Member Pathways for RHOC GTPase cycle

Pathways in the RHOC GTPase cycle SuperPath

Gene overlap in member pathways for RHOC GTPase cycle SuperPath

Associated Genes for RHOC GTPase cycle

Associated Disorders for RHOC GTPase cycle

Disorders associated with RHOC GTPase cycle SuperPath

STRING Interaction Network for RHOC GTPase cycle

Sources for RHOC GTPase cycle