RHOH GTPase cycle

No Pathway Network information available for RHOH GTPase cycle

Pathways in the RHOH GTPase cycle SuperPath

#	Name	Source	Genes
1	RHOH GTPase cycle	Reactome	ARHGDIA ARHGDIB ARHGDIG BUB1B-PAK6 CAV1 CSK DBN1 DBT FAM91A1 JUP LAMTOR1 LCK MTR NIPSNAP2 NSFL1C OSBPL11 PAK1 PAK2 PAK4 PAK5 PAK6 RAB7A RALGAPA1 RHOH ROCK1 ROCK2 SLC1A5 SLC4A7 STOM TFRC TMEM59 TUBA1B UACA VAMP3 VANGL1 VCP WDR11 ZAP70 (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
2	TUBA1B	Tubulin Alpha 1b	Protein Coding	1
3	BUB1B-PAK6	BUB1B-PAK6 Readthrough	Protein Coding	1
4	OSBPL11	Oxysterol Binding Protein Like 11	Protein Coding	1
5	CSK	C-Terminal Src Kinase	Protein Coding	1
6	FAM91A1	Family With Sequence Similarity 91 Member A1	Protein Coding	1
7	DBN1	Drebrin 1	Protein Coding	1
8	DBT	Dihydrolipoamide Branched Chain Transacylase E2	Protein Coding	1
9	STOM	Stomatin	Protein Coding	1
10	RALGAPA1	Ral GTPase Activating Protein Catalytic Subunit Alpha 1	Protein Coding	1
11	NIPSNAP2	Nipsnap Homolog 2	Protein Coding	1
12	JUP	Junction Plakoglobin	Protein Coding	1
13	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
14	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
15	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	1
16	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
17	RHOH	Ras Homolog Family Member H	Protein Coding	1
18	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	1
19	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
20	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
21	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	1
22	UACA	Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats	Protein Coding	1
23	WDR11	WD Repeat Domain 11	Protein Coding	1
24	NSFL1C	NSFL1 Cofactor	Protein Coding	1
25	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
26	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
27	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
28	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	1
29	TFRC	Transferrin Receptor	Protein Coding	1
30	VCP	Valosin Containing Protein	Protein Coding	1
31	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
32	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	1
33	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	1
34	CAV1	Caveolin 1	Protein Coding	1
35	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	1
36	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
37	SLC4A7	Solute Carrier Family 4 Member 7	Protein Coding	1
38	TMEM59	Transmembrane Protein 59	Protein Coding	1

Disorders associated with RHOH GTPase cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B-PAK6, PAK6	4.12
2	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B-PAK6, PAK6	3.67
3	Combined immunodeficiency	Enrichment	TFRC, ZAP70	3.38
4	Combined t cell and b cell immunodeficiency	Enrichment	TFRC, ZAP70	3.38
5	Combined t and b cell immunodeficiency	Enrichment	TFRC, ZAP70	3.38
6	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.55
7	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.55
8	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	2.55
9	Hypogonadotropic hypogonadism 14 with or without anosmia	Enrichment	WDR11	2.55
10	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.55
11	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.55
12	Naxos disease	Enrichment	JUP	2.55
13	Intellectual developmental disorder, autosomal recessive 78	Enrichment	WDR11	2.55
14	Maple syrup urine disease, type ii	Enrichment	DBT	2.55
15	Knobloch syndrome 2	Enrichment	PAK2	2.55
16	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	2.55
17	Immunodeficiency 48	Enrichment	ZAP70	2.55
18	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.55
19	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	2.55
20	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.55
21	Immunodeficiency 46	Enrichment	TFRC	2.55
22	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	2.55
23	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.55
24	Immunodeficiency 22	Enrichment	LCK	2.55
25	Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation	Enrichment	RALGAPA1	2.55
26	Multisystem proteinopathy	Enrichment	VCP	2.55
27	Immunodeficiency 129	Enrichment	RHOH	2.55
28	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	2.55
29	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	2.55
30	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.55
31	Severe combined immunodeficiency	Enrichment	LCK, ZAP70	2.42
32	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	2.25
33	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.25
34	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	2.25
35	Maple syrup urine disease, type ia	Enrichment	DBT	2.08
36	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR	2.08
37	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	2.08
38	Estrogen resistance	Enrichment	TMEM59	2.08
39	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	2.08
40	Homocystinuria	Enrichment	MTR	2.08
41	Intermittent maple syrup urine disease	Enrichment	DBT	2.08
42	Classic maple syrup urine disease	Enrichment	DBT	2.08
43	Sacral defect with anterior meningocele	Enrichment	VANGL1	1.95
44	Neural tube defects, folate-sensitive	Enrichment	MTR	1.95
45	Knobloch syndrome	Enrichment	PAK2	1.95
46	Intermediate maple syrup urine disease	Enrichment	DBT	1.95
47	Dementia, lewy body	Enrichment	VCP	1.86
48	Knobloch syndrome 1	Enrichment	PAK2	1.86
49	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	1.86
50	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.86
51	Limited scleroderma	Enrichment	CAV1	1.78
52	Progressive non-fluent aphasia	Enrichment	VCP	1.60
53	Behavioral variant of frontotemporal dementia	Enrichment	VCP	1.60
54	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	1.56
55	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.52
56	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.48
57	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.48
58	Neural tube defects	Enrichment	VANGL1	1.45
59	Alzheimer's disease	Enrichment	VCP	1.45
60	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.41
61	Pituitary stalk interruption syndrome	Enrichment	WDR11	1.41
62	Wolff-parkinson-white syndrome	Enrichment	JUP	1.36
63	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	1.36
64	Alzheimer disease, familial, 1	Enrichment	VCP	1.33
65	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	WDR11	1.31
66	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	VCP	1.28
67	Kallmann syndrome	Enrichment	WDR11	1.20
68	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	1.04
69	Epilepsy	Enrichment	MTR	0.97
70	West syndrome	Enrichment	RALGAPA1	0.93
71	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VCP	0.82
72	Dilated cardiomyopathy	Enrichment	JUP	0.70
73	Microcephaly	Enrichment	WDR11	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for RHOH GTPase cycle

Member Pathways for RHOH GTPase cycle

Pathways in the RHOH GTPase cycle SuperPath

Associated Genes for RHOH GTPase cycle

Associated Disorders for RHOH GTPase cycle

Disorders associated with RHOH GTPase cycle SuperPath

STRING Interaction Network for RHOH GTPase cycle

Sources for RHOH GTPase cycle