RHOQ GTPase cycle

No Pathway Network information available for RHOQ GTPase cycle

Pathways in the RHOQ GTPase cycle SuperPath

#	Name	Source	Genes
1	RHOQ GTPase cycle	Reactome	ARHGAP1 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP5 ARHGEF7 ARHGEF9 ARL13B CAV1 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CFTR CPNE8 DEPDC1B DIAPH3 DLC1 FNBP1 GFOD1 GIT1 GIT2 GJA1 GOPC IQGAP1 IQGAP3 ITSN1 JUP LAMTOR1 MPP7 OPHN1 PAK1 PAK2 PAK4 PLEKHG3 PREX1 RAB7A RHOQ SCRIB SLC1A5 SLC4A7 SNAP23 SRGAP2 STEAP3 STOM SYDE1 TFRC TRIP10 VAMP3 VANGL1 WASL WWP2 (see all 58) (see less)
2	RHOJ GTPase cycle	Reactome	ARHGAP1 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP5 ARHGEF7 ARL13B CAV1 CDC42 CDC42BPA CDC42BPB CDC42EP1 CPNE8 DEPDC1B DIAPH3 DOCK8 FMNL3 FNBP1 FNBP1L GIT1 GIT2 GJA1 IQGAP3 JUP LAMTOR1 MPP7 NIPSNAP2 OCRL OPHN1 PAK1 PAK2 PAK3 PAK4 PIK3R1 PIK3R2 PREX1 RAB7A RHOJ SCRIB SLC1A5 SLC4A7 SNAP23 STEAP3 STOM SYDE1 TFRC TMPO TRIO VAMP3 VANGL1 WAS WASL WIPF2 WWP2 (see all 55) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	2
2	WWP2	WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	2
3	CDC42EP1	CDC42 Effector Protein 1	Protein Coding	2
4	IQGAP3	IQ Motif Containing GTPase Activating Protein 3	Protein Coding	2
5	MPP7	MAGUK P55 Scaffold Protein 7	Protein Coding	2
6	CPNE8	Copine 8	Protein Coding	2
7	ARL13B	ARF Like GTPase 13B	Protein Coding	2
8	STOM	Stomatin	Protein Coding	2
9	FNBP1	Formin Binding Protein 1	Protein Coding	2
10	ARHGAP26	Rho GTPase Activating Protein 26	Protein Coding	2
11	SCRIB	Scribble Planar Cell Polarity Protein	Protein Coding	2
12	GJA1	Gap Junction Protein Alpha 1	Protein Coding	2
13	GIT1	GIT ArfGAP 1	Protein Coding	2
14	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	2
15	JUP	Junction Plakoglobin	Protein Coding	2
16	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	2
17	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	2
18	OPHN1	Oligophrenin 1	Protein Coding	2
19	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
20	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
21	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	2
22	STEAP3	STEAP3 Metalloreductase	Protein Coding	2
23	DEPDC1B	DEP Domain Containing 1B	Protein Coding	2
24	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	2
25	ARHGAP21	Rho GTPase Activating Protein 21	Protein Coding	2
26	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	2
27	TFRC	Transferrin Receptor	Protein Coding	2
28	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	2
29	DIAPH3	Diaphanous Related Formin 3	Protein Coding	2
30	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	2
31	CDC42BPA	CDC42 Binding Protein Kinase Alpha	Protein Coding	2
32	SYDE1	Synapse Defective Rho GTPase Activating Protein 1	Protein Coding	2
33	CAV1	Caveolin 1	Protein Coding	2
34	SNAP23	Synaptosome Associated Protein 23	Protein Coding	2
35	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	2
36	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	2
37	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	2
38	SLC4A7	Solute Carrier Family 4 Member 7	Protein Coding	2
39	CDC42BPB	CDC42 Binding Protein Kinase Beta	Protein Coding	2
40	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	2
41	GIT2	GIT ArfGAP 2	Protein Coding	2
42	CDC42	Cell Division Cycle 42	Protein Coding	2
43	DLC1	DLC1 Rho GTPase Activating Protein	Protein Coding	1
44	CDC42EP2	CDC42 Effector Protein 2	Protein Coding	1
45	CDC42EP3	CDC42 Effector Protein 3	Protein Coding	1
46	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
47	ARHGAP33	Rho GTPase Activating Protein 33	Protein Coding	1
48	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	1
49	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	1
50	RHOQ	Ras Homolog Family Member Q	Protein Coding	1
51	CDC42EP4	CDC42 Effector Protein 4	Protein Coding	1
52	PLEKHG3	Pleckstrin Homology And RhoGEF Domain Containing G3	Protein Coding	1
53	GFOD1	Gfo/Idh/MocA-Like Oxidoreductase Domain Containing 1	Protein Coding	1
54	ARHGAP17	Rho GTPase Activating Protein 17	Protein Coding	1
55	GOPC	Golgi Associated PDZ And Coiled-Coil Motif Containing	Protein Coding	1
56	ITSN1	Intersectin 1	Protein Coding	1
57	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
58	TRIP10	Thyroid Hormone Receptor Interactor 10	Protein Coding	1
59	WIPF2	WAS/WASL Interacting Protein Family Member 2	Protein Coding	1
60	NIPSNAP2	Nipsnap Homolog 2	Protein Coding	1
61	OCRL	OCRL Inositol Polyphosphate-5-Phosphatase	Protein Coding	1
62	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
63	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
64	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
65	FNBP1L	Formin Binding Protein 1 Like	Protein Coding	1
66	RHOJ	Ras Homolog Family Member J	Protein Coding	1
67	TMPO	Thymopoietin	Protein Coding	1
68	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	1
69	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
70	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	1
71	FMNL3	Formin Like 3	Protein Coding	1

Disorders associated with RHOQ GTPase cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neural tube defects	Enrichment	DLC1, SCRIB, VANGL1	4.69
2	Martsolf syndrome 1	Enrichment	ARHGAP35, ARHGAP5	3.80
3	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	2.39
4	Hypoplastic left heart syndrome 1	Enrichment	GJA1	2.39
5	Thrombocytopenia 1	Enrichment	WAS	2.39
6	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.39
7	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.39
8	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.39
9	Oculodentodigital dysplasia	Enrichment	GJA1	2.39
10	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.39
11	Joubert syndrome 8	Enrichment	ARL13B	2.39
12	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	2.39
13	Naxos disease	Enrichment	JUP	2.39
14	Intellectual developmental disorder, x-linked, syndromic, billuart type	Enrichment	OPHN1	2.39
15	Knobloch syndrome 2	Enrichment	PAK2	2.39
16	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	2.39
17	Short syndrome	Enrichment	PIK3R1	2.39
18	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.39
19	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	2.39
20	Lowe oculocerebrorenal syndrome	Enrichment	OCRL	2.39
21	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	2.39
22	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.39
23	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	2.39
24	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.39
25	Immunodeficiency 46	Enrichment	TFRC	2.39
26	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.39
27	Was-related disorders	Enrichment	WAS	2.39
28	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	2.39
29	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.39
30	Chilton-okur-chung neurodevelopmental syndrome	Enrichment	CDC42BPB	2.39
31	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	2.39
32	Nocarh syndrome	Enrichment	CDC42	2.39
33	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.37
34	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.37
35	Neutropenia, severe congenital, x-linked	Enrichment	WAS	2.09
36	Wiskott-aldrich syndrome	Enrichment	WAS	2.09
37	Dent disease 2	Enrichment	OCRL	2.09
38	Deafness, autosomal recessive 28	Enrichment	TRIO	2.09
39	Anemia, hypochromic microcytic, with iron overload 2	Enrichment	STEAP3	2.09
40	Hallermann-streiff syndrome	Enrichment	GJA1	2.09
41	Syndactyly, type iii	Enrichment	GJA1	2.09
42	Syndactyly, type v	Enrichment	GJA1	2.09
43	Spondyloepiphyseal dysplasia, nishimura type	Enrichment	WWP2	2.09
44	Craniometaphyseal dysplasia	Enrichment	GJA1	2.09
45	Immune system disease	Enrichment	CDC42	2.09
46	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.07
47	Hyper-ige syndrome 2, autosomal recessive, with recurrent infections	Enrichment	DOCK8	1.92
48	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.92
49	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.92
50	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.92
51	Hyper-ige syndrome 3, autosomal recessive, with recurrent infections	Enrichment	DOCK8	1.92
52	Dent disease	Enrichment	OCRL	1.92
53	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.92
54	Immunodeficiency 14	Enrichment	PIK3R1	1.92
55	Nuchal bleb, familial	Enrichment	CFTR	1.89
56	Sacral defect with anterior meningocele	Enrichment	VANGL1	1.79
57	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.79
58	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.79
59	Imerslund-grasbeck syndrome 2	Enrichment	CDC42BPB	1.79
60	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.79
61	Oligohydramnios	Enrichment	OPHN1	1.79
62	Knobloch syndrome	Enrichment	PAK2	1.79
63	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	1.77
64	Idiopathic bronchiectasis	Enrichment	CFTR	1.77
65	Knobloch syndrome 1	Enrichment	PAK2	1.70
66	Cleft upper lip	Enrichment	GJA1	1.70
67	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.70
68	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.62
69	Megaloblastic anemia	Enrichment	CDC42BPB	1.62
70	Limited scleroderma	Enrichment	CAV1	1.62
71	Imerslund-grasbeck syndrome 1	Enrichment	CDC42BPB	1.55
72	Overgrowth syndrome	Enrichment	PIK3R1	1.55
73	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	1.50
74	Hypoplastic left heart syndrome	Enrichment	GJA1	1.50
75	Male infertility due to globozoospermia	Enrichment	GOPC	1.47
76	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.42
77	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.42
78	Peters-plus syndrome	Enrichment	ARHGAP35	1.40
79	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.40
80	Combined immunodeficiency	Enrichment	TFRC	1.36
81	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.36
82	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.36
83	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.36
84	Juvenile myelomonocytic leukemia	Enrichment	ARHGAP26	1.32
85	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	1.32
86	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	1.32
87	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	1.26
88	Hereditary chronic pancreatitis	Enrichment	CFTR	1.23
89	Lynch syndrome	Enrichment	CFTR	1.21
90	Wolff-parkinson-white syndrome	Enrichment	JUP	1.20
91	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	1.20
92	Syndromic intellectual disability	Enrichment	TRIO	1.18
93	Pancreatitis, hereditary	Enrichment	CFTR	1.15
94	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	1.11
95	Microcephaly	Enrichment	PAK3, TRIO	1.05
96	Severe covid-19	Enrichment	DOCK8	0.95
97	Isolated joubert syndrome	Enrichment	ARL13B	0.94
98	Severe combined immunodeficiency	Enrichment	DOCK8	0.90
99	Cystic fibrosis	Enrichment	CFTR	0.89
100	Male infertility	Enrichment	CFTR	0.87
101	Thrombocytopenia	Enrichment	WAS	0.75
102	Joubert syndrome 1	Enrichment	ARL13B	0.73
103	Autosomal dominant non-syndromic intellectual disability	Enrichment	DOCK8	0.73
104	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIAPH3	0.72
105	Familial isolated dilated cardiomyopathy	Enrichment	TMPO	0.71
106	Myeloma, multiple	Enrichment	PIK3R2	0.69
107	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.67
108	Dilated cardiomyopathy	Enrichment	JUP	0.56
109	Colorectal cancer	Enrichment	PIK3R1	0.52
110	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1	0.52
111	Congenital nervous system abnormality	Enrichment	OPHN1	0.45
112	Nervous system disease	Enrichment	OPHN1	0.45
113	Autism spectrum disorder	Enrichment	CDC42BPB	0.44
114	Complex neurodevelopmental disorder	Enrichment	PAK3	0.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for RHOQ GTPase cycle

Member Pathways for RHOQ GTPase cycle

Pathways in the RHOQ GTPase cycle SuperPath

Associated Genes for RHOQ GTPase cycle

Associated Disorders for RHOQ GTPase cycle

Disorders associated with RHOQ GTPase cycle SuperPath

STRING Interaction Network for RHOQ GTPase cycle

Sources for RHOQ GTPase cycle