RHOU GTPase cycle

No Pathway Network information available for RHOU GTPase cycle

Pathways in the RHOU GTPase cycle SuperPath

#	Name	Source	Genes
1	RHOU GTPase cycle	Reactome	ARHGAP30 ARHGAP31 ARHGEF6 ARHGEF7 CDC42 CLTC DEPDC1B DLG5 DST EPHA2 GIT1 GIT2 GRB2 HGS IQGAP1 ITSN2 MYO6 NCK1 NCK2 PAK1 PAK2 PAK3 PAK4 PARD6A PEAK1 PIK3R1 PIK3R2 PTK2B RHOU SPTAN1 SPTBN1 SRC SRGAP2 STAM STAM2 TXNL1 USP9X VANGL1 WDR6 WWP2 (see all 40) (see less)
2	RHOV GTPase cycle	Reactome	ARHGAP12 ARHGEF7 BUB1B-PAK6 CCP110 CDC42 CEP97 CLTC DEPDC1B DLG5 DST EPHA2 GIT1 GIT2 IQGAP1 MAP3K11 MYO9A NCK1 NCK2 PAK1 PAK2 PAK4 PAK6 PARD6A PARD6B PEAK1 PIK3R1 RHOV SH3RF1 SPTAN1 SPTBN1 TPM3 TPM4 TXNL1 USP9X VANGL1 WASL WDR6 ZNF512B (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	2
2	WDR6	WD Repeat Domain 6	Protein Coding	2
3	CLTC	Clathrin Heavy Chain	Protein Coding	2
4	EPHA2	EPH Receptor A2	Protein Coding	2
5	GIT1	GIT ArfGAP 1	Protein Coding	2
6	NCK1	NCK Adaptor Protein 1	Protein Coding	2
7	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
8	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
9	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	2
10	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
11	DEPDC1B	DEP Domain Containing 1B	Protein Coding	2
12	DST	Dystonin	Protein Coding	2
13	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	2
14	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	2
15	PEAK1	Pseudopodium Enriched Atypical Kinase 1	Protein Coding	2
16	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	2
17	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	2
18	NCK2	NCK Adaptor Protein 2	Protein Coding	2
19	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	2
20	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	2
21	DLG5	Discs Large MAGUK Scaffold Protein 5	Protein Coding	2
22	TXNL1	Thioredoxin Like 1	Protein Coding	2
23	GIT2	GIT ArfGAP 2	Protein Coding	2
24	CDC42	Cell Division Cycle 42	Protein Coding	2
25	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	1
26	WWP2	WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1
27	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
28	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	1
29	ARHGAP30	Rho GTPase Activating Protein 30	Protein Coding	1
30	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
31	MYO6	Myosin VI	Protein Coding	1
32	ITSN2	Intersectin 2	Protein Coding	1
33	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
34	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
35	ARHGAP31	Rho GTPase Activating Protein 31	Protein Coding	1
36	RHOU	Ras Homolog Family Member U	Protein Coding	1
37	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
38	STAM	Signal Transducing Adaptor Molecule	Protein Coding	1
39	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	1
40	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
41	BUB1B-PAK6	BUB1B-PAK6 Readthrough	Protein Coding	1
42	RHOV	Ras Homolog Family Member V	Protein Coding	1
43	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
44	MYO9A	Myosin IXA	Protein Coding	1
45	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
46	ZNF512B	Zinc Finger Protein 512B	Protein Coding	1
47	SH3RF1	SH3 Domain Containing Ring Finger 1	Protein Coding	1
48	TPM3	Tropomyosin 3	Protein Coding	1
49	TPM4	Tropomyosin 4	Protein Coding	1
50	CEP97	Centrosomal Protein 97	Protein Coding	1
51	PARD6B	Par-6 Family Cell Polarity Regulator Beta	Protein Coding	1
52	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
53	ARHGAP12	Rho GTPase Activating Protein 12	Protein Coding	1
54	CCP110	Centriolar Coiled-Coil Protein 110	Protein Coding	1

Disorders associated with RHOU GTPase cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inflammatory myofibroblastic tumor	Enrichment	CLTC, TPM3, TPM4	6.39
2	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B-PAK6, PAK6	4.12
3	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B-PAK6, PAK6	3.67
4	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	2.55
5	Congenital myopathy 4b, autosomal recessive	Enrichment	TPM3	2.55
6	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	2.55
7	Bleeding disorder, platelet-type, 25	Enrichment	TPM4	2.55
8	Knobloch syndrome 2	Enrichment	PAK2	2.55
9	Short syndrome	Enrichment	PIK3R1	2.55
10	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.55
11	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	2.55
12	Developmental delay, impaired speech, and behavioral abnormalities	Enrichment	SPTBN1	2.55
13	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.55
14	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.55
15	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.55
16	Myasthenic syndrome, congenital, 24, presynaptic	Enrichment	MYO9A	2.55
17	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	2.55
18	Developmental delay with or without epilepsy	Enrichment	SPTAN1	2.55
19	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	2.55
20	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	2.55
21	Yuksel-vogel-bauer syndrome	Enrichment	DLG5	2.55
22	Nocarh syndrome	Enrichment	CDC42	2.55
23	Congenital generalized hypercontractile muscle stiffness syndrome	Enrichment	TPM3	2.55
24	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.53
25	Deafness, autosomal dominant 22	Enrichment	MYO6	2.53
26	Deafness, autosomal recessive 37	Enrichment	MYO6	2.53
27	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.53
28	Thrombocytopenia 6	Enrichment	SRC	2.53
29	Progressive sensorineural hearing loss-hypertrophic cardiomyopathy syndrome	Enrichment	MYO6	2.53
30	Autosomal dominant nonsyndromic hearing loss 22	Enrichment	MYO6	2.53
31	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6, USP9X	2.30
32	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	2.25
33	Immune system disease	Enrichment	CDC42	2.25
34	Spondyloepiphyseal dysplasia, nishimura type	Enrichment	WWP2	2.23
35	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.08
36	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.08
37	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	SPTBN1	2.08
38	Epidermolysis bullosa simplex 3, localized or generalized intermediate, with bp230 deficiency	Enrichment	DST	2.08
39	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	2.08
40	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	2.08
41	Immunodeficiency 14	Enrichment	PIK3R1	2.08
42	Cap myopathy	Enrichment	TPM3	2.08
43	Hyperpigmentation of the skin	Enrichment	USP9X	2.08
44	Adams-oliver syndrome 1	Enrichment	ARHGAP31	2.05
45	Sacral defect with anterior meningocele	Enrichment	VANGL1	1.95
46	Neuropathy, hereditary sensory and autonomic, type vi	Enrichment	DST	1.95
47	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.95
48	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.95
49	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	1.95
50	Knobloch syndrome	Enrichment	PAK2	1.95
51	Intermediate nemaline myopathy	Enrichment	TPM3	1.95
52	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.93
53	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.93
54	Cataract 6, multiple types	Enrichment	EPHA2	1.86
55	Knobloch syndrome 1	Enrichment	PAK2	1.86
56	Pervasive developmental disorder	Enrichment	SPTBN1	1.86
57	Aniridia	Enrichment	EPHA2	1.86
58	Rare pervasive developmental disorder	Enrichment	SPTBN1	1.86
59	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	MYO6	1.76
60	Noonan syndrome 3	Enrichment	CLTC	1.71
61	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.71
62	Focal epilepsy	Enrichment	SPTAN1	1.71
63	Childhood-onset nemaline myopathy	Enrichment	TPM3	1.71
64	Overgrowth syndrome	Enrichment	PIK3R1	1.71
65	Myelofibrosis	Enrichment	SRC	1.69
66	Adams-oliver syndrome	Enrichment	ARHGAP31	1.69
67	Early-onset posterior polar cataract	Enrichment	EPHA2	1.65
68	Colorectal cancer	Enrichment	PIK3R1, SRC	1.57
69	Nemaline myopathy	Enrichment	TPM3	1.56
70	Autosomal dominant macrothrombocytopenia	Enrichment	TPM4	1.56
71	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.56
72	Presynaptic congenital myasthenic syndromes	Enrichment	MYO9A	1.52
73	Neural tube defects	Enrichment	VANGL1	1.45
74	Multiple sclerosis	Enrichment	DST	1.41
75	Cataract	Enrichment	EPHA2	1.41
76	Osteoporosis	Enrichment	SRC	1.39
77	Congenital myopathy 4a, autosomal dominant	Enrichment	TPM3	1.38
78	Cataract 44	Enrichment	EPHA2	1.33
79	Neuromuscular disease	Enrichment	SPTAN1	1.31
80	Early-onset nuclear cataract	Enrichment	EPHA2	1.31
81	Complex neurodevelopmental disorder	Enrichment	PAK3, SPTBN1	1.29
82	Centronuclear myopathy	Enrichment	TPM3	1.24
83	Jeune thoracic dystrophy	Enrichment	SPTAN1	1.17
84	Ear malformation	Enrichment	MYO6	1.16
85	Asphyxiating thoracic dystrophy	Enrichment	SPTAN1	1.12
86	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	SPTAN1	1.05
87	Developmental and epileptic encephalopathy	Enrichment	SPTAN1	1.02
88	Non-syndromic genetic deafness	Enrichment	MYO6	1.00
89	Myopathy	Enrichment	TPM3	0.97
90	Charcot-marie-tooth disease	Enrichment	DST	0.96
91	Benign epilepsy with centrotemporal spikes	Enrichment	SPTAN1	0.96
92	Cerebral palsy	Enrichment	ARHGAP31	0.96
93	Hereditary spastic paraplegia	Enrichment	SPTAN1	0.95
94	Centralopathic epilepsy	Enrichment	SPTAN1	0.94
95	West syndrome	Enrichment	SPTAN1	0.93
96	Nonsyndromic hearing loss	Enrichment	MYO6	0.93
97	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	0.88
98	Thrombocytopenia	Enrichment	SRC	0.88
99	Spastic ataxia	Enrichment	SPTAN1	0.86
100	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYO6	0.85
101	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC	0.84
102	Myeloma, multiple	Enrichment	PIK3R2	0.82
103	Rare genetic deafness	Enrichment	MYO6	0.68
104	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYO6	0.63
105	Microcephaly	Enrichment	PAK3	0.51

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for RHOU GTPase cycle

Member Pathways for RHOU GTPase cycle

Pathways in the RHOU GTPase cycle SuperPath

Associated Genes for RHOU GTPase cycle

Associated Disorders for RHOU GTPase cycle

Disorders associated with RHOU GTPase cycle SuperPath

STRING Interaction Network for RHOU GTPase cycle

Sources for RHOU GTPase cycle