RNA Polymerase I Promoter Opening

Pathway network for the RNA Polymerase I Promoter Opening SuperPath

Sources:

Reactome
WikiPathways

Pathways in the RNA Polymerase I Promoter Opening SuperPath

#	Name	Source	Genes
1	RNA Polymerase I Promoter Opening	Reactome	H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MAPK3 MBD2 UBTF (see all 62) (see less)
2	Activation of HOX genes during differentiation	Reactome	AJUBA ASH2L CNOT6 CNOT9 CREBBP CTCF DPY30 EED EGR2 EP300 EZH2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC3 HOXA1 HOXA2 HOXA3 HOXA4 HOXB1 HOXB2 HOXB3 HOXB4 HOXC4 HOXD1 HOXD3 HOXD4 JUN KDM6A KMT2C KMT2D MAFB MEIS1 NCOA3 NCOA6 NCOR1 PAGR1 PAX6 PAXIP1 PBX1 PCGF2 PIAS2 PKNOX1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RARA RARB RARG RBBP4 RBBP5 RBBP7 RXRA SUZ12 WDR5 YY1 ZNF335 (see all 122) (see less)
3	Activation of anterior HOX genes in hindbrain development during early embryogenesis	Reactome	AJUBA ASH2L CNOT6 CNOT9 CREBBP CTCF DPY30 EED EGR2 EP300 EZH2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC3 HOXA1 HOXA2 HOXA3 HOXA4 HOXB1 HOXB2 HOXB3 HOXB4 HOXC4 HOXD1 HOXD3 HOXD4 JUN KDM6A KMT2C KMT2D MAFB MEIS1 NCOA3 NCOA6 NCOR1 PAGR1 PAX6 PAXIP1 PBX1 PCGF2 PIAS2 PKNOX1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RARA RARB RARG RBBP4 RBBP5 RBBP7 RXRA SUZ12 WDR5 YY1 ZNF335 (see all 122) (see less)
4	Maternal to zygotic transition (MZT)	Reactome	AGO2 AICDA BTG4 CNOT1 CNOT10 CNOT11 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNOT9 CREBBP DICER1 DIS3L2 DPPA2 DPPA3 DPPA4 DUX4 DUXA DUXB EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 EP300 H1-8 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA KDM4E KDM5A KDM5B KDM6A KDM6B LEUTX METTL23 NPM2 PABPC1 PABPN1 PABPN1L PAIP1 PRM1 PRM2 SRPK1 STPG4 TEAD4 TET3 TNKS1BP1 TP53 TPRX1 TPRX2 TUT4 TUT7 UHRF1 UNG YAP1 ZFP36L2 ZSCAN4 (see all 120) (see less)
5	RNA Polymerase I Transcription	Reactome	CAVIN1 CBX3 CCNH CDK7 CHD3 CHD4 EHMT2 ERCC2 ERCC3 ERCC6 GATAD2A GATAD2B GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 KAT2A KAT2B MAPK3 MBD2 MBD3 MNAT1 MTA1 MTA2 MTA3 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RBBP4 RBBP7 RNA45SN5 RRN3 TAF1A TAF1B TAF1C TAF1D TBP TTF1 UBTF (see all 111) (see less)
6	RNA Polymerase I Promoter Clearance	Reactome	CBX3 CCNH CDK7 CHD3 CHD4 EHMT2 ERCC2 ERCC3 ERCC6 GATAD2A GATAD2B GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 KAT2A KAT2B MAPK3 MBD2 MBD3 MNAT1 MTA1 MTA2 MTA3 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RBBP4 RBBP7 RRN3 TAF1A TAF1B TAF1C TAF1D TBP TTF1 UBTF (see all 109) (see less)
7	Amyloid fiber formation	Reactome	ADAM10 APCS APH1A APH1B APOA1 APOA4 APOE APP B2M BACE1 CALB1 CALCA CST3 FGA FURIN GGA1 GGA2 GGA3 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AX H2AZ1 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HSPG2 IAPP INS ITM2B LTF LYZ MFGE8 NAT8 NCSTN NPPA ODAM PRKN PRL PSENEN RPS27A SAA1 SEMG1 SIAH1 SIAH2 SNCA SNCAIP SORL1 TGFBI TSPAN14 TSPAN15 TSPAN33 TSPAN5 TTR UBA52 UBB UBC UBE2L6 USP9X (see all 109) (see less)
8	Negative epigenetic regulation of rRNA expression	Reactome	ARID4B BAZ2A CCNH CDK7 DNMT1 DNMT3B ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 MBD2 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RNA45SN5 RRP8 SAP130 SAP18 SAP30 SAP30BP SAP30L SIN3A SIN3B SIRT1 SMARCA5 SUDS3 SUV39H1 TAF1A TAF1B TAF1C TAF1D TBP TTF1 UBTF (see all 109) (see less)
9	NoRC negatively regulates rRNA expression	Reactome	ARID4B BAZ2A CCNH CDK7 DNMT1 DNMT3B ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 MBD2 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RNA45SN5 SAP130 SAP18 SAP30 SAP30BP SAP30L SIN3A SIN3B SMARCA5 SUDS3 TAF1A TAF1B TAF1C TAF1D TBP TTF1 UBTF (see all 106) (see less)
10	Positive epigenetic regulation of rRNA expression	Reactome	ACTB BAZ1B CBX3 CHD3 CHD4 DDX21 DEK EHMT2 EP300 ERCC6 GATAD2A GATAD2B GSK3B H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 KAT2A KAT2B MBD3 MTA1 MTA2 MTA3 MYBBP1A MYO1C POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RBBP4 RBBP7 SF3B1 SMARCA5 TAF1A TAF1B TAF1C TAF1D TBP TTF1 (see all 105) (see less)
11	Diseases of programmed cell death	Reactome	APP BCL2L11 C1QBP CAPN1 CAPN2 CAPNS1 CAPNS2 CASP8 CAST CDC25A CDC25B CDC25C CDK5 CDK5R1 CDKN2A DNMT1 DNMT3A DNMT3B EED EZH2 FADD FOXO3 GOLGA2 GSDME H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 JUN LMNA LMNB1 POLA1 POLA2 PRDX1 PRDX2 PRIM1 PRIM2 RBBP4 RBBP7 RIPK1 RIPK3 SOD2 SUZ12 TP53 TRAF2 YWHAE (see all 101) (see less)
12	Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Reactome	ACTB ACTL6A ARID1A ARID1B BCL7A BCL7B BCL7C C19orf84 CHD3 CHD4 DNMT3A DNMT3L DPF1 DPF2 DPF3 GATAD2A GATAD2B H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 MBD3 MTA1 MTA2 MTA3 PIWIL4 RBBP4 RBBP7 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SPOCD1 SS18 SS18L1 (see all 97) (see less)
13	HDACs deacetylate histones	Reactome	ARID4A ARID4B BRMS1 CHD3 CHD4 GATAD2A GATAD2B GPS2 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 HMG20B KDM1A MBD3 MTA1 MTA2 MTA3 NCOR1 NCOR2 PHF21A RBBP4 RBBP7 RCOR1 REST SAP18 SAP30 SAP30L SUDS3 TBL1X TBL1XR1 (see all 94) (see less)
14	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Reactome	AGO1 AGO3 AGO4 ASH2L CBFB DPY30 EP300 GATA1 GP1BA H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 ITGA2B KAT2B KMT2A KMT2B KMT2C KMT2D MOV10 MYL9 NFE2 NR4A3 PF4 PRMT1 PRMT6 RBBP5 RUNX1 SETD1A SETD1B SIN3A SIN3B THBS1 TNRC6A TNRC6B TNRC6C WDR5 ZFPM1 (see all 94) (see less)
15	RHO GTPases activate PKNs	Reactome	AR CDC25C H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 KDM1A KDM4C KLK2 KLK3 MYH10 MYH11 MYH14 MYH9 MYL12B MYL6 MYL9 NCOA2 PAK1 PDPK1 PKN1 PKN2 PKN3 PPP1CB PPP1R12A PPP1R12B PPP1R14A RAC1 RHOA RHOB RHOC SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 93) (see less)
16	RNA Polymerase I Promoter Escape	Reactome	CBX3 CCNH CDK7 ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RRN3 TAF1A TAF1B TAF1C TAF1D TBP UBTF (see all 90) (see less)
17	Formation of the beta-catenin:TCF transactivating complex	Reactome	ASH2L AXIN2 BCL9 BCL9L CDC73 CREBBP CTNNB1 EP300 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 KAT5 KMT2D LEF1 LEO1 MEN1 MYC PYGO1 PYGO2 RBBP5 RUNX3 RUVBL1 SMARCA4 TCF7 TCF7L1 TCF7L2 TERT TLE1 TLE2 TLE3 TLE4 TRRAP (see all 90) (see less)
18	B-WICH complex positively regulates rRNA expression	Reactome	ACTB BAZ1B DDX21 DEK EP300 ERCC6 GSK3B H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 KAT2A KAT2B MYBBP1A MYO1C POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L SF3B1 SMARCA5 TAF1A TAF1B TAF1C TAF1D TBP (see all 90) (see less)
19	Transcriptional regulation of granulopoiesis	Reactome	CBFB CDK2 CDK4 CDKN1A CEBPA CEBPB CEBPE CREB1 CSF3R DEK E2F1 EP300 FLI1 GATA2 GFI1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 IL6R KLF5 KMT2A LEF1 MYB MYC PML RARA RUNX1 RXRA SPI1 STAT3 TAL1 TFDP1 TFDP2 (see all 89) (see less)
20	RMTs methylate histone arginines	Reactome	ACTL6A ACTL6B ARID1A ARID1B ARID2 CARM1 CCND1 CDK4 COPRS DNMT3A H2AB1 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 JAK2 PBRM1 PRMT1 PRMT3 PRMT5 PRMT6 PRMT7 RBBP7 RPS2 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 WDR5 WDR77 (see all 78) (see less)
21	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	Reactome	CBX3 CHD3 CHD4 EHMT2 ERCC6 GATAD2A GATAD2B H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC2 MBD3 MTA1 MTA2 MTA3 RBBP4 RBBP7 TTF1 (see all 75) (see less)
22	Condensation of Prophase Chromosomes	Reactome	CCNB1 CDK1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 KMT5A MCPH1 NCAPD3 NCAPG2 NCAPH2 PHF8 PLK1 RB1 SET SMC2 SMC4 (see all 73) (see less)
23	Defective pyroptosis	Reactome	DNMT1 DNMT3A DNMT3B EED EZH2 GSDME H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 POLA1 POLA2 PRIM1 PRIM2 RBBP4 RBBP7 SUZ12 (see all 72) (see less)
24	PRC2 methylates histones and DNA	Reactome	AEBP2 DNMT1 DNMT3A DNMT3B EED EZH2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 JARID2 MTF2 PHF1 PHF19 RBBP4 RBBP7 SUZ12 (see all 72) (see less)
25	Chromatin modifications during the maternal to zygotic transition (MZT)	Reactome	AICDA DPPA3 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 KDM5A KDM5B KDM6A KDM6B METTL23 STPG4 TET3 UHRF1 UNG (see all 70) (see less)
26	Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	Reactome	ATF7IP EHMT1 EHMT2 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MORC2 MPHOSPH8 MTREX PPHLN1 RBM7 SETDB1 TASOR ZCCHC8 (see all 70) (see less)
27	Assembly of the ORC complex at the origin of replication	Reactome	H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 KPNA1 KPNA6 KPNB1 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 (see all 68) (see less)
28	SIRT1 negatively regulates rRNA expression	Reactome	H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 RRP8 SIRT1 SUV39H1 TAF1A TAF1B TAF1C TAF1D TBP (see all 67) (see less)
29	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Reactome	AR H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 KDM1A KDM4C KLK2 KLK3 NCOA2 PKN1 (see all 66) (see less)
30	DNA methylation	Reactome	DNMT1 DNMT3A DNMT3B DNMT3L H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 UHRF1 (see all 64) (see less)
31	HDMs demethylate histones	Reactome	ARID5B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 JMJD6 KDM1A KDM1B KDM2A KDM2B KDM3A KDM3B KDM4A KDM4B KDM4C KDM4D KDM5A KDM5B KDM5C KDM5D KDM6A KDM6B KDM7A PHF2 PHF8 RIOX2 UTY (see all 50) (see less)
32	Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome	WikiPathways	CBX1 CBX3 CBX5 CHD3 CHD4 E2F1 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 HDAC1 HDAC2 INPP5K KDM1A LEF1 MBD2 MBD3 MTA1 MTA2 MTA3 RB1 RBBP4 RBBP7 SREBF1 SUV39H1 TP53 (see all 37) (see less)
33	Zygotic genome activation (ZGA)	Reactome	CREBBP DPPA2 DPPA4 DUX4 DUXA DUXB EP300 KDM4E LEUTX TEAD4 TP53 TPRX1 TPRX2 TUT4 TUT7 YAP1 ZSCAN4 (see all 17) (see less)
34	Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Reactome	DIS3L2 EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4G1 PABPC1 PABPN1 PAIP1 TUT4 TUT7 (see all 12) (see less)
35	Binding of TCF/LEF:CTNNB1 to target gene promoters	Reactome	AXIN2 CTNNB1 LEF1 MYC RUNX3 TCF7 TCF7L1 TCF7L2 (see all 8) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	H3C14	H3 Clustered Histone 14	Protein Coding	32
2	H3C15	H3 Clustered Histone 15	Protein Coding	32
3	H3C13	H3 Clustered Histone 13	Protein Coding	32
4	H3C1	H3 Clustered Histone 1	Protein Coding	32
5	H3C4	H3 Clustered Histone 4	Protein Coding	32
6	H3C3	H3 Clustered Histone 3	Protein Coding	32
7	H3C6	H3 Clustered Histone 6	Protein Coding	32
8	H3C11	H3 Clustered Histone 11	Protein Coding	32
9	H3C8	H3 Clustered Histone 8	Protein Coding	32
10	H3C12	H3 Clustered Histone 12	Protein Coding	32
11	H3C10	H3 Clustered Histone 10	Protein Coding	32
12	H3C2	H3 Clustered Histone 2	Protein Coding	32
13	H3C7	H3 Clustered Histone 7	Protein Coding	32
14	H4C16	H4 Histone 16	Protein Coding	31
15	H4C15	H4 Clustered Histone 15	Protein Coding	31
16	H4C9	H4 Clustered Histone 9	Protein Coding	31
17	H4C1	H4 Clustered Histone 1	Protein Coding	31
18	H4C4	H4 Clustered Histone 4	Protein Coding	31
19	H4C6	H4 Clustered Histone 6	Protein Coding	31
20	H4C12	H4 Clustered Histone 12	Protein Coding	31
21	H4C11	H4 Clustered Histone 11	Protein Coding	31
22	H4C3	H4 Clustered Histone 3	Protein Coding	31
23	H4C8	H4 Clustered Histone 8	Protein Coding	31
24	H4C2	H4 Clustered Histone 2	Protein Coding	31
25	H4C5	H4 Clustered Histone 5	Protein Coding	31
26	H4C13	H4 Clustered Histone 13	Protein Coding	31
27	H4C14	H4 Clustered Histone 14	Protein Coding	31
28	H2AC8	H2A Clustered Histone 8	Protein Coding	30
29	H2AC7	H2A Clustered Histone 7	Protein Coding	30
30	H2AC19	H2A Clustered Histone 19	Protein Coding	30
31	H2AC14	H2A Clustered Histone 14	Protein Coding	30
32	H2AC6	H2A Clustered Histone 6	Protein Coding	30
33	H2AC4	H2A Clustered Histone 4	Protein Coding	30
34	H2AC18	H2A Clustered Histone 18	Protein Coding	30
35	H2AC20	H2A Clustered Histone 20	Protein Coding	30
36	H2BC26	H2B Clustered Histone 26	Protein Coding	29
37	H2BC1	H2B Clustered Histone 1	Protein Coding	29
38	H2AX	H2A.X Variant Histone	Protein Coding	29
39	H2BC5	H2B Clustered Histone 5	Protein Coding	29
40	H2BC3	H2B Clustered Histone 3	Protein Coding	29
41	H3-3A	H3.3 Histone A	Protein Coding	29
42	H3-3B	H3.3 Histone B	Protein Coding	29
43	H2AB1	H2A.B Variant Histone 1	Protein Coding	29
44	H2BC8	H2B Clustered Histone 8	Protein Coding	29
45	H2BC13	H2B Clustered Histone 13	Protein Coding	29
46	H2BC15	H2B Clustered Histone 15	Protein Coding	29
47	H2BC14	H2B Clustered Histone 14	Protein Coding	29
48	H2BC7	H2B Clustered Histone 7	Protein Coding	29
49	H2BC6	H2B Clustered Histone 6	Protein Coding	29
50	H2BC9	H2B Clustered Histone 9	Protein Coding	29
51	H2BC10	H2B Clustered Histone 10	Protein Coding	29
52	H2BC4	H2B Clustered Histone 4	Protein Coding	29
53	H2BC17	H2B Clustered Histone 17	Protein Coding	29
54	H2BC21	H2B Clustered Histone 21	Protein Coding	29
55	H2BC12	H2B Clustered Histone 12	Protein Coding	29
56	H2BC11	H2B Clustered Histone 11	Protein Coding	29
57	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	28
58	H2AJ	H2A.J Histone	Protein Coding	28
59	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	28
60	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	13
61	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	12
62	HDAC1	Histone Deacetylase 1	Protein Coding	11
63	EP300	EP300 Lysine Acetyltransferase	Protein Coding	9
64	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	9
65	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	9
66	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	9
67	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	9
68	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	9
69	HDAC2	Histone Deacetylase 2	Protein Coding	9
70	TBP	TATA-Box Binding Protein	Protein Coding	8
71	TAF1D	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit D	Protein Coding	8
72	TAF1C	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C	Protein Coding	8
73	TAF1B	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B	Protein Coding	8
74	TAF1A	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A	Protein Coding	8
75	POLR1G	RNA Polymerase I Subunit G	Protein Coding	7
76	CHD3	Chromodomain Helicase DNA Binding Protein 3	Protein Coding	7
77	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	7
78	POLR1F	RNA Polymerase I Subunit F	Protein Coding	7
79	POLR1A	RNA Polymerase I Subunit A	Protein Coding	7
80	POLR1H	RNA Polymerase I Subunit H	Protein Coding	7
81	POLR1D	RNA Polymerase I And III Subunit D	Protein Coding	7
82	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	7
83	MTA3	Metastasis Associated 1 Family Member 3	Protein Coding	7
84	POLR1E	RNA Polymerase I Subunit E	Protein Coding	7
85	POLR1B	RNA Polymerase I Subunit B	Protein Coding	7
86	MTA1	Metastasis Associated 1	Protein Coding	7
87	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	7
88	POLR1C	RNA Polymerase I And III Subunit C	Protein Coding	7
89	UBTF	Upstream Binding Transcription Factor	Protein Coding	6
90	MBD2	Methyl-CpG Binding Domain Protein 2	Protein Coding	6
91	CBX3	Chromobox 3	Protein Coding	6
92	GATAD2A	GATA Zinc Finger Domain Containing 2A	Protein Coding	6
93	GATAD2B	GATA Zinc Finger Domain Containing 2B	Protein Coding	6
94	TTF1	Transcription Termination Factor 1	Protein Coding	6
95	DNMT1	DNA Methyltransferase 1	Protein Coding	6
96	DNMT3B	DNA Methyltransferase 3 Beta	Protein Coding	6
97	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	6
98	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	5
99	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	5
100	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	5
101	KDM6A	Lysine Demethylase 6A	Protein Coding	5
102	EED	Embryonic Ectoderm Development	Protein Coding	5
103	CDK7	Cyclin Dependent Kinase 7	Protein Coding	5
104	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	5
105	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	5
106	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	5
107	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	5
108	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	5
109	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	5
110	GTF2H3	General Transcription Factor IIH Subunit 3	Protein Coding	5
111	GTF2H4	General Transcription Factor IIH Subunit 4	Protein Coding	5
112	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	5
113	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	5
114	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	5
115	CCNH	Cyclin H	Protein Coding	5
116	KDM1A	Lysine Demethylase 1A	Protein Coding	5
117	WDR5	WD Repeat Domain 5	Protein Coding	4
118	RBBP5	RB Binding Protein 5, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	4
119	KMT2D	Lysine Methyltransferase 2D	Protein Coding	4
120	ASH2L	ASH2 Like, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	4
121	TP53	Tumor Protein P53	Protein Coding	4
122	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	4
123	SMARCA5	SNF2 Related Chromatin Remodeling ATPase 5	Protein Coding	4
124	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	4
125	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
126	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
127	CNOT6	CCR4-NOT Transcription Complex Subunit 6	Protein Coding	3
128	KMT2C	Lysine Methyltransferase 2C	Protein Coding	3
129	RARA	Retinoic Acid Receptor Alpha	Protein Coding	3
130	RXRA	Retinoid X Receptor Alpha	Protein Coding	3
131	DPY30	Dpy-30 Histone Methyltransferase Complex Regulatory Subunit	Protein Coding	3
132	HDAC3	Histone Deacetylase 3	Protein Coding	3
133	CNOT9	CCR4-NOT Transcription Complex Subunit 9	Protein Coding	3
134	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	3
135	KDM5B	Lysine Demethylase 5B	Protein Coding	3
136	KDM6B	Lysine Demethylase 6B	Protein Coding	3
137	TUT4	Terminal Uridylyl Transferase 4	Protein Coding	3
138	UHRF1	Ubiquitin Like With PHD And Ring Finger Domains 1	Protein Coding	3
139	KDM5A	Lysine Demethylase 5A	Protein Coding	3
140	TUT7	Terminal Uridylyl Transferase 7	Protein Coding	3
141	RNA45SN5	RNA, 45S Pre-Ribosomal N5	RNA Gene	3
142	RRN3	RNA Polymerase I Transcription Factor RRN3	Protein Coding	3
143	SAP18	Sin3A Associated Protein 18	Protein Coding	3
144	SIN3B	SIN3 Transcription Regulator Family Member B	Protein Coding	3
145	SIN3A	SIN3 Transcription Regulator Family Member A	Protein Coding	3
146	ARID4B	AT-Rich Interaction Domain 4B	Protein Coding	3
147	SUDS3	SIN3A Corepressor Complex Component SDS3	Protein Coding	3
148	SUV39H1	SUV39H1 Histone Lysine Methyltransferase	Protein Coding	3
149	SAP30L	SAP30 Like	Protein Coding	3
150	SAP30	Sin3A Associated Protein 30	Protein Coding	3
151	ACTB	Actin Beta	Protein Coding	3
152	DEK	DEK Proto-Oncogene	Protein Coding	3
153	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	3
154	KDM4C	Lysine Demethylase 4C	Protein Coding	3
155	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	3
156	CTCF	CCCTC-Binding Factor	Protein Coding	2
157	EGR2	Early Growth Response 2	Protein Coding	2
158	PAXIP1	PAX Interacting Protein 1	Protein Coding	2
159	NCOA6	Nuclear Receptor Coactivator 6	Protein Coding	2
160	HOXA1	Homeobox A1	Protein Coding	2
161	HOXA2	Homeobox A2	Protein Coding	2
162	HOXA3	Homeobox A3	Protein Coding	2
163	HOXA4	Homeobox A4	Protein Coding	2
164	HOXB1	Homeobox B1	Protein Coding	2
165	HOXB2	Homeobox B2	Protein Coding	2
166	HOXB3	Homeobox B3	Protein Coding	2
167	HOXB4	Homeobox B4	Protein Coding	2
168	HOXC4	Homeobox C4	Protein Coding	2
169	HOXD1	Homeobox D1	Protein Coding	2
170	HOXD3	Homeobox D3	Protein Coding	2
171	HOXD4	Homeobox D4	Protein Coding	2
172	MEIS1	Meis Homeobox 1	Protein Coding	2
173	PAX6	Paired Box 6	Protein Coding	2
174	PBX1	PBX Homeobox 1	Protein Coding	2
175	PKNOX1	PBX/Knotted 1 Homeobox 1	Protein Coding	2
176	POLR2A	RNA Polymerase II Subunit A	Protein Coding	2
177	POLR2B	RNA Polymerase II Subunit B	Protein Coding	2
178	POLR2C	RNA Polymerase II Subunit C	Protein Coding	2
179	POLR2D	RNA Polymerase II Subunit D	Protein Coding	2
180	POLR2G	RNA Polymerase II Subunit G	Protein Coding	2
181	POLR2I	RNA Polymerase II Subunit I	Protein Coding	2
182	POLR2J	RNA Polymerase II Subunit J	Protein Coding	2
183	RARB	Retinoic Acid Receptor Beta	Protein Coding	2
184	RARG	Retinoic Acid Receptor Gamma	Protein Coding	2
185	ZNF335	Zinc Finger Protein 335	Protein Coding	2
186	YY1	YY1 Transcription Factor	Protein Coding	2
187	PCGF2	Polycomb Group Ring Finger 2	Protein Coding	2
188	PAGR1	PAXIP1 Associated Glutamate Rich Protein 1	Protein Coding	2
189	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	2
190	AJUBA	Ajuba LIM Protein	Protein Coding	2
191	PIAS2	Protein Inhibitor Of Activated STAT 2	Protein Coding	2
192	MAFB	MAF BZIP Transcription Factor B	Protein Coding	2
193	DUXB	Double Homeobox B	Protein Coding	2
194	DUX4	Double Homeobox 4	Protein Coding	2
195	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	2
196	PAIP1	Poly(A) Binding Protein Interacting Protein 1	Protein Coding	2
197	METTL23	Methyltransferase 23, Arginine	Protein Coding	2
198	DIS3L2	DIS3 Like 3''-5'' Exoribonuclease 2	Protein Coding	2
199	DPPA2	Developmental Pluripotency Associated 2	Protein Coding	2
200	EIF4A1	Eukaryotic Translation Initiation Factor 4A1	Protein Coding	2
201	EIF4A2	Eukaryotic Translation Initiation Factor 4A2	Protein Coding	2
202	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	2
203	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	2
204	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	2
205	TET3	Tet Methylcytosine Dioxygenase 3	Protein Coding	2
206	ZSCAN4	Zinc Finger And SCAN Domain Containing 4	Protein Coding	2
207	PABPC1	Poly(A) Binding Protein Cytoplasmic 1	Protein Coding	2
208	TPRX1	Tetrapeptide Repeat Homeobox 1	Protein Coding	2
209	STPG4	Sperm-Tail PG-Rich Repeat Containing 4	Protein Coding	2
210	LEUTX	Leucine Twenty Homeobox	Protein Coding	2
211	DPPA3	Developmental Pluripotency Associated 3	Protein Coding	2
212	KDM4E	Lysine Demethylase 4E	Protein Coding	2
213	TPRX2	Tetrapeptide Repeat Homeobox 2	Protein Coding	2
214	DUXA	Double Homeobox A	Protein Coding	2
215	DPPA4	Developmental Pluripotency Associated 4	Protein Coding	2
216	AICDA	Activation Induced Cytidine Deaminase	Protein Coding	2
217	TEAD4	TEA Domain Transcription Factor 4	Protein Coding	2
218	UNG	Uracil DNA Glycosylase	Protein Coding	2
219	PABPN1	Poly(A) Binding Protein Nuclear 1	Protein Coding	2
220	EIF4A3	Eukaryotic Translation Initiation Factor 4A3	Protein Coding	2
221	APP	Amyloid Beta Precursor Protein	Protein Coding	2
222	BAZ2A	Bromodomain Adjacent To Zinc Finger Domain 2A	Protein Coding	2
223	RRP8	Ribosomal RNA Processing 8	Protein Coding	2
224	SIRT1	Sirtuin 1	Protein Coding	2
225	SAP30BP	SAP30 Binding Protein	Protein Coding	2
226	SAP130	Sin3A Associated Protein 130	Protein Coding	2
227	MYBBP1A	MYB Binding Protein 1a	Protein Coding	2
228	SF3B1	Splicing Factor 3b Subunit 1	Protein Coding	2
229	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	2
230	MYO1C	Myosin IC	Protein Coding	2
231	BAZ1B	Bromodomain Adjacent To Zinc Finger Domain 1B	Protein Coding	2
232	DDX21	DExD-Box Helicase 21	Protein Coding	2
233	GSDME	Gasdermin E	Protein Coding	2
234	POLA2	DNA Polymerase Alpha 2, Accessory Subunit	Protein Coding	2
235	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	2
236	PRIM1	DNA Primase Subunit 1	Protein Coding	2
237	PRIM2	DNA Primase Subunit 2	Protein Coding	2
238	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	2
239	CDC25C	Cell Division Cycle 25C	Protein Coding	2
240	DNMT3L	DNA Methyltransferase 3 Like	Protein Coding	2
241	ARID1B	AT-Rich Interaction Domain 1B	Protein Coding	2
242	SMARCA2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2	Protein Coding	2
243	SMARCB1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1	Protein Coding	2
244	SMARCC1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C1	Protein Coding	2
245	SMARCC2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C2	Protein Coding	2
246	SMARCD1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D1	Protein Coding	2
247	SMARCD2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D2	Protein Coding	2
248	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	2
249	SMARCE1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit E1	Protein Coding	2
250	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	2
251	ACTL6A	Actin Like 6A	Protein Coding	2
252	H2AC1	H2A Clustered Histone 1	Protein Coding	2
253	H2AC21	H2A Clustered Histone 21	Protein Coding	2
254	H2AC13	H2A Clustered Histone 13	Protein Coding	2
255	H2AC15	H2A Clustered Histone 15	Protein Coding	2
256	H2AC16	H2A Clustered Histone 16	Protein Coding	2
257	H2AC17	H2A Clustered Histone 17	Protein Coding	2
258	H2AC12	H2A Clustered Histone 12	Protein Coding	2
259	H2AC11	H2A Clustered Histone 11	Protein Coding	2
260	H2AC25	H2A Clustered Histone 25	Protein Coding	2
261	MYL9	Myosin Light Chain 9	Protein Coding	2
262	PRMT1	Protein Arginine Methyltransferase 1	Protein Coding	2
263	KMT2A	Lysine Methyltransferase 2A	Protein Coding	2
264	PRMT6	Protein Arginine Methyltransferase 6	Protein Coding	2
265	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	2
266	CBFB	Core-Binding Factor Subunit Beta	Protein Coding	2
267	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	2
268	KLK3	Kallikrein Related Peptidase 3	Protein Coding	2
269	AR	Androgen Receptor	Protein Coding	2
270	KLK2	Kallikrein Related Peptidase 2	Protein Coding	2
271	PKN1	Protein Kinase N1	Protein Coding	2
272	CTNNB1	Catenin Beta 1	Protein Coding	2
273	TCF7	Transcription Factor 7	Protein Coding	2
274	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	2
275	H3-4	H3.4 Histone, Cluster Member	Protein Coding	2
276	AXIN2	Axin 2	Protein Coding	2
277	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	2
278	RUNX3	RUNX Family Transcription Factor 3	Protein Coding	2
279	CDK4	Cyclin Dependent Kinase 4	Protein Coding	2
280	E2F1	E2F Transcription Factor 1	Protein Coding	2
281	PHF8	PHD Finger Protein 8	Protein Coding	2
282	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
283	NPM2	Nucleophosmin/Nucleoplasmin 2	Protein Coding	1
284	H1-8	H1.8 Linker Histone	Protein Coding	1
285	CNOT1	CCR4-NOT Transcription Complex Subunit 1	Protein Coding	1
286	DICER1	Dicer 1, Ribonuclease III	Protein Coding	1
287	CNOT6L	CCR4-NOT Transcription Complex Subunit 6 Like	Protein Coding	1
288	CNOT10	CCR4-NOT Transcription Complex Subunit 10	Protein Coding	1
289	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	1
290	CNOT7	CCR4-NOT Transcription Complex Subunit 7	Protein Coding	1
291	PABPN1L	PABPN1 Like, Cytoplasmic	Protein Coding	1
292	CNOT2	CCR4-NOT Transcription Complex Subunit 2	Protein Coding	1
293	CNOT3	CCR4-NOT Transcription Complex Subunit 3	Protein Coding	1
294	CNOT4	CCR4-NOT Transcription Complex Subunit 4	Protein Coding	1
295	BTG4	BTG Anti-Proliferation Factor 4	Protein Coding	1
296	CNOT11	CCR4-NOT Transcription Complex Subunit 11	Protein Coding	1
297	PRM1	Protamine 1	Protein Coding	1
298	PRM2	Protamine 2	Protein Coding	1
299	SRPK1	SRSF Protein Kinase 1	Protein Coding	1
300	ZFP36L2	ZFP36 Ring Finger Protein Like 2	Protein Coding	1
301	HIRA	Histone Cell Cycle Regulator	Protein Coding	1
302	TNKS1BP1	Tankyrase 1 Binding Protein 1	Protein Coding	1
303	CNOT8	CCR4-NOT Transcription Complex Subunit 8	Protein Coding	1
304	CAVIN1	Caveolae Associated Protein 1	Protein Coding	1
305	TSPAN5	Tetraspanin 5	Protein Coding	1
306	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
307	CST3	Cystatin C	Protein Coding	1
308	FGA	Fibrinogen Alpha Chain	Protein Coding	1
309	GGA2	Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2	Protein Coding	1
310	GGA3	Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3	Protein Coding	1
311	NCSTN	Nicastrin	Protein Coding	1
312	TSPAN15	Tetraspanin 15	Protein Coding	1
313	BACE1	Beta-Secretase 1	Protein Coding	1
314	GGA1	Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 1	Protein Coding	1
315	H2AZ1	H2A.Z Variant Histone 1	Protein Coding	1
316	APCS	Amyloid P Component, Serum	Protein Coding	1
317	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	1
318	APOA1	Apolipoprotein A1	Protein Coding	1
319	APOA4	Apolipoprotein A4	Protein Coding	1
320	IAPP	Islet Amyloid Polypeptide	Protein Coding	1
321	TSPAN33	Tetraspanin 33	Protein Coding	1
322	APOE	Apolipoprotein E	Protein Coding	1
323	INS	Insulin	Protein Coding	1
324	LTF	Lactotransferrin	Protein Coding	1
325	LYZ	Lysozyme	Protein Coding	1
326	MFGE8	Milk Fat Globule EGF And Factor V/VIII Domain Containing	Protein Coding	1
327	NPPA	Natriuretic Peptide A	Protein Coding	1
328	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
329	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	1
330	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
331	ODAM	Odontogenic, Ameloblast Associated	Protein Coding	1
332	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
333	PRL	Prolactin	Protein Coding	1
334	B2M	Beta-2-Microglobulin	Protein Coding	1
335	RPS27A	Ribosomal Protein S27a	Protein Coding	1
336	SAA1	Serum Amyloid A1	Protein Coding	1
337	SEMG1	Semenogelin 1	Protein Coding	1
338	SIAH1	Siah E3 Ubiquitin Protein Ligase 1	Protein Coding	1
339	SIAH2	Siah E3 Ubiquitin Protein Ligase 2	Protein Coding	1
340	SNCA	Synuclein Alpha	Protein Coding	1
341	SORL1	Sortilin Related Receptor 1	Protein Coding	1
342	TGFBI	Transforming Growth Factor Beta Induced	Protein Coding	1
343	TTR	Transthyretin	Protein Coding	1
344	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
345	UBB	Ubiquitin B	Protein Coding	1
346	UBC	Ubiquitin C	Protein Coding	1
347	CALB1	Calbindin 1	Protein Coding	1
348	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	1
349	TSPAN14	Tetraspanin 14	Protein Coding	1
350	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	1
351	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	1
352	NAT8	N-Acetyltransferase 8 (Putative)	Protein Coding	1
353	UBE2L6	Ubiquitin Conjugating Enzyme E2 L6	Protein Coding	1
354	ITM2B	Integral Membrane Protein 2B	Protein Coding	1
355	SNCAIP	Synuclein Alpha Interacting Protein	Protein Coding	1
356	BCL2L11	BCL2 Like 11	Protein Coding	1
357	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
358	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
359	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
360	FOXO3	Forkhead Box O3	Protein Coding	1
361	GOLGA2	Golgin A2	Protein Coding	1
362	LMNA	Lamin A/C	Protein Coding	1
363	LMNB1	Lamin B1	Protein Coding	1
364	PRDX1	Peroxiredoxin 1	Protein Coding	1
365	SOD2	Superoxide Dismutase 2	Protein Coding	1
366	PRDX2	Peroxiredoxin 2	Protein Coding	1
367	C1QBP	Complement C1q Binding Protein	Protein Coding	1
368	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
369	CAPN1	Calpain 1	Protein Coding	1
370	CAPN2	Calpain 2	Protein Coding	1
371	CAPNS1	Calpain Small Subunit 1	Protein Coding	1
372	CAST	Calpastatin	Protein Coding	1
373	CASP8	Caspase 8	Protein Coding	1
374	CAPNS2	Calpain Small Subunit 2	Protein Coding	1
375	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
376	FADD	Fas Associated Via Death Domain	Protein Coding	1
377	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
378	CDC25A	Cell Division Cycle 25A	Protein Coding	1
379	CDC25B	Cell Division Cycle 25B	Protein Coding	1
380	PIWIL4	Piwi Like RNA-Mediated Gene Silencing 4	Protein Coding	1
381	C19orf84	Chromosome 19 Open Reading Frame 84	Protein Coding	1
382	SS18L1	SS18L1 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	1
383	DPF2	Double PHD Fingers 2	Protein Coding	1
384	BCL7A	BAF Chromatin Remodeling Complex Subunit BCL7A	Protein Coding	1
385	SS18	SS18 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	1
386	DPF3	Double PHD Fingers 3	Protein Coding	1
387	DPF1	Double PHD Fingers 1	Protein Coding	1
388	SPOCD1	SPOC Domain Containing 1	Protein Coding	1
389	BCL7C	BAF Chromatin Remodeling Complex Subunit BCL7C	Protein Coding	1
390	BCL7B	BAF Chromatin Remodeling Complex Subunit BCL7B	Protein Coding	1
391	HMG20B	High Mobility Group 20B	Protein Coding	1
392	RCOR1	REST Corepressor 1	Protein Coding	1
393	BRMS1	BRMS1 Transcriptional Repressor And Anoikis Regulator	Protein Coding	1
394	GPS2	G Protein Pathway Suppressor 2	Protein Coding	1
395	H2BC18	H2B Clustered Histone 18	Protein Coding	1
396	PHF21A	PHD Finger Protein 21A	Protein Coding	1
397	HDAC8	Histone Deacetylase 8	Protein Coding	1
398	ARID4A	AT-Rich Interaction Domain 4A	Protein Coding	1
399	REST	RE1 Silencing Transcription Factor	Protein Coding	1
400	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	1
401	TBL1XR1	TBL1X/Y Related 1	Protein Coding	1
402	HDAC10	Histone Deacetylase 10	Protein Coding	1
403	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
404	ZFPM1	Zinc Finger Protein, FOG Family Member 1	Protein Coding	1
405	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	1
406	AGO4	Argonaute RISC Component 4	Protein Coding	1
407	SETD1B	SET Domain Containing 1B, Histone Lysine Methyltransferase	Protein Coding	1
408	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	1
409	GATA1	GATA Binding Protein 1	Protein Coding	1
410	AGO1	Argonaute RISC Component 1	Protein Coding	1
411	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	1
412	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	1
413	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
414	MOV10	Mov10 RNA Helicase	Protein Coding	1
415	NFE2	Nuclear Factor, Erythroid 2	Protein Coding	1
416	PF4	Platelet Factor 4	Protein Coding	1
417	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	1
418	THBS1	Thrombospondin 1	Protein Coding	1
419	NR4A3	Nuclear Receptor Subfamily 4 Group A Member 3	Protein Coding	1
420	SETD1A	SET Domain Containing 1A, Histone Lysine Methyltransferase	Protein Coding	1
421	KMT2B	Lysine Methyltransferase 2B	Protein Coding	1
422	MYL12B	Myosin Light Chain 12B	Protein Coding	1
423	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
424	SFN	Stratifin	Protein Coding	1
425	PKN3	Protein Kinase N3	Protein Coding	1
426	RHOA	Ras Homolog Family Member A	Protein Coding	1
427	RHOB	Ras Homolog Family Member B	Protein Coding	1
428	RHOC	Ras Homolog Family Member C	Protein Coding	1
429	MYH9	Myosin Heavy Chain 9	Protein Coding	1
430	MYH10	Myosin Heavy Chain 10	Protein Coding	1
431	MYH11	Myosin Heavy Chain 11	Protein Coding	1
432	MYL6	Myosin Light Chain 6	Protein Coding	1
433	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
434	PPP1R12B	Protein Phosphatase 1 Regulatory Subunit 12B	Protein Coding	1
435	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
436	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
437	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
438	PKN2	Protein Kinase N2	Protein Coding	1
439	RAC1	Rac Family Small GTPase 1	Protein Coding	1
440	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
441	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
442	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
443	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
444	MYH14	Myosin Heavy Chain 14	Protein Coding	1
445	PPP1R14A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A	Protein Coding	1
446	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
447	LEO1	LEO1 Component Of Paf1/RNA Polymerase II Complex	Protein Coding	1
448	PYGO1	Pygopus Family PHD Finger 1	Protein Coding	1
449	BCL9L	BCL9 Like	Protein Coding	1
450	MEN1	Menin 1	Protein Coding	1
451	BCL9	BCL9 Transcription Coactivator	Protein Coding	1
452	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
453	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	1
454	TLE2	TLE Family Member 2, Transcriptional Corepressor	Protein Coding	1
455	TLE3	TLE Family Member 3, Transcriptional Corepressor	Protein Coding	1
456	TLE4	TLE Family Member 4, Transcriptional Corepressor	Protein Coding	1
457	CDC73	Cell Division Cycle 73	Protein Coding	1
458	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	1
459	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	1
460	PYGO2	Pygopus Family PHD Finger 2	Protein Coding	1
461	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
462	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
463	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
464	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
465	CEBPE	CCAAT Enhancer Binding Protein Epsilon	Protein Coding	1
466	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
467	CSF3R	Colony Stimulating Factor 3 Receptor	Protein Coding	1
468	FLI1	Fli-1 Proto-Oncogene, ETS Transcription Factor	Protein Coding	1
469	GATA2	GATA Binding Protein 2~Name Same As:- HGNC:18350	Protein Coding	1
470	GFI1	Growth Factor Independent 1 Transcriptional Repressor	Protein Coding	1
471	IL6R	Interleukin 6 Receptor	Protein Coding	1
472	MYB	MYB Proto-Oncogene, Transcription Factor	Protein Coding	1
473	PML	PML Nuclear Body Scaffold	Protein Coding	1
474	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
475	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
476	KLF5	KLF Transcription Factor 5	Protein Coding	1
477	TAL1	TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor	Protein Coding	1
478	TFDP1	Transcription Factor Dp-1	Protein Coding	1
479	TFDP2	Transcription Factor Dp-2	Protein Coding	1
480	PRMT3	Protein Arginine Methyltransferase 3	Protein Coding	1
481	PRMT5	Protein Arginine Methyltransferase 5	Protein Coding	1
482	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	1
483	ARID2	AT-Rich Interaction Domain 2	Protein Coding	1
484	JAK2	Janus Kinase 2	Protein Coding	1
485	ACTL6B	Actin Like 6B	Protein Coding	1
486	PRMT7	Protein Arginine Methyltransferase 7	Protein Coding	1
487	PBRM1	Polybromo 1	Protein Coding	1
488	COPRS	Coordinator Of PRMT5 And Differentiation Stimulator	Protein Coding	1
489	CCND1	Cyclin D1	Protein Coding	1
490	RPS2	Ribosomal Protein S2	Protein Coding	1
491	WDR77	WD Repeat Domain 77	Protein Coding	1
492	SMC4	Structural Maintenance Of Chromosomes 4	Protein Coding	1
493	SMC2	Structural Maintenance Of Chromosomes 2	Protein Coding	1
494	NCAPD3	Non-SMC Condensin II Complex Subunit D3	Protein Coding	1
495	NCAPH2	Non-SMC Condensin II Complex Subunit H2	Protein Coding	1
496	KMT5A	Lysine Methyltransferase 5A	Protein Coding	1
497	PLK1	Polo Like Kinase 1	Protein Coding	1
498	NCAPG2	Non-SMC Condensin II Complex Subunit G2	Protein Coding	1
499	SET	SET Nuclear Proto-Oncogene	Protein Coding	1
500	MCPH1	Microcephalin 1	Protein Coding	1
501	CCNB1	Cyclin B1	Protein Coding	1
502	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
503	AEBP2	AE Binding Protein 2	Protein Coding	1
504	MTF2	Metal Response Element Binding Transcription Factor 2	Protein Coding	1
505	PHF19	PHD Finger Protein 19	Protein Coding	1
506	JARID2	Jumonji And AT-Rich Interaction Domain Containing 2	Protein Coding	1
507	PHF1	PHD Finger Protein 1	Protein Coding	1
508	RBM7	RNA Binding Motif Protein 7	Protein Coding	1
509	MORC2	MORC Family CW-Type Zinc Finger 2	Protein Coding	1
510	TASOR	Transcription Activation Suppressor	Protein Coding	1
511	MTREX	Mtr4 Exosome RNA Helicase	Protein Coding	1
512	PPHLN1	Periphilin 1	Protein Coding	1
513	MPHOSPH8	M-Phase Phosphoprotein 8	Protein Coding	1
514	ZCCHC8	Zinc Finger CCHC-Type Containing 8	Protein Coding	1
515	ATF7IP	Activating Transcription Factor 7 Interacting Protein	Protein Coding	1
516	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	1
517	SETDB1	SET Domain Bifurcated Histone Lysine Methyltransferase 1	Protein Coding	1
518	ORC6	Origin Recognition Complex Subunit 6	Protein Coding	1
519	ORC3	Origin Recognition Complex Subunit 3	Protein Coding	1
520	KPNA6	Karyopherin Subunit Alpha 6	Protein Coding	1
521	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	1
522	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
523	ORC1	Origin Recognition Complex Subunit 1	Protein Coding	1
524	ORC2	Origin Recognition Complex Subunit 2	Protein Coding	1
525	ORC4	Origin Recognition Complex Subunit 4	Protein Coding	1
526	ORC5	Origin Recognition Complex Subunit 5	Protein Coding	1
527	KDM1B	Lysine Demethylase 1B	Protein Coding	1
528	KDM2A	Lysine Demethylase 2A	Protein Coding	1
529	KDM4B	Lysine Demethylase 4B	Protein Coding	1
530	JMJD6	Jumonji Domain Containing 6, Arginine Demethylase And Lysine Hydroxylase	Protein Coding	1
531	KDM3B	Lysine Demethylase 3B	Protein Coding	1
532	PHF2	PHD Finger Protein 2	Protein Coding	1
533	KDM4D	Lysine Demethylase 4D	Protein Coding	1
534	KDM3A	Lysine Demethylase 3A	Protein Coding	1
535	UTY	Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked	Protein Coding	1
536	KDM7A	Lysine Demethylase 7A	Protein Coding	1
537	KDM5C	Lysine Demethylase 5C	Protein Coding	1
538	KDM5D	Lysine Demethylase 5D	Protein Coding	1
539	ARID5B	AT-Rich Interaction Domain 5B	Protein Coding	1
540	KDM2B	Lysine Demethylase 2B	Protein Coding	1
541	RIOX2	Ribosomal Oxygenase 2	Protein Coding	1
542	KDM4A	Lysine Demethylase 4A	Protein Coding	1
543	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1
544	INPP5K	Inositol Polyphosphate-5-Phosphatase K	Protein Coding	1
545	CBX5	Chromobox 5	Protein Coding	1
546	CBX1	Chromobox 1	Protein Coding	1

Disorders associated with RNA Polymerase I Promoter Opening SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Direct
2	Colon adenocarcinoma	Direct
3	Gastric adenocarcinoma	Direct
4	Squamous cell carcinoma, head and neck	Direct
5	Lung cancer susceptibility 3	Direct
6	Melanoma	Direct
7	Coffin-siris syndrome 1	Enrichment	ARID1A, ARID1B, DPF2, SMARCA4, SMARCB1, SMARCC2, SMARCD1, SMARCE1	10.82
8	Amyloidosis, hereditary systemic 2	Enrichment	APOA1, B2M, FGA, LYZ	7.71
9	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	7.04
10	Glioma susceptibility 1	Enrichment	H3-3A, H3C1, TP53	5.98
11	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	5.14
12	Treacher collins syndrome 1	Enrichment	POLR1B, POLR1C, POLR1D	5.01
13	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.88
14	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.88
15	Meier-gorlin syndrome 1	Enrichment	ORC1, ORC4, ORC6	4.85
16	Myeloma, multiple	Enrichment	CCND1, DNMT3A, H2AC16, H2AC17, H3C1	4.78
17	Osteogenic sarcoma	Enrichment	RB1, TP53	4.66
18	Squamous cell carcinoma	Enrichment	RB1, TP53	4.66
19	Bone osteosarcoma	Enrichment	RB1, TP53	4.66
20	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.66
21	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.66
22	Trichothiodystrophy	Enrichment	ERCC2, ERCC3, GTF2H5	4.64
23	Complex neurodevelopmental disorder	Enrichment	AGO1, H4C3, H4C5, H4C9, KMT2B, SETD1A, TNRC6B	4.62
24	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4, SMARCB1	4.49
25	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	4.40
26	Small cell cancer of the lung	Enrichment	RB1, TP53	4.36
27	Hyperparathyroidism 1	Enrichment	CDC73, MEN1	4.36
28	Witteveen-kolk syndrome	Enrichment	SIN3A, SIN3B	4.32
29	Charge syndrome	Enrichment	EP300, KDM6A, KMT2D	4.24
30	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP, CST3	4.19
31	Acute promyelocytic leukemia	Enrichment	PML, RARA, STAT3	4.13
32	Weaver syndrome	Enrichment	EZH2, SUZ12	4.08
33	Parathyroid adenoma	Enrichment	CDC73, MEN1	3.89
34	Familial isolated hyperparathyroidism	Enrichment	CDC73, MEN1	3.89
35	Leukemia, acute myeloid	Enrichment	CEBPA, GATA2, KMT2A, RUNX1	3.88
36	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.81
37	Nicolaides-baraitser syndrome	Enrichment	ARID1B, SMARCA2	3.71
38	Blepharophimosis	Enrichment	ARID1B, SMARCA2	3.71
39	Smarca2-related nicolaides-baraitser syndrome	Enrichment	ARID1B, SMARCA2	3.71
40	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TP53	3.60
41	Myeloproliferative neoplasm	Enrichment	DNMT3A, JAK2	3.49
42	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	DNMT3B, UHRF1	3.49
43	Thrombocytopenia	Enrichment	GATA1, GP1BA, ITGA2B, RUNX1	3.48
44	Complex hereditary spastic paraplegia	Enrichment	PRKN, SORL1	3.42
45	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA, RUNX1	3.38
46	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2, ERCC3	3.37
47	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYB, MYC, TAL1	3.36
48	Embryonal rhabdomyosarcoma	Enrichment	DICER1, TP53	3.34
49	Acute megakaryocytic leukemia	Enrichment	GATA1, KMT2A	3.33
50	Lip and oral cavity carcinoma	Enrichment	RB1, TP53	3.33
51	Microtia-anotia	Enrichment	HOXA2, KMT2D	3.32
52	Endometrial stromal sarcoma	Enrichment	SUZ12, YWHAE	3.27
53	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	3.23
54	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	3.23
55	Adenoid ameloblastoma	Enrichment	CTNNB1	3.23
56	Microcystic stromal tumor	Enrichment	CTNNB1	3.23
57	Adrenocortical carcinoma	Enrichment	CTNNB1, TERT	3.19
58	Kabuki syndrome 1	Enrichment	KMT2A, KMT2D	3.15
59	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	GP1BA, ITGA2B	3.15
60	Li-fraumeni syndrome	Enrichment	CDKN2A, TP53	3.09
61	Robin sequence with cleft mandible and limb anomalies	Enrichment	EIF4A3	3.05
62	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	3.05
63	Perlman syndrome	Enrichment	DIS3L2	3.05
64	Autism 19	Enrichment	EIF4E	3.05
65	Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures	Enrichment	EIF4A2	3.05
66	Multiple endocrine neoplasia, type i	Enrichment	CDC73, MEN1	3.05
67	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC2, ERCC6	3.03
68	Colorectal cancer	Enrichment	AXIN2, CTNNB1	2.95
69	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	2.95
70	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.93
71	Burkitt lymphoma	Enrichment	MYC	2.93
72	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.93
73	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.93
74	Split hand-foot malformation	Enrichment	LEF1	2.93
75	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.93
76	Teratoma	Enrichment	CTNNB1	2.93
77	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.90
78	Bone marrow failure syndrome 5	Enrichment	TP53	2.90
79	Papilloma of choroid plexus	Enrichment	TP53	2.90
80	Basal cell carcinoma 7	Enrichment	TP53	2.90
81	Anaplastic thyroid carcinoma	Enrichment	TP53	2.90
82	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.90
83	Ductal carcinoma in situ	Enrichment	TP53	2.90
84	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.90
85	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.90
86	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.90
87	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.90
88	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.90
89	Choroid plexus cancer	Enrichment	TP53	2.90
90	Menke-hennekam syndrome	Enrichment	CREBBP	2.90
91	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.90
92	Early-onset autosomal dominant alzheimer disease	Enrichment	APP, SORL1	2.88
93	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	CSF3R, RUNX1	2.83
94	Ovarian cancer	Enrichment	AXIN2, CTNNB1	2.83
95	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	SETD1A, TNRC6B	2.78
96	Meningioma, familial	Enrichment	SMARCB1, SMARCE1	2.76
97	Atrial heart septal defect	Enrichment	ACTL6A, SMARCA4	2.76
98	Interatrial communication	Enrichment	ACTL6A, SMARCA4	2.76
99	Desmoid disease, hereditary	Enrichment	CTNNB1	2.75
100	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.75
101	Anus, imperforate	Enrichment	CTNNB1	2.75
102	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.75
103	Desmoid tumor	Enrichment	CTNNB1	2.75
104	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.75
105	Adult hepatocellular carcinoma	Enrichment	CASP8, TP53	2.72
106	Autosomal dominant macrothrombocytopenia	Enrichment	GP1BA, ITGA2B	2.69
107	Meningioma	Enrichment	SMARCB1, SMARCE1	2.68
108	Xeroderma pigmentosum, variant type	Enrichment	ERCC2, ERCC3	2.64
109	Pilomatrixoma	Enrichment	CTNNB1	2.63
110	Alazami syndrome	Enrichment	CTNNB1	2.63
111	Craniopharyngioma	Enrichment	CTNNB1	2.63
112	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.60
113	Thumb deformity	Enrichment	CREBBP	2.60
114	Cervical cancer	Enrichment	TP53	2.60
115	Lymphoma, hodgkin, classic	Enrichment	TP53	2.60
116	Menke-hennekam syndrome 2	Enrichment	EP300	2.60
117	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.60
118	Congenital fibrosarcoma	Enrichment	TP53	2.60
119	Li-fraumeni syndrome 1	Enrichment	TP53	2.60
120	Sarcoma	Enrichment	TP53	2.60
121	Cervix carcinoma	Enrichment	TP53	2.60
122	Hodgkin's lymphoma	Enrichment	TP53	2.60
123	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.60
124	Oculopharyngeal muscular dystrophy 1	Enrichment	PABPN1	2.58
125	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.56
126	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.56
127	Ifap syndrome 2	Enrichment	SREBF1	2.56
128	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.56
129	Muscular dystrophy, congenital, with cataracts and impaired intellectual development	Enrichment	INPP5K	2.56
130	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.56
131	Trilateral retinoblastoma	Enrichment	RB1	2.56
132	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.56
133	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.56
134	Lung oat cell carcinoma	Enrichment	RB1	2.56
135	Bladder cancer	Enrichment	RB1, TP53	2.55
136	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.53
137	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.45
138	Split-hand/foot malformation 1	Enrichment	LEF1	2.45
139	Autism spectrum disorder	Enrichment	ACTL6B, ARID1B, DNMT3A, SMARCB1	2.45
140	Intellectual developmental disorder, x-linked, syndromic, siderius type	Enrichment	PHF8	2.43
141	Kabuki syndrome 2	Enrichment	KDM6A	2.43
142	Syndromic x-linked intellectual disability siderius type	Enrichment	PHF8	2.43
143	Intellectual developmental disorder, autosomal recessive 65	Enrichment	KDM5B	2.43
144	Rare genetic epilepsy	Enrichment	KDM3B	2.43
145	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	ARID1A, ARID1B	2.43
146	Nasopharyngeal carcinoma	Enrichment	TP53	2.43
147	Tethered spinal cord syndrome	Enrichment	CREBBP	2.43
148	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.43
149	Anaplastic astrocytoma	Enrichment	TP53	2.43
150	Adenocarcinoma	Enrichment	TP53	2.43
151	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.43
152	Early-onset parkinson's disease	Enrichment	PRKN, SNCA	2.40
153	Gallbladder cancer	Enrichment	CTNNB1	2.38
154	Exudative vitreoretinopathy	Enrichment	CTNNB1	2.33
155	Alzheimer's disease	Enrichment	APOE, APP	2.33
156	Heyn-sproul-jackson syndrome	Enrichment	DNMT3A	2.33
157	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.31
158	Androgen insensitivity, partial	Enrichment	AR	2.31
159	Complete androgen insensitivity syndrome	Enrichment	AR	2.31
160	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.30
161	Lung sarcomatoid carcinoma	Enrichment	TP53	2.30
162	Malignant epithelioid hemangioendothelioma	Enrichment	YAP1	2.30
163	Meier-gorlin syndrome 3	Enrichment	ORC6	2.30
164	Meier-gorlin syndrome 2	Enrichment	ORC4	2.30
165	Intellectual developmental disorder, autosomal recessive 44	Enrichment	METTL23	2.29
166	Tet3-related beck-fahrner syndrome	Enrichment	TET3	2.29
167	Beck-fahrner syndrome	Enrichment	TET3	2.29
168	Developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy	Enrichment	MORC2	2.29
169	Charcot-marie-tooth disease, axonal, type 2z	Enrichment	MORC2	2.29
170	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 5	Enrichment	ZCCHC8	2.29
171	Tooth agenesis, selective, 1	Enrichment	AXIN2	2.28
172	Wilms tumor 5	Enrichment	DIS3L2	2.28
173	Imagawa-matsumoto syndrome	Enrichment	SUZ12	2.28
174	Developmental delay with variable intellectual disability and dysmorphic facies	Enrichment	JARID2	2.28
175	Cohen-gibson syndrome	Enrichment	EED	2.28
176	Khan-khan-katsanis syndrome	Enrichment	NCAPG2	2.27
177	Microcephaly 22, primary, autosomal recessive	Enrichment	NCAPD3	2.27
178	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	2.26
179	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.26
180	Snijders blok-campeau syndrome	Enrichment	CHD3	2.26
181	Familial retinoblastoma	Enrichment	RB1	2.26
182	Gand syndrome	Enrichment	GATAD2B	2.26
183	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	Enrichment	GATAD2B	2.26
184	Polycystic liver disease	Enrichment	CTNNB1, RUVBL1	2.26
185	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, RUVBL1	2.26
186	Torticollis	Enrichment	ACTL6A	2.24
187	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.24
188	Acanthosis nigricans	Enrichment	PRMT7	2.24
189	Coffin-siris syndrome 5	Enrichment	SMARCE1	2.24
190	Intellectual developmental disorder with severe speech and ambulation defects	Enrichment	ACTL6B	2.24
191	Coffin-siris syndrome 11	Enrichment	SMARCD1	2.24
192	Hydrocephalus, congenital, 5	Enrichment	SMARCC1	2.24
193	Rhabdoid tumor predisposition syndrome 1	Enrichment	SMARCB1	2.24
194	Neurilemmoma	Enrichment	SMARCB1	2.24
195	Coffin-siris syndrome 3	Enrichment	SMARCB1	2.24
196	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.24
197	Arid1b-related disorder	Enrichment	ARID1B	2.24
198	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.24
199	Short stature, brachydactyly, impaired intellectual development, and seizures	Enrichment	PRMT7	2.24
200	Blepharophimosis-impaired intellectual development syndrome	Enrichment	SMARCA2	2.24
201	Facial cleft	Enrichment	SMARCE1	2.24
202	Autosomal recessive severe congenital neutropenia	Enrichment	SMARCD2	2.24
203	Microphthalmia/coloboma 12	Enrichment	PAX6, RARB	2.23
204	Gliosarcoma	Enrichment	DNMT3A, TP53	2.21
205	Rhabdomyosarcoma 2	Enrichment	TP53	2.20
206	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.20
207	Lymphoma	Enrichment	TP53	2.20
208	Immunodeficiency 108 with autoinflammation	Enrichment	CEBPE	2.18
209	Bleeding disorder, platelet-type, 21	Enrichment	FLI1	2.18
210	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.18
211	Lymphedema, primary, with myelodysplasia	Enrichment	GATA2	2.18
212	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.18
213	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.18
214	Immunodeficiency 21	Enrichment	GATA2	2.18
215	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.18
216	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.18
217	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.18
218	Deafness-lymphedema-leukemia syndrome	Enrichment	GATA2	2.18
219	Acute myeloid leukemia with mll rearrangement	Enrichment	KMT2A	2.18
220	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.18
221	Agammaglobulinemia	Enrichment	SPI1	2.18
222	Isolated delta-storage pool disease	Enrichment	FLI1	2.18
223	Cebpe-associated autoinflammation-immunodeficiency-neutrophil dysfunction syndrome	Enrichment	CEBPE	2.18
224	Chronic neutrophilic leukemia	Enrichment	CSF3R	2.18
225	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.18
226	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.18
227	Xeroderma pigmentosum, complementation group b	Enrichment	ERCC3	2.18
228	Leukodystrophy, hypomyelinating, 27	Enrichment	POLR1A	2.18
229	Treacher collins syndrome 4	Enrichment	POLR1B	2.18
230	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	2.18
231	Trichothiodystrophy 2, photosensitive	Enrichment	ERCC3	2.18
232	Xeroderma pigmentosum group b	Enrichment	ERCC3	2.18
233	Treacher collins syndrome 2	Enrichment	POLR1D	2.18
234	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	2.18
235	Trichothiodystrophy 3, photosensitive	Enrichment	GTF2H5	2.18
236	Xeroderma pigmentosum group d	Enrichment	ERCC2	2.18
237	Branchial cleft anomalies	Enrichment	KMT2D	2.18
238	Parathyroid carcinoma	Enrichment	CDC73	2.18
239	Hyperparathyroidism 2 with jaw tumors	Enrichment	CDC73	2.18
240	Adrenal cortical adenoma	Enrichment	MEN1	2.18
241	Cdc73-related disorders	Enrichment	CDC73	2.18
242	Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome	Enrichment	KMT2D	2.18
243	Deafness, autosomal dominant 75	Enrichment	TRRAP	2.18
244	Developmental delay with or without dysmorphic facies and autism	Enrichment	TRRAP	2.18
245	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.18
246	Adrenal adenoma	Enrichment	MEN1	2.18
247	Baraitser-winter syndrome 1	Enrichment	ACTB	2.18
248	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.18
249	Becker nevus syndrome	Enrichment	ACTB	2.18
250	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.18
251	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.18
252	Baraitser-winter syndrome	Enrichment	ACTB	2.18
253	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.18
254	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.18
255	Deafness, autosomal dominant 17	Enrichment	MYH9	2.16
256	Deafness, autosomal dominant 4a	Enrichment	MYH14	2.16
257	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.16
258	Peripheral neuropathy, myopathy, hoarseness, and hearing loss	Enrichment	MYH14	2.16
259	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.16
260	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.16
261	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.16
262	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.16
263	Autosomal dominant nonsyndromic hearing loss 17	Enrichment	MYH9	2.16
264	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.16
265	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.16
266	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	2.16
267	Wilms tumor 6	Enrichment	REST	2.16
268	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.16
269	Deafness, autosomal dominant 27	Enrichment	REST	2.16
270	Intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism with or without seizures	Enrichment	PHF21A	2.16
271	Fibromatosis, gingival, 5	Enrichment	REST	2.16
272	Bernard-soulier syndrome, type a2, autosomal dominant	Enrichment	GP1BA	2.16
273	Anemia, congenital, nonspherocytic hemolytic, 9	Enrichment	GATA1	2.16
274	Thrombocytopenia, x-linked, with or without dyserythropoietic anemia	Enrichment	GATA1	2.16
275	Nonarteritic anterior ischemic optic neuropathy	Enrichment	GP1BA	2.16
276	Thrombocytopenia with beta-thalassemia, x-linked	Enrichment	GATA1	2.16
277	Von willebrand disease, platelet-type	Enrichment	GP1BA	2.16
278	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.16
279	Neurodevelopmental disorder with speech impairment and dysmorphic facies	Enrichment	SETD1A	2.16
280	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.16
281	Anemia, x-linked, with or without neutropenia and/or platelet abnormalities	Enrichment	GATA1	2.16
282	Epilepsy, early-onset, 2, with or without developmental delay	Enrichment	SETD1A	2.16
283	Intellectual developmental disorder with seizures and language delay	Enrichment	SETD1B	2.16
284	Kleefstra syndrome 2	Enrichment	KMT2C	2.16
285	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.16
286	Intellectual developmental disorder, autosomal dominant 68	Enrichment	KMT2B	2.16
287	Generalized isolated dystonia	Enrichment	KMT2B	2.16
288	Acute megakaryoblastic leukemia in children with down syndrome	Enrichment	GATA1	2.16
289	Kmt2b-related disorders	Enrichment	KMT2B	2.16
290	Bernard-soulier syndrome type a2	Enrichment	GP1BA	2.16
291	Thrombocytopenia with congenital dyserythropoietic anemia	Enrichment	GATA1	2.16
292	Chromosome 15q24 deletion syndrome	Enrichment	SIN3A	2.16
293	Giant cell glioblastoma	Enrichment	DNMT3A, TP53	2.16
294	Inherited cancer-predisposing syndrome	Enrichment	CDK4, SMARCA4, SMARCB1, SMARCE1	2.15
295	Coffin-siris syndrome 7	Enrichment	DPF2	2.15
296	Intellectual developmental disorder, autosomal dominant 65	Enrichment	KDM4B	2.13
297	Diets-jongmans syndrome	Enrichment	KDM3B	2.13
298	El hayek-chahrour neurodevelopmental syndrome	Enrichment	KDM5A	2.13
299	Stolerman neurodevelopmental syndrome	Enrichment	KDM6B	2.13
300	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.13
301	Van esch-o'driscoll syndrome	Enrichment	POLA1	2.13
302	Caspase 8 deficiency	Enrichment	CASP8	2.13
303	Microvascular complications of diabetes 6	Enrichment	SOD2	2.13
304	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.13
305	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	2.13
306	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	2.13
307	Pulmonary hypertension, primary, 6	Enrichment	CAPNS1	2.13
308	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.13
309	Deafness, autosomal dominant 5	Enrichment	GSDME	2.13
310	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.13
311	Developmental delay with hypotonia, myopathy, and brain abnormalities	Enrichment	GOLGA2	2.13
312	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.13
313	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.13
314	Atypical werner syndrome	Enrichment	LMNA	2.13
315	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.13
316	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.13
317	Mandibuloacral dysplasia	Enrichment	LMNA	2.13
318	Atrioventricular block	Enrichment	LMNA	2.13
319	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.13
320	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.13
321	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.13
322	Laminopathy	Enrichment	LMNA	2.13
323	Facioscapulohumeral muscular dystrophy 1	Enrichment	DUX4	2.13
324	Breast adenocarcinoma	Enrichment	TP53	2.13
325	Hypertrichosis	Enrichment	CREBBP	2.13
326	Neuromuscular disease	Enrichment	GOLGA2, LMNA	2.11
327	Coloboma of macula	Enrichment	PAX6, RARB	2.11
328	Carpal tunnel syndrome 1	Enrichment	TTR	2.09
329	Corneal dystrophy, epithelial basement membrane	Enrichment	TGFBI	2.09
330	Hyperthyroxinemia, dystransthyretinemic	Enrichment	TTR	2.09
331	Corneal dystrophy, groenouw type i	Enrichment	TGFBI	2.09
332	Cerebral amyloid angiopathy, itm2b-related, 1	Enrichment	ITM2B	2.09
333	Parkinson disease 1, autosomal dominant	Enrichment	SNCA	2.09
334	Sea-blue histiocyte disease	Enrichment	APOE	2.09
335	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	2.09
336	Corneal dystrophy, avellino type	Enrichment	TGFBI	2.09
337	Macular degeneration, age-related, 11	Enrichment	CST3	2.09
338	Cerebral amyloid angiopathy, itm2b-related, 2	Enrichment	ITM2B	2.09
339	Acne inversa, familial, 1	Enrichment	NCSTN	2.09
340	Lipoprotein glomerulopathy	Enrichment	APOE	2.09
341	Amyloidosis, hereditary systemic 1	Enrichment	TTR	2.09
342	Corneal dystrophy, lattice type i	Enrichment	TGFBI	2.09
343	Parkinson disease 4, autosomal dominant	Enrichment	SNCA	2.09
344	Leprosy 2	Enrichment	PRKN	2.09
345	Immunodeficiency 43	Enrichment	B2M	2.09
346	Corneal dystrophy, thiel-behnke type	Enrichment	TGFBI	2.09
347	Tubulointerstitial kidney disease, autosomal dominant 6	Enrichment	APOA4	2.09
348	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	2.09
349	Epithelial-stromal tgfbi dystrophy	Enrichment	TGFBI	2.09
350	Dialysis-related amyloidosis	Enrichment	B2M	2.09
351	Alzheimer disease 18	Enrichment	ADAM10	2.09
352	Corneal dystrophy, lattice type iiia	Enrichment	TGFBI	2.09
353	Corneal dystrophy, reis-bucklers type	Enrichment	TGFBI	2.09
354	Granular corneal dystrophy	Enrichment	TGFBI	2.09
355	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.09
356	Retinal dystrophy with inner retinal dysfunction and ganglion cell abnormalities	Enrichment	ITM2B	2.09
357	Immunoglobulin light chain amyloidosis	Enrichment	LYZ	2.09
358	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.09
359	Amyloidosis, hereditary systemic 5	Enrichment	LYZ	2.09
360	Serum amyloid a amyloidosis	Enrichment	SAA1	2.09
361	Amyloidosis, hereditary systemic 6	Enrichment	B2M	2.09
362	Epithelial basement membrane dystrophy	Enrichment	TGFBI	2.09
363	Amyloidosis	Enrichment	TTR	2.09
364	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	2.09
365	Leukodystrophy, adult-onset, autosomal dominant, without amyloid angiopathy	Enrichment	CST3	2.09
366	Hereditary amyloidosis	Enrichment	TTR	2.09
367	Pash syndrome	Enrichment	NCSTN	2.09
368	Attrv30m amyloidosis	Enrichment	TTR	2.09
369	Retinal dystrophy with inner retinal dysfunction and ganglion cell anomalies	Enrichment	ITM2B	2.09
370	Attrv122i amyloidosis	Enrichment	TTR	2.09
371	Alzheimer disease, familial, 1	Enrichment	APOE, APP	2.09
372	Retinoblastoma	Enrichment	RB1	2.09
373	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	2.09
374	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.09
375	Hypotrichosis 8	Enrichment	RB1	2.09
376	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	2.09
377	Lipodystrophy, congenital generalized, type 4	Enrichment	CAVIN1	2.09
378	Medulloblastoma	Enrichment	CTNNB1	2.08
379	Hepatoblastoma	Enrichment	CTNNB1, TERT	2.07
380	Rhabdomyosarcoma	Enrichment	DICER1, TP53	2.07
381	Esophageal cancer	Enrichment	TP53	2.06
382	Essential thrombocythemia	Enrichment	TP53	2.06
383	Rhabdomyosarcoma, embryonal, 2	Enrichment	DICER1	2.05
384	Holoprosencephaly 12 with or without pancreatic agenesis	Enrichment	CNOT1	2.05
385	Oocyte/zygote/embryo maturation arrest 13	Enrichment	ZFP36L2	2.05
386	Dicer1 syndrome	Enrichment	DICER1	2.05
387	Pleuropulmonary blastoma	Enrichment	DICER1	2.05
388	Global developmental delay, lung cysts, overgrowth, and wilms tumor	Enrichment	DICER1	2.05
389	Vissers-bodmer syndrome	Enrichment	CNOT1	2.05
390	Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies	Enrichment	CNOT2	2.05
391	Oocyte/zygote/embryo maturation arrest 8	Enrichment	BTG4	2.05
392	Malignant sertoli-leydig cell tumor of ovary	Enrichment	DICER1	2.05
393	Supratentorial primitive neuroectodermal tumor	Enrichment	DICER1	2.05
394	Gynandroblastoma	Enrichment	DICER1	2.05
395	Dicer1 tumor predisposition	Enrichment	DICER1	2.05
396	Female infertility due to an implantation defect of genetic origin	Enrichment	ZFP36L2	2.05
397	Pancreatic agenesis-holoprosencephaly syndrome	Enrichment	CNOT1	2.05
398	Multicentric carpotarsal osteolysis syndrome	Enrichment	MAFB	2.05
399	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.05
400	Microtia, hearing impairment, and cleft palate	Enrichment	HOXA2	2.05
401	Facial paresis, hereditary congenital, 3	Enrichment	HOXB1	2.05
402	Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay	Enrichment	PBX1	2.05
403	Athabaskan brainstem dysgenesis syndrome	Enrichment	HOXA1	2.05
404	Microcephaly 10, primary, autosomal recessive	Enrichment	ZNF335	2.05
405	Microphthalmia, syndromic 12	Enrichment	RARB	2.05
406	Ctcf-related disorder	Enrichment	CTCF	2.05
407	Duane retraction syndrome 3 with or without deafness	Enrichment	MAFB	2.05
408	Turnpenny-fry syndrome	Enrichment	PCGF2	2.05
409	Microcephalic primordial dwarfism due to znf335 deficiency	Enrichment	ZNF335	2.05
410	Congenital hereditary facial paralysis-variable hearing loss syndrome	Enrichment	HOXB1	2.05
411	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.05
412	Duane retraction syndrome 3	Enrichment	MAFB	2.05
413	Duane retraction syndrome with congenital deafness	Enrichment	MAFB	2.05
414	Bosley-salih-alorainy syndrome	Enrichment	HOXA1	2.05
415	Hepatocellular carcinoma	Enrichment	CTNNB1, TERT	2.04
416	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	Enrichment	DNMT3B	2.03
417	Facioscapulohumeral muscular dystrophy 4, digenic	Enrichment	DNMT3B	2.03
418	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	2.03
419	Tatton-brown-rahman syndrome	Enrichment	DNMT3A	2.03
420	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.01
421	46,xy sex reversal 1	Enrichment	AR	2.01
422	Androgen insensitivity syndrome	Enrichment	AR	2.01
423	Hypospadias 1, x-linked	Enrichment	AR	2.01
424	Posterior hypospadias	Enrichment	AR	2.01
425	Spinocerebellar ataxia 17	Enrichment	TBP	2.01
426	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.00
427	Immunodeficiency with hyper-igm, type 2	Enrichment	AICDA	1.99
428	Immunodeficiency with hyper-igm, type 5	Enrichment	UNG	1.99
429	Kleefstra syndrome	Enrichment	EHMT1	1.99
430	Kleefstra syndrome due to a point mutation	Enrichment	EHMT1	1.99
431	Myopia 6	Enrichment	NCAPH2	1.97
432	Lymphatic malformation 10	Enrichment	MCPH1	1.97
433	Intellectual developmental disorder, autosomal dominant 58	Enrichment	SET	1.97
434	Lynch syndrome 4	Enrichment	RB1	1.96
435	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	KDM5C	1.96
436	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	KDM5C	1.96
437	Cockayne syndrome type 3	Enrichment	ERCC6	1.96
438	Primary hyperaldosteronism	Enrichment	TP53	1.95
439	Alopecia, androgenetic, 1	Enrichment	SMARCD1	1.94
440	Trichomegaly	Enrichment	ARID1B	1.94
441	Specific granule deficiency 1	Enrichment	SMARCD2	1.94
442	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.94
443	Schwannomatosis 1	Enrichment	SMARCB1	1.94
444	Chromosome 6q24-q25 deletion syndrome	Enrichment	ARID1B	1.94
445	Thrombocythemia 3	Enrichment	JAK2	1.94
446	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	ARID1B	1.94
447	Coffin-siris syndrome 6	Enrichment	ARID2	1.94
448	Epilepsy, progressive myoclonic, 12	Enrichment	PRMT7	1.94
449	Specific granule deficiency 2	Enrichment	SMARCD2	1.94
450	Coffin-siris syndrome 8	Enrichment	SMARCC2	1.94
451	Otosclerosis 12	Enrichment	SMARCA4	1.94
452	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.94
453	Polycythemia	Enrichment	JAK2	1.94
454	Blepharophimosis - intellectual disability syndrome	Enrichment	SMARCA2	1.94
455	Developmental and epileptic encephalopathy 76	Enrichment	ACTL6B	1.94
456	Hypereosinophilic syndrome	Enrichment	JAK2	1.94
457	Specific granule deficiency	Enrichment	SMARCD2	1.94
458	Autism	Enrichment	CREBBP, KMT2D, TCF7L2	1.92
459	Leukemia, chronic lymphocytic	Enrichment	TP53	1.90
460	Familial colorectal cancer	Enrichment	TP53	1.90
461	Primary autosomal recessive microcephaly	Enrichment	MCPH1, NCAPD3	1.89
462	Tooth agenesis	Enrichment	AXIN2	1.89
463	Storage pool platelet disease	Enrichment	RUNX1	1.88
464	Thrombocytopenia, paris-trousseau type	Enrichment	FLI1	1.88
465	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.88
466	Neutropenia, nonimmune chronic idiopathic, of adults	Enrichment	GFI1	1.88
467	Neutrophilia, hereditary	Enrichment	CSF3R	1.88
468	Neutropenia, severe congenital, 2, autosomal dominant	Enrichment	GFI1	1.88
469	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	CSF3R	1.88
470	Cardiomyopathy, dilated, 1ff	Enrichment	KLF5	1.88
471	Acute basophilic leukemia	Enrichment	MYB	1.88
472	Cleidocranial dysplasia 2	Enrichment	CBFB	1.88
473	Severe congenital neutropenia 7	Enrichment	CSF3R	1.88
474	Angiocentric glioma	Enrichment	MYB	1.88
475	Acute myeloid leukemia with t(6;9) (p23;q34.1)	Enrichment	DEK	1.88
476	Acute myeloid leukemia with t(9;11)(p22;q23)	Enrichment	KMT2A	1.88
477	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	KMT2A	1.88
478	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KMT2A	1.88
479	Tafro syndrome	Enrichment	RUNX1	1.88
480	Wilms tumor 1	Enrichment	DIS3L2	1.88
481	Treacher collins syndrome 3	Enrichment	POLR1C	1.88
482	Waardenburg syndrome, type 4c	Enrichment	POLR2F	1.88
483	Leukoencephalopathy, progressive, with ovarian failure	Enrichment	POLR1C	1.88
484	Leukodystrophy, hypomyelinating, 11	Enrichment	POLR1C	1.88
485	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	1.88
486	Acrofacial dysostosis, cincinnati type	Enrichment	POLR1A	1.88
487	Complement component c1s deficiency	Enrichment	KMT2D	1.88
488	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	1.88
489	Choanal atresia, posterior	Enrichment	KMT2D	1.88
490	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.88
491	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	1.88
492	Medullary thyroid carcinoma	Enrichment	MEN1	1.88
493	Melanoma, cutaneous malignant 9	Enrichment	TERT	1.88
494	Insulinoma	Enrichment	MEN1	1.88
495	Idiopathic interstitial pneumonia	Enrichment	TERT	1.88
496	Null pituitary adenoma	Enrichment	MEN1	1.88
497	Silent pituitary adenoma	Enrichment	MEN1	1.88
498	Gigantism	Enrichment	MEN1	1.88
499	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	1.88
500	Neurodegeneration, childhood-onset, with brain atrophy	Enrichment	UBTF	1.86
501	Aortic aneurysm, familial thoracic 4	Enrichment	MYH11	1.86
502	Cataract 35	Enrichment	MYH9	1.86
503	Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	Enrichment	MYH11	1.86
504	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.86
505	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.86
506	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	1.86
507	Pseudosarcomatous fibromatosis	Enrichment	MYH9	1.86
508	Visceral myopathy 2	Enrichment	MYH11	1.86
509	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	1.86
510	Myelodysplastic syndrome	Enrichment	TP53	1.86
511	Fibromatosis, gingival, 1	Enrichment	REST	1.86
512	Syndactyly, type iii	Enrichment	HDAC8	1.86
513	Wilson-turner syndrome	Enrichment	HDAC8	1.86
514	Myeloproliferative syndrome, transient	Enrichment	GATA1	1.86
515	Porphyria, congenital erythropoietic	Enrichment	GATA1	1.86
516	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	1.86
517	Dystonia 28, childhood-onset	Enrichment	KMT2B	1.86
518	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	1.85
519	Pancreatic cancer	Enrichment	CDKN2A, TP53	1.83
520	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.83
521	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	1.83
522	Heart-hand syndrome, slovenian type	Enrichment	LMNA	1.83
523	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	1.83
524	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.83
525	Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads	Enrichment	CAST	1.83
526	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	1.83
527	Spastic paraplegia 76, autosomal recessive	Enrichment	CAPN1	1.83
528	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	1.83
529	Restrictive dermopathy 2	Enrichment	LMNA	1.83
530	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	1.83
531	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.83
532	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	1.83
533	Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Enrichment	PRIM1	1.83
534	Autosomal dominant primary microcephaly	Enrichment	LMNB1	1.83
535	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	1.83
536	Familial partial lipodystrophy	Enrichment	LMNA	1.83
537	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	1.83
538	Oculootodental syndrome	Enrichment	FADD	1.83
539	Parkinson disease, late-onset	Enrichment	PRKN, SNCA	1.80
540	Alzheimer disease 3	Enrichment	APOE	1.80
541	Parkinson disease 12	Enrichment	PRKN	1.80
542	Alzheimer disease 9	Enrichment	SORL1	1.80
543	Atrial fibrillation, familial, 6	Enrichment	NPPA	1.80
544	Mononeuropathy of the median nerve, mild	Enrichment	TTR	1.80
545	Maturity-onset diabetes of the young, type 10	Enrichment	INS	1.80
546	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	1.80
547	Hyperproinsulinemia	Enrichment	INS	1.80
548	Nephrotic syndrome, type 17	Enrichment	GGA3	1.80
549	Hyperlipoproteinemia, type iii	Enrichment	APOE	1.80
550	Parkinson disease 15, autosomal recessive early-onset	Enrichment	SNCA	1.80
551	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	1.80
552	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	1.80
553	Buratti-harel syndrome	Enrichment	SIAH1	1.80
554	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	1.80
555	Isolated atrial standstill	Enrichment	NPPA	1.80
556	Submucosal cleft palate	Enrichment	UBB	1.80
557	Cleft hard palate	Enrichment	UBB	1.80
558	Mitochondrial complex iv deficiency, nuclear type 2	Enrichment	NCAPH2	1.79
559	Microphthalmia	Enrichment	PAX6, RARB	1.78
560	De sanctis-cacchione syndrome	Enrichment	ERCC6	1.78
561	Uv-sensitive syndrome 1	Enrichment	ERCC6	1.78
562	Uv-sensitive syndrome	Enrichment	ERCC6	1.78
563	Premature ovarian failure 11	Enrichment	ERCC6	1.78
564	Hirschsprung disease 1	Enrichment	AXIN2	1.77
565	Visceral steatosis, congenital	Enrichment	PRMT7	1.77
566	Polycythemia vera	Enrichment	JAK2	1.77
567	Nail disorder, nonsyndromic congenital, 9	Enrichment	ARID1B	1.77
568	Coffin-siris syndrome 2	Enrichment	ARID1A	1.77
569	Umbilical hernia	Enrichment	ACTL6A	1.77
570	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.77
571	Dedifferentiated liposarcoma	Enrichment	CDK4	1.77
572	Periventricular leukomalacia	Enrichment	ARID1A	1.77
573	Desmoplastic/nodular medulloblastoma	Enrichment	ARID2	1.77
574	Schwannomatosis	Enrichment	SMARCB1	1.77
575	Well-differentiated liposarcoma	Enrichment	CDK4	1.77
576	Steatotic liver disease	Enrichment	PRMT7	1.77
577	Heart disease	Enrichment	CREBBP	1.76
578	Premature ovarian failure 3	Enrichment	AGO2	1.75
579	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	DICER1	1.75
580	Vertebral anomalies and variable endocrine and t-cell dysfunction	Enrichment	DICER1	1.75
581	Alopecia-intellectual disability syndrome 4	Enrichment	CNOT1	1.75
582	Pineoblastoma	Enrichment	DICER1	1.75
583	Malignant granulosa cell tumor of the ovary	Enrichment	DICER1	1.75
584	Keratitis, hereditary	Enrichment	PAX6	1.75
585	Foveal hypoplasia 1	Enrichment	PAX6	1.75
586	Duane retraction syndrome 1	Enrichment	MAFB	1.75
587	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2	1.75
588	Optic nerve hypoplasia, bilateral	Enrichment	PAX6	1.75
589	Duane retraction syndrome 2	Enrichment	MAFB	1.75
590	Gabriele-de vries syndrome	Enrichment	YY1	1.75
591	Intellectual developmental disorder, autosomal dominant 21	Enrichment	CTCF	1.75
592	Developmental and epileptic encephalopathy 78	Enrichment	YY1	1.75
593	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	PBX1	1.75
594	Renal hypoplasia, bilateral	Enrichment	PBX1	1.75
595	Polydactyly, postaxial, type a1	Enrichment	EP300	1.73
596	Corpus callosum, agenesis of	Enrichment	CREBBP	1.73
597	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.73
598	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.73
599	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.71
600	Jacobsen syndrome	Enrichment	FLI1	1.71
601	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	RUNX1	1.71
602	Hyper ige syndrome	Enrichment	STAT3	1.71
603	Adenoid cystic carcinoma	Enrichment	MYB	1.71
604	Melanoma of soft tissue	Enrichment	CREB1	1.71
605	Mixed phenotype acute leukemia with t	Enrichment	KMT2A	1.71
606	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	RUNX1	1.71
607	Waardenburg syndrome, type 2a	Enrichment	POLR2F	1.70
608	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	1.70
609	Burn-mckeown syndrome	Enrichment	POLR1A	1.70
610	Wieacker-wolff syndrome	Enrichment	CCNH	1.70
611	Pituitary adenoma 1, multiple types	Enrichment	MEN1	1.70
612	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	1.70
613	Interstitial lung disease	Enrichment	TERT	1.70
614	Cellular ependymoma	Enrichment	MEN1	1.70
615	Tanycytic ependymoma	Enrichment	MEN1	1.70
616	Macrocytic anemia	Enrichment	TERT	1.70
617	Papillary ependymoma	Enrichment	MEN1	1.70
618	Growth hormone secreting pituitary adenoma	Enrichment	MEN1	1.70
619	Aip familial isolated pituitary adenomas	Enrichment	MEN1	1.70
620	Clear cell ependymoma	Enrichment	MEN1	1.70
621	Myelodysplastic syndrome with ring sideroblasts	Enrichment	SF3B1	1.70
622	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	MYH9	1.69
623	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.69
624	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.69
625	Tricuspid valve insufficiency	Enrichment	MYH11	1.69
626	Pierpont syndrome	Enrichment	TBL1XR1	1.69
627	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	1.69
628	Dystonia 12	Enrichment	KMT2B	1.69
629	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B	1.69
630	Sarcoma, synovial	Enrichment	SS18	1.67
631	Macular degeneration, age-related, 5	Enrichment	ERCC6	1.66
632	Partington syndrome	Enrichment	POLA1	1.65
633	Restrictive dermopathy 1	Enrichment	LMNA	1.65
634	Body mass index quantitative trait locus 12	Enrichment	CAST	1.65
635	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.65
636	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.65
637	Proprotein convertase 1/3 deficiency	Enrichment	CAST	1.65
638	Restrictive dermopathy	Enrichment	LMNA	1.65
639	Rare syndromic intellectual disability	Enrichment	UBTF	1.64
640	Erythrocytosis, familial, 1	Enrichment	JAK2	1.64
641	Budd-chiari syndrome	Enrichment	JAK2	1.64
642	Lipodystrophy, congenital generalized, type 2	Enrichment	ACTL6B	1.64
643	Mantle cell lymphoma	Enrichment	CCND1	1.64
644	Full schwannomatosis	Enrichment	SMARCB1	1.64
645	Clear cell papillary renal cell carcinoma	Enrichment	PBRM1	1.64
646	Glioblastoma	Enrichment	DNMT3A	1.63
647	Type 1 diabetes mellitus 2	Enrichment	INS	1.62
648	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	1.62
649	Uvula, bifid	Enrichment	UBB	1.62
650	Alzheimer disease 4	Enrichment	APOE	1.62
651	Cleft soft palate	Enrichment	UBB	1.62
652	Dysfibrinogenemia, congenital	Enrichment	FGA	1.62
653	Atrial standstill 2	Enrichment	NPPA	1.62
654	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	1.62
655	Familial dysfibrinogenemia	Enrichment	FGA	1.62
656	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	1.62
657	Familial hypofibrinogenemia	Enrichment	FGA	1.62
658	Hyperpigmentation of the skin	Enrichment	USP9X	1.62
659	Type 2 diabetes mellitus	Enrichment	TCF7L2	1.61
660	2q23.1 microduplication syndrome	Enrichment	ORC4	1.61
661	Inherited acute myeloid leukemia	Enrichment	ZCCHC8	1.59
662	Blood platelet disease	Enrichment	RUNX1	1.59
663	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	CBFB	1.59
664	Intellectual developmental disorder, autosomal dominant 26	Enrichment	KMT2D	1.58
665	Prolactinoma	Enrichment	MEN1	1.58
666	Primary hyperparathyroidism	Enrichment	MEN1	1.58
667	Benign ependymoma	Enrichment	MEN1	1.58
668	Aminoacylase 1 deficiency	Enrichment	ACTB	1.58
669	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	SF3B1	1.58
670	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.58
671	Lessel-kreienkamp syndrome	Enrichment	AGO2	1.58
672	Microcephaly 1, primary, autosomal recessive	Enrichment	MCPH1	1.57
673	Gillespie syndrome	Enrichment	PAX6	1.57
674	Duane retraction syndrome	Enrichment	MAFB	1.57
675	Charcot-marie-tooth disease type 1	Enrichment	EGR2	1.57
676	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYH11	1.57
677	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.57
678	Mitral valve insufficiency	Enrichment	MYH11	1.57
679	Cockayne syndrome a	Enrichment	ERCC6	1.56
680	Potocki-shaffer syndrome	Enrichment	PHF21A	1.56
681	Gingival fibromatosis	Enrichment	REST	1.56
682	Down syndrome	Enrichment	GATA1	1.56
683	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	DNMT3A	1.55
684	Von hippel-lindau syndrome	Enrichment	CCND1	1.55
685	Diamond-blackfan anemia 1	Enrichment	TP53	1.55
686	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.53
687	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	1.53
688	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	1.53
689	Sick sinus syndrome	Enrichment	LMNA	1.53
690	Scoliosis	Enrichment	CREBBP	1.53
691	Kleefstra syndrome 1	Enrichment	EHMT1	1.51
692	Dowling-degos disease 1	Enrichment	ADAM10	1.50
693	Afibrinogenemia, congenital	Enrichment	FGA	1.50
694	Macular degeneration, age-related, 1	Enrichment	APOE	1.50
695	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	1.50
696	Neonatal diabetes mellitus	Enrichment	INS	1.50
697	Dowling-degos disease	Enrichment	PSENEN	1.50
698	Corneal dystrophy	Enrichment	TGFBI	1.50
699	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M	1.50
700	Congenital generalized lipodystrophy	Enrichment	CAVIN1	1.49
701	Autosomal dominant severe congenital neutropenia	Enrichment	GFI1	1.49
702	Aggressive systemic mastocytosis	Enrichment	RUNX1	1.49
703	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	1.49
704	Cockayne syndrome b	Enrichment	ERCC6	1.49
705	Capillary malformations, congenital	Enrichment	CCNH	1.48
706	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	1.48
707	Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR1C	1.48
708	Amblyopia	Enrichment	KMT2D	1.48
709	Idiopathic aplastic anemia	Enrichment	TERT	1.48
710	Congenital nervous system abnormality	Enrichment	CREBBP, CTNNB1, KMT2D	1.48
711	Nervous system disease	Enrichment	CREBBP, CTNNB1, KMT2D	1.48
712	Body mass index quantitative trait locus 11	Enrichment	DNMT3A, PRMT7	1.48
713	Visceral myopathy 1	Enrichment	MYH11	1.47
714	Deafness, autosomal recessive 63	Enrichment	MYH9	1.47
715	Congenital ptosis	Enrichment	MYH10	1.47
716	Wiedemann-steiner syndrome	Enrichment	ARID1B	1.47
717	Inguinal hernia	Enrichment	ACTL6A	1.47
718	Renal hypoplasia	Enrichment	PRMT7	1.47
719	Clear cell renal cell carcinoma	Enrichment	PBRM1	1.47
720	Early myoclonic encephalopathy	Enrichment	PRMT7	1.47
721	Bernard-soulier syndrome	Enrichment	GP1BA	1.47
722	Chondrosarcoma, extraskeletal myxoid	Enrichment	NR4A3	1.47
723	Intellectual developmental disorder with speech delay, autism, and dysmorphic facies	Enrichment	CNOT3	1.46
724	Aniridia 1	Enrichment	PAX6	1.45
725	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.45
726	Eyelid coloboma	Enrichment	PAX6	1.45
727	Lens coloboma	Enrichment	PAX6	1.45
728	Prostate cancer	Enrichment	TP53	1.45
729	Autosomal recessive non-syndromic intellectual disability	Enrichment	KDM5B, METTL23	1.44
730	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.44
731	Histiocytoid hemangioma	Enrichment	LMNA	1.44
732	Cockayne syndrome	Enrichment	ERCC6	1.42
733	Difference of sex development	Enrichment	AR	1.42
734	Pancytopenia	Enrichment	RUNX1	1.41
735	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	1.41
736	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	1.41
737	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.41
738	Hemangioma, capillary infantile	Enrichment	CCNH	1.41
739	Basal cell carcinoma 1	Enrichment	CCNH	1.41
740	Waardenburg syndrome	Enrichment	POLR2F	1.41
741	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT	1.41
742	Pulmonary fibrosis	Enrichment	TERT	1.41
743	Hoyeraal-hreidarsson syndrome	Enrichment	TERT	1.41
744	Kidney clear cell sarcoma	Enrichment	TERT	1.41
745	Melanoma, uveal	Enrichment	SF3B1	1.41
746	Alzheimer disease 2	Enrichment	APOE	1.40
747	Dementia, lewy body	Enrichment	SNCA	1.40
748	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	1.40
749	Parkin type of early-onset parkinson disease	Enrichment	PRKN	1.40
750	Myelofibrosis	Enrichment	JAK2	1.40
751	Brachydactyly	Enrichment	PRMT7	1.40
752	Congenital hydrocephalus	Enrichment	SMARCC1	1.40
753	Hemihyperplasia, isolated	Enrichment	RHOA	1.39
754	Intestinal pseudo-obstruction	Enrichment	MYH11	1.39
755	Gastric cancer	Enrichment	CDKN2A, TP53	1.39
756	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.36
757	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.36
758	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.36
759	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.36
760	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2	1.35
761	Aniridia	Enrichment	PAX6	1.35
762	Coloboma of choroid and retina	Enrichment	PAX6	1.35
763	Diamond-blackfan anemia	Enrichment	TP53	1.35
764	Leukemia, chronic myeloid	Enrichment	RUNX1	1.35
765	Gastroesophageal reflux	Enrichment	ACTL6A	1.35
766	Neuroblastoma	Enrichment	SMARCA4	1.35
767	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.34
768	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.34
769	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	1.34
770	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	1.34
771	Gastrointestinal stromal tumor	Enrichment	MEN1	1.34
772	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT	1.34
773	Type 1 diabetes mellitus	Enrichment	INS	1.33
774	Lipid metabolism disorder	Enrichment	APOE	1.33
775	Glanzmann thrombasthenia 1	Enrichment	ITGA2B	1.32
776	Microcephaly	Enrichment	CTNNB1, EP300, KMT2D	1.32
777	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYH14, MYH9	1.31
778	Polymicrogyria	Enrichment	EHMT1	1.30
779	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.30
780	Ventricular septal defect	Enrichment	SMARCA4	1.30
781	Specific learning disability	Enrichment	DNMT3A	1.29
782	Bethlem myopathy 1a	Enrichment	LMNA	1.29
783	Alzheimer's disease 1	Enrichment	APP	1.29
784	Ewing sarcoma	Enrichment	FLI1	1.29
785	Severe congenital neutropenia	Enrichment	CSF3R	1.29
786	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.29
787	46,xy complete gonadal dysgenesis	Enrichment	AR	1.28
788	Coloboma of optic nerve	Enrichment	PAX6	1.28
789	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	PAX6	1.28
790	Anterior segment dysgenesis 5	Enrichment	PAX6	1.28
791	Hereditary breast carcinoma	Enrichment	TP53	1.27
792	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.27
793	Thrombophilia due to thrombin defect	Enrichment	FGA	1.26
794	Primary bone dysplasia	Enrichment	PRMT7	1.25
795	Cornelia de lange syndrome 1	Enrichment	KMT2A	1.24
796	Cornelia de lange syndrome	Enrichment	KMT2A	1.24
797	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	PRDX1	1.24
798	Congenital muscular dystrophy	Enrichment	LMNA	1.24
799	Myocarditis	Enrichment	LMNA	1.24
800	Inflammatory bowel disease 1	Enrichment	ERCC2	1.24
801	Arteriovenous malformation	Enrichment	CCNH	1.24
802	Hypotrichosis simplex	Enrichment	ERCC2	1.24
803	Familial thoracic aortic aneurysm and dissection	Enrichment	MYH11	1.22
804	Osteochondrodysplasia	Enrichment	PRMT7	1.21
805	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1, TP53	1.20
806	Autosomal non-syndromic agammaglobulinemia	Enrichment	SPI1	1.20
807	Pituitary stalk interruption syndrome	Enrichment	DNMT1	1.19
808	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	1.19
809	Aplastic anemia	Enrichment	TERT	1.19
810	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.19
811	Stereotypic movement disorder	Enrichment	JARID2	1.17
812	Septooptic dysplasia	Enrichment	ARID1A	1.17
813	Diabetes mellitus	Enrichment	MEN1	1.15
814	Primary ovarian insufficiency	Enrichment	DPPA2	1.15
815	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.14
816	Nk-cell enteropathy	Enrichment	SMARCB1	1.14
817	Orofacial cleft 1	Enrichment	MAFB	1.11
818	Immune deficiency disease	Enrichment	RIPK1	1.10
819	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.10
820	Isolated congenital microcephaly	Enrichment	MCPH1	1.08
821	Renal cell carcinoma, nonpapillary	Enrichment	PBRM1	1.08
822	Familial hypercholesterolemia	Enrichment	SMARCA4	1.08
823	Cardiac conduction defect	Enrichment	LMNA	1.07
824	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.07
825	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.07
826	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.07
827	Cat eye syndrome	Enrichment	PAX6	1.06
828	Peters-plus syndrome	Enrichment	PAX6	1.06
829	Protein-deficiency anemia	Enrichment	GATA1	1.06
830	Parkinson's disease	Enrichment	TBP	1.05
831	Aortic aneurysm, familial thoracic 1	Enrichment	MYH11	1.04
832	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.03
833	Cleft palate, isolated	Enrichment	SMARCA4	1.03
834	Dyskeratosis congenita	Enrichment	ZCCHC8	1.03
835	Male infertility with spermatogenesis disorder	Enrichment	KMT2D	1.02
836	Myopia	Enrichment	MYH11	1.01
837	Seckel syndrome	Enrichment	PRIM1	1.00
838	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.00
839	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2	1.00
840	Hypertension	Enrichment	MEN1	1.00
841	Digeorge syndrome	Enrichment	HIRA	0.99
842	Interstitial lung disease 2	Enrichment	TERT	0.97
843	Dandy-walker syndrome	Enrichment	KMT2D	0.97
844	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	0.95
845	Polycystic kidney disease	Enrichment	HDAC8	0.93
846	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	0.92
847	Leukodystrophy	Enrichment	ERCC2	0.90
848	Williams-beuren syndrome	Enrichment	BAZ1B	0.90
849	Anterior segment dysgenesis	Enrichment	PAX6	0.90
850	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	0.88
851	Hydrops fetalis, nonimmune	Enrichment	ARID1A	0.86
852	Kallmann syndrome	Enrichment	POLR2F	0.85
853	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	0.84
854	Noonan syndrome 1	Enrichment	PPP1CB	0.83
855	Maturity-onset diabetes of the young	Enrichment	INS	0.83
856	Charcot-marie-tooth disease type 4	Enrichment	EGR2	0.82
857	West syndrome	Enrichment	KDM2B	0.82
858	Male infertility	Enrichment	AR	0.82
859	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	0.80
860	Lung cancer	Enrichment	ERCC6	0.79
861	Skin disease	Enrichment	NCSTN	0.79
862	Non-immune hydrops fetalis	Enrichment	ARID1A	0.79
863	Rasopathy	Enrichment	PPP1CB	0.79
864	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	0.78
865	Muscular dystrophy	Enrichment	LMNA	0.78
866	Strabismus	Enrichment	KMT2D	0.78
867	Macs syndrome	Enrichment	PAX6	0.78
868	Autosomal dominant non-syndromic intellectual disability	Enrichment	KDM5B	0.77
869	Differentiated thyroid carcinoma	Enrichment	TERT	0.76
870	Familial atrial fibrillation	Enrichment	NPPA	0.75
871	Brugada syndrome	Enrichment	LMNA	0.75
872	Cerebral palsy	Enrichment	SMARCA4	0.70
873	Long qt syndrome	Enrichment	LMNA	0.68
874	Peripheral nervous system disease	Enrichment	LMNA	0.67
875	Neuropathy	Enrichment	LMNA	0.67
876	Dystonia	Enrichment	KMT2B	0.67
877	Non-syndromic genetic deafness	Enrichment	MYH14	0.66
878	Spastic ataxia	Enrichment	DNMT1	0.65
879	Left ventricular noncompaction	Enrichment	LMNA	0.64
880	Familial isolated dilated cardiomyopathy	Enrichment	TAF1A	0.64
881	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR	0.62
882	Epilepsy	Enrichment	SETD1B	0.61
883	Nonsyndromic hearing loss	Enrichment	MYH14	0.60
884	Non-syndromic x-linked intellectual disability	Enrichment	USP9X	0.60
885	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYH11	0.58
886	Schizophrenia	Enrichment	EHMT1	0.58
887	Charcot-marie-tooth disease	Enrichment	LMNA	0.58
888	Undetermined early-onset epileptic encephalopathy	Enrichment	ACTL6B	0.56
889	Joubert syndrome 1	Enrichment	RCOR1	0.53
890	Hypertelorism	Enrichment	MYH10	0.52
891	Dilated cardiomyopathy	Enrichment	NCAPH2	0.45
892	Deafness, autosomal recessive	Enrichment	MYH9	0.45
893	Autosomal recessive nonsyndromic deafness	Enrichment	MYH9	0.45
894	Rare genetic deafness	Enrichment	POLR2F	0.39
895	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYH9	0.34
896	Mitochondrial disease	Enrichment	C1QBP	0.32

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RNA Polymerase I Promoter Opening

Pathway Network for RNA Polymerase I Promoter Opening

Pathway network for the RNA Polymerase I Promoter Opening SuperPath

Member Pathways for RNA Polymerase I Promoter Opening

Pathways in the RNA Polymerase I Promoter Opening SuperPath

Associated Genes for RNA Polymerase I Promoter Opening

Associated Disorders for RNA Polymerase I Promoter Opening

Disorders associated with RNA Polymerase I Promoter Opening SuperPath

STRING Interaction Network for RNA Polymerase I Promoter Opening

Sources for RNA Polymerase I Promoter Opening