RNA Polymerase I Transcription Termination

Pathway network for the RNA Polymerase I Transcription Termination SuperPath

Sources:

Reactome
QIAGEN

Pathways in the RNA Polymerase I Transcription Termination SuperPath

#	Name	Source	Genes
1	RNA Polymerase I Transcription Termination	Reactome	CAVIN1 CCNH CDK7 ERCC2 ERCC3 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 MNAT1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RNA45SN5 TAF1A TAF1B TAF1C TAF1D TBP TTF1 UBTF (see all 32) (see less)
2	RNA Polymerase I Transcription Initiation	Reactome	CCNH CDK7 CHD3 CHD4 EHMT2 ERCC2 ERCC3 ERCC6 GATAD2A GATAD2B GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 HDAC1 HDAC2 KAT2A KAT2B MBD3 MNAT1 MTA1 MTA2 MTA3 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H POLR2E POLR2F POLR2H POLR2K POLR2L RBBP4 RBBP7 RRN3 TAF1A TAF1B TAF1C TAF1D TBP TTF1 UBTF (see all 47) (see less)
3	Assembly of RNA Polymerase-I Initiation Complex	QIAGEN	POLR1A POLR1B POLR1C POLR1D POLR1E TAF1A TAF1B TAF1C TBP UBTF (see all 10) (see less)

Gene overlap in member pathways for RNA Polymerase I Transcription Termination SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	POLR1A	RNA Polymerase I Subunit A	Protein Coding	3
2	POLR1D	RNA Polymerase I And III Subunit D	Protein Coding	3
3	POLR1E	RNA Polymerase I Subunit E	Protein Coding	3
4	TBP	TATA-Box Binding Protein	Protein Coding	3
5	UBTF	Upstream Binding Transcription Factor	Protein Coding	3
6	POLR1B	RNA Polymerase I Subunit B	Protein Coding	3
7	TAF1C	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C	Protein Coding	3
8	TAF1B	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit B	Protein Coding	3
9	TAF1A	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A	Protein Coding	3
10	POLR1C	RNA Polymerase I And III Subunit C	Protein Coding	3
11	CDK7	Cyclin Dependent Kinase 7	Protein Coding	2
12	POLR1G	RNA Polymerase I Subunit G	Protein Coding	2
13	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	2
14	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	2
15	POLR1F	RNA Polymerase I Subunit F	Protein Coding	2
16	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	2
17	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	2
18	GTF2H3	General Transcription Factor IIH Subunit 3	Protein Coding	2
19	GTF2H4	General Transcription Factor IIH Subunit 4	Protein Coding	2
20	POLR1H	RNA Polymerase I Subunit H	Protein Coding	2
21	GTF2H5	General Transcription Factor IIH Subunit 5	Protein Coding	2
22	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	2
23	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	2
24	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	2
25	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	2
26	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	2
27	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	2
28	TTF1	Transcription Termination Factor 1	Protein Coding	2
29	TAF1D	TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit D	Protein Coding	2
30	CCNH	Cyclin H	Protein Coding	2
31	RNA45SN5	RNA, 45S Pre-Ribosomal N5	RNA Gene	1
32	CAVIN1	Caveolae Associated Protein 1	Protein Coding	1
33	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	1
34	CHD3	Chromodomain Helicase DNA Binding Protein 3	Protein Coding	1
35	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	1
36	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	1
37	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
38	HDAC1	Histone Deacetylase 1	Protein Coding	1
39	HDAC2	Histone Deacetylase 2	Protein Coding	1
40	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	1
41	RRN3	RNA Polymerase I Transcription Factor RRN3	Protein Coding	1
42	GATAD2A	GATA Zinc Finger Domain Containing 2A	Protein Coding	1
43	GATAD2B	GATA Zinc Finger Domain Containing 2B	Protein Coding	1
44	MTA3	Metastasis Associated 1 Family Member 3	Protein Coding	1
45	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
46	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	1
47	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
48	MTA1	Metastasis Associated 1	Protein Coding	1
49	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	1

Disorders associated with RNA Polymerase I Transcription Termination SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Treacher collins syndrome 1	Enrichment	POLR1B, POLR1C, POLR1D	8.00
2	Trichothiodystrophy	Enrichment	ERCC2, ERCC3, GTF2H5	6.00
3	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2, ERCC3	4.27
4	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC2, ERCC6	3.76
5	Xeroderma pigmentosum, variant type	Enrichment	ERCC2, ERCC3	3.53
6	Leukodystrophy, hypomyelinating, 27	Enrichment	POLR1A	3.13
7	Treacher collins syndrome 4	Enrichment	POLR1B	3.13
8	Treacher collins syndrome 2	Enrichment	POLR1D	3.13
9	Treacher collins syndrome 3	Enrichment	POLR1C	2.83
10	Spinocerebellar ataxia 17	Enrichment	TBP	2.83
11	Leukoencephalopathy, progressive, with ovarian failure	Enrichment	POLR1C	2.83
12	Leukodystrophy, hypomyelinating, 11	Enrichment	POLR1C	2.83
13	Acrofacial dysostosis, cincinnati type	Enrichment	POLR1A	2.83
14	Burn-mckeown syndrome	Enrichment	POLR1A	2.66
15	Neurodegeneration, childhood-onset, with brain atrophy	Enrichment	UBTF	2.66
16	Xeroderma pigmentosum, complementation group b	Enrichment	ERCC3	2.63
17	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	2.63
18	Trichothiodystrophy 2, photosensitive	Enrichment	ERCC3	2.63
19	Xeroderma pigmentosum group b	Enrichment	ERCC3	2.63
20	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	2.63
21	Trichothiodystrophy 3, photosensitive	Enrichment	GTF2H5	2.63
22	Lipodystrophy, congenital generalized, type 4	Enrichment	CAVIN1	2.63
23	Xeroderma pigmentosum group d	Enrichment	ERCC2	2.63
24	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.46
25	Gand syndrome	Enrichment	GATAD2B	2.46
26	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	Enrichment	GATAD2B	2.46
27	Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR1C	2.43
28	Rare syndromic intellectual disability	Enrichment	UBTF	2.43
29	Waardenburg syndrome, type 4c	Enrichment	POLR2F	2.33
30	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	2.33
31	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	2.16
32	Snijders blok-campeau syndrome	Enrichment	CHD3	2.16
33	Cockayne syndrome type 3	Enrichment	ERCC6	2.16
34	Waardenburg syndrome, type 2a	Enrichment	POLR2F	2.15
35	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	2.15
36	Wieacker-wolff syndrome	Enrichment	CCNH	2.15
37	Congenital generalized lipodystrophy	Enrichment	CAVIN1	2.03
38	Craniopharyngioma	Enrichment	ERCC2	2.03
39	De sanctis-cacchione syndrome	Enrichment	ERCC6	1.98
40	Uv-sensitive syndrome 1	Enrichment	ERCC6	1.98
41	Uv-sensitive syndrome	Enrichment	ERCC6	1.98
42	Premature ovarian failure 11	Enrichment	ERCC6	1.98
43	Capillary malformations, congenital	Enrichment	CCNH	1.93
44	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	1.93
45	Macular degeneration, age-related, 5	Enrichment	ERCC6	1.86
46	Parkinson's disease	Enrichment	TBP	1.86
47	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	1.85
48	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	1.85
49	Waardenburg syndrome, type 4a	Enrichment	POLR2F	1.85
50	Hemangioma, capillary infantile	Enrichment	CCNH	1.85
51	Basal cell carcinoma 1	Enrichment	CCNH	1.85
52	Waardenburg syndrome	Enrichment	POLR2F	1.85
53	Waardenburg syndrome, type 1	Enrichment	POLR2F	1.79
54	Waardenburg syndrome, type 2e	Enrichment	POLR2F	1.79
55	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	1.79
56	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH	1.79
57	Cockayne syndrome a	Enrichment	ERCC6	1.76
58	Parkinson disease, late-onset	Enrichment	TBP	1.76
59	Cockayne syndrome b	Enrichment	ERCC6	1.69
60	Inflammatory bowel disease 1	Enrichment	ERCC2	1.68
61	Arteriovenous malformation	Enrichment	CCNH	1.68
62	Hypotrichosis simplex	Enrichment	ERCC2	1.68
63	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	1.63
64	Ovarian cancer	Enrichment	ERCC2, ERCC3	1.63
65	Cockayne syndrome	Enrichment	ERCC6	1.62
66	Corpus callosum, agenesis of	Enrichment	ERCC2	1.46
67	Isolated corpus callosum agenesis	Enrichment	ERCC2	1.46
68	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ERCC2	1.46
69	Familial isolated dilated cardiomyopathy	Enrichment	TAF1A	1.42
70	Leukodystrophy	Enrichment	ERCC2	1.34
71	Hepatoblastoma	Enrichment	ERCC2	1.31
72	Kallmann syndrome	Enrichment	POLR2F	1.28
73	Bladder cancer	Enrichment	ERCC2	1.18
74	Hirschsprung disease 1	Enrichment	POLR2F	1.18
75	Lung cancer	Enrichment	ERCC6	0.98
76	Rare genetic deafness	Enrichment	POLR2F	0.77
77	Inherited cancer-predisposing syndrome	Enrichment	ERCC3	0.57

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RNA Polymerase I Transcription Termination

Pathway Network for RNA Polymerase I Transcription Termination

Pathway network for the RNA Polymerase I Transcription Termination SuperPath

Member Pathways for RNA Polymerase I Transcription Termination

Pathways in the RNA Polymerase I Transcription Termination SuperPath

Gene overlap in member pathways for RNA Polymerase I Transcription Termination SuperPath

Associated Genes for RNA Polymerase I Transcription Termination

Associated Disorders for RNA Polymerase I Transcription Termination

Disorders associated with RNA Polymerase I Transcription Termination SuperPath

STRING Interaction Network for RNA Polymerase I Transcription Termination

Sources for RNA Polymerase I Transcription Termination