RNA Polymerase III Transcription Initiation

Pathway network for the RNA Polymerase III Transcription Initiation SuperPath

Sources:

Reactome
QIAGEN

Pathways in the RNA Polymerase III Transcription Initiation SuperPath

#	Name	Source	Genes
1	RNA Polymerase III Transcription Initiation	Reactome	BDP1 BRF1 BRF2 CRCP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 TBP ZNF143 (see all 36) (see less)
2	RNA Polymerase III Abortive And Retractive Initiation	Reactome	BDP1 BRF1 BRF2 CRCP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 NFIA NFIB NFIC NFIX POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SSB TBP ZNF143 (see all 41) (see less)
3	RNA Polymerase III Transcription	Reactome	BDP1 BRF1 BRF2 CRCP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 NFIA NFIB NFIC NFIX POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SSB TBP ZNF143 (see all 41) (see less)
4	RNA Polymerase III Transcription Initiation From Type 3 Promoter	Reactome	BDP1 BRF2 CRCP POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POU2F1 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 TBP ZNF143 (see all 28) (see less)
5	RNA Polymerase III Transcription Initiation From Type 1 Promoter	Reactome	BDP1 BRF1 CRCP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K TBP (see all 28) (see less)
6	RNA Polymerase III Transcription Initiation From Type 2 Promoter	Reactome	BDP1 BRF1 CRCP GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K TBP (see all 27) (see less)
7	RNA Polymerase III Transcription Termination	Reactome	CRCP NFIA NFIB NFIC NFIX POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K SSB (see all 23) (see less)
8	Transcription of tRNA	QIAGEN	BDP1 BRF1 BRF2 GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 POLR3A POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K TBP TSEN2 TSEN34 (see all 20) (see less)
9	Assembly of RNA Polymerase-III Initiation Complex	QIAGEN	BDP1 BRF1 BRF2 GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 POLR3A POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K TBP (see all 19) (see less)
10	RNA Polymerase III Chain Elongation	Reactome	CRCP POLR1C POLR1D POLR2E POLR2F POLR2H POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K (see all 18) (see less)

Gene overlap in member pathways for RNA Polymerase III Transcription Initiation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	POLR3F	RNA Polymerase III Subunit F	Protein Coding	10
2	POLR3G	RNA Polymerase III Subunit G	Protein Coding	10
3	POLR3C	RNA Polymerase III Subunit C	Protein Coding	10
4	POLR3A	RNA Polymerase III Subunit A	Protein Coding	10
5	POLR3H	RNA Polymerase III Subunit H	Protein Coding	10
6	POLR3K	RNA Polymerase III Subunit K	Protein Coding	10
7	POLR3E	RNA Polymerase III Subunit E	Protein Coding	10
8	POLR3D	RNA Polymerase III Subunit D	Protein Coding	10
9	POLR3GL	RNA Polymerase III Subunit GL	Protein Coding	10
10	CRCP	CGRP Receptor Component	Protein Coding	8
11	POLR1D	RNA Polymerase I And III Subunit D	Protein Coding	8
12	POLR2E	RNA Polymerase II, I And III Subunit E	Protein Coding	8
13	POLR2F	RNA Polymerase II, I And III Subunit F	Protein Coding	8
14	POLR2H	RNA Polymerase II, I And III Subunit H	Protein Coding	8
15	POLR2K	RNA Polymerase II, I And III Subunit K	Protein Coding	8
16	POLR2L	RNA Polymerase II, I And III Subunit L	Protein Coding	8
17	POLR3B	RNA Polymerase III Subunit B	Protein Coding	8
18	BDP1	BDP1 General Transcription Factor IIIB Subunit	Protein Coding	8
19	TBP	TATA-Box Binding Protein	Protein Coding	8
20	POLR1C	RNA Polymerase I And III Subunit C	Protein Coding	8
21	BRF1	BRF1 General Transcription Factor IIIB Subunit	Protein Coding	7
22	GTF3C1	General Transcription Factor IIIC Subunit 1	Protein Coding	7
23	GTF3C2	General Transcription Factor IIIC Subunit 2	Protein Coding	7
24	GTF3C5	General Transcription Factor IIIC Subunit 5	Protein Coding	7
25	GTF3C4	General Transcription Factor IIIC Subunit 4	Protein Coding	7
26	GTF3C3	General Transcription Factor IIIC Subunit 3	Protein Coding	7
27	BRF2	BRF2 General Transcription Factor IIIB Subunit	Protein Coding	6
28	GTF3C6	General Transcription Factor IIIC Subunit 6	Protein Coding	5
29	GTF3A	General Transcription Factor IIIA	Protein Coding	5
30	SNAPC5	Small Nuclear RNA Activating Complex Polypeptide 5	Protein Coding	4
31	POU2F1	POU Class 2 Homeobox 1	Protein Coding	4
32	SNAPC1	Small Nuclear RNA Activating Complex Polypeptide 1	Protein Coding	4
33	SNAPC2	Small Nuclear RNA Activating Complex Polypeptide 2	Protein Coding	4
34	SNAPC3	Small Nuclear RNA Activating Complex Polypeptide 3	Protein Coding	4
35	SNAPC4	Small Nuclear RNA Activating Complex Polypeptide 4	Protein Coding	4
36	ZNF143	Zinc Finger Protein 143	Protein Coding	4
37	NFIA	Nuclear Factor I A	Protein Coding	3
38	NFIB	Nuclear Factor I B	Protein Coding	3
39	NFIC	Nuclear Factor I C	Protein Coding	3
40	NFIX	Nuclear Factor I X	Protein Coding	3
41	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	3
42	TSEN34	TRNA Splicing Endonuclease Subunit 34	Protein Coding	1
43	TSEN2	TRNA Splicing Endonuclease Subunit 2	Protein Coding	1

Disorders associated with RNA Polymerase III Transcription Initiation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR1C, POLR3A, POLR3B	7.71
2	Polr3-related leukodystrophy	Enrichment	POLR3A, POLR3B	5.30
3	Hypomyelinating leukodystrophy 7	Enrichment	POLR3A, POLR3B	5.00
4	Treacher collins syndrome 1	Enrichment	POLR1C, POLR1D	4.46
5	Pontocerebellar hypoplasia, type 2e	Enrichment	TSEN2, TSEN34	4.36
6	Leukodystrophy	Enrichment	POLR3A, POLR3B	3.51
7	Immunodeficiency 101	Enrichment	POLR3F	2.88
8	Leukodystrophy, hypomyelinating, 21	Enrichment	POLR3K	2.88
9	Treacher collins syndrome 2	Enrichment	POLR1D	2.88
10	Odontoleukodystrophy	Enrichment	POLR3A	2.88
11	Cerebellofaciodental syndrome	Enrichment	BRF1	2.85
12	Neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures	Enrichment	GTF3C3	2.85
13	Deafness, autosomal recessive 112	Enrichment	BDP1	2.85
14	Inner ear disease	Enrichment	BRF1	2.85
15	Pontocerebellar hypoplasia, type 2b	Enrichment	TSEN2	2.83
16	Pontocerebellar hypoplasia, type 2c	Enrichment	TSEN34	2.83
17	Macrocephaly, acquired, with impaired intellectual development	Enrichment	NFIB	2.77
18	Marshall-smith syndrome	Enrichment	NFIX	2.77
19	Malan syndrome	Enrichment	NFIX	2.77
20	Brain malformations with or without urinary tract defects	Enrichment	NFIA	2.77
21	19p13.3 microduplication syndrome	Enrichment	NFIX	2.77
22	Sotos syndrome 2	Enrichment	NFIX	2.77
23	Bilateral polymicrogyria	Enrichment	NFIA	2.77
24	Neurodevelopmental disorder with motor regression, progressive spastic paraplegia, and oromotor dysfunction	Enrichment	SNAPC4	2.69
25	Treacher collins syndrome 3	Enrichment	POLR1C	2.58
26	Leukodystrophy, hypomyelinating, 4	Enrichment	POLR3A	2.58
27	Waardenburg syndrome, type 4c	Enrichment	POLR2F	2.58
28	Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism	Enrichment	POLR3B	2.58
29	Leukoencephalopathy, progressive, with ovarian failure	Enrichment	POLR1C	2.58
30	Charcot-marie-tooth disease, demyelinating, type 1i	Enrichment	POLR3B	2.58
31	Short stature, oligodontia, dysmorphic facies, and motor delay	Enrichment	POLR3GL	2.58
32	Leukodystrophy, hypomyelinating, 11	Enrichment	POLR1C	2.58
33	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	POLR2F	2.58
34	Hyperostosis	Enrichment	POLR3GL	2.58
35	Spinocerebellar ataxia 17	Enrichment	TBP	2.55
36	Hemolytic-uremic syndrome	Enrichment	TSEN2	2.53
37	Waardenburg syndrome, type 2a	Enrichment	POLR2F	2.40
38	Wiedemann-rautenstrauch syndrome	Enrichment	POLR3A	2.40
39	Infantile cerebellar-retinal degeneration	Enrichment	POLR3H	2.40
40	Optic atrophy 9	Enrichment	POLR3H	2.40
41	Viss syndrome	Enrichment	POLR3B	2.40
42	Neonatal pseudo-hydrocephalic progeroid syndrome	Enrichment	POLR3A	2.40
43	Glass syndrome	Enrichment	GTF3C3	2.38
44	Laryngomalacia	Enrichment	NFIX	2.29
45	Megalocornea	Enrichment	NFIX	2.29
46	Adenoid cystic carcinoma	Enrichment	NFIB	2.29
47	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	POLR2F	2.18
48	Waardenburg syndrome, type 4a	Enrichment	POLR2F	2.10
49	Waardenburg syndrome	Enrichment	POLR2F	2.10
50	Waardenburg syndrome, type 1	Enrichment	POLR2F	2.03
51	Waardenburg syndrome, type 2e	Enrichment	POLR2F	2.03
52	Movement disease	Enrichment	POLR3A	1.84
53	46 xx gonadal dysgenesis	Enrichment	POLR3H	1.80
54	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	POLR3B	1.73
55	Isolated congenital microcephaly	Enrichment	BRF1	1.65
56	Heart, malformation of	Enrichment	BRF1	1.60
57	Pontocerebellar hypoplasia	Enrichment	TSEN2	1.58
58	Esophageal atresia/tracheoesophageal fistula	Enrichment	GTF3C1	1.58
59	Parkinson's disease	Enrichment	TBP	1.58
60	Cleft palate, isolated	Enrichment	NFIA	1.55
61	Tooth agenesis	Enrichment	POLR3GL	1.54
62	Kallmann syndrome	Enrichment	POLR2F	1.52
63	Parkinson disease, late-onset	Enrichment	TBP	1.48
64	Hirschsprung disease 1	Enrichment	POLR2F	1.42
65	Strabismus	Enrichment	NFIX	1.35
66	Optic atrophy plus syndrome	Enrichment	POLR3H	1.25
67	Sensorineural hearing loss	Enrichment	BRF1	1.19
68	Spastic ataxia	Enrichment	POLR3A	1.17
69	Rare genetic deafness	Enrichment	POLR2F	1.00
70	Colorectal cancer	Enrichment	BRF1	0.94
71	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	BDP1	0.93

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RNA Polymerase III Transcription Initiation

Pathway Network for RNA Polymerase III Transcription Initiation

Pathway network for the RNA Polymerase III Transcription Initiation SuperPath

Member Pathways for RNA Polymerase III Transcription Initiation

Pathways in the RNA Polymerase III Transcription Initiation SuperPath

Gene overlap in member pathways for RNA Polymerase III Transcription Initiation SuperPath

Associated Genes for RNA Polymerase III Transcription Initiation

Associated Disorders for RNA Polymerase III Transcription Initiation

Disorders associated with RNA Polymerase III Transcription Initiation SuperPath

STRING Interaction Network for RNA Polymerase III Transcription Initiation

Sources for RNA Polymerase III Transcription Initiation