RND2 GTPase cycle

Pathway network for the RND2 GTPase cycle SuperPath

Sources:

Reactome

Pathways in the RND2 GTPase cycle SuperPath

#	Name	Source	Genes
1	RND2 GTPase cycle	Reactome	ALDH3A2 ANKRD26 ARHGAP1 ARHGAP35 ARHGAP5 BLTP3B CAV1 CKAP4 DEPDC1B DLG5 DST EPHA2 FAM83B FNBP1 FRS2 FRS3 GOLGA3 KCTD13 KIDINS220 KIF14 KTN1 LEMD3 LRRC1 MUC13 NISCH NUDC PIK3R1 PIK3R2 PKP4 PLXND1 PRAG1 PTPN13 RBMX RND2 SCRIB TFRC TNFAIP1 TXNL1 UBXN11 VANGL1 VANGL2 WDR6 (see all 42) (see less)
2	RND1 GTPase cycle	Reactome	ALDH3A2 ANKRD26 ARHGAP35 ARHGAP5 CAV1 CCDC88A CPD DEPDC1B DLG5 DST EPHA2 EPSTI1 FAM135A FAM83B FRS2 FRS3 GRB7 KIDINS220 KIF14 LEMD3 MUC13 PIK3R1 PIK3R2 PKP4 PLEKHG5 PLXNA1 PTPN13 RASAL2 RBMX RND1 RRAS2 STIP1 STMN2 TFRC TMEM59 TXNL1 UBXN11 VANGL1 VANGL2 WDR6 (see all 40) (see less)
3	RND3 GTPase cycle	Reactome	ANKRD26 ARHGAP21 ARHGAP35 ARHGAP5 CAV1 CCDC88A CKAP4 CKB CPD DDX4 DEPDC1B DLG5 DST EPHA2 FAM83B KCTD13 KTN1 LEMD3 MUC13 NISCH PICALM PIK3R1 PIK3R2 PKP4 PLEKHG5 PTPN13 RASAL2 RBMX RND3 ROCK1 SCRIB SEMA4F TMOD3 TNFAIP1 TXNL1 UBXN11 VANGL1 VANGL2 WDR6 (see all 39) (see less)

Gene overlap in member pathways for RND2 GTPase cycle SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	WDR6	WD Repeat Domain 6	Protein Coding	3
2	EPHA2	EPH Receptor A2	Protein Coding	3
3	FAM83B	Family With Sequence Similarity 83 Member B	Protein Coding	3
4	ANKRD26	Ankyrin Repeat Domain Containing 26	Protein Coding	3
5	LEMD3	LEM Domain Containing 3	Protein Coding	3
6	RBMX	RNA Binding Motif Protein X-Linked	Protein Coding	3
7	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	3
8	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	3
9	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
10	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
11	DEPDC1B	DEP Domain Containing 1B	Protein Coding	3
12	MUC13	Mucin 13, Cell Surface Associated	Protein Coding	3
13	VANGL2	VANGL Planar Cell Polarity Protein 2	Protein Coding	3
14	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	3
15	DST	Dystonin	Protein Coding	3
16	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	3
17	PKP4	Plakophilin 4	Protein Coding	3
18	CAV1	Caveolin 1	Protein Coding	3
19	UBXN11	UBX Domain Protein 11	Protein Coding	3
20	DLG5	Discs Large MAGUK Scaffold Protein 5	Protein Coding	3
21	TXNL1	Thioredoxin Like 1	Protein Coding	3
22	FRS3	Fibroblast Growth Factor Receptor Substrate 3	Protein Coding	2
23	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	2
24	CKAP4	Cytoskeleton Associated Protein 4	Protein Coding	2
25	NISCH	Nischarin	Protein Coding	2
26	ALDH3A2	Aldehyde Dehydrogenase 3 Family Member A2	Protein Coding	2
27	SCRIB	Scribble Planar Cell Polarity Protein	Protein Coding	2
28	KCTD13	Potassium Channel Tetramerization Domain Containing 13	Protein Coding	2
29	KTN1	Kinectin 1	Protein Coding	2
30	KIDINS220	Kinase D Interacting Substrate 220	Protein Coding	2
31	TFRC	Transferrin Receptor	Protein Coding	2
32	TNFAIP1	TNF Alpha Induced Protein 1	Protein Coding	2
33	KIF14	Kinesin Family Member 14	Protein Coding	2
34	CPD	Carboxypeptidase D	Protein Coding	2
35	CCDC88A	Coiled-Coil And HOOK Domain Protein 88A	Protein Coding	2
36	PLEKHG5	Pleckstrin Homology And RhoGEF Domain Containing G5	Protein Coding	2
37	RASAL2	RAS Protein Activator Like 2	Protein Coding	2
38	NUDC	Nuclear Distribution C, Dynein Complex Regulator	Protein Coding	1
39	PRAG1	PEAK1 Related, Kinase-Activating Pseudokinase 1	Protein Coding	1
40	FNBP1	Formin Binding Protein 1	Protein Coding	1
41	BLTP3B	Bridge-Like Lipid Transfer Protein Family Member 3B	Protein Coding	1
42	PLXND1	Plexin D1	Protein Coding	1
43	GOLGA3	Golgin A3	Protein Coding	1
44	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	1
45	LRRC1	Leucine Rich Repeat Containing 1	Protein Coding	1
46	RND2	Rho Family GTPase 2	Protein Coding	1
47	STIP1	Stress Induced Phosphoprotein 1	Protein Coding	1
48	STMN2	Stathmin 2	Protein Coding	1
49	RRAS2	RAS Related 2	Protein Coding	1
50	RND1	Rho Family GTPase 1	Protein Coding	1
51	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	1
52	PLXNA1	Plexin A1	Protein Coding	1
53	FAM135A	Family With Sequence Similarity 135 Member A	Protein Coding	1
54	EPSTI1	Epithelial Stromal Interaction 1	Protein Coding	1
55	TMEM59	Transmembrane Protein 59	Protein Coding	1
56	SEMA4F	Ssemaphorin 4F	Protein Coding	1
57	CKB	Creatine Kinase B	Protein Coding	1
58	TMOD3	Tropomodulin 3	Protein Coding	1
59	RND3	Rho Family GTPase 3	Protein Coding	1
60	DDX4	DEAD-Box Helicase 4	Protein Coding	1
61	ARHGAP21	Rho GTPase Activating Protein 21	Protein Coding	1
62	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
63	PICALM	Phosphatidylinositol Binding Clathrin Assembly Protein	Protein Coding	1

Disorders associated with RND2 GTPase cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neural tube defects	Enrichment	SCRIB, VANGL1, VANGL2	5.21
2	Martsolf syndrome 1	Enrichment	ARHGAP35, ARHGAP5	4.10
3	Buschke-ollendorff syndrome	Enrichment	LEMD3	2.54
4	Intellectual developmental disorder, x-linked, syndromic, gustavson type	Enrichment	RBMX	2.54
5	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.54
6	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.54
7	Thrombocytopenia 2	Enrichment	ANKRD26	2.54
8	Spinal muscular atrophy, facioscapulohumeral type	Enrichment	PLEKHG5	2.54
9	Short syndrome	Enrichment	PIK3R1	2.54
10	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.54
11	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.54
12	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.54
13	Peho-like syndrome	Enrichment	CCDC88A	2.54
14	Melorheostosis with osteopoikilosis	Enrichment	LEMD3	2.54
15	Yuksel-vogel-bauer syndrome	Enrichment	DLG5	2.54
16	Isolated osteopoikilosis	Enrichment	LEMD3	2.54
17	Ventriculomegaly and arthrogryposis	Enrichment	KIDINS220	2.53
18	Immunodeficiency 46	Enrichment	TFRC	2.53
19	Microcephaly 20, primary, autosomal recessive	Enrichment	KIF14	2.53
20	Dworschak-punetha neurodevelopmental syndrome	Enrichment	PLXNA1	2.53
21	Meckel syndrome 12	Enrichment	KIF14	2.53
22	Intellectual developmental disorder, x-linked, syndromic, shashi type	Enrichment	RBMX	2.24
23	Neuronopathy, distal hereditary motor, autosomal recessive 4	Enrichment	PLEKHG5	2.24
24	Charcot-marie-tooth disease, recessive intermediate c	Enrichment	PLEKHG5	2.24
25	Syndromic x-linked intellectual disability shashi type	Enrichment	RBMX	2.24
26	Osteopoikilosis	Enrichment	LEMD3	2.24
27	Isolated anencephaly	Enrichment	VANGL2	2.24
28	12q14 microdeletion syndrome	Enrichment	LEMD3	2.24
29	Isolated exencephaly	Enrichment	VANGL2	2.24
30	Cerebral palsy	Enrichment	ALDH3A2, KIDINS220	2.23
31	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	KIDINS220	2.23
32	Sjogren-larsson syndrome	Enrichment	ALDH3A2	2.23
33	Noonan syndrome 12	Enrichment	RRAS2	2.23
34	Congenital heart defects, multiple types, 9	Enrichment	PLXND1	2.21
35	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.07
36	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.07
37	Epidermolysis bullosa simplex 3, localized or generalized intermediate, with bp230 deficiency	Enrichment	DST	2.07
38	Immunodeficiency 14	Enrichment	PIK3R1	2.07
39	Estrogen resistance	Enrichment	TMEM59	2.05
40	Sacral defect with anterior meningocele	Enrichment	VANGL1	1.94
41	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.94
42	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.94
43	Neuropathy, hereditary sensory and autonomic, type vi	Enrichment	DST	1.94
44	Blood platelet disease	Enrichment	ANKRD26	1.94
45	Trichorhinophalangeal syndrome, type ii	Enrichment	STMN2	1.93
46	Cataract 6, multiple types	Enrichment	EPHA2	1.84
47	Autosomal thrombocytopenia with normal platelets	Enrichment	ANKRD26	1.84
48	Aniridia	Enrichment	EPHA2	1.84
49	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.84
50	Moebius syndrome	Enrichment	PLXND1	1.81
51	Persistent truncus arteriosus	Enrichment	PLXND1	1.81
52	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.77
53	Limited scleroderma	Enrichment	CAV1	1.77
54	Kabuki syndrome 1	Enrichment	KIDINS220	1.76
55	Overgrowth syndrome	Enrichment	PIK3R1	1.70
56	Early-onset posterior polar cataract	Enrichment	EPHA2	1.64
57	Juvenile amyotrophic lateral sclerosis	Enrichment	PLEKHG5	1.59
58	Peters-plus syndrome	Enrichment	ARHGAP35	1.55
59	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.55
60	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.51
61	Combined immunodeficiency	Enrichment	TFRC	1.50
62	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.50
63	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.50
64	Multiple sclerosis	Enrichment	DST	1.40
65	Cataract	Enrichment	EPHA2	1.40
66	Cataract 44	Enrichment	EPHA2	1.32
67	Early-onset nuclear cataract	Enrichment	EPHA2	1.30
68	Arteriovenous malformations of the brain	Enrichment	LEMD3	1.27
69	Precursor t-cell acute lymphoblastic leukemia	Enrichment	PICALM	1.19
70	Noonan syndrome 1	Enrichment	RRAS2	1.18
71	Rasopathy	Enrichment	RRAS2	1.13
72	Primary autosomal recessive microcephaly	Enrichment	KIF14	1.04
73	Leukemia, acute myeloid	Enrichment	PICALM	0.96
74	Charcot-marie-tooth disease	Enrichment	DST	0.95
75	Hereditary spastic paraplegia	Enrichment	PLEKHG5	0.94
76	Thrombocytopenia	Enrichment	ANKRD26	0.89
77	Joubert syndrome 1	Enrichment	KIF14	0.86
78	Body mass index quantitative trait locus 11	Enrichment	NUDC	0.84
79	Myeloma, multiple	Enrichment	PIK3R2	0.83
80	Colorectal cancer	Enrichment	PIK3R1	0.65
81	Ovarian cancer	Enrichment	RRAS2	0.59
82	Complex neurodevelopmental disorder	Enrichment	PLXNA1	0.51

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for RND2 GTPase cycle

Pathway network for the RND2 GTPase cycle SuperPath

Member Pathways for RND2 GTPase cycle

Pathways in the RND2 GTPase cycle SuperPath

Gene overlap in member pathways for RND2 GTPase cycle SuperPath

Associated Genes for RND2 GTPase cycle

Associated Disorders for RND2 GTPase cycle

Disorders associated with RND2 GTPase cycle SuperPath

STRING Interaction Network for RND2 GTPase cycle

Sources for RND2 GTPase cycle