Robo4 and VEGF signaling pathways crosstalk

No Pathway Network information available for Robo4 and VEGF signaling pathways crosstalk

#	Name	Source	Genes
1	Robo4 and VEGF signaling pathways crosstalk	WikiPathways	KDR RAC1 ROBO4 SLIT2 SRC VEGFA (see all 6) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLIT2	Slit Guidance Ligand 2	Protein Coding	1
2	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
3	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
4	RAC1	Rac Family Small GTPase 1	Protein Coding	1
5	ROBO4	Roundabout Guidance Receptor 4	Protein Coding	1
6	KDR	Kinase Insert Domain Receptor	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Aortic valve disease 3	Enrichment	ROBO4	3.35
2	Microvascular complications of diabetes 1	Enrichment	VEGFA	3.35
3	Thrombocytopenia 6	Enrichment	SRC	3.35
4	Tufted angioma of skin	Enrichment	KDR	3.35
5	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.35
6	Angioma, tufted	Enrichment	KDR	3.05
7	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	3.05
8	Hemangioma, capillary infantile	Enrichment	KDR	2.58
9	Myelofibrosis	Enrichment	SRC	2.51
10	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.40
11	Aortic valve disease 1	Enrichment	ROBO4	2.24
12	Diaphragmatic hernia, congenital	Enrichment	ROBO4	2.24
13	Osteoporosis	Enrichment	SRC	2.21
14	Aortic aneurysm, familial thoracic 1	Enrichment	ROBO4	2.21
15	Tetralogy of fallot	Enrichment	KDR	1.94
16	Cakut	Enrichment	SLIT2	1.83
17	Thrombocytopenia	Enrichment	SRC	1.68
18	Primary ovarian insufficiency	Enrichment	KDR	1.59
19	Colorectal cancer	Enrichment	SRC	1.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Robo4 and VEGF signaling pathways crosstalk