Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy

No Pathway Network information available for Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy

Pathways in the Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy SuperPath

#	Name	Source	Genes
1	Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy	WikiPathways	ACAN AKT1 AKT2 AKT3 ARNT CCN2 CEBPB CNMD COL10A1 COL1A1 COL2A1 COL3A1 DDR2 DIO2 EPAS1 FGFR1 FGFR2 FGFR3 FGFR4 FOS FOSB FOSL1 FOSL2 GANC HIF1A IBSP JAK2 JUN JUNB JUND KDR LAMTOR1 MAPK1 MAPK3 MMP13 NFKB1 NGF NTRK1 P4HTM PIK3CA PRKCA RELA RELB RUNX2 SOX9 STAT3 VEGFA VHL (see all 48) (see less)
2	Signalling to STAT3	Reactome	NGF NTRK1 STAT3

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	2
2	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
3	NGF	Nerve Growth Factor	Protein Coding	2
4	CNMD	Chondromodulin	Protein Coding	1
5	P4HTM	Prolyl 4-Hydroxylase, Transmembrane	Protein Coding	1
6	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
7	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
8	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
9	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	1
10	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	1
11	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
12	DDR2	Discoidin Domain Receptor Tyrosine Kinase 2	Protein Coding	1
13	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
14	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
15	GANC	Glucosidase Alpha, Neutral C	Protein Coding	1
16	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
17	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
18	SOX9	SRY-Box Transcription Factor 9	Protein Coding	1
19	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
20	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
21	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
22	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
23	PRKCA	Protein Kinase C Alpha	Protein Coding	1
24	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
25	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
26	MMP13	Matrix Metallopeptidase 13	Protein Coding	1
27	KDR	Kinase Insert Domain Receptor	Protein Coding	1
28	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
29	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
30	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
31	JAK2	Janus Kinase 2	Protein Coding	1
32	IBSP	Integrin Binding Sialoprotein	Protein Coding	1
33	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
34	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
35	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
36	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
37	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
38	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
39	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	1
40	ACAN	Aggrecan	Protein Coding	1
41	DIO2	Iodothyronine Deiodinase 2	Protein Coding	1
42	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
43	COL10A1	Collagen Type X Alpha 1 Chain	Protein Coding	1
44	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	1
45	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	1
46	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
47	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
48	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1

Disorders associated with Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	6.16
2	Multiple enchondromatosis, maffucci type	Enrichment	COL2A1, HIF1A, VHL	5.84
3	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.91
4	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.91
5	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.91
6	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.91
7	Colorectal cancer	Enrichment	AKT1, FGFR2, FGFR3, PIK3CA, SOX9	4.88
8	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.44
9	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.44
10	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.44
11	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA	4.14
12	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	4.14
13	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.91
14	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.91
15	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.91
16	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.74
17	Lung squamous cell carcinoma	Enrichment	FGFR3, PIK3CA	3.74
18	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	EPAS1, VHL	3.74
19	Connective tissue disease	Enrichment	COL2A1, FGFR3, SOX9	3.72
20	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.66
21	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.66
22	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.66
23	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.66
24	Nevus, epidermal	Enrichment	FGFR3, PIK3CA	3.59
25	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.36
26	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	3.35
27	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	3.35
28	Primary bone dysplasia	Enrichment	COL1A1, FGFR3	3.27
29	Osteochondrodysplasia	Enrichment	COL1A1, FGFR3	3.18
30	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	3.18
31	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	3.18
32	Hyper ige syndrome	Enrichment	STAT3	3.18
33	Meningioma	Enrichment	AKT1, PIK3CA	3.10
34	Hypertelorism	Enrichment	COL1A1, FGFR2, PIK3CA	3.09
35	Primary ovarian insufficiency	Enrichment	JAK2, KDR, NTRK1	2.93
36	Gliosarcoma	Enrichment	FGFR1, FGFR3	2.85
37	Giant cell glioblastoma	Enrichment	FGFR1, FGFR3	2.79
38	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.75
39	Heart, malformation of	Enrichment	COL2A1, MAPK1	2.74
40	Ehlers-danlos syndrome	Enrichment	COL1A1, COL3A1	2.70
41	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.65
42	Breast cancer	Enrichment	AKT1, JUN, PIK3CA	2.63
43	Endometrial cancer	Enrichment	FGFR2, PIK3CA	2.61
44	Acute promyelocytic leukemia	Enrichment	STAT3	2.54
45	Stickler syndrome, type i	Enrichment	COL2A1	2.45
46	Short stature and advanced bone age with or without early-onset osteoarthritis and/or osteochondritis dissecans	Enrichment	ACAN	2.45
47	Hypochondroplasia	Enrichment	FGFR3	2.45
48	Macrodactyly	Enrichment	PIK3CA	2.45
49	Proteus syndrome	Enrichment	AKT1	2.45
50	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.45
51	Osteoglophonic dysplasia	Enrichment	FGFR1	2.45
52	Epiphyseal dysplasia, multiple, with myopia and conductive deafness	Enrichment	COL2A1	2.45
53	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.45
54	Trigonocephaly 1	Enrichment	FGFR1	2.45
55	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.45
56	Spondylometaphyseal dysplasia, algerian type	Enrichment	COL2A1	2.45
57	Muenke syndrome	Enrichment	FGFR3	2.45
58	Osteoarthritis with mild chondrodysplasia	Enrichment	COL2A1	2.45
59	Avascular necrosis of femoral head, primary, 1	Enrichment	COL2A1	2.45
60	Czech dysplasia	Enrichment	COL2A1	2.45
61	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.45
62	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.45
63	Kniest dysplasia	Enrichment	COL2A1	2.45
64	Apert syndrome	Enrichment	FGFR2	2.45
65	Platyspondylic lethal skeletal dysplasia, torrance type	Enrichment	COL2A1	2.45
66	Cowden syndrome 5	Enrichment	PIK3CA	2.45
67	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.45
68	Spondyloepiphyseal dysplasia, stanescu type	Enrichment	COL2A1	2.45
69	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.45
70	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.45
71	Acrogeria, gottron type	Enrichment	COL3A1	2.45
72	Achondrogenesis, type ii	Enrichment	COL2A1	2.45
73	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.45
74	Noonan syndrome 13	Enrichment	MAPK1	2.45
75	46,xy sex reversal 10	Enrichment	SOX9	2.45
76	Hypotonia, hypoventilation, impaired intellectual development, dysautonomia, epilepsy, and eye abnormalities	Enrichment	P4HTM	2.45
77	46,xx sex reversal 2	Enrichment	SOX9	2.45
78	Spondyloperipheral dysplasia	Enrichment	COL2A1	2.45
79	Spondylometaepiphyseal dysplasia, short limb-hand type	Enrichment	DDR2	2.45
80	Spondyloepimetaphyseal dysplasia, aggrecan type	Enrichment	ACAN	2.45
81	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.45
82	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.45
83	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.45
84	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.45
85	Spondyloepiphyseal dysplasia, kimberley type	Enrichment	ACAN	2.45
86	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.45
87	Stickler syndrome, type i, nonsyndromic ocular	Enrichment	COL2A1	2.45
88	Erythrocytosis, familial, 4	Enrichment	EPAS1	2.45
89	Cowden syndrome 6	Enrichment	AKT1	2.45
90	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.45
91	Hartsfield syndrome	Enrichment	FGFR1	2.45
92	Immunodeficiency 53	Enrichment	RELB	2.45
93	Warburg-cinotti syndrome	Enrichment	DDR2	2.45
94	Vitreoretinopathy with phalangeal epiphyseal dysplasia	Enrichment	COL2A1	2.45
95	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.45
96	Tufted angioma of skin	Enrichment	KDR	2.45
97	Asphyxia neonatorum	Enrichment	COL1A1	2.45
98	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.45
99	Hypospadias	Enrichment	PIK3CA	2.45
100	Capillary hemangioma	Enrichment	AKT3	2.45
101	Multiple paragangliomas associated with polycythemia	Enrichment	EPAS1	2.45
102	Autosomal dominant rhegmatogenous retinal detachment	Enrichment	COL2A1	2.45
103	Rare venous malformation	Enrichment	PIK3CA	2.45
104	Multiple epiphyseal dysplasia with myopia and deafness	Enrichment	COL2A1	2.45
105	Diaphragmatic eventration	Enrichment	PIK3CA	2.45
106	Hypochondrogenesis	Enrichment	COL2A1	2.45
107	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.45
108	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.45
109	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.45
110	Osteochondritis dissecans	Enrichment	ACAN	2.45
111	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.45
112	Dysspondyloenchondromatosis	Enrichment	COL2A1	2.45
113	Rare combined vascular malformation	Enrichment	PIK3CA	2.45
114	Abdominal aortic aneurysm	Enrichment	COL3A1	2.45
115	Cavernous lymphangioma	Enrichment	PIK3CA	2.45
116	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.45
117	Type 2 collagen-related bone disorder	Enrichment	COL2A1	2.45
118	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.45
119	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.45
120	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.45
121	Short stature-advanced bone age-early-onset osteoarthritis syndrome	Enrichment	ACAN	2.45
122	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.45
123	Macrodactyly of toe	Enrichment	PIK3CA	2.45
124	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.45
125	Retinal hemangioblastoma	Enrichment	VHL	2.45
126	Diffuse large b-cell lymphoma	Enrichment	STAT3	2.38
127	Bladder cancer	Enrichment	FGFR3, PIK3CA	2.33
128	Ovarian cancer	Enrichment	AKT1, NTRK1, PIK3CA	2.26
129	Differentiated thyroid carcinoma	Enrichment	NTRK1	2.19
130	Peripheral nervous system disease	Enrichment	NGF	2.15
131	Neuropathy	Enrichment	NGF	2.15
132	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.15
133	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.15
134	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.15
135	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.15
136	Metaphyseal chondrodysplasia, schmid type	Enrichment	COL10A1	2.15
137	Campomelic dysplasia	Enrichment	SOX9	2.15
138	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	COL2A1	2.15
139	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	COL2A1	2.15
140	Metaphyseal dysplasia, spahr type	Enrichment	MMP13	2.15
141	Otospondylomegaepiphyseal dysplasia, autosomal recessive	Enrichment	COL2A1	2.15
142	Kyphomelic dysplasia	Enrichment	CCN2	2.15
143	Spondyloepimetaphyseal dysplasia, missouri type	Enrichment	MMP13	2.15
144	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.15
145	Cervical cancer	Enrichment	FGFR3	2.15
146	Aural atresia, congenital	Enrichment	FGFR2	2.15
147	Legg-calve-perthes disease	Enrichment	COL2A1	2.15
148	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.15
149	Angioma, tufted	Enrichment	KDR	2.15
150	Otospondylomegaepiphyseal dysplasia, autosomal dominant	Enrichment	COL2A1	2.15
151	Noonan syndrome 8	Enrichment	PIK3CA	2.15
152	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.15
153	Thrombocythemia 3	Enrichment	JAK2	2.15
154	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.15
155	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.15
156	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.15
157	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1	2.15
158	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.15
159	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.15
160	Rela fusion-positive ependymoma	Enrichment	RELA	2.15
161	Aortic dissection	Enrichment	COL3A1	2.15
162	Senior-loken syndrome 7	Enrichment	AKT3	2.15
163	Split hand-foot malformation	Enrichment	FGFR2	2.15
164	Erythrocytosis, familial, 3	Enrichment	EPAS1	2.15
165	Stickler syndrome, type ii	Enrichment	COL1A1	2.15
166	Familial avascular necrosis of the femoral head	Enrichment	COL2A1	2.15
167	Cervix carcinoma	Enrichment	FGFR3	2.15
168	Bardet-biedl syndrome 16	Enrichment	AKT3	2.15
169	Polycythemia	Enrichment	JAK2	2.15
170	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.15
171	Metaphyseal anadysplasia	Enrichment	MMP13	2.15
172	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1	2.15
173	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.15
174	Hypereosinophilic syndrome	Enrichment	JAK2	2.15
175	Acute leukemia of ambiguous lineage	Enrichment	VHL	2.15
176	Common variable immunodeficiency 12	Enrichment	NFKB1	2.15
177	Campomelic dysplasia and related disorders	Enrichment	SOX9	2.15
178	Gastric cancer	Enrichment	FGFR2, PIK3CA	2.00
179	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, COL3A1	1.98
180	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.98
181	Cleidocranial dysplasia 1	Enrichment	RUNX2	1.98
182	Achondroplasia	Enrichment	FGFR3	1.98
183	Mccune-albright syndrome	Enrichment	COL2A1	1.98
184	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.98
185	Larsen syndrome	Enrichment	FGFR3	1.98
186	Spondyloepiphyseal dysplasia congenita	Enrichment	COL2A1	1.98
187	Polycythemia vera	Enrichment	JAK2	1.98
188	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.98
189	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	VHL	1.98
190	46,xx sex reversal 1	Enrichment	SOX9	1.98
191	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	1.98
192	Caffey disease	Enrichment	COL1A1	1.98
193	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.98
194	Primary polycythemia	Enrichment	VHL	1.98
195	Hamartoma	Enrichment	FGFR3	1.98
196	Testicular germ cell cancer	Enrichment	FGFR3	1.98
197	Cleidocranial dysplasia	Enrichment	RUNX2	1.98
198	Spermatocytoma	Enrichment	FGFR3	1.98
199	High bone mass osteogenesis imperfecta	Enrichment	COL1A1	1.98
200	Enchondromatosis	Enrichment	HIF1A	1.98
201	Multiple epiphyseal dysplasia	Enrichment	COL2A1	1.98
202	Testicular cancer	Enrichment	FGFR3	1.98
203	Keratoacanthoma	Enrichment	PIK3CA	1.98
204	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1	1.85
205	Erythrocytosis, familial, 1	Enrichment	JAK2	1.85
206	Phenylketonuria	Enrichment	COL1A1	1.85
207	Erythrocytosis, familial, 2	Enrichment	VHL	1.85
208	Budd-chiari syndrome	Enrichment	JAK2	1.85
209	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.85
210	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.85
211	Au-kline syndrome	Enrichment	VHL	1.85
212	Congenital generalized lipodystrophy	Enrichment	FOS	1.85
213	Cerebrovascular disease	Enrichment	PIK3CA	1.85
214	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.85
215	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1	1.85
216	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.85
217	Glioma	Enrichment	FGFR2	1.85
218	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.85
219	Capillary malformations, congenital	Enrichment	PIK3CA	1.76
220	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.76
221	Retinal detachment	Enrichment	COL2A1	1.76
222	Fanconi anemia, complementation group d2	Enrichment	VHL	1.76
223	Von hippel-lindau syndrome	Enrichment	VHL	1.76
224	Myeloproliferative neoplasm	Enrichment	JAK2	1.76
225	Holoprosencephaly	Enrichment	FGFR1	1.76
226	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SOX9	1.76
227	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	1.76
228	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.76
229	Familial cerebral saccular aneurysm	Enrichment	COL3A1	1.76
230	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1	1.68
231	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	ACAN	1.68
232	Developmental dysplasia of the hip 1	Enrichment	COL2A1	1.68
233	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.68
234	Osteogenesis imperfecta, type i	Enrichment	COL1A1	1.68
235	Cowden syndrome 1	Enrichment	PIK3CA	1.68
236	Split-hand/foot malformation 1	Enrichment	FGFR2	1.68
237	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.68
238	Pierre robin syndrome	Enrichment	SOX9	1.68
239	Holoprosencephaly 1	Enrichment	FGFR1	1.68
240	Testicular germ cell tumor	Enrichment	FGFR3	1.68
241	Hemangioma, capillary infantile	Enrichment	KDR	1.68
242	Keratoconus	Enrichment	COL1A1	1.68
243	Limited scleroderma	Enrichment	CCN2	1.68
244	Classic ehlers-danlos syndrome	Enrichment	COL1A1	1.68
245	46,xy disorder of sex development	Enrichment	FGFR3	1.68
246	Autosomal dominant secondary polycythemia	Enrichment	EPAS1	1.68
247	Osteogenesis imperfecta, type ii	Enrichment	COL1A1	1.61
248	Myelofibrosis	Enrichment	JAK2	1.61
249	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.61
250	Renal cell carcinoma, papillary, 1	Enrichment	VHL	1.61
251	Essential thrombocythemia	Enrichment	JAK2	1.61
252	Gallbladder cancer	Enrichment	PIK3CA	1.61
253	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.61
254	Megacolon	Enrichment	AKT3	1.61
255	Common variable immunodeficiency	Enrichment	NFKB1	1.61
256	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1	1.55
257	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.50
258	Arteriovenous malformation	Enrichment	PIK3CA	1.50
259	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.50
260	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.50
261	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1	1.50
262	Marfan syndrome	Enrichment	COL2A1	1.46
263	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.46
264	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.46
265	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.46
266	Stickler syndrome	Enrichment	COL2A1	1.46
267	Polymicrogyria	Enrichment	AKT3	1.46
268	46,xy complete gonadal dysgenesis	Enrichment	SOX9	1.42
269	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.42
270	Specific learning disability	Enrichment	MAPK1	1.42
271	Septooptic dysplasia	Enrichment	FGFR1	1.38
272	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.38
273	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.38
274	Osteogenesis imperfecta, type iv	Enrichment	COL1A1	1.35
275	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.31
276	Osteoporosis	Enrichment	COL1A1	1.31
277	Pheochromocytoma	Enrichment	VHL	1.31
278	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1	1.31
279	46,xy partial gonadal dysgenesis	Enrichment	SOX9	1.31
280	Renal cell carcinoma, nonpapillary	Enrichment	VHL	1.29
281	Osteogenesis imperfecta, type iii	Enrichment	COL1A1	1.29
282	Hydrocephalus	Enrichment	FGFR2	1.29
283	Myopia	Enrichment	COL2A1	1.29
284	Lynch syndrome	Enrichment	PIK3CA	1.29
285	Microform holoprosencephaly	Enrichment	FGFR1	1.26
286	Lobar holoprosencephaly	Enrichment	FGFR1	1.26
287	Semilobar holoprosencephaly	Enrichment	FGFR1	1.21
288	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.21
289	Hepatoblastoma	Enrichment	FGFR3	1.14
290	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	VHL	1.14
291	Hepatocellular carcinoma	Enrichment	PIK3CA	1.12
292	Tooth agenesis	Enrichment	FGFR1	1.12
293	Brittle bone disorder	Enrichment	COL1A1	1.11
294	Kallmann syndrome	Enrichment	FGFR1	1.11
295	Scoliosis	Enrichment	COL2A1	1.09
296	Tetralogy of fallot	Enrichment	KDR	1.05
297	Prostate cancer	Enrichment	PIK3CA	1.01
298	Stargardt disease 1	Enrichment	COL2A1	1.00
299	Lung cancer	Enrichment	PIK3CA	0.97
300	Fanconi anemia, complementation group a	Enrichment	VHL	0.93
301	Leukemia, acute myeloid	Enrichment	JAK2	0.88
302	Type 2 diabetes mellitus	Enrichment	AKT2	0.86
303	Nephrotic syndrome	Enrichment	RUNX2	0.85
304	Myeloma, multiple	Enrichment	FGFR3	0.74
305	Congenital nervous system abnormality	Enrichment	FGFR3	0.50
306	Nervous system disease	Enrichment	FGFR3	0.50
307	Microcephaly	Enrichment	MAPK1	0.45
308	Inherited cancer-predisposing syndrome	Enrichment	VHL	0.43
309	Hereditary retinal dystrophy	Enrichment	COL2A1	0.19
310	Fundus dystrophy	Enrichment	COL2A1	0.19

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Role of hypoxia, angiogenesis, and FGF pathway in OA chondrocyte hypertrophy

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